• Earthquakes and Structures
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• 제24권6호
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• pp.439-453
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• 2023

Older brick masonry structures generally suffer from low strength defects. Using a cement mortar layer (CML) or steel-meshed cement mortar layer (S-CML) to reinforce existing low-strength brick masonry structures (LBMs) is still an effective means of increasing seismic performance. However, performance indices such as lateral displacement ratios and skeleton curves for LBMs reinforced with CML or S-CML need to be clarified in performance-based seismic design and evaluation. Therefore, research into the failure mechanisms and seismic performance of LBMs reinforced with CML or S-CML is imperative. In this study, thirty low-strength brick walls (LBWs) with different cross-sectional areas, bonding mortar types, vertical loads, and CML/S-CML thicknesses were constructed. The failure modes, load-carrying capacities, energy dissipation capacity and lateral drift ratio limits in different limits states were acquired via quasi-static tests. The results show that 1) the primary failure modes of UBWs and RBWs are "diagonal shear failure" and "sliding failure through joints." 2) The acceptable drift ratios of Immediate Occupancy (IO), Life Safety (LS), and Collapse Prevention (CP) for UBWs can be 0.04%, 0.08%, and 0.3%, respectively. For 20-RBWs, the acceptable drift ratios of IO, LS, and CP for 20-RBWs can be 0.037%, 0.09%, and 0.41%, respectively. Moreover, the acceptable drift ratios of IO, LS, and CP for 40-RBWs can be 0.048%, 0.09%, and 0.53%, respectively. 3) Reinforcing low-strength brick walls with CML/S-CML can improve brick walls' bearing capacity, deformation, and energy dissipation capacity. Using CML/S-CML reinforcement to improve the seismic performance of old masonry houses is a feasible and practical choice.

• Archives of Pharmacal Research
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• 제24권4호
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• pp.333-337
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• 2001

The pharmacokinetic changes of diltiazem (DTZ) and its main metabolite, deacetyldiltiazem (DAD) were studied after oral administration of DTZ to normal rabbits and mild and medium folate-induced renal failure rabbits. DTZ 10 mg/kg was given to the rabbits either orally (n=6). Plasma concentrations of DTZ and DAD were determined by a high performance liquid chromatography assay. The area under the plasma concentration-time curves (AUC) and maximum plasma concentration ($C_{max}$) of DTZ were significantly increased in mild and medium folate-induced renal failure rabbits. The metabolite ratio of the DTZ to DAD were significantly decreased in mild and medium folate-induced renal failure rabbits. The volume of distribution ($V_{d}$) and total body clearance ($CL_{t}$) of DTZ were significantly decreased in mild and medium folate-induced renal failure rabbits. The elimination rate constant ($\beta$) of DTZ was significantly decreased in folate-induced renal failure rabbits, but that of DAD was significantly increased. These findings suggest that the hepatic metabolism of DTZ was inhibited and the $V_{d}$, $CL_{t}$ and $\beta$ of DTZ were significantly decreased in mild and medium folate-induced renal failure rabbits.

• Archives of Pharmacal Research
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• 제25권4호
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• pp.541-545
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• 2002

Pharmacokinetic characteristics of Acebutolol and its main metabolite, diacetolol, following a single 10 mg/kg oral dose, were investigated in rabbits with carbon tetrachloride-induced hepatic failure. Plasma concentrations of acebutolol and diacetolol were determined by a high performance liquid chromatography assay. The area under the plasma concentration-time curves (AUC) and maximum plasma concentration ($C_{max}$) of acebutolol were significantly increased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. The ratio of the diacetolol to total acebutolol in plasma (i.e., metabolite percentage rate) was significantly decreased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. Volume of distribution ($V_{d}$) and total body clearance ($CL_{t}$) of acebutolol were significantly decreased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. Slope of terminal phase ($\beta$) of acebutolol was significantly decreased in hepatic failure rabbits. These findings suggest that the $V_{d},{\;}CL_{t}$ and $\beta$ of acebutolol were significantly decreased as a result of inhibition of the hepatic metabolism in moderate to severe hepatic failure rabbits. Therefore, dose adjustment may be necessary for acebutolol in hypertensive patients with hepatic damage.

• Geomechanics and Engineering
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• 제31권4호
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• pp.375-384
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• 2022

The variation of the undrained shear strength (c_u) is an important consideration for assessing slope stability in engineering practice. Previous studies focused on the three-dimensional (3D) stability of slopes in normally consolidated clays generally assume the undrained shear strength increases linearly with depth but does not vary in the horizontal direction. To assess the 3D stability of slopes with spatially varying undrained shear strength, the kinematic approach of limit analysis was adopted to obtain the upper bound solution to the stability number based on a modified failure mechanism. Three types failure mechanism: the toe failure, face failure and below-toe failure were considered. A serious of charts was then presented to illustrate the effect of key parameters on the slope stability and failure geometry. It was found that the stability and failure geometry of slopes are significantly influenced by the gradient of c_u in the depth direction. The influence of c_u profile inclination on the slope stability was found to be pronounced when the increasing gradient of c_u in the depth direction is large. Slopes with larger width-to-height ratio B/H are more sensitive to the variation of c_u profile inclination.

• 품질경영학회지
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• 제25권3호
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• pp.96-107
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• 1997

The recent stream to reliability prediction is that it is totally inclusive in depth to consider even the operating and environmental condition at the level of finished goods as well as component itselves. In this study, firstly we present the reliability prediction methods by entire failure rate model which failure rate at the system level is added to the failure rate model at the component level. Secondly we build up the improved bases of reliability demonstration through a, pp.ication of Kaplan-Meier, Cumulative hazard, Johnson's methods as non-parametric and Maximum Likelihood Estimator under exponential & Weibull distribution as parametric. And also present the methods of curve fitting to piecewise failure rate under Weibull distribution, PRST (Probability Ratio Sequential Test), curve fitting to S-shaped reliability growth curve, computer programs of each methods. Lastly we show the practical for determination of optimal burn-in time as a method of reliability enhancement, and also verify the practical usefulness of the above study through the a, pp.ication of failure and test data during 1 year.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2003년도 봄 학술발표회 논문집
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• pp.311-314
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• 2003

Concrete structures such as bridge, pavement, airfield, and offshore structure are normally subjected to repeated load. This paper proposes a failure probability models of concrete subjected to split tension repeated-loads, based on experimental results. The fatigue tests were performed at the stress ratio of 0.1, the loading shape of sine, the frequency of 20Hz, and the stress levels of 90, 80 and 70%. The fatigue test specimen was 150mm in diameter and 75mm in thickness. The fatigue analysis did not include which exceeded 0.9 of statistical coefficient of determination values or did not failure at 2$\times$$10^6$ cycles. The graphical method, the moment method, and maximum likelihood estimation method were used to obtain Weibull distribution parameters. The goodness-of-fit test by Kolmogorov-Smirnov test was acceptable 5% level of significance. As a result, the proposed failure probability model based on the two-parameter($\alpha and \mu$) Weibull distribution was good enough to estimate accurately the fatigue life subjected to tension mode.

• 한국항공운항학회지
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• 제21권2호
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• pp.21-25
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• 2013

The system and components for aircraft are required the design data on which the safety requirements are properly reflected for their certification. This paper presents the procedure and results of a safety assessments analysis for the rotorcraft fuel pumps in oder to confirm and verify them. The fuel pumps design assessment must be performed, including a detailed failure analysis to identify all failures that will prevent continued safe flight or safe landing. In order to assess the fuel pumps design safety, not only system safety hazard analysis and but FTA(Fault Tree Analysis) for proofing the safety objective of the fuel pumps are performed. The results of the safety assessment for fuel pumps validate that no single failure or malfunction could result in catastrophic failure or critical accidents of the rotorcraft.

• Structural Engineering and Mechanics
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• 제4권5호
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• pp.485-496
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• 1996

This paper describes a numerical and experimental study on the stability and failure behaviour of rectangular symmetric laminated composite plates. The plates are simply supported along the unloaded edges and clamped along the loaded ends, and they are subjected to uniaxial in-plane compression. The finite element method was employed for the theoretical study. The study examines the effect of the plate's stacking sequence and aspect ratio on the stability and failure response of rectangular symmetric laminated carbon fibre reinforced plastics composite plates. The study also includes the effect of the unloaded edge support conditions on the postbuckling response and failure of the plates. Extensive experimental investigation were also carried out to supplement the finite element study. A comprehensive comparison between theory and experimental data are presented and discussed in this contribution.

• 한국항공운항학회지
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• 제27권2호
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• pp.9-15
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• 2019

The initial buckling of thin walled structures does not result in immediate failure. This post buckling capability is used to achieve light weight design, and final failure of thin walled structure is called crippling. To predict the failure load, empirical methods are often used for thin walled structures in design stage. But empirical method accuracy depend on geometry. In this study, experimental, empirical and numerical study of the crippling behavior of I-section beam made of carbon-epoxy are performed. The progressive failure analysis model to simulate the crippling failure is evaluated using the test results. In this study, commercial software LS-DYNA is utilized to compute the collapse load of composite specimen. Six kinds of specimens were tested in axial compression where correlation between analytical and experimental results has performed. From the results, we have partially conclude that the flange width-to-thickness ratio is found to influence the accuracy of empirical and numerical method.

• 한국농공학회지
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• 제32권4호
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• pp.71-80
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• 1990

Model tests for the ultimate pullout resistance of anchorages and investigation of failure behaviors in cohesionless soil have been conducted. The factors affecting the anchorage are mostly the geometry of the system, and soil properties of sands. The main conclusions of the experimental work were as follows. 1. The load - displacement relationship can be a form of parabolic curve for all plates. 2. The change in ultimate pullout resistance of anchor is mostly affected by embedment ratio and size of anchor, and influenced to a lesser degree by its shape. 3. Critical embedment ratio which is defined as the failure mode changes from shallow to deep mode is increased with increasing height of anchor. 4. For a constant anchor height, as the width of anchor increases the ultimate pullout resistance also increases. However, considering the efficiency of anchor for unit area, width of anchor does not appear to have any sigrnificant contribution on increasing anchor city. 5. Anchor capacity has a linear relation to sand density for any given section and the rate of change increases as the section increases. Critical depth determining the failure patterns of anchor is decreased with a decrease of sand density. 6. With increasing inclination angle, size of anchor, and decreasing embedment ratio, the ultimate pullout resistance of anchor under inclined loading is significantly decreased. 7. The ultimate pullout resistance of double anchor, a method of improving single of anchor capacity, is influenced by the center - to - center spacing adjacent anchors. It is also found that tandem and parallel anchor rigging arrangements decrease the anchor system capacity to less than twice the single anchor capacity due to anchor interference.