• Korean Chemical Engineering Research
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• v.55 no.2
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• pp.180-189
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• 2017

Pharmaceutical co-crystals primarily to improve the solubility as well as stability of insoluble drug are to be investigated more intensively for IMDs as US FDA has reclassified co-crystal as a special case of solvates in August this year. In this study, we proposed a mechanism of indomethacin-saccharin co-crystal formation and the creation of transient indomethacin meta-stable form using in-line monitoring tools with the addition rate of anti-solvent as a critical process parameter. Among various instruments, we combined PVM (particle vision measurement) and FBRM (focused beam reflectance measurement) for the in-line monitoring of anti-solvent co-crystallization process. The off-line characterization of resulting powders was carried out employing the PXRD (powder x-ray diffraction) and DSC (differential scanning calorimeter). It was observed that the pathway to the final IMC-SAC co-crystal was significantly dependent upon the anti-solvent addition rate. The process conditions to obtain high quality co-crystal powder effectively were established. Consequently, we concluded that in-line monitoring combing the PVM and FBRM should be useful for the in-line monitoring of pharmaceutical co-crystallization processes.

• Magazine of the Korea Concrete Institute
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• v.8 no.4
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• pp.171-179
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• 1996

A proposal of the basic fbrm on the design of joint parts that can increase the shear strength by the useful joint shapes of each member is intended. The vertical joint parameters are the number of' shear key and a variety of' reinfbrcement details and the horizontal joint paramctcrs arc t,hc number of shear key and the direction of' shear f'orcc. 10 PC panel vortical joint arid 12 PC panel horizontal joint specimens were tested to investigate the effects of these parameters. Test results show that : 1. The ductility of the test specimen that has the horizontal reinforcing steels is larger than that does not have. 2. The maximum resisting force of round bar specimen is similar to that of strand wire specimen under the condition of fixed horizontal displacement.