• 제목/요약/키워드: Family BOM

검색결과 24건 처리시간 0.02초

비만 역설-편향 혹은 실제 (Obesity Paradox-Bias or Fact?)

  • 김범택
    • 비만대사연구학술지
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    • 제1권1호
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    • pp.33-38
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    • 2022
  • Although it has been confirmed that excessive body fat increases health risks and all-cause mortality, several epidemiological studies have reported that overweight or obesity in patients with chronic diseases and in older adults is advantageous with respect to mortality. Several mechanisms have been proposed to explain the biological basis of this obesity paradox. The marked heterogeneity of findings observed across studies and the possibility of systematic errors in these studies have cast doubt on the actual existence of the obesity paradox. However, the obesity paradox questioned the validity of body mass index as the best indicator for obesity in terms of predicting its comorbidities and urges clinicians to focus more on changes in body composition and related metabolic derangements, rather than body weight per se.

Three Cases of Paragonimiasis in a Family

  • Sohn, Byeong-Seok;Bae, Yun-Jeong;Cho, You-Sook;Moon, Hee-Bom;Kim, Tae-Bum
    • Parasites, Hosts and Diseases
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    • 제47권3호
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    • pp.281-285
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    • 2009
  • Paragonimiasis typically results from the consumption of raw or improperly cooked crustacea, especially crabs and crayfish. Although previously endemic in Korea, the prevalence of this disease decreased in the early 1970s because of educational campaigns and fewer intermediate hosts as a result of ecological changes. Recently, we were presented with a family where all members were infected with Paragonimus after ingestion of Kejang (= drunken crab). The mother was hospitalized for general myalgia and weakness first, followed by the father, who was hospitalized for dyspnea 2 month later. After the parents were diagnosed with paragonimiasis, we recommended their daughter to visit our hospital for a checkup, because they all had eaten freshwater crabs soaked in soybean sauce. She complained of generalized myalgia, fever, and pleuritic pain, and was also diagnosed with paragonimiasis. Peripheral blood of the 3 patients revealed hypereosinophilia, and computed tomography (CT) scans of their chests showed pleural effusion. The results of antibody tests by ELISA were positive for paragonimiasis. We report here the case series of familial paragonimiasis in a modern urban city, rather than in a typical endemic area.

네이버 뉴스 댓글을 활용한 '비혼출산'에 대한 감성분석 (Sentiment Analysis on 'Non-maritalism Childbirth' Using Naver News Comments)

  • 허세영;김초원;정안용;이새봄
    • 한국콘텐츠학회논문지
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    • 제22권1호
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    • pp.74-85
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    • 2022
  • 한국 사회에서 결혼가치관의 변화, 비혼 만연 현상과 더불어 비혼출산이라는 새로운 가족 구성의 형태가 나타났고, 출생률 감소 문제와 결부되면서 사회적 논의가 이루어지고 있다. 이에 본 연구는 비혼출산에 대한 사람들의 감성과 인식을 알아보기 위해 방송인의 비혼출산 사실이 알려진 2020년 11월 16일부터 최근 2021년 8월 16일까지 비혼출산에 관한 뉴스기사 댓글을 이용해 감성분석을 수행하였다. 연구 결과, 방송인의 비혼출산 사실이 알려진 사회이슈기에는 긍정적인 댓글이 다수인 반면, 정부여당이 정책적 검토를 시작한 정책의제기부터 정책결정기까지는 부정적인 댓글이 다수였다. 단어 동시출현빈도에 기반한 네트워크를 살펴본 결과, 댓글에는 전통적 가족규범 측면, 정책적 측면, 개인적 측면의 인식이 나타났다. 본 연구는 비혼출산 이슈가 정책의 제화 이후 정책결정과정 동안 부정적 인식이 만연하였다는 점을 밝혀냈으며, 비혼출산에 대한 사회적 논의의 초석이 되었다는 점에서 의의가 있다.

The Genetic Organization of the Linear Mitochondrial Plasmid mlp1 from Pleurotus ostreatus NFFA2

  • Kim, Eun-Kyoung;Youn, Hye-Sook;Koo, Yong-Bom;Roe, Jung-Hye
    • Journal of Microbiology
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    • 제35권4호
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    • pp.264-270
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    • 1997
  • The structure of plasmid mlp1, a linear 10.2kb mitochondrial plasmid of Pleurotus ostreatus NFF A2 was determined by restriction enzyme mapping and partial sequencing. The plasmid encodes at least two proteins; a putative RNA polymerase showing homology to yeast mitochondrial RNA polymerase and to viral-encoded RNA polymerases, and a putative DNA polymerase showing significant homology to the family B thpe DNA polymerases. It also contains terminal inverted repeat sequences at both ends which are longer than 274 bp. A 1.6 kb EcoRI restriction fragment of m1p1 containing the putative RNA polymerase gene did not hybridize to the nuclear or motochondrial genomes from P. ostreatus, suggesting that it may encode plasmidspecific RNA polymerase. The gene fragment also did not hybridize with the RNA polymerase gene (RPO41) from Saccaromyces cerevisiae. The relationship between genes in m1p1 and those in another linear plasmid pC1K1 of Claviceps purpurea was examined by DNA hybridization. The result indicates that the genes for DNA and RNA polymerases are not closely related with those in C. purpurea.

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배초향으로부터 Grb2-Shc domain 결합저해 물질의 분리 (Isolation of Grb2-Shc Domain Binding Inhibition Component from Agastache rugosa)

  • 이은숙;안병태;이새봄;김혜경;복성해;정태숙
    • 생약학회지
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    • 제30권4호
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    • pp.404-408
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    • 1999
  • SH2 domains and their associated catalytic or noncatalytic proteins constitute critical signal transduction targets for drug discovery. Grb2 associates with phosphotyrosine sites of the activated receptors or Shc via their SH2 domain to link receptor tyrosine kinases to ras signalling. Blocking of the Grb2-Shc complex may be to intervene the oncogenic signal transduction pathways and to develop a new antitumor drug. In the search for blockers of Grb2 SH2-Shc interaction, Lutein, a family of carotenoids, was isolated from the extract of the leaf of Agastache rugosa O. Kuntze as SH2 domain antagonists. The $IC_{50}$ of Lutein against Grb2-Shc binding was $6.8\;{\mu}M$.

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무정자증을 보이는 남성과 정상 생식력을 가진 여성의 가계에서 관찰된 X 염색체의 Pericentric Inversion (Pericentric Inversion of the X Chromosome in a Male with Azoospermia and in the Family of a Pregnant Female Carrier)

  • 이봄이;류현미;이문희;박주연;김진우;이중식;김혜옥;김민형;박소연
    • Journal of Genetic Medicine
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    • 제5권2호
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    • pp.139-144
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    • 2008
  • 무정자증을 보이는 40세 남성과 3대에 걸쳐 정상 생식력과 표현형을 보이는 38세 산모의 가계에서 동원체를 포함한 X 염색체의 역위를 경험한 바, 이를 문헌고찰과 함께 보고하고자 한다. 첫 번째 증례의 남성 환자는 정상범위의 LH, prolactin, estradiol, testosterone 혈중농도를 보였으나 FSH는 20 mIU/mL을 보여 정상수치보다 높았다. 조직학적 소견으로는 정소 내 제 1, 제 2 정모세포의 발달이 정지되어 있었지만 Y 염색체의 sY84, sY129, sY134, sY254, sY255, SRY 부위에 대한 미세결실은 없었다. 그 외 특이할 만한 임상적 소견은 보이지 않았다. 환자의 말초혈액으로부터 세포유전학적 검사로 GTL-분염법 판독을 한 결과, 46,Y,inv(X)(p22.1q27)로 나타났다. 두 번째 증례의 산모와 그 태아는 각각 46,X,inv(X)(p22.11q27.2), 46,X,inv(X)(p22.1q27)의 핵형이 관찰되었다. 이 산모의 가계는 본 연구실에서 친언니의 산전진단 시 언니, 언니의 태아, 환자의 아버지가 각각 46,X,inv(X)(p22.11q27.2), 46,Y,?inv(X), 46,Y,inv(X)(p22.11q27.2)의 형태로 inv(X)가 관찰된 기록이 있었고 대상자 모두 inv(X)로 인한 특징적인 임상적 증상은 보이지 않았다. 또한 RBG-분염법을 통해 관찰한 X 염색체의 비활성화는 언니의 inv(X) 비활성화 비율이 4.1%, 환자는 69.5%로 혈액세포 내에서의 X 염색체의 비활성화 비율은 서로 다르게 관찰되었다. 따라서 이 가계의 inv(X)는 특정 유전자의 손상이 없는 균형적 역위이며, X염색체의 역위현상으로 인한 비정상 표현형이나 생식기능의 결함은 관찰되지 않았다. 그러나 증례 1의 남성의 경우 세포유전학적으로 동일한 위치에 절단점을 가졌으나 생식세포의 발달과정의 결함이 관찰되었으며, 절단점 주변에 위치한 중요한 유전인자들의 손상 가능성이 제기되었다.

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Interaction Models of Substrate Peptides and β-Secretase Studied by NMR Spectroscopy and Molecular Dynamics Simulation

  • Lee, Jee-Young;Lee, Sung-Ah;Kim, Jin-Kyoung;Chae, Chi-Bom;Kim, Yangmee
    • Molecules and Cells
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    • 제27권6호
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    • pp.651-656
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    • 2009
  • The formation of ${\beta}$-amyloid peptide ($A{\beta}$) is initiated from cleavage of amyloid precursor protein (APP) by a family of protease, ${\alpha}$-, ${\beta}$-, and ${\gamma}$-secretase. Sub W, a substrate peptide, consists of 10 amino acids, which are adjacent to the ${\beta}$-cleavage site of wild-type APP, and Sub M is Swedish mutant with double mutations on the left side of the ${\beta}$-cleavage site of APP. Sub W is a normal product of the metabolism of APP in the secretary pathway. Sub M is known to increase the efficiency of ${\beta}$-secretase activity, resulting in a more specific binding model compared to Sub W. Three-dimensional structures of Sub W and Sub M were studied by CD and NMR spectroscopy in water solution. On the basis of these structures, interaction models of ${\beta}$-secretase and substrate peptides were determined by molecular dynamics simulation. Four hydrogen bonds and one water-mediated interaction were formed in the docking models. In particular, the hydrogen bonding network of Sub M-BACE formed spread over the broad region of the active site of ${\beta}$-secretase (P5-P3'), and the side chain of P2- Asn formed a hydrogen bond specifically with the side chain of Arg235. These are more favorable to the cleavage of Sub M by ${\beta}$-secretase than Sub W. The two substrate peptides showed different tendency to bind to ${\beta}$-secretase and this information may useful for drug development to treat and prevent Alzheimer's disease.

cAMP/PKA Agonist Restores the Fasting-Induced Down-Regulation of nNOS Expression in the Paraventricular Nucleus

  • Yoo, Sang-Bae;Lee, Seoul;Lee, Joo-Young;Kim, Bom-Taeck;Lee, Jong-Ho;Jahng, Jeong-Won
    • The Korean Journal of Physiology and Pharmacology
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    • 제16권5호
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    • pp.333-337
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    • 2012
  • Gene expression of neuronal nitric oxide synthase (nNOS) changes in the hypothalamic paraventricular nucleus (PVN) depending on feeding conditions, which is decreased during food deprivation and restored by refeeding, and phosphorylated cAMP response element binding protein (pCREB) was suggested to play a role in its regulation. This study was conducted to examine if the fasting-induced down-regulation of the PVN-nNOS expression is restored by activation of cAMP-dependent protein kinase A (cAMP/PKA) pathway. Freely moving rats received intracerebroventricular (icv) injection of cAMP/PKA activator Sp-cAMP (40 nmol) or vehicle (sterilized saline) following 48 h of food deprivation. One hour after drug injections, rats were transcardially perfused with 4% paraformaldehyde, and the PVN tissues were processed for nNOS or pCREB immunohistochemistry. Sp-cAMP significantly increased not only nNOS but also pCREB immunoreactivities in the PVN of food deprived rats. Fastinginduced down-regulation of the PVN-nNOS was restored by 1 h after the icv Sp-cAMP. Results suggest that cAMP/PKA pathway may mediate the regulation of the PVN-nNOS expression depending on different feeding conditions.

Role of Neuropeptide Y and Proopiomelanocortin in Fluoxetine- Induced Anorexia

  • Myung Chang-Seon;Kim Bom-Taeck;Choi Si Ho;Song Gyu Yong;Lee Seok Yong;Jahng Jeong Won
    • Archives of Pharmacal Research
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    • 제28권6호
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    • pp.716-721
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    • 2005
  • Fluoxetine is an anorexic agent known to reduce food intake and weight gain. However, the molecular mechanism by which fluoxetine induces anorexia has not been well-established. We examined mRNA expression levels of neuropeptide Y (NPY) and proopiomelanocortin (POMC) in the brain regions of rats using RT-PCR and in situ hybridization techniques after 2 weeks of administering fluoxetine daily. Fluoxetine persistently suppressed food intake and weight gain during the experimental period. The pair-fed group confirmed that the reduction in body weight in the fluoxetine treated rats resulted primarily from decreased food intake. RT-PCR analyses showed that mRNA expression levels of both NPY and POMC were markedly reduced by fluoxetine treatment in all parts of the brain examined, including the hypothalamus. POMC mRNA in situ signals were significantly decreased, NPY levels tended to increase in the arcuate nucleus (ARC) of fluoxetine treated rats (compared to the vehicle controls). In the pair-fed group, NPY mRNA levels did not change, but the POMC levels decreased (compared with the vehicle controls). These results reveal that the chronic administration of fluoxetine decreases expression levels in both NPY and POMC in the brain, and suggests that fluoxetine-induced anorexia may not be mediated by changes in the ARC expression of either NPY or POMC. It is possible that a fluoxetine raised level of 5-HT play an inhibitory role in the orectic action caused by a reduced expression of ARC POMC ($\alpha$-MSH).

Edwardsiella tarda 인위감염에 의한 넙치, Paralichthys olivaceus의 가계별 내성변이 (Family variation in survival of olive flounder Paralichthys olivaceus after Edwardsiella tarda infection in challenge tests)

  • 김현철;손새봄;정종근;이정호;최혜승;노재구;박철지;민병화;김종현;김경길;명정인
    • 한국어병학회지
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    • 제22권3호
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    • pp.275-282
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    • 2009
  • 본 연구는 에드워드 내성 정도를 기준으로 선발된 넙치 친어를 이용하여 $4{\times}4$ 펙토리얼 교배를 통해 얻어진 16가계 넙치의 에드워드 인위 감염 결과를 이용하여 교배 그룹, 교배 암컷, 교배 수컷의 효과를 분석하였다. 내성 친어간의 교배에 의해 생산된 교배구(RR)의 내성 지수, 생존율, 생존 일수는 각각 17.98, 13.77%, 18.36일로 나타났으나, 민감 친어간의 교배에 의해 생산된 교배구(SS)는 각각 12.46, 2.71%, 12.40일로 나타났다. 이상의 결과에서, 에드워드 질병내성 형질에 대한 가계간, 개체간 내성 정도의차이가 존재하는 것을 확인하였고, 인위 감염 결과를 이용하여 질병 저항성에 대한 선발이 가능할 것으로 판단된다.