• Journal of Hospice and Palliative Care
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• 제18권4호
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• pp.314-321
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• 2015

목적: 말기암환자는 다양한 증상을 경험하기 때문에 말기 암이라는 상태는 환자뿐만 아니라, 그들의 가족 구성원들에게도 영향을 준다. 이 연구에서는 가족간병인의 삶의 질, 우울, 불안지수에 영향을 주는 환자의 증상조절과 같은 교정 가능한 요소들을 알아보고자 한다. 방법: 2015년 1월부터 2015년 5월말까지, 5개월 동안 부산광역시 내의 2개 대학병원 호스피스병동, 1개의 시립병원 호스피스병동에 입원한 61명의 가족간병인을 대상으로 설문조사를 시행하였다. 설문지는 가족간병인의 특성과 환자의 특성, 가족간병인의 CQOLC-K, BDI-II, BAI와 가족간병인이 수치화한 환자의 증상조절 점수로 구성되어 있다. 결과: 가족간병인의 우울지수는 종교와 연관성이 있으며, 삶의 질과 우울지수는 한달 가정소득에 영향을 받았다. 환자의 나이는 가족간병인의 삶의 질과 역의 상관관계를 가지고 있다. 가족간병인의 CQOLC-K는 환자의 불안조절 점수에 영향을 받았으며, 가족간병인의 BDI-II는 환자의 변비, 불안, 주간 졸음조절 점수에 영향을 받았다. 가족간병인의 BAI는 환자의 수면장애, 우울, 불안조절 점수에 영향을 받았다. 결론: 가족 간병인의 삶의 질, 우울, 불안지수는 환자의 증상이 잘 조절될 때 삶의 질이 높고, 우울, 불안지수가 낮은 경향을 보여주었다.

• 생명과학회지
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• 제17권3호통권83호
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• pp.350-355
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• 2007

흰쥐유래의 비만세포인 RBL-2H3 세포는 다양한 Src-family kinase를 발현한다. 현재까지의 연구결과에 의하면 비만세포의 초기 활성화에 Lyn kinase가 중요한 역할을 한다고 알려져 왔다. 그러나 그 세포에서 발현되는 다양한 다른 Src-family kinase의 역할은 불분명하다. 본 연구에서는 비만세포에서 다양한 Src-family kinase가 세포내 다른 곳에서 다양하게 발현되고 있다는 사실을 RT-PCR, immunoblotting 그리고 confocal microscopy 기법을 이용하여 증명하였다. 그 결과 Lyn 및 Fgr kinase는 세포막에 위치하고 c-Src 및 Yes kinase는 세포 내 과립에 존재하는 것을 알 수 있었다. 모든 Src-family kinase를 클로닝하고 과발현하여 탈과립 대한 영향을 평가하였다. 그 결과 fyn과 Fgr kinase는 비만세포에서 항원 유도의 탈과립을 증가시켰으며 반면 Lyn kinsae는 탈과립을 억제시키는 것을 확인할 수 있었다. 이러한 결과는 비만세포 초기 신호전달계에서 Fgr가 중요한 역할을 할 가능성을 제시한다.

• Journal of Hospice and Palliative Care
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• 제8권1호
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• pp.57-64
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• 2005

Cyclooxygenase-2 (COX-2) selective inhibitors were specifically developed to reduce the risks of gastrointestinal bleeding associated with other NSAID drugs. However, the APPROVe (Adenomatous Polyp Prevention on VIOXX) trials revealed that rofecoxib sometimes exerts prothrombotic effects. Meanwhile, cancer patients, who also carry a risk of thrombosis due to a variety of mechanisms, are often treated with COX-2 selective inhibitors, due to their relative gastrointestinal safety. This report concerns the case of a 46-year old woman with advanced cervical cancer, who had been treated with opioids and a COX-2 selective inhibitor (celecoxib) for 2 months, for the relief of pain associated with her cancer. The patient was admitted due to swelling of the left leg, which was also accompanied by pain. A computerized tomography scan revealed deep vein thrombosis occurring in multiple veins of both legs. After the administration of low-molecular weight heparin and oral warfarin, the patient's symptoms were relieved initially. However, her prothrombin time was found to be prolonged, necessitating the discontinuation of anticoagulation therapy. The patient's dyspnea worsened, ultimately resulting in her death. In conclusion, the administration of cox-2 selective inhibitors should be carefully considered in patients with a number of different risk factors, and assessed on a case-by-case basis.

• Journal of Hospice and Palliative Care
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• 제10권2호
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• pp.85-90
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• 2007

목적: 성적 요구도가 높고 상대적으로 성병에 취약한 인구집단인 대학생들에게 올바른 성지식은 성 관련 질환의 예방에 매우 중요하다. 미래의 의사로서 국민의 건강에 대해 지도자적 역할을 수행해 나갈 의대생의 AIDS 및 성병 관련 지식 정도를 조사하고 문제점을 분석함으로써 성병 예방교육의 중요성을 상기시키고, 이에 따른 예방교육의 기초를 마련하기 위한 목적으로 연구를 시행하였다. 방법: 2004년 3월, 서울 소재 일개 대학교의 의대생 110명과 동 대학 비의과대학생 200명을 대상으로 AIDS 및 성병 관련 지식과 성경험 여부를 묻는 자기기입식의 설문조사를 시행하였다. 결과: 최종 의대생 86명과 비의대학생 59명이 분석에 포함되었는데, 성경험이 있다고 응답한 군은 남성이 여성보다(44.00% vs 7.14%, P<0.001), 의대생이 비의대생보다(36.1% vs 11.9%, P=0.015) 높았다. AIDS 및 성병 관련지식은 총 19문항 중에서 8개 문항의 평균 점수가 두 군 간에 유의한 차이를 보였는데, 그 중 한 개의 문항을 제외한 모든 문항 및 총점에서 의대생의 점수가 높았다(P=0.001). 성경험 유무에 따른 AIDS 및 성병 관련 지식 정도는 통계적으로 유의하지 않았다. 결론: 의대생들이 비의대생에 비해 AIDS 및 성병에 대한 지식 점수가 높았다. 하지만 AIDS 및 성병에 대한 지식정도와 성경험 여부와는 연관성이 없었다.

• 동의생리병리학회지
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• 제25권4호
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• pp.734-742
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• 2011

The purpose of this study was to investigate the distribution and correlation of stroke risk factor according to age with stroke patients. This study was based on clinical data registered in Daejeon Oriental Medical Hospital from November 2006 to December 2010. Study subjects consisted of 779 patients with stroke within 1 month and they were classified according to age and existence of past history such as hypertension, diabetes mellitus, ischemic heart diseaseand stroke family history. Stroke family history was distributed differently according to age unlike past history and in their 50's showed a particularly high rate. There was not statistically significant correlation between stroke family history and past history except for only between stroke family history and diabetes mellitus in the patients in their 80's and more. There was statistically significant correlation between hypertension and diabetes mellitus and especially in the patients in their 60's and 70's. There was statistically significant correlation between hypertension and ischemic heart disease and especially in the patients in their 80's and more. There was statistically significant correlation between diabetes mellitus and ischemic heart disease in the patients in their 60's. There was statistically significant correlation among hypertension, diabetes mellitus and ischemic heart disease, but stroke family history and past history had independence, so management and research for this subject should be required further and further.

• Journal of Preventive Medicine and Public Health
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• 제54권5호
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• pp.317-329
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• 2021

Objectives: The aim of this study was to identify the association between cohabitation status and sleep quality in family members of people with dementia (PwDs). Methods: Data of 190 365 participants aged ≥19 years from the 2018 Korea Community Health Survey were analyzed. Participants were categorized according to their cohabitation status with PwDs. Multiple logistic regression and ordinal logistic regression analyses were performed to evaluate the relationship between the cohabitation status of PwDs' relatives and sleep quality measured using the Pittsburgh Sleep Quality Index (PSQI) and PSQI subscales. Results: Compared to participants without PwDs in their families, both cohabitation and non-cohabitation with PwDs were associated with poor sleep quality (cohabitation, male: odds ratio [OR],1.28; 95% confidence interval [CI], 1.08 to 1.52; female: OR, 1.40; 95% CI, 1.20 to 1.64; non-cohabitation, male: OR, 1.14; 95% CI, 1.05 to 1.24; female: OR, 1.23; 95% CI, 1.14 to 1.33). In a subgroup analysis, non-cohabiting family members showed the highest odds of experiencing poor sleep quality when the PwD lived alone (male: OR, 1.48; 95% CI, 1.14 to 1.91; female: OR, 1.58; 95% CI, 1.24 to 2.01). Cohabiting male and female participants had higher odds of poor subjective sleep quality and use of sleeping medications than non-cohabiting male and female participants, respectively. Conclusions: The residence of PwDs and cohabitation status may contribute to poor sleep quality among PwDs' family members. The circumstances faced by cohabiting and non-cohabiting family members should be considered when evaluating sleep quality in family members of PwDs, and appropriate interventions may be needed to improve sleep quality in both cohabiting and non-cohabiting family members.

• Nutrition Research and Practice
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• 제12권2호
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• pp.173-173
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• 2018

• Parasites, Hosts and Diseases
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• 제53권1호
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• pp.109-112
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• 2015

Diphyllobothrium latum and Diphyllobothrium nihonkaiense are morphologically similar to each other, and only genetic method can differentiate clearly between the 2 species. A strobila of diphyllobothriid tapeworm discharged from a 7-year-old boy was analyzed to identify the species by mitochondrial cytochrome c oxidase subunit 1 (cox1) gene sequencing. He and his family (total 4 persons) ate slices of 3 kinds of raw fish 16 days before visiting our outpatient clinic. All family members complained of abdominal pain and watery diarrhea. They all expelled tapeworm strobilae in their stools. They were treated with a single oral dose of praziquantel and then complained of no more symptoms. The cox1 gene sequencing of the strobila from the boy revealed 99.9% (687/688 bp) similarity with D. nihonkaiense and only 93.2% (641/688 bp) similarity with D. latum. Thus, we assigned this tapeworm as D. nihonkaiense. This is the first report of D. nihonkaiense infection in a family in Korea, and this report includes the 8th pediatric case in Korea. The current report is meaningful because D. nihonkaiense infection within a family is rare.

• 대한한의학회지
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• 제43권1호
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• pp.60-72
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• 2022

Objectives: This study aimed to analyze the Korean medical utilization and Korean medical expenses by characteristics of multicultural family members to investigate whether it affects Korean medical utilization. Methods: This study utilized The Korea Health Panel data in 2018, with 238 final participants. We performed a t-test and ANOVA on the difference between Korean medical utilization and Korean medical expenses according to Anderson's Model of Health Service Utilization variables. Logistic regression analysis and generalized linear model analysis were conducted to analyze Korean medical utilization factors. Results: The Korean Medical utilization was 12.61% among the multicultural family members. As a result of regression analysis, the female had high Korean medical utilization(p=.008), and rural area residents had low utilization(p=.017). Korean medical expenses were high when they were female or married. Including the utilization of western medical services by outpatients, Korean medical expenses were high when they were female or outpatients who received western medical services. Conclusions: As a result of this study, the factors influencing Korean medical utilization were gender and residence area. There were differences in Korean medical expenses depending on western medical services use or gender. Therefore, it is necessary to use these factors to expand the Korean Medical utilization by multicultural family members, and research of the Korean medical utilization by disease is needed.

• 대한불안의학회지
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• 제6권1호
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• pp.17-23
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• 2010

Objective : This study compared the psychological stresses of depressed patients' families with those of schizophrenic patients' families. We investigated the influence of depressive patients' clinical features and their families' demographic characteristics on the families' depressive symptoms and stresses. Methods : Participants were 23 family members of depressed patients and 20 family members of schizophrenic patients. We measured the patients' clinical features (duration of illness, number of previous hospitalizations, and satisfaction with medication), and each family member's socioeconomic status and psychological characteristics (depressive mood, anxiety, family stress, and stress response), analyzing the data via independent t-test, chi-square test, and correlation and hierarchical multiple regression analyses. Results : The depressed patients' average clinical global impression (CGI) was significantly higher than that of the schizophrenic patients. The depressed patients' family members showed stress responses significantly higher than those of schizophrenic patients' family members. Furthermore, in depressed patients, frequency of hospitalization was positively correlated with family members' stat anxiety. For both patient types, family stress was positively correlated with the patient's severity of illness and the family's state anxiety, trait anxiety, and stress response ; socioeconomic status was positively correlated with the family's depressive symptoms ; the family's state anxiety positively correlated with the family's trait anxiety and stress response ; and the family's trait anxiety positively correlated with the family's stress response. Socioeconomic status predicted the family's depressive symptoms, and socioeconomic, illness severity and stress response predicted family stress. Conclusion : These findings suggest that both depressed patients' families and schizophrenic patients' families suffer from psychological stress. The study data also have important clinical implications, in that families of depressed patients need psychiatric intervention, as well as the patients themselves. In particular, family intervention should focus on psycho-education and stress coping strategies.