• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7781-7784
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• 2015

Background: The commonly held view of the tumor suppressor p53 is as a regulator of cell proliferation, apoptosis and many other biological processes as well as external and internal stress responses. Mdm2 SNIP309 is a negative regulator of p 53. Therefore, this study aimed to determine the correlation between the patterns of Mdm2 SNIP 309 and the inflammation grading of Helicobacter pylori associated gastritis in a Thai population. Materials and Methods: A cross-sectional study was carried out from November 2014 through June 2015. Biopsy specimens were obtained from infected patients and infection was proved by positive histology. The gastric mucosa specimens were sent to the Molecular Genetic Unit, Institute of Medicine, Suranaree University of Technology where they were tested by molecular methods to detect the patterns of Mdm2 SNIP 309 using the real-time PCR hybridization probe method. The results were analyzed and compared with the Updated Sydney classification. Results: A total of 100 infected patients were interviewed and gastric mucosa specimens were collected. In this study the percentage of Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous was 78% and 19 % respectively whereas Mdm2 SNIP309 G/G homozygous was 3%. Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous correlated with mild to moderate inflammation (P<0.01) whereas Mdm2 SNIP309 G/G homozygous correlated with severe inflammation (P<0.01). Conclusions: Our study found the frequency of Mdm2 SNP309 G/G in our Thai population to be very low, and suggests that this can explain to some extent the low incidence of severe inflammation and gastric cancer changes in the Thai population. Mild to moderate inflammation are the most common pathologic gradings due to the unique genetic polymorphism of Mdm2 SNIP 309 in the Thai population.

• Journal of the Korea Convergence Society
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• v.8 no.10
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• pp.201-207
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• 2017

This study focuses on the social problems such as aging and nuclear family in our society, and aims at carrying out basic research for the new residential culture plan corresponding to this socail phenomenons. The subject of this study is $Unit{\acute{e}}$ d'Habitation in Marseille, a French public collective housing designed by architect Le Corbusier. Among the important national ideologies that the French government has built through the long history and cultural growth, the theme of 'Residence' is not only a residence but a foundation of citizen welfare. In this context, the value of $Unit{\acute{e}}$ d'Habitation as common collective housing is very high because it presents the spirit of citizen welfare pursued by the country as residential community where various generations of households can coexist together. It is expected that the study on residential community, which is the subject of this study, will positively influence the presentation of a new residential culture for various subdivided generations of our society.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7479-7486
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• 2014

Background: Colorectal cancer (CRC) is one of the most common cancers worldwide. This study aimed to investigate the interaction between the presence of a polymorphism of the XRCC1 gene and known risk factors for colorectal cancer in Thailand. Materials and Methods: A hospital-based case-control study was conducted in Thailand. The participants were 230 histologically confirmed new cases and 230 controls matched by sex and age and recruited from the same hospital. Information about demographic characteristics, life style, and dietary habits was collected using structured interviews, and blood samples were taken which were used for the detection of a homozygous and heterozygous polymorphisms of XRCC1. Associations were assessed using multiple conditional logistic regression. Results: In the univariate analysis, factors found to be significantly associated with an increased risk for CRC were the presence of the XRCC1 AA homozygote (OR= 4.95; 95% CI: 1.99-12.3), a first degree family history of cancer (OR= 1.74; 95% CI: 1.18-2.58), and a high frequency of pork consumption (OR= 1.49; 95% CI: 1.00-2.21). Intakes of fish fruit and vegetables appeared to be protective factors, but the associations were not statistically significant. In the multivariate analysis only the XRCC1 AA homozygote polymorphism and a family history of cancer emerged as risk factors (OR= 4.96; 95% CI: 1.90- 12.95 and OR=1.80; 95% CI: 1.18-2.72, respectively). Conclusions: While the XRCC1 AA homozygote and a family history of cancer were found to be associated with an increased risk of CRC, none of the dietary intake variables were clearly identified as risk or protective factors. There is a need for further research to determine the reasons for this.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.6
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• pp.2269-2276
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• 2015

Colorectal cancer (CRC) is now common in Thailand with an increase in incidence over time. Health authorities are planning to implement a nationwide CRC screening program using fecal immunochemical test (FIT) as a primary screening tool. This study aimed to estimate preferences and acceptance of FIT and colonoscopy, explore factors influencing the acceptance, and investigate reasons behind choosing and rejecting to screen before the program was implemented. Patients aged 50-69, visiting the primary care unit during the study period, were invited to join this study. Patients with a history of cancer or past CRC screening were excluded. Face-to-face interviews were conducted. Subjects were informed about CRC and the screening tests: FIT and colonoscopy. Then, they were asked for their opinions regarding the screening. The total number of subjects was 437 (86.7% response rate). Fifty-eight percent were females. The median age was 58 years. FIT was accepted by 74.1% of subjects compared to 55.6% for colonoscopy. The acceptance of colonoscopy was associated with perceived susceptibility to CRC and family history of cancer. No symptoms, unwilling to screen, healthy, too busy and anxious about diagnosis were reasons for refusing to screen. FIT was preferred for its simplicity and non-invasiveness compared with colonoscopy. Those rejecting FIT expressed a strong preference for colonoscopy. Subjects chose colonoscopy because of its accuracy; it was refused for the process and complications. If the screening program is implemented for the entire target population in Thailand, we estimate that 106,546 will have a positive FIT, between 8,618 and 12,749 identified with advanced adenoma and between 2,645 and 3,912 identified with CRC in the first round of the program.

• Human Ecology Research
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• v.54 no.1
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• pp.13-26
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• 2016

The purpose of this paper is to investigate the rationale behind the transformation process of unique shophouse spatial organization in Phnom Penh. We selected 20 representative shophouses located in the Chinese district of Phnom Penh according to construction period. A qualitative study methodology was applied and field surveys were conducted that included interviews with residents, photographs, sketches, measurements, collecting historic photos, and cataloging maps. Selected cases were analyzed in terms of: basic house data, urban block analysis, and unit analysis. Cases were then classified into two types: private courtyard shophouse (PCS) and shared courtyard shophouse (SCS). PCS refers to shophouse typology that maintains most of the characteristics of early shophouses while being transformed into a modern multi-story apartment within a limited one bay plot. However, SCS refers to shophouses adapted from the indigenous forms of PCS that evolved into a multi-storey and multi-family housing typology that includes features that might have been adapted from Western apartment buildings such as sharing a big courtyard, staircase and corridors. We conclude that shophouses in Phnom Penh have positively adopted a Western building typology, adapted it to local traditions, and finally formulated a new building type that represent indicators of a modernization process gradually accepted by society.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.16 no.1
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• pp.92-102
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• 2009

Purpose: Relocation stress is a common phenomenon in patients discharged from an intensive care unit(ICU) to a ward. Therefore, nurses need to be aware of the problems that can arise during the transfer process. The aim of this study was to identify nurses' experiences in transferring critically ill patients from the ICU to a ward. Method: Focus group interviews were done with 13 nurses from wards and ICU, which participated in receiving and sending of ICU patients. The debriefing notes and field notes were analyzed using the consistent comparative data analysis method. Result: Seven major categories were identified in the analysis of the data. These were 'mixed feeling about transfer', 'lack of transfer readiness', 'increase in family burden', 'uncertainty with unfamiliar environment', 'difficulty in decision making', 'difference of perception of the relationships between patients and health care providers', 'need for continuity of nursing care'. Conclusion: Transferring out of the critical care area should be presented to the patient and family as a positive step in the recovery process. However, a more universal method of passing information from nurse to nurse is needed to assist in a smooth transition.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.373-376
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• 2016

The Mini Parasep SF fecal parasite concentrator (MPSFC) is a new modification of the closed concentration system, which can easily be adopted in any routine clinical pathology laboratory. Here we describe our experience with the system in diagnosing Opisthorchis viverrini. A total of 199 fecal samples was submitted for routine examination in the clinical pathology laboratory of Suranaree University of Technology hospital, Nakhon Ratchasima province, Thailand, during August to October 2015. Out of all samples examined, 10 (5.03%) were positive with intestinal parasites including O. viverrini (2.01%), followed by Strongyloided stercoralis (1.51%), Hookworm (0.5%), Taenia spp. (0.5%), and Entamoeba coli (0.5%). Regarding the distribution of intestinal parasites in relation to the methods used, and found that 4 samples (2.01%) were positive using the direct wet smear method while 10 (5.03%) were positive with the Mini Parasep SF method; the difference was statistically significant ($X^2$-test = 116.506, p-value =0.001). Mean time for processing using the Parasep system was 6.03 min/sample, the conventional direct wet smear method at 0.3 min/sample. Cost per test, conventional direct wet smear method costing less than the Parasep method at USD 0.74/sample versus USD 1.47/sample. This first report of O. viverrini detection using MPSFC indicates that Parasep concentration test is useful in the routine laboratory, increasing the yield of parasites as compared to direct microscopy, but with greater processing time and cost. Further comparisons between the Parasep concentration test and common methods for O. viverrini detection are required, particularly concerning use in epidemiological surveys.

• Proceedings of the Korean Institute of Interior Design Conference
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• 2008.05a
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• pp.149-154
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• 2008

Housing may be construed as a place where people are settled for living, namely, family members make a home and a place, where all human living is grounded. Also, the common housing type of a certain time reflects the living of the time. With the advent of the lifestyle of a new social class attaching importance to the multi-purpose of act and function, complexity, and convenience from the 21st century, people required a housing space where work, rest, living, and recreational activities are overlapped, fused, and integrated on the axes of space and time. In addition, along with the expansion of network and digital convergence from a social perspective, the appearance of new businesses, products, and business models affects the life and culture of consumers, which leads to the destruction of the borders and spheres throughout society. Thus, the study analyzed the characteristics of the spatial organizational type of collective housing in Japanese cities since the 1990s and withdrew the organizational type of each room in order to identify the uniquely differentiated characteristics of Japanese housing.

• Journal of the Korean housing association
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• v.13 no.2
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• pp.55-64
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• 2002

This study aims at the suggestion of possibility that a housing density will maintain properly and that an ecological hill housing will recover a rapport with the ground. That is, both residential planning on the hillside and ecological architecture as a concept for development are chosen for study category, and relationship between the hillside and the hill housing is theorized and then propriety is analysed through application of the ecological planning elements. The results of this study are as follows: 1. Now that the hillside is regarded as an idle land that preserves natural environment and maintains ecosystem, it must be developed on the basis of awareness that nature and human beings exist together. 2. Analysis of geographical factors must be advanced because it is inevitable that the development of the hill housing should be performed properly to the geographical characteristics. 3. Planning elements of ecological residential block which are possible for constructing on the hillside can be developed and applied, on the basis of geographical characteristics, by classifying them into two areas; housing estate, building and unit.

• Korean Institute of Interior Design Journal
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• no.22
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• pp.39-45
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• 2000

This study aims at developing the interior design method of Guest Room Space in resort condominium. There needs new concepts in Guest Room Space in resort condominium where we felt sleeping, eating, in the past. And the behavior in the Guest Room Space in resort condominium become various such as refreshing, making a group, harmony a family and so on. Nowadays, The resort condominium change to complex style and it's space design reflecting user's needs. This study treats with the design item such as unit space plan, furniture, furnishing and equipment of Guest Room Space in resort condominium. As a result of this study, the interior design methods of Guest Room Space in resort condominium must reflect of fitting material, color plan, user's needs and functional divide space. (Living, Dinning, Kitchen, Toilet and Foyer) These result will become basic data future interior design in Guest Room Space in resort condominium.