• Title/Summary/Keyword: Feasibility studies

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Formulation and Pharmaceutical Properties of Transdermal Patch of Flurbiprofen (플루비프로펜 함유 경피 패취제의 제제설계 및 약제학적 성질)

  • 이계주;고유현;우종수;황성주
    • YAKHAK HOEJI
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    • v.43 no.4
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    • pp.447-457
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    • 1999
  • The purpose of this study is to prepare the adhesive type patch containing flurbiprofen, and to demonstrate the feasibility of flurbiprofen administration through the intact skin using adhesive type patch preparation. For this purpose, two pressure sensitive adhesives, Polyisobutylene(PIB) and $Gelva^{\circledR}737$, were selected from the chemical grade of polymers, and the adhesive type patches of flurbiprofen were prepared. The release rate of flurbiprofen from the PIB-based adhesive patch was higher than that from $Gelva^{\circledR}737$ based adhesive patch. The release rate of flurbiprofen from the PIB-based A-type patch with 1.0mm, 1.5mm or 2.0mm thicknesses followed the first order kinetics. In the skin permeation study, using male hairless mouse skin, a monophasic skin permeation profile was observed with 1% flurbiprofen loading dose. The inclusion of palmitic acid or SLS(0.25~0.5%) as an enhancer produced a remarkable enhancement in the skin permeation rate of flurbiprofen, and the percentile ratio of drug and enhancer appeared to be important for the effective enhancement. In the in vivo percutaneous absorption study, the plasma concentration of the optimal formulation was significantly (p<0.01) higher than that of the conventional cataplasma ($Bifen^{\circledR}$). These studies demonstrate a good feasibility of flurbiprofen administration through the intact skin using a transdermal patch, and show a possibility of the development of flurbiprofen patches.

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Health-enhancing Physical Activity Guidelines for Koreans: the Status and Directions for Revision (국민 건강증진을 위한 신체활동 지침)

  • Kim, Wan-Soo
    • Korean Journal of Health Education and Promotion
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    • v.26 no.2
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    • pp.103-117
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    • 2009
  • Objectives: There have been no specific as well as evidence-based physical activity guidelines issued on the governmental level. There just have been physical activity recommendations and guidelines released from governmental agencies or organizations as well as individual researchers and these are not consistent, thereby giving the public and even some professionals quite a confusion. As such, this study was aimed to suggest key factors to include when issuing national physical activity recommendations for Koreans. Methods: Since chronological evolution of modern physical activity recommendations reflects key factors to consider when establishing those recommendations and guidelines, that released for several decades was reviewed. Results: The evolution was found to be based on the basis of strong evidence from both epidemiological and exercise physiology studies and the key concepts of such evolution were feasibility, efficacy, and safety. Conclusion: On the basis of three key factors found in the review process, this study concluded that the upcoming national physical activity guidelines should include the following to maximize the outcomes of the efforts which have long been put by the division of physical activity under the 'New Health Plan 2010'. First, guidelines for achieving health benefits (ie, preventing chronic diseases such as cardiovascular disease, diabetes, and cancers or weight management) as well as improving cardiorespiratory fitness should be included to enhance efficacy. Second, safety measures should be included to enhance safety. Third, various alternative forms of physical activity should be included to enhance feasibility.

A study on the necessity and feasibility of Recreational Fishing license System in Korea (낚시면허제 도입의 필요성과 실현 가능성에 대한 고찰)

  • 이광남
    • The Journal of Fisheries Business Administration
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    • v.34 no.1
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    • pp.115-136
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    • 2003
  • As of late, people who enjoy fishing as a pastime in Korea has dramatically increased on the back of the increased national income and 5-day working system being in place. In the past, people used to fish in inland waters, but fishing on the sea has also shown a steady increase. The expanded fishing community along with increasing types of fishing, however, led to destruction of ecosystem by littering the waters of both inland and sea with wastes and reckless exploitation of fish resources. Fishing activities are usually taking place in inland waters, or on the sea, which is, by definition, a common property, and side effects such as free riding and diseconomy are frequently observed occurring. In other words, everyone can use the property free of charge(except paying fishing lot), and littering the waters with pollutants and wastes stemming from fishing activities is currently rampant. In this context, this paper studies the necessity of introducing fishing license system and its feasibility in Korea from a perspective to improve the national welfare through policy measures based on 'polluter pays principle' to prevent further environmental pollution in the fishing lot and preserve fishery resources. Study shows that introduction of Recreational fishing license system is urgently needed, but it is concluded that it should take more time to implement the system so as to accomodate the differing interests of all parties involved including recreational fishing industry, while strengthening public relation activities to solicit for the people's understanding of the system to be introduced.

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Development and Feasibility of a Video Recording-Based Standardized Handoff Program for Ward Nurses: A pilot study (비디오 녹화 기반 병동 간호 인수인계 프로그램 개발 및 적용가능성 : 예비연구)

  • Seo, Eun Koung;Kim, Sun-Hee;Son, Youn-Jung
    • Journal of Korean Critical Care Nursing
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    • v.11 no.3
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    • pp.71-84
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    • 2018
  • Purpose : This study develop a Video Recording-Based Standardized Handoff (VRSH) program at shift change for ward nurses. Methods : The study was conducted in five medical, three surgical, and one comprehensive nursing care service wards affiliated with a secondary general hospital. In this methodological study, the VRSH program was developed between April and December, 2017. It is noted that 65 nurses who were involved in the VRSH program participated in this study. Results : In line with the modified Situation, Background, Assessment, Recommendation tool, the VRSH program consisted of three phases. In the VRSH program, the average time for handoff duration was 3-5 minutes per patient. More than 90% of the ward nurses were satisfied with the VRSH program since it benefited them by reducing overtime work and improving the performance, as well as effective communication, of nurses. The content analysis of nurses' VRSH program experience, revealed three categories and eight sub-categories. Conclusions : This study provides evidence that the VRSH program improves effective nursing performance and, the handoff communication and relationships between nurses. Future studies on large sample sizes and multiple settings are required to substantially evaluate the impact of the VRSH program on clinical outcomes.

Integrated vibration control and health monitoring of building structures: a time-domain approach

  • Chen, B.;Xu, Y.L.;Zhao, X.
    • Smart Structures and Systems
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    • v.6 no.7
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    • pp.811-833
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    • 2010
  • Vibration control and health monitoring of building structures have been actively investigated in recent years but treated separately according to the primary objective pursued. This paper presents a general approach in the time domain for integrating vibration control and health monitoring of a building structure to accommodate various types of control devices and on-line damage detection. The concept of the time-domain approach for integrated vibration control and health monitoring is first introduced. A parameter identification scheme is then developed to identify structural stiffness parameters and update the structural analytical model. Based on the updated analytical model, vibration control of the building using semi-active friction dampers against earthquake excitation is carried out. By assuming that the building suffers certain damage after extreme event or long service and by using the previously identified original structural parameters, a damage detection scheme is finally proposed and used for damage detection. The feasibility of the proposed approach is demonstrated through detailed numerical examples and extensive parameter studies.

Pain Assessment using CRIES, FLACC and PIPP in High-Risk Infants (CRIES, FLACC, PIPP를 이용한 고위험영아의 통증사정)

  • Ahn, Young-Mee;Kang, Hee-Ok;Shin, Eun-Jin
    • Journal of Korean Academy of Nursing
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    • v.35 no.7
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    • pp.1401-1409
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    • 2005
  • Purpose: Infants at neonatal intensive care units (NICU) are invariably exposed to various procedural and environmental stimuli. The study was performed to compare the pain responses in three NICU stimulants and to examine the clinical feasibility for NICU infants using CRIES, FLACC and PIPP. Method: In a correlational study, a total of 94 NICU stimulants including angio-catheter insertions, trunk-rubbings and loud noises, was observed for pain responses among 64 infants using CRIES, FLACC and PIPP. Results: A significant difference was identified among the mean scores in CRIES($F_{(2, 91)}$=47.847, p=.000), FLACC($F_{(2, 91)}$=41.249, p=.000) and PIPP($F_{(2. 91)}$=16.272, p=.000) to three stimulants. In a Post-hoc Scheff test, an angio-catheter insertion showed the highest scores in CRIES, FLACC and PIPP compared to the other two stimulations. A strong correlation was identified between CRIES and FLACC in all three stimulations(.817 < r < .945) while inconsistent findings were identified between PIPP and CRIES or FLACC. Conclusions: The results of the study support that CRIES and FLACC are reliable and clinically suitable pain measurements for NICU infants. Further studies are needed in data collection time-point as well as clinical feasibility on PIPP administration to assess pain response in infants, including premature infants.

Economic Analysis of High-tech Glass Greenhouse through the Convergence of New Renewable Energy -Focusing on the Convergence of Geothermal and Solar Power- (신.재생에너지 융합을 통한 첨단 유리온실의 경제성 분석 -지열과 태양광 융합을 중심으로-)

  • Chung, Jong-Hwa;Yoon, Sung-Yi
    • Korean Journal of Organic Agriculture
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    • v.22 no.4
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    • pp.593-610
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    • 2014
  • The whole world concentrates on the reduction of greenhouse gas to effectively cope with policy toward global climate change. To effectively react to climate change, even the agricultural sector requires construction of new farming systems that utilizes new and renewable energy because of rising oil prices and regulations for greenhouse gas emissions. For this reason, we need to fuse the new and renewable energy with the horticulture sector of which the light and heat energy cost accounts for great part, moreover, efforts and researches should me done which can increase income of farmers through reducing carbon dioxide and energy cost in agricultural production expenses. Therefore, this study analyzes economic feasibility and applicability of fusing geothermal heat pump and solar power facilities with high-tech glass greenhouse. As a result, it is concluded that there surely are an applicability and economic feasibility if we apply new development system that can be an alternative for problems of securing premises of existing geothermal heat pump and the RPS system as a power generation company in case of solar power. Therefore, using this analysis data, if new empirical studies fusing and implementing agriculture sector with new and renewable energy fields proliferate and be applied to actual rural and agricultural field, it will increase actual income and will become a new advanced agricultural system that effectively deals with world-wide environmental problems.

Legislation feasibility studies for expanding the business scope of paramedics: Focused on high level task in importance, need and allowance (응급구조사 업무범위 확대를 위한 입법 타당성 연구 : 중요도와 필요도 및 허용도가 높은 업무를 중심으로)

  • Han, Song-Yi;Ji, Hyun-Kyung;Yoon, Seong-Woo;Lee, Chang-Hee
    • The Korean Journal of Emergency Medical Services
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    • v.19 no.3
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    • pp.117-138
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    • 2015
  • Purpose: This study was performed targeted to paramedic and doctors, to examine the frequency, importance, and admissibility of the tasks of paramedics, and to establish as a basis for expanding their business scope. Methods: The subjects were 282 paramedics and 58 doctors, and the study was performed from October 20 to November 19, 2014. The statistical analysis was done by using SPSS/WIN 20.0. Results: The results showed the difference between the legal business scope of paramedics and the actually performed work. The frequently covered areas were trauma, cardiac arrest, and respiratory care; however, severity classifications were the most important. Concerning drug administration, epinephrine administration seemed to be the most necessary. Conclusions: The findings of this study can be used as basic data to broaden the capacity building and business scope of paramedics. Furthermore, to increase the resuscitation rate of emergency patients, the various tasks of paramedics must be incorporated, and these should be supported by laws and institutions.

A novel low-profile flow sensor for monitoring of hemodynamics in cerebral aneurysm

  • Chen, Yanfei;Jankowitz, Brian T.;Cho, Sung Kwon;Yeo, Woon-Hong;Chun, Youngjae
    • Biomaterials and Biomechanics in Bioengineering
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    • v.2 no.2
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    • pp.71-84
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    • 2015
  • A low-profile flow sensor has been designed, fabricated, and characterized to demonstrate the feasibility for monitoring hemodynamics in cerebral aneurysm. The prototype device is composed of three micro-membranes ($500-{\mu}m$-thick polyurethane film with $6-{\mu}m$-thick layers of nitinol above and below). A novel super-hydrophilic surface treatment offers excellent hemocompatibility for the thin nitinol electrode. A computational study of the deformable mechanics optimizes the design of the flow sensor and the analysis of computational fluid dynamics estimates the flow and pressure profiles within the simulated aneurysm sac. Experimental studies demonstrate the feasibility of the device to monitor intra-aneurysmal hemodynamics in a blood vessel. The mechanical compression test shows the linear relationship between the applied force and the measured capacitance change. Analytical calculation of the resonant frequency shift due to the compression force agrees well with the experimental results. The results have the potential to address important unmet needs in wireless monitoring of intra-aneurysm hemodynamic quiescence.

A pilot study of Korean Medical Examination

  • Yoo, Junghun;Lee, Sanghun;Kim, Soyoung;Kim, Daehyeok;Park, Jeong Hwan
    • The Journal of Korean Medicine
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    • v.42 no.4
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    • pp.1-9
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    • 2021
  • Objectives: This study aimed to evaluate the feasibility of the Korean medical examination protocol, which included 14 questionnaires and 20 medical examination devices. Methods: We conducted a pilot observational study of 90 subjects to measure the time required to fulfill each item of the Korean medical examination, to evaluate patient satisfaction, and to report improvements that can be made to the Korean medical examination protocol based on clinical coordinator and subject feedback. Results: Among the 90 subjects included in the study (59 women and 31 men; mean [standard deviation] age, 37.2 [12.3] years), over 80% intended to receive a Korean medical examination if hospitals provided it and would recommend a Korean medical examination to others. The average time spent on the overall Korean medical examination was approximately 88.0 (21.4) minutes. Three areas for improvements were reported: survey issues, including the number of items, understanding, and readability; error issues in device measurements; and environmental issues affecting the sequence of medical examinations and temperature. Conclusions: Most subjects were satisfied with the Korean medical examination. Future studies should be conducted with larger samples to collect data continuously.