• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2020.11a
• /
• pp.12-13
• /
• 2020

Free-form buildings usually have large curved shapes on the outside. In order to construct this curved shape, the exterior of the building must be divided into easy-to-manufacture shapes, and the segmented panel is called the FCP(Free-form Concrete Panel). These FCPs have different shapes and cannot reuse molds. To solve these problems, the researchers developed FCP manufacturing equipment to manufacture a mould of FCP. However, the developed equipment alone cannot completely manufacture FCP's mould. This is because there is no mould to implement side of FCP. Therefore, it is necessary to develop a side form of FCP that can be applied to FCP manufacturing equipment. To this end, this study analyzes the basic requirements that side mould should have before developing side mould.

• Journal of Sericultural and Entomological Science
• /
• v.40 no.2
• /
• pp.131-135
• /
• 1998

Changes of silk fibroin molecular weight was studied by enzymatic proteolysis and reverse reaction of enzymatic proteolysis (plastein reaction) using chromatography, X-ray diffraction and thermal analysis methods. When the treatment of enzymatic proteolysis with $\alpha$-chymotripsin to silk fibroin solution, a precipitate of Fcp fractions was formed. And, this was dissolved in LiBr aqueous solution, the precipitate of PIFcp fractions was obtained again. Fcp and PIFcp fractions showed silk IIand silk Itype structure, respectively. Fcp fractions was about 6,900 in molecular weight, PIFcp fractions obtained by plastein reaction on the precipitate of Fcp fractions increased molecular weight to abort 15,000. The molecular weight of Fcp fractions was increased by plastein reaction, but Fcp fractions almost transited to silk I type crystal. The structure of silk I type of PIFcp fractions was steady identified by X-ray diffraction and thermal analysis. As molecular weight of Fcp fractions was gradually low, PIFcp fractions was become to macromolecule little by little.

• Journal of Sericultural and Entomological Science
• /
• v.39 no.1
• /
• pp.73-78
• /
• 1997

The crystalline fraction of silk fibroin (Fcp) was obtained from the aqueous solution of silk fibroin hydrolyzed by $\alpha$-chymotrypsin. The molecular weight of Fcp was found approximately 7000 by using high speed GPC. On the other hand, a high molecular weight of PIFcp product could be obtained by the reverse reaction of enzymatic proteolysis of Fcp precipitates. Some parts of this PIFcp have the molecular weights of approximately 17000 and 24000. As a result of x-ray diffraction analysis, the crystal structure of Fcp and PIFcp was turned out silk-II type and silk-I type, respectively. Upon the reverse reaction of enzymatic protelysis, the structural transition occured from silk-II type to silk-I type crystal for the most of Fcp precipitates. It was confirmed that PIFcp might be somewhat stable crystal structure of silk-I type according to the thermal analysis as well as x-ray diffraction method.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2019.11a
• /
• pp.4-5
• /
• 2019

With recent advances in computer technology, the ratio of free-form building designs to those of the past is increasing gradually. However, the current technology of free-form structure is very low. The core technology for free-form building implementation is the manufacturing technology of FCP (Free-form Concrete Panel), which indicates an unformed outside, and through the development of FCP manufacturing technology, the construction technology of free-form architecture can be enhanced. The inside and outside of an free-form building should be represented by the designer's intended curvature, and the panel's thickness by segment should be constant. For this reason, the technology that keeps the thickness of panels constant during the FCP production process is a key technology that can improve the quality of FCP. In this study, a basic study on ways to maintain a constant thickness of FCP is conducted.

• Journal of Sericultural and Entomological Science
• /
• v.39 no.1
• /
• pp.67-72
• /
• 1997

As a condition for obtaining the silk I type crystal that has stability and high reproducibility, after dissolving silk fibroin crystalline part (Fcp), the changes of recrystallized crystal structure according to dialytic pH were examined by x-ray diffraction and differential thermal analysis. The Fcp was obtained from the aqueous solution of silk fibroin enzymatic proteolyzed by chymotrypsin. The crystal structure of Fcp showed silk II type. When the Fcp was dissolved by 10M LiBr aqueous solution, the Fcp1 showed the silk II type at pH 9. However, besides the silk II type, the silk I type structure begins to appear at pH 8 and only the silk I type structure was found below pH 6. On the other hand, the Fcp2 that calcium chloride was used in the dissolution found only the silk I type crystal structure below pH8.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2021.05a
• /
• pp.8-9
• /
• 2021

FCP requires different curvatures and shapes according to the method of division, and it is necessary to manufacture a formwork accordingly. FCP production equipment consists of CNC equipment and side shape control equipment. This can be implemented in various shapes of upper, lower, and side surfaces. In the side shape control equipment, it is implemented as a variable side formwork. Among the required performance of the variable side formwork, there is stiffness against side pressure, which needs to be verified. Therefore, in this study, the FCP fabrication experiment is conducted with the developed variable side formwork. By analyzing the error in the shape of the fabricated FCP, the lateral pressure resistance capability of the side form is measured and verified.

• Proceedings of the Korean Institute of Building Construction Conference
• /
• 2023.05a
• /
• pp.165-166
• /
• 2023

Free-form Concrete Panel(FCP) is each panel that composes the concrete exterior skin of Free-form building. FCPs contain curved surfaces, and FCPs have different curvature, size, and angles. In order to manufacture FCP, high technology is required, and it is currently difficult to manufacture it according to the design shape. In particular, many errors occur in the side shape of FCP. This is because when the side silicone mold is applied, it is installed without a coupling method between molds and support device. In this study, basic research was conducted to develop a side silicone mold support device to solve the above problems. We classified the required performance and derived the detailed requirements. Also, Based on this, we drew the basic design of the support device. We plans to conduct design improvement, mock-up making, and FCP manufacturing experiments through future research.

• Toxicological Research
• /
• v.8 no.2
• /
• pp.161-170
• /
• 1992

The objectives of this sutdy were to investigate the effects of 8-fluorociprofloxacin(8-FCP) on the central nervous system (CNS) and to compare with those of ciprofloxacin(CP). The $LD_{50}$ values of intravenous 8-FCP were similar or slightly lower in rat (M;203.6mg/kg, F;186.1mg/kg)and markedly lower in mice (M;126.5mg/kg, F;163.1mg/kg), as compared to those of CP. However, no recognizable differences in the clinical signs and recovery were found between 8-FCP and CP in both species. In combination with fenbufen, the convulsive liability of 8-FCP was higher than that of CP. At an intravenous dose of 10mg/kg, 8-FCP provoked convulsive signs and subsequent death in mice, whereas CP produced convulsion at a dose of 40mg/kg. The hexobabital -induced sleeping time was markedly lengthened by the oral administration of 8-FCP, but slightly increased by CP. In addition, the two quinolone derivatives had analgesic effects. The analgesic activity of 8-FCP was approximately two times higher than that at CP. However, both 8-FCP and CP had little effects of pentylenetetrazole-or strychnine-induced convulsion and muscle relaxation. Our finding that 8-FCP had more remarkable CNS effects than CP strongly suggests that there should be differences in the pharmacokinetic characteristics and/or in the binding affinity for specific biologic targets, or receptors, in the CNS.

• YAKHAK HOEJI
• /
• v.37 no.3
• /
• pp.235-242
• /
• 1993

8-Fluorociprofloxacin(8-FCP) is an investigational quinolone derivative that is substituted with fluorine at the C-8 position of ciprofloxacin(CP). It was found that the in vitro activity of 8-FCP against Gram(+) bacteria was more potent that of CP, but the opposite against Gram(-) bacteria was true. However, 8-FCP showed better in vivo efficacy than CP against representative Gram(-) organisms, E. coli and K pneumoniae. In an attempt to seek for factors causing this discrepancy in the antibacterial activities, a comparative pharmacokinetic study of 8-FCP and CP was conducted in mice and rats treated either intravenously or orally at a single dose of 30 mg/kg. The pharmacokinetic parameters in mice were as follows; the mean peak serum concentrations(C$_{max}$) following i.v. and oral doses were 12.4 and 5.3 $\mu\textrm{g}$/ml for 8-FCP, and 9.5 and 2.5 $\mu\textrm{g}$/ml for CP, respectively. The terminal half-life(t$_{1/2\beta}$) was 72.9 min for 8-FCP, and 98.2 min for CP, and the oral bioavailability(F) was 89.9% for 8-FCP, and 50.5% for CP. In rats, the mean ($\pm$SD) $C_{max}$ after i.v. administration were 11.6$\pm$1.6 $\mu\textrm{g}$/ml for 8-FCP, and 10.2$\pm$1.3 $\mu\textrm{g}$/ml for CP, whereas oral administration produced $C_{max}$ of 5.9$\pm$1.8 $\mu\textrm{g}$/ml for 8-FCP and 1.1$\pm$0.9 $\mu\textrm{g}$/ml for CP, respectively. The t$_{1/2\beta}$ was 67.9$\pm$8.4 min for 8-FCP, and 76.4$\pm$7.2 min for CP. The F was 88.6$\pm$6.3% for 8-FCP, and 40.7$\pm$6.5% for CP. Marked differences were observed between the two quinolones in the $C_{max}$ and the area under the concentration-time curve obtained after oral administration in mice and rats. The extent of 8-FCP absorption in both mice and rats was approximately 2-fold higher than that of CP, suggesting that the fluorine atom attached to C-8 plays an important role in facilitating oral absorption from the gastrointestinal tract.

• ALGAE
• /
• v.30 no.2
• /
• pp.147-161
• /
• 2015

Brown algal extracts have long been used as feed supplements to promote health of farm animals. Here, we show new molecular insights in to the mechanism of action of a fucose containing polymer (FCP) rich fraction from the brown seaweed Ascophyllum nodosum using the Caenorhabditis elegans-Pseudomonas aeruginosa PA14 infection model. FCP enhanced survival of C. elegans against pathogen stress, correlated with up-regulation of key immune response genes such as: lipases, lysozyme (lys-1), saponin-like protein (spp-1), thaumatin-like protein (tlp-1), matridin SK domain protein (msk-1), antibacterial protein (abf-1), and lectin family protein (lfp). Further, FCP caused down regulation of P. aeruginosa quorum sensing genes: (lasI, lasR, rhlI, and rhlR), secreted virulence factors (lipase, proteases, and elastases) and toxic metabolites (pyocyanin, hydrogen cyanide, and siderophore). Biofilm formation and motility of pathogenic bacteria were also greatly attenuated when the culture media were treated with FCP. Interestingly, FCP failed to mitigate the pathogen stress in skn-1, daf-2, and pmk-1 mutants of C. elegans. This indicated that, FCP treatment acted on the regulation of fundamental innate immune pathways, which are conserved across the majority of organisms including humans. This study suggests the possible use of FCP, a seaweed component, as a functional food source for healthy living.