• Journal of Life Science
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• v.17 no.9 s.89
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• pp.1298-1302
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• 2007

A hallmark of cancers is 'leaky' tight junctions (Tjs). TJs mediated paracellular permeability is elevated and TJs maintained cell polarity is frequently lost. Concomitantly, TJs-associated proteins including members of the claudin family of proteins are dysregulated. Recent findings indicate that these TJs changes can contribute to cancer progression. In this study, we examined the effects of ${\beta}-lapachone$, a quinone compound obtained from the bark of the lapacho tree (Tabebuia avellanedae), on the Tjs-associated regulators in human hepatocarcinoma cell lines, HepG2 and Hep3B. ${\beta}-lapachone$ treatment downregulated the levels of insulin-like growth factor 1 receptor (IGF-lR) proteins in both HepG2 and Hep3B cells. But the levels of claudin-3 and -4 proteins were increased in ${\beta}-lapachone$-treated HepG2 and Hep3B cells. And also the zonnula occludens-l (la-I) and p-catenin protein levels by ${\beta}-lapachone$ were increased in a time-dependent manner. However, claudin-3 and -4 mRNA levels were uninhibited by ${\beta}-lapachone$ in HepG2 and Hep3B. The present results suggest that the upregulation of claudin-3 and -4 protein levels by ${\beta}-lapachone$ occurs by a post-transcriptional mechanism and points to a novel mechanism by ${\beta}-lapachone$.

• Journal of Korean Public Health Nursing
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• v.4 no.2
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• pp.35-57
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• 1990

This study was conducted to provide information useful in developing a nursing curriculum. The sample consisted of 158 nursing students in Hanyang University and 34 faculty members who has taught them in their college & the practical area. Data were collected by using a structured questionnaire, which consisted of general characteristics of the students & their self-concept, teacher's perception of student's professional roles. The results are summarized as follows; 1. General characteristics of the students When the students applied for the university, they decided what they would specialized in. Because the motive of application for their major was simply based on their high school records, they were admitted to their university without previous knowledge of their major. The reason why they wanted to tranfer to another course after the admission was the same as above. The level of satisfaction of their major was the highest in Freshman, but in other grades the higher the;, grades were, the more they satisfied with their major and they had a better prospects about their speciality. 2. Self-concept in profermance for their major Self-concept in horne aspects was more positive perception than in social aspects & self control aspects. It resulted from tile fact that all students were females and the nursing uniqueness was based on the spirit of humanity & service. The students who had graduated from the high school in rural area wanted to tranfer to another course and taken counsel their personal problems with their parents had higher self-concept in horne aspects. As their grades were higher, the self-concept in social aspects bacame higher. The students who were satisfied with their major and took counsel their personal problems with their parents had more positive self - concept in social aspects. Self-concept in self control aspects was lower than other aspects. The students who didn't take counsel their problems with their parents, were burdened with their educational expenses and their curriculum had more negative self-concept in self control aspects. Therefore the university should be concerned about student's welfare and provide detailed orientation about their curriculum. 3. Teacher's perception about learner's professional role The role model of democratic group leader, role models for learners facilitator in a students' reach for knowledge and teaching based on soundly researched theory showed more positive perception than other factors. Their mean values were over 4. 32. The professionalism of allnurshing area, reinforcement with reinforcement for learning, nursing as part of the meaningful context of the whole showed nagative perception. Their mean values were below 3. 00. Therefore the nurse as a teacher should try to promote the locus of nursing profession and participate in their research actively.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.15 no.4
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• pp.97-108
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• 2020

This study analyzes factors of the influence of university start-up education and start-up support on the employment rate. For this purpose, we study prior research on university factors that affect the employment rate. we add university startup education & support to the university factors that are the type of university establishment and the university location, affecting the employment rate. The information of start-up education and start-up support is derived from the university disclosure information. In the start-up education, the number of participants in the start-up lecture, the number of participants in the start-up club, the number of participants in the start-up competition, the number of participants in the start-up camp and in the start-up support, the number of dedicated faculty members for start-up support, and the start-up training budget are added. The research model is empirically analyzed with 118 universities, excluding special purpose universities and universities with less than 1,000 graduates as a national 4-year university. Empirical analysis shows that the type of university establishment has a positive effect on the employment rate, and the university location has a positive effect on the employment rate. Among the factors of start-up education and start-up support, the number of participants in entrepreneurship courses is found to have a positive effect on the employment rate. In addition, although the number of participants in the start-up camp don't have a positive effect on the employment rate, it is found that the significance level p=0.070. Based on the results of this empirical analysis, academic and policy implications are presented.

• The Journal of Korean Academic Society of Nursing Education
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• v.5 no.1
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• pp.58-71
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• 1999

Nursing process is an essential part for nursing practice. Nursing faculty members must focus on the clinical application for students and try to identify the possible problems that students might face in the fields. The purpose of this study is to examine the actual condition of nursing process education in curricula and to investigate the response of students in clinical experience of nursing process. From 462 students in the 6 associate programs(ADN) and the 6 baccalaureate programs (BSN) data was collected by questionnaire. The results were as followed. 1. Seven programs (58.3%) opened the nursing process in mainly sophomore (BSN) or freshman(ADN). If not opened, the nursing process was taught at the major subjects(espcially fundamental nursing or adult nursing). 2. All Students responded they we supposed to use nursing process in preparing the case report. The majority(94.6%) used NANDA lists for nursing diagnosis and 55.7% of subjects consulted the Korean terms by KNA when translating. The tutors for nursing process in clinical settings were the professor in charge of the subject (68.6) or clinical instructors (48.1%) , assistants(34%). 3. The problems in clinical application that students experienced consisted of 17 items and the mean was 2.27. The biggest problem was 'the lack of the model for RN of applying the nursing process in clinical settings'(2.97). Next the big problem was 'the lack of the competency for implementing the established nursing plans'(2.69). All items were significantly different according to the level of educational programs(ADN or BSN). ADN students had more problems in applying the each step of nursing process and BSN students perceived the NANDA as a guidance of nursing diagnosis and the inconsistency of advices from several instructors or practicum to be mere problematic. 4. The mean of merits after application of nursing process was relatively fair (2.82). The best merit was 'they can identify nursing problems more exactly'(3.07). The second high merit was 'they can study the rational of nursing action' (3.03). BSN than ADN and the subjects of second year than of one year in clinical experience perceived the use of nursing process to be better. Based on this results we need to enforce the application of nursing diagnosis in the class. The use of sample cases can be the efficient method. Students can identify the possible health problems for patient from the cases in imaginary world and discuss them each other. Also we can use the discussion session after practice every other day or as needed. All this is on the good interaction between tutor and student. We must consider to have enough time for student to seize the essence of the nursing process.

• Journal of Society of Preventive Korean Medicine
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• v.21 no.1
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• pp.19-30
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• 2017

Objectives : The purpose of this study was to examine the changes of health perception, satisfaction survey and lifestyle in Korean medicine counseling for Daejeon University faculty members. Methods : In this study, the demographic questionnaire, lifestyle habit questionnaire, Mibyeong questionnaire, quality of life questionnaire(SF-12, EQ5D), pattern-based questionnaire, constitutional questionnaire(KS-15) and instrumental examination were performed on the first and second visit. We carried out 1:1 consultation at every visit. Results : A total of 189 participants participated in this study. 66% of respondents answered that they felt the change in health perception and more than 93% of the respondents felt satisfaction due to the Korean medicine health counseling. In the demographic characteristics, it was found that women were more satisfied with the Korean medicine health counseling than men(p <.05), the higher the education level(p <.05) and the higher the age(p <.05), managed their health continuously after receiving Korean medicine health counseling.(p <.05) In addition, in the change of lifestyle habit, the group who smoked and drank in the past answered that the consciousness to manage and improve health was higher than other group after Korean medicine health counseling.(p <.05) Conclusions : Korean medicine health counseling had a positive effect on overall health perception change and satisfaction was high. Since the Korean medicine health counseling has different effects on lifestyle and health perception change and the satisfaction of Korean medicine health counseling is different according to demographic characteristics and existing lifestyle habits. In the future, it will be expected that the effect of Korean medicine health counseling program on health care and disease prevention will be further enhanced if the Korean medicine health counseling program reflecting such characteristics is implemented.

• Korean Institute of Interior Design Journal
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• v.13 no.5
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• pp.206-214
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• 2004

본 연구는 사무공간에 영향을 주는 물리적 환경 요소 (공간, 가구배치, 미, 주변요소)를 제시하고 각 환경 요소들과의 관계를 파악하며 각 물리적 환경요소들과 직업 만족도 (급여, 진급, 책무, 상사와의 관계, 물리적 공간과 배치, 수업방법의 향상, 현재 직업 만족도)와의 관계를 분석하는데 연구의 목적이 있다. 또한 물리적 환경 요소들, 직업 만족도와 개인 신상 (나이, 성별, 지위, 교육수준, 교육 경력) 의 특성들과의 상관관계를 알아보고자 한다. 본 연구는 오클라호마 주립대학교의 종신 재직권을 가진 교육대학 교수들을 대상으로 세 가지 가설을 바탕으로 작성된 설문지를 배포하여 조사되었다. 각 교수들의 사무공간은 1997년에 개보수를 마치고 그 해 여름부터 사용하고 있다. 설문은 현재 사용하고 있는 사무공간에 대한 평가, 직업 만족도에 대한 평가와 개인 신상의 특성에 대한 질문으로 조사되었다. 조사 결과 사무공간에 영향을 주는 물리적 환경 요소들 간에 밀접한 관계가 있다는 가설이 입증되었고, 또한 조사 결과 물리적 환경의 만족도가 증가할수록 직업만족도가 증가하는 것으로 물리적 사무환경에 대한 만족도와 직업에 대한 만족도가 직접적인 관계가 있다는 가설 또한 확증되었다. 물리적 환경요소, 직업 만족도와 개인 신상의 특성들과의 상관관계가 있다는 가설은 전체적으로는 입증되지는 않았지만 부분적으로 요소들 간에 관계를 보여주고 있다. 남성이 여성보다 가구배치에 대해 불만족스러웠고 교육경력이 적을수록 사무공간의 냉난방과 환기에 대한 불만족을 보였다. 본 연구의 결과는 교수들의 사무환경의 부정적, 긍정적 견해를 지각하여 사무 환경의 질을 높이는데 도움이 되는데 중요한 역할을 할 수 있겠다. 본 연구는 교육대학의 교수들에 국한되어 있었던 바 추후에는 전체 교육자들을 대상으로 장기간의 관찰을 통한 연구가 요구되어 진다.신만의 고유한 해결책으로 발전시키는지를 고찰하고자 한다. 본 논문의 목적은 서울을 사례분석 중 하나로 사용하여 인테리어 디자인 분야의 경계를 대도시로 확장하는 동시에 새로운 적용영역의 가능성을 탐구하는데 있다 하겠다.[C/N]의 값을 나타내었다.다.다.화 기술, 구동방법등에 대한 기술개요와 국내외 기술동향에 대하여 소개하고자 한다.었다.다._{2}$가 0.25[wt%] 첨가된 시편의 20[.deg.C]에서의 유전상수는 16,700으로 최대값을 유전손실을 1.28[%]로 최소값을 나타내었다. 또한 모든 시편은 온도 및 주파수에 따라 유전상수가 완만하게 변화하는 유전이완 특성을 나타내었다.다.수적인 물의 양에 따른 DIAION WA30의 라세미화 효율에 관하여 실험한 결과, 물의 양이 증가할수록 그 효율은 감소하였다. DIAION WA30을 라세미화 촉매로 사용하여 아이소옥탄 내에서 라세믹 나프록센 2,2,2-트리플로로에틸 씨오에스터의 효소적 DKR 반응을 수행해 보았다. 그 결과 DIAION WA30을 사용하지 않은 경우에 비해 반응 전환율과 생성물의 광학 순도는 급격히 향상되었다. 전통적 광학분할 반응의 최대 50%라는 전환율의 제한이 본 연구에서 찾은 DIAION WA30을 첨가함으로써 성공적으로 극복되었다. 또한 고체 염기촉매인 DIAION WA30의 사용은 라세미화 촉매의 회수 및 재사용이 가능하게 해준다.해준다.다. TN5 세포주를 0.2 L 규모 (1 L spinner flask)oJl에서 세포간의 응집현상 없이 부유배양에 적응,배양시킨 후 세포성장 시기에 따른 발현을 조사한 결과 1 MOI의 감염조건 하에서는 $0.6\times10^6$cell/mL의 early exponential시기의 세포밀도에서 72시간 배양하였을 대 최대 발현양을 나타내었다. 나타내었다.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.3163-3167
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• 2014

Background: Breast-conserving surgery (BCS) plus radiotherapy is equivalent to modified radical mastectomy (MRM) in terms of outcome. However there is wide variation in mastectomy rates dependent both on tumour and patient characteristics. Objective: This study aimed to assess the determinants of surgery choice in Asian patients with early breast cancer in a middle-income country. Materials and Methods: 184 patients with early breast cancer treated between Jan 2008 and Dec 2010 were recruited to complete a questionnaire. Chi-square test was used to analyze the association between surgery choice and demographic and tumour factors, surgeon recommendation, family member and partner opinions, fear of recurrence, avoidance of second surgery, fear of disfigurement, interference with sex life, fear of radiation and loss of femininity. Results: 85 (46%) had BCS while 99 (54%) had mastectomy. Age >60, Chinese ethnicity, lower education level, and larger tumour size were significantly associated with mastectomy. Surgeon recommendation was important in surgery choice. Although both groups did not place much importance on interference with sex life, 14.1% of the BCS group felt it was very important compared to 5.1% in the mastectomy group and this was statistically significant. There was no statistical difference between the two groups in terms of the other factors. When analyzed by ethnicity, significantly more Malay and Indian women considered partner and family member opinions very important and were more concerned about loss of femininity compared to Chinese women. There were no statistical differences between the three ethnic groups in terms of the other factors. Conclusions: When counseling on surgical options, the surgeon has to take into account the ethnicity, social background and education level, age and reliance on partner and family members. Decision-making is usually a collective effort rather than just between the patient and surgeon, and involving the whole family into the process early is important.

• Journal of Korean Ophthalmic Optics Society
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• v.11 no.4
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• pp.337-344
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• 2006

Purpose: To evaluate the vision-specific Quality of Life according to modes of refractive error correction in myopia. Method: This study included subjects from two different universities in Korea during March 2005 to June 2005. The following subjects (470) were university students, university faculty members, and their immediate families; all of whom were over the age of 19 and all who had refractive error of some sort. The four focus groups consisted of 171 spectacle wearers, 154 contact lens wearers, 123 refractive surgery patients, and 22 post-refractive surgery patients who returned to wearing glasses. The study of Vision-Specific Quality of Life used QIRC - The Quality of Life Impact of refractive Correction Questionnaire, which was translated by our group from English into Korean. Using analysis of co-variance (ANCOVA) and adjusting for age, sex, job, economic status, and education level, we examined and compared the QOL mean scores of the three groups (glass & contact lenses wears, refractive surgery patients, and post-refractive surgery patients who returned to wearing glasses). Results: After adjusting for major compounding variance, the research results showed the highest QOL mean score of 43.2 for the group who had received refractive surgery, 37.1 for the glasses & contact lenses group, and 33.4 for patients who had returned to wearing glasses after refractive surgery. There were significant differences between the three groups (p=0.001). Conclusion: Refractive surgery has shown a significant contribution to improve the QOL in myopia patients. However, upon our investigation, patients who underwent refractive surgery and returned to wearing glasses had a lower QOL compared to non-refractive surgery patients who wore glasses/contact lenses. Upon concluding our studies that shows that refractive surgery does not always conclusively bring higher QOL, we would like patients to carefully consider their options before undergoing refractive surgery in the future.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5111-5116
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• 2013

Background: Early in the 21st century, cancers are the second cause of death worldwide. Colon cancer is third most common cancer and one of the few amenable to early diagnosis and treatment. Evaluation of factors affecting this cancer is important to increase survival time. Some of these factors affecting all diseases including cancer are social determinants of health. According to the importance of this disease and relation with these factors, this study was conducted to assess the relationship between social determinants of health and colon cancer survival. Materials and Methods: This was a cross-sectional, descriptive study for patients with colon cancer registered in the Cancer Research Center of Shahid Beheshti University of Medical Science, from April 2005 to November 2006, performed using questionnaires filled by telephone interview with patients (if patients had died, with family members). Data was analyzed with SPSS software (version 19) for descriptive analysis and STATA software for survival analysis including log rank test and three step Cox Proportional Hazard regression. Results: Five hundred fifty nine patients with ages ranging from 23 to 88 years with mean${\pm}$standard deviation of $63{\pm}11.8$ years were included in the study. The five year survival was 68.3%( 387 patients were alive and 172 patients were dead by the end of the study). The Cox proportional hazard regression showed 5-year survival was related to age (HR=0.53, p=0.042 for>50 years versus<50 years old) in first step, gender (HR=0.60, p=0.006 for female versus male) in second step, job (HR=1.7, p=0.001 for manual versus non manual jobs), region of residency (HR=3.49, p=0.018 for west versus south regions), parents in childhood (HR=2.87, p=0.012 for having both parents versus not having), anatomical cancer location (HR=2.16, p<0.033 for colon versus rectal cancer) and complete treatment (HR=5.96, p<0.001 for incomplete versus complete treatment). Conclusions: Social determinants of health such as job, city region residency and having parents during childhood have significant effects in 5-year survival of colon cancer and it may be better to consider these factors in addition to developing cancer treatment and to focus on these determinants of health in long-time planning.

• Journal of Korean Academy of Nursing
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• v.29 no.4
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• pp.963-976
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• 1999

This study was undertaken to investigate the general characteristics of students, which include the degree of satisfaction, motives of admission, the recognition of advantages and disadvantages, opinion of students on self-directed learning, and planning and anticipatory effects after graduation. Data was collected through a questionnaire survey over a period of four months, from May 1997 to August 1997. The subjects used for this study consisted of 322 RN students sampled from six RN-to-BSN programs in Korea using the census sampling method. Statistical methods employed for this study included discriptive statistics, M ANOVA, and F-test. The results of the study are as follows 1. The RN students' motives of admission to RN-to-BSN programs were ‘for personal advancement’, ‘to earn a BSN degree’, and ‘for professional development’ in this order. 2. The RN students' responses to the advantages of RN-to-BSN programs were ‘acquisition of new knowledge and a BSN degree’ and ‘to gain professional thinking and a broader view’, while as the disadvantages of RN-to-BSN programs were ‘geographical isolation of institutions’, ‘limitation of information’, and ‘underdeveloped school environments’ in this order. 3. The survey based on opinions toward self-directed learning showed that there was a need of detailed guidelines for self-directed learning. Most agreed that it was a very effective learning method for a RN student, and the self-directed learning method Increases motives for learning. 4. The students' anticipatory effect after graduation were ‘self-achievement’, ‘development of professional skills’, and ‘admission to post-graduate school or programs to study abroad’. 5. The students were very satisfied with the quality of faculty members, and satisfied with the quality of lectures and teaching. However, students were unsatisfied with rented lecture rooms, and very unsatisfied with self-directed learning methods. 6. School nurses showed higher statistical significances in the need for teaching material and anticipatory effect after graduation than other RN students working in hospitals and public health agencies. Also, school nurses, public health nurses, and industry nurses showed higher statistical significances in motives of admission than RN students working in hospitals. Further more, staff nurses, school nurses, and industry nurses showed higher levels of satisfaction toward a RN-to-BSN programs than nurses in higher positions, such as administrators or directors of nursing. 7 City residents were more satisfied with RN-to-BSN programs than rural residents. Otherwise, the rural residents had higher motives for admission, a bigger need for teaching materials, and recognition of the disadvantages of RN-to-BSN programs than city residents. Finally, RN students who earned below a monthly income of ￦1,000,000 showed higher motivation for admission than those who earned more than ￦1,000,000.