• Parasites, Hosts and Diseases
• /
• 제45권2호
• /
• pp.95-102
• /
• 2007

The mRNA expression of several cytokines was evaluated in splenocytes and mesenteric lymph node (MLN) cells of rats infected with Capillaria hepatica by reverse-transcription (RT)-PCR until week 12 after infection. IgG1 and IgG2a, which are associated with Th1 and Th2 response, respectively, were also assessed by ELISA. The results indicated that the majority of cytokines, including the Th1 (IL-2 and $IFN-{\gamma}$ and Th2 cytokines (IL-4, IL-5 and IL-10) were expressed at maximal levels during the early stage of infection (after week 1-2), and the ELISA data also evidenced a similar pattern of changes in IgG1 arid IgG2a. Th1 and Th2 cytokines responded in a similar fashion in this rat model. The expression of cytokines in splenocytes was significantly higher than that in MLN cells, thereby indicating that cytokine production is controlled more by spleen than by MLN. In addition, the observation that $IFN-{\gamma}$ expression increased unexpectedly at the time of maximal egg production (6 weeks after infection) indicated that $IFN-{\gamma}$ is a cytokine reacting against egg production. However, increased IL-5 expression occurring in tandem with worm activity indicated that the activity of C. hepatica might be controlled by IL-5 expression.

• 대한임상검사과학회지
• /
• 제41권2호
• /
• pp.83-92
• /
• 2009

This study was undertaken to examine the effect of oxidants on membrane transport function in renal epithelial cells. Hydrogen peroxide ($H_2O_2$) was used as a model oxidant and the membrane transport function was evaluated by measuring $Na^+$-dependent phosphate ($Na^+$-Pi) uptake in opossum kidney (OK) cells. $H_2O_2$ inhibited $Na^+$-Pi uptake in a dose-dependent manner. The oxidant also caused loss of cell viability in a dose-dependent fashion. However, the extent of inhibition of the uptake was larger than that in cell viability. $H_2O_2$ inhibited $Na^+$-dependent uptake without any effect on $Na^+$-independent uptake. $H_2O_2$-induced inhibition of $Na^+$-Pi uptake was prevented completely by catalase, dimethylthiourea, and deferoxamine, suggesting involvement of hydroxyl radical generated by an iron-dependent mechanism. In contrast, antioxidants Trolox, N,N'-diphenyl-p-phenylenediamine, and butylated hydroxyanisole did not affect the $H_2O_2$ inhibition. Kinetic analysis indicated that $H_2O_2$ decreased Vmax of $Na^+$-Pi uptake with no change in the Km value. Phosphonoformic acid binding assay did not show any difference between control and $H_2O_2$-treated cells. $H_2O_2$ also did not cause degradation of $Na^+$-Pi transporter protein. Reduction in $Na^+$-Pi uptake by $H_2O_2$ was associated with ATP depletion and direct inhibition of $Na^+$-$K^+$-ATPase activity. These results indicate that the effect of $H_2O_2$ on membrane transport function in OK cells is associated with reduction in functional $Na^+$-pump activity. In addition, the inhibitory effect of $H_2O_2$ was not associated with lipid peroxidation.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
• /
• 제5권6호
• /
• pp.801-808
• /
• 1999

지금까지, 전기통신망과 장비들의 관리에 대해서는 많은 연구들이 진행되었지만, TMN 상위 계층의 서비스 관리와 비즈니스 관리에 대한 연구는 많이 수행되지 못했다. 최근 전세계적으로 TMN 상위 계층의 관리기능 구현을 위해서 CORBA 기술을 적용하고자하는 관심이 증가하고 있다. 본 논문에서는, 정보모델과 상호운용에 관한 TMN과 CORBA의 주요특징들을 비교하고, TMN 프레임웍와 효율적인 CORBA 기술 연동을 위한 플랫폼 구조를 제안한다. 제안된 구조에서, TMN 관리 정보를 CORBA IDL 인터페이스로 변환해주는 GDMO/ASN.1 - CORBA IDL 변환기가 고안, 구현되었고, JIDM의 상호 작용 변환의 구현을 위해서 TMN/CORBA 게이트웨이 또한 고안되었다. 그리고 이러한 기능의 확장을 위해서 모듈 형식으로 라이브러리들과 코드 생성기들이 설계, 구현되었다.Abstract Up to now, a lot of efforts have been made for the management of telecommunication networks and equipment, but less effort has been made for the realization of higher-layer service and business management. There are recently worldwide growing interests for applying CORBA technology for the realization of higher layer Telecommunication Management Network (TMN) management functions. In this paper, we compare the features of TMN and CORBA with respect to information model, and operational behavior. And then, we propose a platform architecture for the efficient integration of CORBA technology within TMN framework. Within platform architecture, GDMO/ASN.1 to IDL translator has been designed and implemented for translating TMN management information into CORBA IDL interface. The TMN/CORBA gateway is also designed for realization of the interaction translation specification of JIDM task force. The libraries and code generators have been designed and implemented in a modular fashion to provide the functional extensibility.

• 고려인삼학회:학술대회논문집
• /
• 고려인삼학회 2002년도 학술대회지
• /
• pp.401-415
• /
• 2002

Lim and his coworkers (1987; 1988; 1989) have also found that all of total Ginseng saponin, panaxadiol-and panaxatriol-type saponins cause the increased secretion of catecholamines (CA) in a $Ca^{2+}$ -dependent fashion from the isolated perfused rabbit adrenal glands through the activation of cholinergic (both nicotinic and muscarinic) receptors. These CA secretory effects are partly due to the direct action on the rabbit adrenomedullary chromaffin cells. However, the present study was designed to examine the effect of total ginseng saponin on CA secretion evoked by activation of cholinergic nicotinic receptors in the isolated perfused model of the rat adrenal gland. Total ginseng saponin given (100 ${\mu}g$/20 min) into an adrenal vein did fail to produce alteration of spontaneous CA release from the rat adrenal medulla. Acetylcholine(5.32 mM)- and DMPP(100 ${\mu}M$, a selective nicotinic receptor agonist)-evoked CA secretory responses were reduced markedly after the pretreatment with the total ginseng saponin at a rate of 100 ${\mu}g$/6.2 ml/20 min, respectively. Pretreatment with total ginseng saponin also depressed greatly high potassium (56 mM, a membrane depolarizing agent)- and Bay-K-8644 (10 ${\mu}M$, a calcium channel activator)-induced CA secretions. Taken together, it is thought that total ginseng saponin can inhibit the releasing effect of CA evoked by nicotinic receptor stimulation from the isolated perfused rat adrenal medulla, which seems to be associated to the direct inhibition of influx through L-type calcium channel into the rat adrenomedullary chromaffin cells. It seems that there is species differences in the adrenomedullary catecholamine secretion between the rabbit and rat.

• Safety and Health at Work
• /
• 제1권1호
• /
• pp.29-36
• /
• 2010

This article describes a systematic roadmap master plan for advanced industrial safety and health policy in Korea, with an emphasis on. Since Korean industries had first emergence of industrial safety and health policy in 1953, enormous efforts have been made on upgrading the relevant laws in order to reflect real situation of industrial work environment in accordance with rapid changes of Korean and global business over three decades. Nevertheless, current policy has major defects; too much techniques-based articles, diverged contents in less organization, combined enforcement and punishments and finally enforcing regulations full of commands and control. These deficiencies have make it difficult to accommodate changes of social, industrial and employment environment in customized fashion. The approach to the solution must be generic at the level of paradigm-shift rather than local modifications and enhancement. The basic idea is to establish a new system integrated with a risk assessment scheme, which encourages employers to apply to their work environment under comprehensive responsibility. The risk assessment scheme is designed to enable to inspect employers' compliances afterwards. A project comprises four yearly phases based on applying zones; initially designating and operating a specified risk zone, gradually expanding the special zones during a period of 3 years (2010-2012) and the final zone expanded to entire nation. In each phase, the intermediate version of the system is updated through a process of precise and unbiased validation in terms of its operability, feasibility and sustainability with building relevant infrastructures as needed.

• 품질경영학회지
• /
• 제49권3호
• /
• pp.433-446
• /
• 2021

Purpose: The main purpose of this study is to analyze the case of the transparent PET bottle resource circulation project of BYN Black Yak Co., Ltd., present implications, and propose ways to spread it in the future. Methods: In this study, the logic of the Double Diamond Model is applied to analyze the development process of sustainable fashion made from BYN Black Yak Co., Ltd.'s PET Bottle Resource Circulation System. Results: The K-rPET Resource Circulation Project of BYN Black Yak Co., Ltd. is recognized as a best example for its contribution to eco-friendly activities, solving social problems, raising consumer awareness, and sharing recycling habits. Before the plastic bottle becomes a garment, five steps are taken (discharge of PET bottle → collection of PET bottle → recycling of PET bottle → fabrication of yarn → production of the finished product out of the fabric). BYN Black Yak Co., Ltd. has successfully commercialized it by recycling reverse-recovery PET bottles by making solutions to problems that have not been solved at each stage. Conclusion: In addition to efforts to find and strengthen weak links presented in the Theory of Constrains (TOC), it appears to have systematically carried out activities to convert stakeholder discomforts into a package of gain points. As shown in the slogan "We are all in!" the proposal and implementation for the completion of a true environmental system is judged to have truly performed ESG management well for the company's business. ESG management activities at BYN Black Yak Co., Ltd. are expected to continue.

• 복식문화연구
• /
• 제29권5호
• /
• pp.706-718
• /
• 2021

The purpose of this study is to identify the relationship between experience marketing using makeup services and theme park users' satisfaction, loyalty, and revisit intention. This is because it can identify the usefulness of makeup services and provide implications for effective field marketing strategies. In order to achieve the purpose, 668 users of the theme park were surveyed after convenience screening as research participants. The main theme was the makeup service for visitors to Lotte world, Everland, and Hapcheon Ghost theme park. this study reviewed previous studies and applied them to the makeup service. Based on this, the research model and the hypothesis were established, and as part of the empirical research, the hypothesis was verified through analysis methods such as frequency analysis, reliability verification, factor analysis, and structural equation modeling. The summary of the research results based on empirical analysis is as follows. First, as a result of analyzing experience marketing using makeup services has a positive impact on the satisfaction of customers using theme parks. Second, experience marketing using makeup services has a positive effect on customer loyalty. Third, experience marketing using makeup services has a positive effect on intention to return. Fourth, satisfaction and loyalty were found to affect the intention to return. Based on this research, we hope that the makeup service as experiential marketing can be effectively applied in various fields, and that the research can be used as basic data to make the makeup service into the representative cultural contents marketing.

• 한국융합학회논문지
• /
• 제12권7호
• /
• pp.7-17
• /
• 2021

본 연구는 온라인 패션 리테일링에서 최근 이용이 증가하고 있는 데이터 융합 기반 사이즈 추천 테크놀로지 서비스 품질이 정보 신뢰와 만족 및 구매 의도에 미치는 영향을 검증하였다. 연구를 위한 설문은 아마존 미케니컬 터크에서 시행되었으며, 사이즈 추천 테크놀로지의 사용 경험이 없는 18세 이상 60세 이하의 미국 거주 여성을 대상으로 하였다. 이들은 설문에 제시된 링크를 클릭하여 특정 패션 온라인 리테일러의 웹페이지에서 사이즈 추천 테크놀로지를 경험한 뒤, 설문에 답하였다. 불성실한 응답을 제외한 213부를 SPSS 27.0과 Process Macro(모델 6번, 5,000 bootstrapping sample)를 이용하여 분석한 결과, 사이즈 추천 테크놀로지 서비스 품질의 하위차원은 반응성과 사용 편의성으로 나타났으며, 두 하위차원은 모두 정보 신뢰와 만족을 매개로 하여 구매 의도에 영향을 미치고 있는 것으로 나타났다. 본 연구는 이와 같은 결과를 바탕으로 사이즈 추천 테크놀로지의 상용화를 위한 전략을 제언하였다.

• 복식문화연구
• /
• 제27권5호
• /
• pp.512-523
• /
• 2019

Contemporary University students are considered the Z generation who were born after 1995. They are more tech savvy than millennials. To target the generation, traditional class management platforms have evolved to smart LMS that is more customized and accessible for smart devices. Global level information search and collaboration can also be implemented using such smart LMS. However, switching from one LMS to another LMS requires great effort from teachers and support from staffs. This study measured the learners' perception of the system when they were exposed to a new smart-LMS. Blackboard Learn Ultra was used for 15 weeks and at the end of the semester, a questionnaire was administered to the students of these classes. Results indicated that experience with previous LMS discouraged students from adopting Blackboard Learn. Result of TAM modeling indicated that perceived usefulness, compared to perceived ease of use and attitude, was an effective aspect to bring positive acceptance of the system. A qualitative approach and network analysis were also conducted based on students' responses. Both positive and negative responses were detected. Inconvenience due to mechanical aspects was mentioned. Dissatisfaction compared to previous local LMS use was also mentioned. Mobile application and communication effectiveness were positive aspects. Revised course development and promoting how useful the system may help enhance the acceptance of the new system.

• 디지털융복합연구
• /
• 제19권11호
• /
• pp.445-456
• /
• 2021

본 연구는 소비자의 구매행동에 영향을 미치는 거시경제변수와 소비자 판매가격을 변수로 여성 골프웨어 판매량에 영향을 미치는 변수의 중요도를 확인하고 골프웨어의 판매 증진을 위한 가격전략을 제안하는 것을 목적으로 한다. 국내 여성 골프웨어 브랜드의 매출자료를 의사결정나무 알고리즘과 앙상블을 이용해 분석하였다. 티셔츠, 팬츠와 니트류는 소비자 판매가격이 판매량에 가장 중요한 영향을 미치는 요인인 것으로 밝혀졌으며, 스커트와 원피스의 경우 소비자 판매가격 외에 카테고리가 중요 요인인 것으로 밝혀졌다. 이러한 연구 결과는 아이템에 따라 소비자의 구매 행동에 영향을 주는 경제 변수가 다르다는 것을 의미하는 것으로 적절한 가격전략을 통해 매출 및 이윤을 극대화할 수 있음을 시사하고 있다.