• Bulletin of the Korean Space Science Society
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• 2004.04a
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• pp.87-87
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• 2004

FIMS(Far-Ultraviolet Imaging Spectrograph)는 2003년에 발사된 과학 위성 1호의 주탑재체이다. FIMS는 우주의 고온 플라즈마에서 방출되는 원적외선(900-1750$\AA$) 영역을 2$\AA$의 분해능을 갖고 관측하는 기기로써 관측 영역의 범위는 선택된 천문학 target과 지구 북반구의 aurora에서 지구 대기의 glow까지 포함하고 있다. 본 연구에서는 위성발사 후 과학 위성 1호의 FIMS로부터 관측되어 내려온 data 중에서 aurora 관측 자료를 이용하여 aurora의 특성 spectrum에 대하여 분석해 보고자 한다. (중략)

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7291-7296
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• 2014

Different plant parts of Flacourtia indica have long been used in Ayurvedic medicine. Previous studies have demonstrated that the methanolic extract of F. indica possess anti-inflammatory properties. The present study was aimed at investigating the anticancer effects of methanol extract of Flacourtia indica (FIM) aerial parts in human colon cancer (HCT116) cells. Treatment of cells with FIM at a concentration of $500{\mu}g/ml$ for 24 hours significantly reduced cell viability and induced apoptosis, which was associated with the increased cytoplasmic expression of cytochrome c, activation of caspase-3, and the cleavage of poly-(ADP-ribose) polymerase. Incubation with FIM also inhibited the levels of Bcl-2, Bcl-xl and survivin, which are the markers of cell proliferation, whereas the expression of Bax remained unchanged. Treatment with FIM led to the generation of reactive oxygen species (ROS) in a concentration-dependent manner. Pharmacological inhibition of ROS generation by pretreatment of cells with N-acetyl cysteine abrogated FIM-induced apoptosis in HCT116 cells. Thus, these results demonstrate that FIM has anti-proliferative and pro-apoptotic effects in HCT116 cells and the effects are, at least in part, due to the ROS dependent activation of caspases.

• Journal of the Korea institute for structural maintenance and inspection
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• v.13 no.2 s.54
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• pp.129-136
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• 2009

The paper presents an algorithm of selecting optimal locations for measuring displacements(OLD) to adjust cable tension forces during the construction of cable-stayed bridges. The rank for optimal locations can be determined from the effective independence distribution vectors(EIDV) that are computed from the Fisher Information Matrices(FIM) formulated with the displacement sensitivities. To examine the efficiency and reliability of the proposed algorithm for determining OLD, a simulation study on a cable-stayed bridge has been carried out. The results using FIM formulated with displacements are compared with those using FIM with displacement sensitivities through the simulation study. The effects of measurement noise and error in cable length on the adjustment of cable tension forces are evaluated statistically by applying the Monte Carlo scheme.

• Journal of Korean Physical Therapy Science
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• v.15 no.1
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• pp.11-20
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• 2008

This study was designed to test the effects of comprehensive rehabilitation management on functional recovery after attack of cerebrovascular disease. 16 cerebrovascular disease patients applied comprehensive rehabilitation management of physical therapy at department of physical Therapy, C medical center in Gwang－ju. The collection of the data had been executed for 4months(April 15, 2007${\sim}$July 15, 2007). For evaluating, Functional Independence measure(FIM) and Somatosensory Evoked Potential(SSEP) were used to assess functional recovery. The results of this study were as follows: 1. In the comparison of latency of median nerve SSEP before and after treatment, the lat. N20 and P25 increased, the ampl. P25/N20 was decreased. In the comparison difference data of median nerve SSEP, however there was no significant difference in the group(p>0.05). 2. In the comparison of latency of Post Tibial nerve SSEP before and after treatment, the lat. P40, P50, P60 increased, the ampl. P40 was decreased. In the comparison difference data of post tibial nerve SSEP, however there was no significant difference in the group(p>0.05). 3. In the comparison of FIM scores of Self－care, Sphincter Control, Mobility: Transfer, Locomotion before and after treatment, the scores of FIM was significantly increased. In the comparison of difference of the motor part of FIM, however there was significant difference(p<0.05). 4. In the comparison of FIM scores of Communication, Social Cognition before and after treatment, the scores of FIM was significantly increased. In the comparison of difference of the motor part of FIM, however there was no significant difference in the group(p>0.05). Based on these results, it is concluded that the comprehensive rehabilitation management for cerebrovascular disease case was not significant difference in the SSEP, was significant difference in the motor part of FIM. Further study should be done to analyze the effect of intervention duration of treatment, optimal time to apply the treatment in more long period.

• Therapeutic Science for Rehabilitation
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• v.1 no.1
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• pp.71-79
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• 2012

Objective : To investigate the correlation between relationship ability and ADL performance ability of patients with TBI. Methods : This study was carried out from March 2012 to April 2012 with 20 patients with TBI. Relationship ability assessed using Relationship Change Scale(RCS), ADL performance ability assessed using Functional Independence Measure(FIM). Results : The RCS showed a high level of correlation with marital status and duration of illness. The RCS showed a high level of correlation with the FIM total score and the FIM cognition area. However the RCS did not show a correlation with the FIM motor area. Conclusions : Functional disability of social cognition is a factor that disturbs rehabilitation after TBI and it has a negative influence on the relationship in ADL. If accurate evaluation and treatment on relationship ability after TBI are carried out side by side from the initial stages of onset, we could expect more patients to improve their social cognition and ADL performance ability.

• Physical Therapy Korea
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• v.4 no.2
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• pp.89-99
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• 1997

임상 결과의 측정에서 새로운 관점을 갖는 것은 중요하다. 의료 재활은 심리적 측정의 질들(표준화, 신뢰도, 타당도)에서 충분한 노력에 수행되어지지 않아 왔기 때문에 환자와 프로그램 사이에 일반화된 기능적인 평가 범위가 부족하다. 장애의 적절한 측정을 위한 요구는 기능적인 상태에서 변화들을 알리고 치료의 필요성을 평가하고 치료를 계획하고 결과를 예측하고 보상 방법을 측정하기 위한 환자의 치료와 임상 연구에서 모두 나타난다. 세계적으로 사용되어지고 있는 기능 평가 도구인 FIM으로부터 이 연구는 신체적 측정의 기대되어진 것에 유사한 비율로 기능적 평가 측정들을 구성한다. 노인 재활에서 기능적인 결과의 측정은 중요한 몇 가지 점이 있다. 첫째는 접근에 기초한 기능적인 결과는 치료 목표 설정에 필요하다. 둘째는 도구는 기능적인 향상을 예상하는데 유용해야 한다. 셋째는 기능 평가는 적절한 타당도와 신뢰도와 함께 고려되어져야만 한다. 넷째는 다른 기능적 도구들이 함께 평가되어져야 할 필요가 있다는 것이다. FIM의 목록의 어려운 접들은 손상을 입은 집단에서는 다소 다양하다. 가장 중요한 부분이기 때문에 하나의 운동범위는 요통과 화상을 입은 환자를 제외한 모든 손상을 입은 집단들에게 적용되어 질 수 있다. 기능의 운동과 인지적인 면은 구분되어지는 것이 중요하였고 분리되어져서 치료되어 졌다. 어려운 목록들은 손상을 입은 집단에서 다양하였고, 다양한 손상의 종류의 독특한 영향을 반영하였다. FIM은 기능적인 장애를 측정하기 위해 고안되어진 또 다른 도구이다. 그리고 다른 것들은 의료 재활을 위한 국제적 자료 체계를 만들기 위한 것이다. FIM의 목적은 의료 재활의 결과를 확인하고 장애의 정도의 측정을 포함한다. FIM은 7가지 수준에서 사회적 인지, 의사 소통, 이동, 움직임 (mobility), 소변 관리, 자조 활동을 평가한다. 범위는 총체적 도움의 비율로부터 완전하게 독립적인 것까지의 범위이고 도움, 감독, 도구의 사용의 범위를 고려한다. 27,009의 환자를 조사한 최근 검사 기록들은 FIM이 움직임(motor)과 인지 기능을 평가하는 것이라는 것을 보여준다(Hinemann, 1993). FIM의 저자들은 자료가 프로그램 평가의 시도에서 즉각적으로 적용 할 수 있기를 기대한다. FSI은 어떤 과제의 수행에서 어려움에 관계된 정보를 제공하는 것을 나타내고 과제를 수행하기 위한 환자를 위한 변경된 전략들을 발달시키기 위해 노력하는 임상가들에게 유용할 수 있다. 두 도구 모두는 전통적인 범위들보다 고관절 골절을 동반한 장애의 좀더 정확한 정보를 모으도록 할 수 있다. 고찰된 모든 연구의 결과들은 골절 후에 남아 있는 잔여 장애의 중요한 수준을 강조한다. 골절 전의 보행으로 회복된 사람은 매우 드물었다. 대부분은 기본적인 움직임 혹은 옷입기, 개인 위생에 관계된 활동들에서 의존적이었다. 많은 사람들은 사회에서 활동을 할 수 없었다. 장애의 적절한 측정의 요구는 환자 치료와 기능적인 상태에서 변화를 알고 치료의 요구도를 측정하고 치료를 계획하고 결과를 예상하고 보상 수단을 결정하는 임상적 연구에서 모두 나타난다. 물리치료 분야는 분야의 다른 영역에서 기능적인 결과를 충족시키고 발달시키는 것이 필요하다.

• Physical Therapy Korea
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• v.7 no.3
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• pp.49-61
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• 2000

Although the availability of home care rehabilitation services have been greatly increased since community-based rehabilitation was introduced to Korea, there is still a dearth of studies investigating the performance level of ADL (activities of daily living) for the physically disabled in the rural areas. The purposes of this study were to investigate the ADL performance level of disabled persons living at home in the rural areas of Wonju city, Korea, using FIM (functional independence measure) and to identify the specific areas of the ADL to be trained or evaluated by physical therapists or occupational therapists. 298 disabled people were interviewed by 10 physical therapy students. Analysis of the interviews indicated: 1) Forty seven point seven percent of the respondents were elderly-disabled persons whose ages were 61 years old or above, and 69.5% of respondents has the history of chronic disability period of 5 years or more. 2) FIM score of bathing, and stairs climbing showed severe dependent trend 3) FIM scores of self-feeding, urination, defecation, and comprehension ability were mildly dependent. These results revealed that functional evaluation/treatment for discharging from hospitals to the rural areas should be emphasized on the specific ADL performance areas such as bathing, and stairs climbing.

• IMMUNE NETWORK
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• v.9 no.5
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• pp.203-207
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• 2009

Background: The FimA of Porphyromonas gingivalis is a crucial pathogenic component of the bacteria and has been implicated as a target for vaccine development against the periodontal diseases. Methods: In this study, the purified fimbriae (FimA subunit polymers) protein was used for immunization in their native form and B hybridoma clones producing antibodies specific to FimA were established. Results: The monoclonal antibodies prepared from selected two clones, designated #123 (IgG2b/ kappa) and #265 (IgG1/kappa), displayed different patterns of binding activity against the cognate antigen. Both antibodies reacted with conformational epitopes expressed by partially dissociated oligomers, but not with monomer as elucidated by Western blot analysis. Ascites fluid containing the monoclonal antibodies showed the inhibitory activity against P. gingivalis to saliva-coated hydroxyapatite beads, an in vitro model for the pellicle-coated tooth surface. Conclusion: These results suggest that the monoclonal antibodies could be used as vaccine material against the periodontal diseases through passive immunization.

• Journal of Korean Physical Therapy Science
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• v.6 no.4
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• pp.251-262
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• 1999

This study is designed to evaluate the effects of aggressive fine motor exercise of unaffected hand in the hemiplegic patients. The 36 hemiplegic patients were classified into two groups: The experimental 18, who were treated by aggressive fine motor exercise in unaffected hand and the control, 18, who were treated by conventional exercise program. We evaluate the effects of aggressive fine motor exercise by Functional Independence Measure(FIM) and Jebsen Hand Function Test(JHFT) after 6 weeks program. After exercise program, the experimental group showed score change from $43.05{\pm}15.68$ to $58.05{\pm}17.12$ in FIM score and from $24.12{\pm}22.03$ to $55.44{\pm}21.50$ in Jebsen, and the control showed score change from $51.11{\pm}22.61$ to $57.50{\pm}23.66$ in FIM score and from $40.88{\pm}21.17$ to $52.77{\pm}19.42$ in Jebsen. The experimental group had significantly higher score in FIM and JHFT than that of the control group. The aggressive fine motor exercise is beneficial in unaffected hand in the hemiplegic patients.

• The Journal of Internal Korean Medicine
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• v.21 no.1
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• pp.146-155
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• 2000

Objectives : This study was to investigate using FIM(functional independence measure) in 70patients with stroke and to evaluate prognosis. Methods : The subjects of this study were 70 patients who were admitted to the Dong-Eui oriental hospital within 7days after stroke. Improving rate were measured by using the FIM(at admission, after 2week and 4week). Each patients was diagnosed with sasang constitutional analysis(QSCC ll), Brain-CT, MRI scan and clinical observation. Results : There were significant results statistically between FIM(degree of improvement) and sex, age, side of hemiparesis, and hypertension. While diabetes mellitus, heart disease, hypercholesterolemia, and severity of early state were not significant meaning statistically. Conclusions : Sex, age, side of hemiparesis, and hypertension were relevant factors in predicting the functional outcome in the patients with stroke. I thought that the meaning of man-left and woman-right(男左女右) is not severity of early state but degree of improvement.