• Journal of Ginseng Research
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• v.48 no.3
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• pp.266-275
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• 2024

Cancer stem cells (CSCs) are a rare subpopulation of cancer cells that exhibit stem cell-like characteristics, including self-renewal and differentiation in a multi-stage lineage state via symmetric or asymmetric division, causing tumor initiation, heterogeneity, progression, and recurrence and posing a major challenge to current anticancer therapy. Despite the importance of CSCs in carcinogenesis and cancer progression, currently available anticancer therapeutics have limitations for eradicating CSCs. Moreover, the efficacy and therapeutic windows of currently available anti-CSC agents are limited, suggesting the necessity to optimize and develop a novel anticancer agent targeting CSCs. Ginseng has been traditionally used for enhancing immunity and relieving fatigue. As ginseng's long history of use has demonstrated its safety, it has gained attention for its potential pharmacological properties, including anticancer effects. Several studies have identified the bioactive principles of ginseng, such as ginseng saponin (ginsenosides) and non-saponin compounds (e.g., polysaccharides, polyacetylenes, and phenolic compounds), and their pharmacological activities, including antioxidant, anticancer, antidiabetic, antifatigue, and neuroprotective effects. Notably, recent reports have shown the potential of ginseng-derived compounds as anti-CSC agents. This review investigates the biology of CSCs and efforts to utilize ginseng-derived components for cancer treatment targeting CSCs, highlighting their role in overcoming current therapeutic limitations.

• Food Science and Preservation
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• v.30 no.4
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• pp.663-668
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• 2023

Ginseng root is a medicinal plant widely used in Korea for its immunity enhancing and anti-fatigue properties. However, its bitter taste has a negative impact on the expansion of the ginseng market. In this study, we determined the bitter tasting compounds of ginseng using an electronic tongue. The results of measuring bitterness showed that phenolic compounds and polyacetylenes of ginseng had low bitterness. On the other hand, the bitterness was strong in ginsenosides and alkaloids of ginseng. Among them, the bitterness of ginseng was higher in ginsenosides than in alkaloids. Theses results suggest that ginsenosides have a significant affect on the bitter taste of ginseng.

• Structural Engineering and Mechanics
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• v.90 no.5
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• pp.435-446
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• 2024

The use of cold-formed steel members is increasing day by day, especially in regions where earthquake effects are intensively experienced. Among cold-formed steel members (CFS), "channel" members are used more than other crosssectional members, especially in buildings or industrial structures. In recent years, several studies have been carried out on the axial load and flexural performance of these members under monotonic loading. In this study, CFS beam-column members were cyclically and monotonically loaded under combined axial load and biaxial bending moments, and their buckling behavior, load bearing capacity, stiffness, ductility, and energy absorption capacity were determined. For this purpose, monotonic and cyclic loading experiments were carried out on 30 CFS channel members at 15 different eccentricities. Then, material properties were determined by axial monotonic tensile and very low cycle fatigue tests for use in numerical studies. From the experimental results, the buckling modes, bearing capacities, ductility, stiffness, and energy absorption capacities of the members were obtained. The characteristics of the members were compared according to the stress state of the lips. According to the data obtained from the displacement transducer placed on the lips and on the back of the web, information about the buckling mode and curvature of the members was obtained. Finally, monotonic, and cyclic loading results were compared to determine the differences in the buckling behavior of the members.

• Fashion & Textile Research Journal
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• v.26 no.2
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• pp.190-197
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• 2024

With increasing global interest in environmentally friendly materials and the consequent rise in demand, there is a growing need for alternatives to synthetic fibers, which can cause skin diseases and other side effects. The fashion industry is emphasizing material sustainability owing to concerns about increasing carbon emissions. Moreover, consumers express a strong desire for ecofriendly and sustainable materials. Therefore, clothing brand companies are developing eco-friendly products to enhance their corporate image. Hemp fibers are recognized for their functionality and are utilized as crucial materials in the development of eco-friendly products by global fashion companies. In this study, we produced socks that effectively improve foot health using hemp stem bark extract fibers and demonstrated the positive efficacy of natural fibers through functional and wearability evaluations. Hemp stem bark extract fibers showed 99.9% antimicrobial effectiveness against bacteria responsible for sweat-induced bacterial proliferation and odor, when blended with lyocell fibers and woven into fabric to manufacture socks. Wearability evaluations of these terry cloth socks confirmed a reduction in foot odor and fatigue among the participants with a consumer satisfaction of 4.63/5. These findings confirm the effectiveness and positive impact of the natural antimicrobial properties of hemp fibers and terry cloth structure in improving foot health.

• Journal of the Korean Society of Radiology
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• v.11 no.7
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• pp.611-617
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• 2017

In this study, it was expected that long-term stability against external mechanical external force could be secured if the phosphor layer had ductility. In this study, a bendable $Gd_2O_2S:Tb$ sensitized paper was fabricated by screen printing method and the image uniformity was evaluated through RMS analysis and histogram analysis to investigate the effect of fatigue accumulation due to long-term external force and repetitive external force. As a result, the dominant pixel area is maintained constant and the relative standard deviation is less than 10% for the long-term external force. However, for the repetitive external force, the dominant pixel area is divided into three areas and the image uniformity is adversely affected. Based on these results, it is suggested that the curved surface detector can be applied by securing the mechanical stability against the existing radiation sensitized paper. However, further studies are needed to apply it to the flexible detector. As a result, flexible radiation sensitizers can be applied to various curved surfaces, and it is expected to be applicable to various fields such as nuclear medicine, medical treatment, and industrial fields in the future.

• Journal of the Society of Naval Architects of Korea
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• v.28 no.1
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• pp.108-116
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• 1991

In the non-linear behavior of many materials, there is difference between the monotonic behavior by static load and the cyclic behavior by cyclic load. In particular, the short fatigue cracks to propagate in elasto-plastic stress concentrations(notches), are governed significantly by the cyclic behavior of materials. Accordingly, it is needed to investigate and compare the monotonic and cyclic behavior of materials. In the pressent study, the stress-strain relations of materials by monotonic and cyclic load tests were examined for 2 kinds of steels(SS41, HT80) and 5 kinds of Al-alloys(A5083-O, A6N01-T5, A7N01-T4, A7016-T6, A7178-T6). And the constants for mechanical properties of the materials were determined by experimental results, Moreover, when a notch was subjected to cyclic load, the effect of cyclic hardening property of materials on the variation of stress-strain amplitude in the notch tip was discussed by the application of Neuber's rule and experiments for a center notched plate.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.1
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• pp.71-77
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• 2023

With the continuous industrial development, not only natural resource depletion, waste generation, but also various weather conditions are becoming more frequent. Efforts are continuing to recycle industrial by-products to overcome the climate crisis and save resources. Slag is a representative by-product generated in the steel industry, and it is characterized by improving rutting resistance and moisture sensitivity by increasing strength and reducing deformation when used as a material for asphalt concrete. On the other hand, slag has expansion properties so it is used as a relatively low-value-added material such as embankment and refilling materials. In order to expand the application of slag, an experiment was conducted to evaluate the crack resistance of slag asphalt concrete pavement. As a result of the indirect tensile strength test, it was found that the asphalt mixture using slag aggregate showed a value 1.13 times higher than that of the general HMA with the same particle size, and the toughness was 1.17 units, improving crack resistance. In addition, it was found that the failure number of the 4-point beam fatigue experiment and the slag asphalt mixture was 20,409, which was more than doubled compared to the general HMA. Furthermore, Overlay Test showed a tensile load residual rate of 4 times or more, improving crack resistance to repeated fatigue. Accordingly, the use of slag aggregate will likely have various advantages in improving the performance of asphalt concrete pavement.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.11
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• pp.4781-4786
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• 2015

Siberian ginseng (Eleutherococcus senticosus) is used primarily as an adaptogen herb and also for its immune stimulant properties in Western herbal medicine. Another closely related species used in East Asian medicine systems i.e. Kampo, TCM (Manchuria, Korea, Japan and Ainu of Hokkaido) and also called Siberian ginseng (Acanthopanax senticosus) also displays immune-stimulant and anti-cancer properties. These may affect tumour growth and also provide an anti-fatigue effect for cancer patients, in particular for those suffering from lung cancer. There is some evidence that a carbohydrate in Siberian ginseng may possess not only immune stimulatory but also anti-tumour effects and also display other various anti-cancer properties. Our study aimed to determine the inhibitory and also proliferative effects of a methanol plant extract of Siberan ginseng (E. senticosus) on various cancer and normal cell lines including: A-549 (small cell lung cancer), XWLC-05 (Yunnan lung cancer cell line), CNE (human nasopharyngeal carcinoma cell line), HCT-116 (human colon cancer) and Beas-2b (human lung epithelial). These cell lines were treated with an extract from E. senticosus that was evaporated and reconstituted in DMSO. Treatment of A-549 (small cell lung cancer) cells with E. senticosus methanolic extract showed a concentration-dependent inhibitory trend from $12.5-50{\mu}g/mL$, and then a plateau, whereas at 12.5 and $25{\mu}g/mL$, there is a slight growth suppression in QBC-939 cells, but then a steady suppression from 50, 100 and $200{\mu}g/mL$. Further, in XWLC-05 (Yunnan lung cancer cell line), E. senticosus methanolic extract displayed an inhibitory effect which plateaued with increasing dosage. Next, in CNE (human nasopharyngeal carcinoma cell line) there was a dose dependent proliferative response, whereas in Beas-2 (human lung epithelial cell line), an inhibitory effect. Finally in colon cancer cell line (HCT-116) we observed an initially weak inhibitory effect and then plateau.

• Composites Research
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• v.24 no.1
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• pp.45-50
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• 2011

Transparent and conductive carbon nanotube on polyethylene terephthalate (PET) were prepared by dip-coating method for self-sensing multi-functional nanocomposites. The changes in the electrical and optical properties of CNT coating mainly depended on the number of dip-coating, concentration of CNT solution. Consequently, the surface resistance and transmittance of CNT coating were sensitively controlled by the processing parameters. Surface resistance of CNT coating was measured using four-point method, and surface resistance of coated CNT could be better calculated by using the dual configuration method. Optical transmittance of PET film with CNT coating was evaluated using UV spectrum. Surface properties of coated CNT investigated by wettability test via static and dynamic contact angle measurement were consistent with each other. As dip-coating number increased, surface resistance of coated CNT decreased seriously, whereas the transmittance exhibited little lower due to the thicker CNT networks layer. Interfacial microfailure properties were investigated for CNT and indium tin oxide (ITO) coatings on PET substrates by electrical resistance measurement under cyclic loading fatigue test. CNT with high aspect ratio exhibited no change in surface resistance up to 2000 cyclic loading, whereas ITO with brittle nature showed a linear increase of surface resistance up to 1000 cyclic loading and then exhibited the level-off due to reduced electrical contact points based on occurrence of many micro-cracks.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.12 no.2
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• pp.77-85
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• 1992

Layer material properties of asphalt concrete changes with climatic conditions. Pavement design and analysis should be performed in the representative climatic condition that gives standard physical properties of pavement layer materials. In this study, an evaluation procedure of pavement design temperature is proposed and programed based on damage effect analysis using fatigue failure criterion. Three regions, Seoul, Daegeon, and Pusan, are chosen to obtain the representative climatic data of South Korea. Domestic pavement design temperature is developed by applying the proposed algorithm to 6 domestic pavement section models with the respective regional climatic data. Asphalt concrete pavement failure criterion is also proposed for the condition of developed domestic pavement design temperature. The design temperature for the region of South Korea is estimated as $l7^{\circ}C$, which is converted to $23.6^{\circ}C$ for the AC surface layer temperature. It is found that the procedure to determine design properties of AC surface layer material at $20^{\circ}C$ gives overestimated results of AC moduli for the domestic pavement system. From the comparison study, it is also found that the estimated pavement design temperature is similar to the result of SHELL Design Chart.