• Korean Circulation Journal
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• 제54권7호
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• pp.382-394
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• 2024

Background and Objectives: Fractional flow reserve (FFR) is an invasive standard method to identify ischemia-causing coronary artery disease (CAD). With the advancement of technology, FFR can be noninvasively computed from coronary computed tomography angiography (CCTA). Recently, a novel simpler method has been developed to calculate onsite CCTA-derived FFR (CT-FFR) with a commercially available workstation. Methods: A total of 319 CAD patients who underwent CCTA, invasive coronary angiography, and FFR measurement were included. The primary outcome was the accuracy of CT-FFR for defining myocardial ischemia evaluated with an invasive FFR as a reference. The presence of ischemia was defined as FFR ≤0.80. Anatomical obstructive stenosis was defined as diameter stenosis on CCTA ≥50%, and the diagnostic performance of CT-FFR and CCTA stenosis for ischemia was compared. Results: Among participants (mean age 64.7±9.4 years, male 77.7%), mean FFR was 0.82±0.10, and 126 (39.5%) patients had an invasive FFR value of ≤0.80. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of CT-FFR were 80.6% (95% confidence interval [CI], 80.5-80.7%), 88.1% (95% CI, 82.4-93.7%), 75.6% (95% CI, 69.6-81.7%), 70.3% (95% CI, 63.1-77.4%), and 90.7% (95% CI, 86.2-95.2%), respectively. CT-FFR had higher diagnostic accuracy (80.6% vs. 59.1%, p<0.001) and discriminant ability (area under the curve from receiver operating characteristic curve 0.86 vs. 0.64, p<0.001), compared with anatomical obstructive stenosis on CCTA. Conclusions: This novel CT-FFR obtained from an on-site workstation demonstrated clinically acceptable diagnostic performance and provided better diagnostic accuracy and discriminant ability for identifying hemodynamically significant lesions than CCTA alone.

• Korean Circulation Journal
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• 제52권1호
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• pp.47-59
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• 2022

Background and Objectives: The influence of pre-intervention coronary physiologic status on outcomes post percutaneous coronary intervention (PCI) is not well known. We sought to investigate the prognostic implications of pre-PCI fractional flow reserve (FFR) combined with post-PCI FFR. Methods: A total of 1,479 PCI patients with pre-and post-PCI FFR data were analyzed. The patients were classified according to the median values of pre-PCI FFR (0.71) and post-PCI FFR (0.88). The primary outcome was target vessel failure (TVF) at 2 years. Results: The risk of TVF was higher in the low pre-PCI FFR group than in the high pre-PCI FFR group (hazard ratio, 1.82; 95% confidence interval, 1.15-2.87; p=0.011). In 4 group comparisons, the cumulative incidences of TVF at 2 years were 3.8%, 4.1%, 4.8%, and 10.2% in the high pre-/high post-, low pre-/high post-, high pre-/low post-, and low pre-/low post-PCI FFR groups, respectively. The risk of TVF was the highest in the low pre-/low post-PCI FFR group among the groups (p values for comparisons <0.05). In addition, the high pre-/low post-PCI FFR group presented a comparable risk of TVF with the high post-PCI FFR groups (p values for comparison >0.05). When the prognostic value of the post-PCI FFR was evaluated according to the pre-PCI FFR, the risk of TVF significantly decreased with an increase in post-PCI FFR in the low pre-PCI FFR group, but not in the high pre-PCI FFR group. Conclusions: Pre-PCI FFR was associated with clinical outcomes after PCI, and the prognostic value of post-PCI FFR differed according to the pre-PCI FFR.

• Korean Journal of Radiology
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• 제22권12호
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• pp.1964-1973
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• 2021

Objective: To investigate the diagnostic performance of CT fractional flow reserve (CT-FFR) for myocardial bridging-related ischemia using dynamic CT myocardial perfusion imaging (CT-MPI) as a reference standard. Materials and Methods: Dynamic CT-MPI and coronary CT angiography (CCTA) data obtained from 498 symptomatic patients were retrospectively reviewed. Seventy-five patients (mean age ± standard deviation, 62.7 ± 13.2 years; 48 males) who showed myocardial bridging in the left anterior descending artery without concomitant obstructive stenosis on the imaging were included. The change in CT-FFR across myocardial bridging (ΔCT-FFR, defined as the difference in CT-FFR values between the proximal and distal ends of the myocardial bridging) in different cardiac phases, as well as other anatomical parameters, were measured to evaluate their performance for diagnosing myocardial bridging-related myocardial ischemia using dynamic CT-MPI as the reference standard (myocardial blood flow < 100 mL/100 mL/min or myocardial blood flow ratio ≤ 0.8). Results: ΔCT-FFR_systolic (ΔCT-FFR calculated in the best systolic phase) was higher in patients with vs. without myocardial bridging-related myocardial ischemia (median [interquartile range], 0.12 [0.08-0.17] vs. 0.04 [0.01-0.07], p < 0.001), while CT-FFR_systolic (CT-FFR distal to the myocardial bridging calculated in the best systolic phase) was lower (0.85 [0.81-0.89] vs. 0.91 [0.88-0.96], p = 0.043). In contrast, ΔCT-FFR_diastolic (ΔCT-FFR calculated in the best diastolic phase) and CT-FFR_diastolic (CT-FFR distal to the myocardial bridging calculated in the best diastolic phase) did not differ significantly. Receiver operating characteristic curve analysis showed that ΔCT-FFR_systolic had largest area under the curve (0.822; 95% confidence interval, 0.717-0.901) for identifying myocardial bridging-related ischemia. ΔCT-FFR_systolic had the highest sensitivity (91.7%) and negative predictive value (NPV) (97.8%). ΔCT-FFR_diastolic had the highest specificity (85.7%) for diagnosing myocardial bridging-related ischemia. The positive predictive values of all CT-related parameters were low. Conclusion: ΔCT-FFR_systolic reliably excluded myocardial bridging-related ischemia with high sensitivity and NPV. Myocardial bridging showing positive CT-FFR results requires further evaluation.

• 전기학회논문지
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• 제66권4호
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• pp.629-635
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• 2017

Free-Flooded Ring (FFR) transducer array for use in Sonar system can be driven with large amplitude in a wide frequency band due to its structural characteristics, in which two resonances of a ring mode (1st radial mode) and an inner cavity vibration mode occur in a low frequency band. Since its sound wave generation characteristics are not influenced by the water pressure, the FFR transducer array is widely used in the deep sea. So FFR has been recognized as a low-frequency active sound source and has received much attention ever since. In order to utilize the FFR transducer array for SONAR systems in military and industrial applications, its equivalent electric circuit model is necessary especially to design the matching circuit between the driving power amplifier and the FFR transducer array. Thus this paper proposes the equivalent electric circuit model of FFR transducer array by using measured values of parameter, and suggest the improved method of parameter identification. Finally it verifies the effectiveness of the proposed circuit model of FFR transducer array by experimental measurements.

• EDISON SW 활용 경진대회 논문집
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• 제6회(2017년)
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• pp.628-630
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• 2017

관상동맥의 협착 병변의 위험성을 치료 및 예방하기 위하여 FFR(Fractional flow reserve)이라는 지표를 사용한다. 기존의 임상에서 FFR을 측정하기 위하여 침습적인 방법을 이용하여 진행하였다. 이러한 침습적 방법은 부작용의 위험성을 가지고 있기 때문에 컴퓨터 시뮬레이션을 통해 계산하면 위험성을 해소할 수 있다. 하지만 현재 컴퓨터 시뮬레이션은 CT image를 이용하기 때문에 칼슘을 정확히 구별하거나 지질의 위치 등을 확인하는 것이 어렵기 때문에 FFR 결과에 오류를 발생시킬 수도 있고, 또한 전체 관상동맥을 해석하기 때문에 많은 계산량이 필요하다. 본 연구에서는 최근 높은 해상도를 가진 OCT(Optical Coherence Tomography)를 이용하여 이러한 한계점을 극복하고자 하고, 임상에서 측정한 FFR과 OCT에서 측정된 FFR은 비교하는 것이 목적이다.

• 통합자연과학논문집
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• 제13권1호
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• pp.1-7
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• 2020

This paper proposes a novel fractional frequency reuse(FFR) based on dynamic user distribution. In the FFR, a macro cell is divided into two regions, i.e., the inner region(IR) and outer region(OR). The criterion for dividing the IR and OR is the distance ratio of the radius. However, these distance-based criteria are uncertain in measuring user performance. This is because there are various attenuation phenomena such as shadowing and wall penetration as well as path loss. Therefore, we propose a novel FFR based on dynamic user classification with signal to interference plus noise ratio(SINR) of macro users and classify the FFR into two regions newly. Simulation results show that the proposed scheme has better performance than the conventional FFR in terms of SINR and throughput of macro cell users.

• 한국통신학회논문지
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• 제37권8B호
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• pp.687-694
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• 2012

OFDMA(Orthogonal Frequency Division Multiple Access) 기반 셀룰러 시스템에서 셀 간 간섭은 셀 가장자리에 위치한 단말의 수신 성능을 악화시킴으로써 전체 시스템의 성능을 감소시킨다. 따라서 셀 간 간섭을 제거하는 것은 셀룰러 시스템의 성능 향상에 가장 중요한 요소 중 하나이다. 이를 위해 4세대 통신망에는 부분 주파수 재사용(FFR : Fractional Frequency Reuse)이 도입되었다. FFR은 간섭 제어 기술 중의 하나로써, 하나의 셀을 내부 셀과 외부 셀로 분할하고 내부 셀의 경우 전체 시스템 대역폭을, 외부 셀의 경우 섹터에 따라 서로 다른 주파수 파티션을 할당한다. 이렇게 함으로써 외부 셀에 속한 단말은 인접한 셀로부터의 간섭을 무시할 수 있게 되고 이에 따라 셀 가장자리에 위치한 단말의 수신 성능이 대폭 개선된다. 하지만 FFR은 대역폭 측면에서 치명적인 부작용을 가진다. 외부 셀의 각 섹터에 서로 다른 주파수 파티션을 할당하기 위해서 하나의 섹터에는 전체 시스템 대역폭의 1/3만을 할당할 수 있게 된다. 이렇게 감소한 대역폭은 시스템 전송률을 직접적으로 감소시킨다. 이러한 문제를 해결하기 위해 본 논문에서는 분할대역을 일정 비율만큼 중첩해서 사용하는 새로운 FFR 방법을 제안하고 실제 셀룰러 시스템에 적합한 중첩 비율을 제시한다.

• 한국음향학회지
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• 제41권3호
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• pp.278-286
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• 2022

본 연구에서는 압전세라믹 기반의 상용 Free-Flooded Ring(FFR) 트랜스듀서 대비 소형이면서 저주파 고감도 특성을 확보하기 위해, 높은 압전상수와 전기-기계 결합계수를 가지는 압전단결정 PIN-PMN-PT를 적용한 33-모드 FFR 트랜스듀서를 설계하였다. FFR 트랜스듀서의 광대역 특성을 확보하기 위해 비능동소자를 삽입한 링 구조를 적용하였으며, 3종의 비능동소자 소재 별 특성 해석 결과를 비교하여 최적의 소재를 선정하였다. 링 트랜스듀서의 특성 변화를 최소화하기 위해 오일 충진형 FFR 트랜스듀서로 제작하였으며, 음향시험을 통해 송신감도, 수중 임피던스 및 수평/수직 빔패턴이 해석결과와 잘 일치하는지 확인하였다. 해석 및 시험 결과를 비교한 결과, 송신감도는 공동공진 주파수에서 약 1.3 dB, 구조공진 주파수에서는 약 0.3 dB 차이를 보였다. 또한 상용 트랜스듀서 대비 높은 송신감도를 보유하면서도 직경을 약 17 % 축소하여 제작할 수 있었다. 이를 통해 소형이면서 고출력 특성을 가지는 압전단결정적용 FFR 트랜스듀서의 구현 가능성과 해석을 통한 특성 예측 방법의 유효성을 확인하였다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권12호
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• pp.4819-4834
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• 2015

The spectral efficiency of cellular networks can be improved when proximate users engage in device-to-device (D2D) communications to communicate directly without going through a base station. However, D2D communications that are not properly designed may generate interference with existing cellular networks. In this paper, we study resource allocation and power control to minimize the probability of an outage and maximize the overall network throughput. We investigate three power control-based schemes: the Partial Co-channel based Overlap Resource Power Control (PC.OVER), Fractional Frequency Reuse based Overlap Resource Power Control (FFR.OVER) and Fractional Frequency Reuse based Adaptive Power Control (FFR.APC) and also compare their performance. In PC.OVER, a certain portion of the total bandwidth is dedicated to the D2D. The FFR.OVER and FFR.APC schemes combine the FFR techniques and the power control mechanism. In FFR, the entire frequency band is partitioned into two parts, including a central and edge sub-bands. Macrocell users (mUEs) transmit using uniform power in the inner and outer regions of the cell, and in all three schemes, the D2D receivers (D2DRs) transmit with low power when more than one D2DRs share a resource block (RB) with the macrocells. For PC.OVER and FFR.OVER, the power of the D2DRs is reduced to its minimum, and for the FFR.APC scheme, the transmission power of the D2DRs is iteratively adjusted to satisfy the signal to interference ratio (SIR) threshold. The three schemes exhibit a significant improvement in the overall system capacity as well as in the probability of a user outage when compared to a conventional scheme.

• 한국환경보건학회지
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• 제25권3호
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• pp.108-112
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• 1999

A study was conducted for the effects of input energy on fume formation ratios based on electrode(FFR$_{electrode}(g/kg_{electrode})),\;deposited\;metal(FFR_{weld}(g/kg_{weld}))\;and\;slag(FFR_{slag}(g/kg_{slag}))\;at\;CO_2$ flux cored arc welding on stainless steel. Experiments were run in well designed welding fume box. Six types of flux cored wires were used and three levels of current and voltages were given. The measured values of $FFR_{electrode},\;FFR_{weld},\;FFR_{slag}\;are\;7.90{\pm}1.47\;g/kg_{electrode},\;9.18{\pm}1.65\;g/kg_{\electrode},\;71.8{\pm}24.2\;g/kg_{slag}$ respectively. Fume formation ratios are not increased dramatically by input energy because of simultaneous increasing of melted electrodes, deposited metal and slag. The results indicate that the test of fume formation ratios in the research on production of low fume welding wire can be run at the fixed condition of input energy rather than various condition.