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Study on Genetic Evaluation using Genomic Information in Animal Breeding - Simulation Study for Estimation of Marker Effects (가축 유전체정보 활용 종축 유전능력 평가 연구 - 표지인자 효과 추정 모의실험)

  • Cho, Chung-Il;Lee, Deuk-Hwan
    • Journal of Animal Science and Technology
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    • v.53 no.1
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    • pp.1-6
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    • 2011
  • This simulation study was performed to investigate the accuracy of the estimated breeding value by using genomic information (GEBV) by way of Bayesian framework. Genomic information by way of single nucleotide polymorphism (SNP) from a chromosome with length of 100cM were simulated with different marker distance (0.1cM, 0.5cM), heritabilities (0.1, 0.5) and half sibs families (20 heads, 4 heads). For generating the simulated population in which animals were inferred to genomic polymorphism, we assumed that the number of quantitative trait loci (QTL) were equal with the number of no effect markers. The positions of markers and QTLs were located with even and scatter distances, respectively. The accuracies of estimated breeding values by way of indicating correlations between true and estimated breeding values were compared on several cases of marker distances, heritabilities and family sizes. The accuracies of breeding values on animals only having genomic information were 0.87 and 0.81 in marker distances of 0.1cM and 0.5cM, respectively. These accuracies were shown to be influenced by heritabilities (0.87 at $h^2$ =0.10, 0.94 at $h^2$ =0.50). According to half sibs' family size, these accuracies were 0.87 and 0.84 in family size of 20 and 4, respectively. As half sibs family size is high, accuracy of breeding appeared high. Based on the results of this study it is concluded that the amount of marker information, heritability and family size would influence the accuracy of the estimated breeding values in genomic selection methodology for animal breeding.

Investigation of Coat Color Candidate Genes in Korean Cattle(Hanwoo) (한우에서 모색관련 유전자 변이에 관한 연구)

  • Do, K.T.;Shin, H.Y.;Lee, J.H.;Kim, N.S.;Park, E.W.;Yoon, D.H.;Kim, K.S.
    • Journal of Animal Science and Technology
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    • v.49 no.6
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    • pp.711-718
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    • 2007
  • Most cattle breeds have a coat color pattern that is characteristic for the breed. Korean cattle(Hanwoo) has a coat color ranging from yellowish brown to dark brown including a red coat color. Variation in the Hanwoo coat color is likely to be the effects of modified genes segregating within the Hanwoo breed. MC1R encoded by the Extension(E) locus was almost fixed with recessive red e allele in the Hanwoo, but other gene(s) might be affecting the variation of the Hanwoo coat color into yellowish to red brown. We have analyzed a segregation of coat color in the F2 families generated from two Hanwoo bulls(yellowish brown) mated to six F1 dams(black) derived from Hanwoo and Holstein crosses. Segregation of coat color in the offspring found a ratio of 1(yellowish brown) : 1(black) and this ratio indicates that a single gene may play a major role for the Hanwoo coat color. We further investigated SNPs in MC1R, ASIP and TYRP1 loci to determine genetic cause of the Hanwoo coat color. Several polymorphisms within ASIP intron 2 and TYRP1 exons were found but not conserved within the Hanwoo population. However, the segregation of the MC1R e allele was completely associated with the Hanwoo coat color. Based on this information, it is clear that the MC1R e allele is mainly responsible for the yellowish red Hanwoo coat color. Further study is warrant to identify possible genetic interaction between MC1R e allele and other coat color related gene(s) for the variation of Hanwoo coat color from yellowish brown to dark brown. (Key words : Hanwoo, Coat color, SNP, MC1R, ASIP, TYRP1)

A Study on Comics Outreach Programs for Contents marginalized Areas (콘텐츠 소외지역의 만화 아웃리치 프로그램 모델링 연구)

  • Lee, Seung-Jin
    • Cartoon and Animation Studies
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    • s.49
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    • pp.359-382
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    • 2017
  • Content is the complex of art and technology of trend, so it is important to experience different technologies for content education. Today, many non-profit organizations plan and operate numbers of programs for disabilities, low-income, and minority families to enhance the quality of life and the realization of social integration. These programs are limited to museums and galleries, not so pro-actively in progressing. Various contend education is necessary to the expansion of cultural exchange for the culturally alienated area. Naver is running an outreach program named . It is an experience-based outreach program where current cartoon / webtoon writers come directly to the school to inform students about the basic story of comics and comic techniques. However, the fact that the is not centered on the marginalized area but is centered on the Seoul Gyeonggi area, has the limitation that they can not benefit from a wide range of programs because they have a space limit of 'school', and, has a spatial limitation that the experience of the work is excluded. 'Outreach programs in marginalized areas' must be reorganized into a fluid dimension, not a fixed, single-system program. You should be able to experience and experience your work by directly using various professional equipment of comics based on your capacity and experience, local culture, religion, and society. These program participants will gain the effect of attractive and effective learning with empathy with their comic experience. Meanings of Comics content outreach program are following: First, the rich cultural archive can be used efficiently by providing various contents to existing outreach programs with the educational limitation of museums and galleries. Second, Comics contents can be enjoyed as a part of our life by understanding diversity and technology of contents. Third, because it is the program of expertise' participation, it can remodel, and restructure the severed experience in remote areas for the continuous growth and development, and furthermore, it can enhance the understanding of society.

Development of Wholistic Hospice Nursing Intervention Program for In-patient of Hospice Palliative Care Unit (병동형 호스피스 대상자를 위한 전인적 호스피스 간호중재 프로그램의 개발)

  • Kang, Eun-Sil;Choi, Sung-Eun;Kang, Sung-Nyun
    • Korean Journal of Hospice Care
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    • v.7 no.1
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    • pp.29-45
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    • 2007
  • People in the end of life and their families suffer in their physical disease and other aspects as a whole person. They need hospice care to palliate their total suffering in physical, emotional, social and also spiritual aspect through professional hospice team. To care their whole personal needs, hospice team must be a multi-discipline team which consists of medical doctors, nurses, social workers, pastors and volunteers. Recently those who die in hospice palliative care unit have trend to increase more than in home year by year. So it is necessary to develop the nursing intervention program to be performed by multi-discipline team approach for in-patient of hospice palliative care unit. The purposes of this study were to develop of wholistic hospice nursing intervention program for inpatient of hospice palliative care unit. The subjects of study were collected from 30 patients those who were over 18 years old and admitted in hospice palliative care unit of S hospital in P city with agreement in hospice palliative care in their terminal disease. The period of data collection was from December 15, 2003 to March 15, 2004. The result were as follows : 1. The result of Wholistic Hospice Nursing Program's development was as follow : A Wholistic Hospice Nursing Program was developed by me in this study is one of the service program for hospice palliative care unit. It was named as ‘Rainbow Program’ to be approached easily by hospice patients. The purposes of it are to improve the quality of life of the terminal patients with their dignity, to help them live in abundant and meaningful in their lives, to care them in peaceful in dying process with understanding them in whole personal, and also to palliate the grief and suffering of the bereaved. It was provided by hospice professionals(nurses, medical doctors, social worker, pastors, art therapists) and volunteers those who were educated in hospice for multi-diciplinary team approach to collaborate with each role play I 20-30 minuters of each through visiting their rooms individually and a place of hospice palliative care unit of S hospital in P city. The subjects of it were the terminal patients those who admitted hospice palliative care unit and their familes. with agreement in hospice palliative care in their terminal disease. The characteristics of it were multi-disciplinary team approach, whole personal care, individual care and total care according to their needs in their condition. The contents of it were pain control, symptom control, counseling patient, counseling family, hair cutting, hair shampooing, bed bath, recreation, taking a walk, event of culture(screen, recital, festival of praises, exhibition and so on), pastoral counseling, ritual service in bed, praying, service in bed, sing a worship praise, listening to the music, sharing remembrance of life, individual visiting music service(sing and praying), meditation Bible, art therapies(dance and drawing), social worker's counselling, confessing and sharing love and thanksgiving. The experimental group subjects participated in Wholistic Hospice Nursing Program which takes 120 minutes per session, total 10 sessions(total 1,200 minutes) altogether. In conclusion, this Wholistic Hospice Nursing Intervention can be used actively for whole personal well-being of the patients in hospice palliative in hospice palliative care unit and also applied in hospice practice as an useful model of multi-disciplinary team approach by hospice professionals.

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Factors Affecting to the Instrumental Ability of Daily Living(IADL) in the Urban Elderly (도시지역 노인들의 도구적 일상생활 수행능력(IADL)에 영향을 미치는 요인)

  • Lee in hak;Moon Seng ki;Kim kun joo;Park Jae-Young
    • The Journal of Korean Physical Therapy
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    • v.14 no.3
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    • pp.238-272
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    • 2002
  • This study was intended to find out the factors affecting to the IADL, allowing objective assessment of physical function status of increasing elderly populations. The subjects of 635 elderly persons aged over 65 years old who live in Taejon metropolitan city were interviewed during the two-month period from June to July of 2000. The IADL of Older American Resources and Services(OARS), developed in Duke medical college of USA, was interpreted for use. The study results were statistically processed using SPSSWIN(ver 10.0) and conferred the following results: 1. Among the seven items of IADL, the women showed higher rates of 'yes' in items about using the telephone, getting to the places out of walking distance, going shopping for groceries, taking their own medicine while outnumbered by the men only in the item about managing their own money, without significant differences between them in items about preparing their own meals and doing their own housework. 2. In terms of IADL scores, $82.0\%$ of subjects showed the normal range of scores and $18.0\%$ were under the normal range, meaning dysfunction IADL. Specifications of general characteristics revealed that more dysfunctional were the male subjects, the higher age groups who are more than 75 years old, the higher educated groups, the groups who live in nursing homes, the groups without a spouse. 3. Based on daily activities, lower scores of IADL were found in the subjects who don't go out, who don't have recreational activities, who don't attend elderly gatherings in their neighborhood, who don't hold social meetings. Specifications of psychological traits revealed that more dysfunctional were IADL in the subjects who don't feel satisfied with their lives of the past or the present, who have a deep feeling of isolation, and who don't have the will to live. 4. Among 7 items of health habits, only the subjects who don't regular exercise had lower scores of IADL than those who do. According to HPI, the lower HPI, the more dysfunctional. 5. Based on the factors associated with IADL, the odds ratio of the subjects who don't live together with their families were 1.53 times that of the ones who do, who are educated 3.22 times that of the ones who are not, who don't have spouses 2.09 times that of the ones who do, who don't go out 4.35 times that of the ones who frequently go out, who don't recreational activities for an interest 2.64 times that of the ones who do, who don't attend elderly gatherings in their neighborhood 1.47 times that of the ones who do, who don't hold social meetings 2.23 times that of the ones who do, who don't feel satisfied with their present living 1.43 times that of the ones who do, who have a feeling of isolation 1.53times that of the ones who don'1, who have the weak will to live 3.21 times that of the ones who have the strong one, and who don't regular exercise 2.45 times that of the ones who do. 6. Logistic regression analysis of the study results found that such factors are significantly related as the degree of education, with/without spouse, social meetings, the will to live, and regular exercise, and that higher rates of dysfunctional subjects were in the more educated group, in the group without spouse, in the group who don't frequently go out, who don't have social meetings, who have the weak will to live, and who don't exercise.

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Changes of Benthic Macroinvertebrate Communities after a Small Dam Removal from the Gyeongan Stream in Gyeonggi-do, Korea (경기도 경안천에서 소형 보(洑)의 철거 이후에 변화된 저서성 대형무척추동물 군집)

  • Kil, Hye-Kyung;Kim, Dong-Gun;Jung, Sang-Woo;Shin, Il-Kwon;Cho, Kang-Hyun;Woo, Hyo-Seop;Bae, Yeon-Jae
    • Korean Journal of Environmental Biology
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    • v.25 no.4
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    • pp.385-393
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    • 2007
  • Benthic macroinvertebrate communities were studied after a small dam removal from the mid-section of the Gyeongan stream in Gyeonggi-do, Korea. Quantitative sampling was conducted at immediately upstream (upper) and downstream (lower) sites from the dam as well as at the site where the dam was located (dam site: middle) using a Surber sampler (50$\times$50 cm, mesh 0.25 mm), four times (November 2004, May 2005, January 2006, and May 2006) after the dam removal. As a result, 46 species of benthic macroinvertebtates, belonged in 35 genera, 27 families, 11 orders, 5 classes, and 4 phyla, were sampled from the stream sites, but the number of species that occurred at each sampling trial was different (ranged 3$\sim$17 spp.) according to the seasons and sites. Approximately one year after the dam removal, the species number has in-creased and taxa composition has changed as the microhabitat became more heterogeneously due to a riffle formation in the upstream site. Chironomid larvae and tubificid worms, which are common in Korean urban streams, were the dominant species, while Hydropsyche kozhantschikovi was the 2nd dominant species at some sampling trials. In general, McNaughton's dominance indices decreased and Shannon species diversity indices increased approximately one year after the dam removal. Compositions of collector-filterers, clingers, and swimmers increased as hydropsychid caddisflies, heptageniid mayflies, and baetid mayflies increased, respectively, in the upstream site. The group pollution index and the ecological score using benthic macroinvertebrates both indicated that water environment has been improved in the upstream site after the dam removal.

The population characteristics of Nile tilapia (Oreochromis niloticus) in Dalseo Stream, South Korea (달서천에 서식하는 나일틸라피아(Oreochromis niloticus) 개체군 특성)

  • Wang, Ju Hyoun;Choi, Jun Kil;Lee, Hwang Goo
    • Korean Journal of Environmental Biology
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    • v.38 no.1
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    • pp.127-136
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    • 2020
  • This study was conducted to investigate the population characteristics of Nile tilapia (Oreochromis niloticus) in the Daegu Metropolitan City thermal effluent stream (Dalseo Stream) from January to November 2019. The collected fish were identified as 4,247 individuals of 20 species from a total of eight families. The dominant species was O. niloticus with 1,306 individuals and a high relative abundance (30.75%). The water temperature of Dalseo Stream was maintained above 10℃ throughout the year, which means that O. niloticus could inhabit it even in winter. The length-weight analysis showed a regression coefficient b of 3.1496, and a condition factor (k) of 0.0025 with a positive slope. Comparing the water temperature of Dalseo Stream and the total length of O. niloticus per investigation period, the 0-age individuals appeared May 29 when the water temperature was maintained above 22℃. In conclusion, the thermal effluent of Dalseo Stream allowed O. niloticus to survive in winter and maintain stable growth conditions and life cycles. The results of this study will inform ecological information on O. niloticus, which suggests that river management efforts should consider the management of O. niloticus populations for the conservation of fish species diversity.

Study on Flora and Comparative Example of Gulup-do in Ongjin, Incheon (인천 옹진 굴업도의 식물상과 비교사례 연구)

  • Oh, Hyun-Kyung;Han, Yun-Hee;Kim, Eun-Ok;Kim, Young-Ha
    • Journal of Environmental Impact Assessment
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    • v.25 no.2
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    • pp.103-123
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    • 2016
  • This study is a comparison of the flora and case studies distributed in Gulup-do Ongjingun, Incheon. The numbers of vascular plants were summarized as 282 taxa including 81 families, 201 genera, 252 species, 3 subspecies, 22 varieties and 5 forms. The Raunkiaer life forms are analyzed in hemicryptophytes were 66 taxa (23.4%) in dormancy form, non-clonal growth ($R_5$) were 160 taxa (56.7%) in propagation form of radicoid form, having no special modification for dissemination ($D_4$) were 197 taxa (48.6%) in propagation form of disseminule form, erect form (e) were 117 taxa (41.5%) in growth form. The halophytes were 23 taxa including Salsola collina, Asparagus oligoclonos and so on. The rare plants were 7 taxa including Pyrrosia hastata (VU), Senecio nemorensis (VU) and so on. The Korean endemic plants were 5 taxa including Hepatica insularis, Lespedeza maritima and so on. In the specific plants by floristic region were 38 taxa, a degree I were 23 taxa (Dictamnus dasycarpus, Vitex rotundifolia and so on), 6 taxa of a degree II (Morus cathayana, Euphorbia esula and so on), 8 taxa of a degree III (Pyrrosia hastata, Rhodotypos scandens and so on), Senecio nemorensis of a degree V and degree IV were not found. The naturalized plants were 17 taxa including Robinia pseudoacacia, Bromus tectorumand so on. Of those Ambrosia artemisiifolia is a invasive alien plants. Naturalization rate (NR) was 6.0% of all 282 taxa of vascular plants and urbanization index (UI) was 5.3% of all 321 taxa of naturalized plants. Gulup-do and adjacent Baega-do were locally investigated field work and it summarizes the results of a total of 41 islands literature in Ongjin-gun and Ganghwa-gun, Incheon including uninhabited islands, Baengnyeong-do, Daecheong-do and so on. The average number of species were each analyzed in about 89 taxa, rare plants are about 2 taxa, endemic plants are about 1 taxa, naturalized plants are about 4 taxa. This study was the comparison of the flora and literature distribution case that the Gulup-do maintain the naturalness and continuously conducted to explore the future conservation measures the adjacent islands.

Change of Flora of Damaged Land in Juwangsan National Park for Five Years (2010~2014) (주왕산국립공원 내 훼손지의 5년간(2010~2014년) 식물상 변화)

  • You, Juhan;Kim, Mijin
    • Journal of Environmental Impact Assessment
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    • v.25 no.4
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    • pp.233-247
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    • 2016
  • The purpose of this study is to offer the basic data for management of National Park by surveying and analysing the change of flora of damaged lands in Juwangsan National Park, Korea. In cause of occurring the damaged lands, site-1 was the vegetation damage by stamping, the removing Gwangamsa of site-2, 3, 4 and the removing Naewon village of site-5, 6, 7. Whole sites are caused by the artificial disturbance and interference. The numbers of flora were summarized as 135 taxa including 52 families, 109 genera, 116 species, 2 subspecies and 17 varieties in whole sites. The status of flora by sites, site-6 is the largest number of 52 taxa, site-1 is the lowest of 23 taxa. The rare plant is 1 taxa, 4 taxa of endemic plants, 10 taxa of specific plants by floristic region, 9 taxa of naturalized plants and 1 taxa of invasive alien plant. In the results of analysis about the change of coverage ratio, for this shrub layer, site-7 was changed to the most $0%{\rightarrow}50%$, and the herb layer, site-5 was changed to the most $75%{\rightarrow}95%$. In case of the change of species numbers, most sites tended to increase in the sites introduced different species or generated by the growth. It is contemplated that is similar to the restoration with the surrounding natural vegetation that is in progress is a transition occurs with the passage of time. In the dominant species, the shrub layer is Fraxinus sieboldiana, Lespedeza bicolor, Rhus javanica, Lespedezamaximowiczii, Salix koreensis and Zelkova serrata, and Miscanthus sinensis var. purpurascens, Oplismenus undulatifolius, Artemisia princeps, Bothriochloa ischaemum and Erigeron annuus of herb layer. In the results of analysing Naturalized Index(NI) and Urbanized Index(UI), NI was increased or decreased this phenomenon with the lapse of time, UI was the most increase. In particular, the increase in UI is due to the transition process, the pioneering plant, naturalized plant was imported to continue.

A Study on Dose Assessment by 18F-FDG injected into Patients (환자에게 주입된 18F-FDG 의한 선량 평가에 대한 연구)

  • Kim, Chang-Ju;Kim, Jang-Oh;Jeong, Geun-Woo;Shin, Ji-Hey;Lee, Ji-Eun;Jeon, Chan-Hee;Min, Byung-In
    • Journal of the Korean Society of Radiology
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    • v.14 no.4
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    • pp.467-475
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    • 2020
  • The purpose of this study is to assess doses to 18F-FDG, a radioactive drug, during PET examinations, to alleviate anxiety about radiation in patients and carers, to minimize the indiscriminate examination progress caused by medical institution personnel and space clearance problems, and health examination. The dose assessment was measured using a thermo-fluorescent dosimeter (TLD) and an electronic personal dosimeter (EPD) at the location of the cervical (hypothyroid), thorax (heart), and lower abdomen (breeding line) which are the three highest tissue areas of the radiation tissue weighting. In addition, spatial dose rates and radioactivity in urine were measured using GM counters and ion boxes. The results are as follows: First, the personal dosimeter TLD was measured 0.0425±0.0277 mSv in the cervical region, 0.0440±0.0386 mSv in the thorax and 0.0485±0.0436 mSv in the lower abdomen, with little difference in the heart dose depending on radiation sensitivity. The EPD was measured at 0.942±0.141 mSv/h immediately after the cervical position, and 0.192±0.031 mSv/h after 120 minutes. Immediately after the thorax position, 0.516±0.085 mSv/h, 120 minutes later 0.128±0.040 mSv/h. Immediately after the lower abdomen position, 0.468±0.091 mSv/h, and after 120 minutes 0.105±0.021 mSv/h were measured. The spatial dose rate at the GM counter was measured immediately at 0.041±0.005 mSv/h, 120 minutes later at 0.014±0.002 mSv/h. The radioactivity in urine using ion chamber was measured at 0.113±0.24 MBq/cc after 60 minutes and 0.063±0.13 MBq/cc after 120 minutes. As a result, 18F-FDG should be administered, dose re-evaluated two hours after the PET test is completed, and caregivers should be avoided. In addition, it is deemed necessary to provide patients and carers with sufficient explanations and expected values of exposure dose to avoid reckless testing. It is hoped that the data tested in this study will help patients and families relieve anxiety about radiation, and that the radiation workers' exposure management system and institutional improvements will contribute to the development of medical radiation.