• Korean Journal of Clinical Pharmacy
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• v.22 no.2
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• pp.181-186
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• 2012

Objective: To report a fatal case of Multidrug-resistant Acinetobacter baumannii (MDR-AB) in a patient with interstitial lung disease (ILD) on high-dose glucocorticoids. Case Summary: A 66-year-old man with a history of coniosis was transferred to the hospital with progressive cough and sputum production. This patient has been diagnosed with pneumonia and ILD on admission, requires antimicrobial therapy and systemic immunosuppressants. He received high dose of methylprednisolone and cyclophosphamide for ILD as well as ceftriaxone and azithromycin for pneumonia. On day 7 in the intensive care units (ICUs), patient had fever and leukocytosis, thus antimicrobials were switched to piperacillin. After 13 days in the ICU, Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus (MRSA) were isolated on transtracheal aspirate (TTA) and meropenem was initiated. However, it was revealed a multidrug-resistant Acinetobacter baumannii (MDR-AB) species, resistant to carbapenem. Patient was administered colistin but expired due to septic shock on day 84. Discussion: Systemic immunosuppressive therapy can result in infections that may compromise patient's survival. MDR-AB has emerged as a serious cause of nosocomial infections in immunocompromised patients. MDR-AB is resistant to most standard antimicrobials and therapeutic options are limited. Conclusion: We report our recent experience with a fatal MDR-AB pneumonia in a patient with ILD, who had to be treated with high dose glucocorticoids and immunosuppressnts.

• Journal of Environmental Health Sciences
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• v.34 no.5
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• pp.369-373
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• 2008

The indoor environment is an important source of exposure to various aeroallergens and pathogenic microorganism. It has been shown that exposure to aeroallergens enhances the risk of indoor inhabitants developing asthma. Since the skin prick test, a typical clinical method for identification of subjects positive to allergens, can rarely cause fatal or non-fatal reactions in susceptible persons, an in vitro assay such as ELISA using serum has been considered for testing positivity against various allergens. We evaluated the validity of a serum ELISA kit for screening positive subjects to major aeroallergens including Dermatophagoides farinae, Dermatophagoides pteronyssinus, cockroach, Alternaria, Cladosporium, Aspergillus, Penicillium, dog hair, cat fur, mugwort, and ragweed. The ELISA results were compared with the skin prick test results, and sensitivity, specificity, and overall accuracy were calculated to each allergen. Higher sensitivities were obtained from D. farinae, (77.8%) and D. pteronyssinus (69.2%), but sensitivities to Aspergillus, Penicillium, dog hair, cat fur, and ragweed were very low down to 0%. Specificity ranged from 88.7% (cat fur) to 100% (mugwort and ragweed). Overall the accuracy of the serum ELISA kit was relatively high, in that the lowest was 85.1% for cat fur and the highest was 98.6% for Alternaria, Cladosporium, and ragweed. Considering specificity and overall accuracy for the serum ELISA kit, it may be considered reliable. However, when the kit is used for screening purpose, positivity to aeroallergens should be carefully determined since sensitivity for the kit is low.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.1
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• pp.1-6
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• 2017

Ballistic impact on a soldier wearing a helmet can induce fatal injury, even if the helmet is not penetrated. Although studies on this type of injury have been performed, most of them have used an analytical model focused on head injury only. The injury of the neck muscles and cervical vertebrae by non-penetrating ballistic impact affects the survivability of soldiers, despite not inflicting fatal injury to the human body. Therefore, an analytical model of the head and neck muscles are necessary. In this study, an analysis of human body injury using the previously developed head model, as well as a cervical model with muscles, was performed. For the quantitative prediction of injury, the stress, strain, and HIC were compared. The results from the model including the cervical system indicated a lower extent of injury than the results from the model excluding them. The results of head injury were compared with other references for reliability.

• Analytical Science and Technology
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• v.11 no.2
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• pp.88-91
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• 1998

Bromide($Br^-$) was separated and quantified with $2.8mM-NaHCO_3/2.2mM-Na_2CO_3$ by Ion Chromatography. Bromide was eluted at 8.9 min. and the detectetion limit was 2.5 ng. We compared with bromide concentration in normal or methylbromide intoxicated bloods and tissues. Bromide concentrations were 2.0~5.8 ppm in normal bloods and 1.0~5.3 ppm in normal tissues. In fatal cases of methylbromide intoxication, blood bromide concentrations (4 cases) of 74.2~139 ppm and tissue bromide concentration (1 case) of 76 (heart)~201 (lung) ppm were detected. In fatal cases, blood bromide concentrations. were 12~22 times higher than those of normal bloods.

• Korean Journal of Construction Engineering and Management
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• v.6 no.3 s.25
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• pp.120-127
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• 2005

This study examines the occurrence of accidents when workers were travelling on construction sites and the differences in risk involved in each occupation. An analysis of 750 fatal accident reports found that in 138 cases, the fatality occurred when the workers were travelling on site. The 138 cases were then divided according to occupation and were then examined to determine how the workers in each occupation had been affected by various hazardous situations. There were significant differences in accident occurrence between the occupations and in the various hazardous situations. The results imply that the cultural aspect of each occupation leads to a substantial difference in the possibility of fatal injuries or death and that such differences in risk should be taken into account when planning the workers' movements on site. The findings of this study aim to help workers to understand the risks entailed when travelling on site and also to assist managers in the planning of workers, movements on construction sites.

• Clinical and Experimental Pediatrics
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• v.59 no.3
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• pp.145-148
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• 2016

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially fatal condition characterized by skin rash, fever, eosinophilia, and multiorgan involvement. Various drugs may be associated with this syndrome including carbamazepine, allopurinol, and sulfasalazine. Renal involvement in DRESS syndrome most commonly presents as acute kidney injury due to interstitial nephritis. An 11-year-old boy was referred to the Children's Hospital of Pusan National University because of persistent fever, rash, abdominal distension, generalized edema, lymphadenopathy, and eosinophilia. He previously received vancomycin and ceftriaxone for 10 days at another hospital. He developed acute kidney injury with nephrotic range proteinuria and hypocomplementemia. A subsequent renal biopsy indicated the presence of acute tubular necrosis (ATN) and late exudative phase of postinfectious glomerulonephritis (PIGN). Systemic symptoms and renal function improved with corticosteroid therapy after the discontinuation of vancomycin. Here, we describe a biopsy-proven case of severe ATN that manifested as a part of vancomycin-induced DRESS syndrome with coincident PIGN. It is important for clinicians to be aware of this syndrome due to its severity and potentially fatal nature.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.41 no.9
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• pp.740-746
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• 2013

Design with crashworthiness concept has been emphasized for almost aircraft and motor vehicles. However, crashes accompanied serious injury and death have been continuously occurred, and will be occurred subsequently. What was worse, it is a well-known fact that there were a good many crashes classified as survivable accidents in which fatal injuries were reported. But we cannot say that fatal injuries were inevitable consequences of those crashes. If crashworthy design for seat, restraint systems, and cabin strength were adequate or right, survivability in a crash event could be maximized greatly. To substantiate the right crashworthiness, we must thoroughly understand the characteristics of human tolerance under abrupt acceleration change, and the cabin design should be combined with proper use of energy absorbing technologies that reduce accelerations experienced by the occupants. In this paper, the emphasis on the human tolerance under abrupt accelerations as well as the necessity of change in design requirements for crash environment will be stressed to widen the belt of consensus for the right crashworthy design.

• Journal of the Korean Society of Safety
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• v.29 no.5
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• pp.129-135
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• 2014

In recent studies, construction industry workers with higher job stress and lower work ability were more likely to experience accidents at their workplace. Likewise, fatal accidents rate was higher among simple labor workers compared to technical workers. Therefore the evaluation of a worker's job stress and work ability seems to be important in preventing the occurrence of fatal accidents. To search for ways to reduce job stress and to improve work ability, the current study conducted a job stress analysis based on age, years of service, skill level, hobbies, sleep patterns, and monthly income. For this, the Korean occupational stress questionnaire short form and the Work Ability Index (WAI) developed by the Finnish Institute of Occupational Health (FIOH) were used. In this study, SPSS 12.0K statistics program was used for statistical analysis and significance was verified by the Kruskal-Wallis test and non-parametric tests. The results of this study can be summarized as follows : (1) Simple labor workers had higher job stress and less work ability than technical workers. (2) The more experienced workers had lower job stress and higher work ability. (3) In the case of workers who slept a lot, work ability was higher and job stress was less. (4) Monthly income influenced on the job stress and work ability. (5) Job stress and work ability in accordance with the age difference was not significant.

• Journal of Korean Medical classics
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• v.33 no.1
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• pp.135-147
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• 2020

Objectives : This study focuses on the condition Yinynagjiao, which was first mentioned in 『Huangdineijing』, on the cause, mechanism and reason for it being described as fatal. Later doctors's understanding and treatment of this condition were examined subsequently. Methods : Verses related to Yinyangjiao from texts such as 『Huangdineijing』, 『Jinkuiyuhanjing』, 『Maijing』 were cross-examined focusing on their context and difference in expression with reference to annotations and later texts that mention Yinyangjiao. Based on the findings, its mechanism and treatment methods as found in Wenbing texts were compared with descriptions from previous texts. Results & Conclusions : According to 『Huangdineijing』, heat disease belongs to the Shanghan category, treated through promoting perspiration. In the confrontational position between JingQi and XieQi, perspiration could be understood as the result of JingQi's victory that lead to the discharge of XieQi in the form of sweat. Yinyangjiao is the opposite situation where Jing is discharged while heat toxin sinks into the body, thus being fatal, and treatment aimed for perspiration not adequately addressing the main problem which was ultimately expected to resolve through means of solid Yin Jing that would stabilize the pulse in due time. On the other hand, Wenbing scholars saw the pathogen as heat, shifting previous perspectives entirely. As a result, instead of applying pungent/warm medicinals to promote sweating, they suggested the use of cool, sweet/moist medicinals to cool the heat and nourish Yin as means of treating the condition.

• Safety and Health at Work
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• v.4 no.4
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• pp.201-209
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• 2013

Background: The study was conducted to investigate the current status of the occupational health and safety management system (OHSMS) in the construction industry and the effect of OHSMS on accident rates. Differences of awareness levels on safety issues among site general managers and occupational health and safety (OHS) managers are identified through surveys. Methods: The accident rates for the OHSMS-certified construction companies from 2006 to 2011, when the construction OHSMS became widely available, were analyzed to understand the effect of OHSMS on the work-related injury rates in the construction industry. The Korea Occupational Safety and Health Agency 18001 is the certification to these companies performing OHSMS in South Korea. The questionnaire was created to analyze the differences of OHSMS awareness between site general managers and OHS managers of construction companies. Results: The implementation of OHSMS among the top 100 construction companies in South Korea shows that the accident rate decreased by 67% and the fatal accident rate decreased by 10.3% during the period from 2006 to 2011. The survey in this study shows different OHSMS awareness levels between site general managers and OHS managers. The differences were motivation for developing OHSMS, external support needed for implementing OHSMS, problems and effectiveness of implementing OHSMS. Conclusion: Both work-related accident and fatal accident rates were found to be significantly reduced by implementing OHSMS in this study. The differences of OHSMS awareness between site general managers and OHS managers were identified through a survey. The effect of these differences on safety and other benefits warrants further research with proper data collection.