• Steel and Composite Structures
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• v.16 no.4
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• pp.389-415
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• 2014

This study deals with dynamic model of composite sandwich panels with functionally graded flexible cores under low velocity impacts of multiple large or small masses using a new improved higher order sandwich panel theory (IHSAPT). In-plane stresses were considered for the functionally graded core and face sheets. The formulation was based on the first order shear deformation theory for the composite face sheets and polynomial description of the displacement fields in the core that was based on the second Frostig's model. Fully dynamic effects of the functionally graded core and face-sheets were considered in this study. Impacts were assumed to occur simultaneously and normally over the top and/or bottom of the face-sheets with arbitrary different masses and initial velocities. The contact forces between the panel and impactors were treated as internal forces of the system. Nonlinear contact stiffness was linearized with a newly presented improved analytical method in this paper. The results were validated by comparing the analytical, numerical and experimental results published in the latest literature.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.5947-5954
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• 2012

The cancer stem cell (CSC) model states that cancers are organized in cellular hierarchies, which explains the functional heterogeneity often seen in tumors. Like normal tissue stem cells, CSCs are capable of self-renewal, either by symmetric or asymmetric cell division, and have the exclusive ability to reproduce malignant tumors indefinitely. Current systemic cancer therapies frequently fail to eliminate advanced tumors, which may be due to their inability to effectively target CSC populations. It has been shown that embryonic pathways such as Wnt, Hedgehog, and Notch control self-renewal and cell fate decisions of stem cells and progenitor cells. These are evolutionary conserved pathways, involved in CSC maintenance. Targeting these pathways may be effective in eradicating CSCs and preventing chemotherapy or radiotherapy resistance.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.13
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• pp.5149-5152
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• 2015

Cancer-testis antigens (CTAs) are a group of tumor-associated antigens with more than 140 members whose expression has been shown to be limited to gametogenic tissues and placenta among normal tissues. However, malignant tissues of different origins have shown aberrant and elevated expression of these antigens. Such a pattern of expression endows beneficial properties for use as cancer biomarkers as well as immunotherapeutic targets as a result of the immune-privileged status of the testes. CTAs have been shown to be expressed in pediatric brain tumors, different types of sarcomas, leukemias, and lymphomas as well as neuroblastomas. Although data regarding their expression pattern in childhood tumors are not as comprehensive as for adult tumors, it is supposed that CTA-based immunotherapeutic approaches can also be used for pediatric cancers. However, there are limited data about the objective clinical responses following immunotherapy in such patients. Here we try to review the available information.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.5005-5006
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• 2015

Gastric cancer as one of the most common cancers worldwide has various genetic and environmental risk factors including Helicobacter pylori (H.pylori) infection. Recently, loss of a tumor suppressor gene named promyelocytic leukemia (PML) has been identified in gastric cancer. However, no mutation has been found in this gene in gastric cancer samples. Cag A H.pylori protein has been shown to exert post transcriptional regulation of some tumor suppressor genes. In order to assess such a mechanism for PML degradation, we performed in silico analyses to establish any interaction between PML and Cag A proteins. In silico interaction and docking studies showed that these two proteins may have stable interactions. In addition, we showed that imatinib kinase inhibitor can restore PML function by inhibition of casein kinase 2.

• Journal of applied mathematics & informatics
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• v.18 no.1_2
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• pp.73-93
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• 2005

In this paper, we attempt to present a new numerical approach to solve non-linear backward stochastic differential equations. First, we present some definitions and theorems to obtain the conditions, from which we can approximate the non-linear term of the backward stochastic differential equation (BSDE) and we get a continuous piecewise linear BSDE correspond with the original BSDE. We use the relationship between backward stochastic differential equations and stochastic controls by interpreting BSDEs as some stochastic optimal control problems, to solve the approximated BSDE and we prove that the approximated solution converges to the exact solution of the original non-linear BSDE in two different cases.

• Proceedings of the Korea Water Resources Association Conference
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• 2004.05b
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• pp.1162-1166
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• 2004

본 연구에서는 미국의 Environmental Modeling Research Laboratory(EMRL)에서 개발한 지리정보시스템과 수문유출모형이 접목된 WMS(Watershed Modeling System) Ver.6.1 모형을 HEC-1모형과 연계하여 한강수계 안성천의 제1지류인 한천의 유출 해석을 실시하였다. 이를 위해 유역내의 지형특성인자 추출 및 하천망 구성(WMS), 재현기간별 지속시간별 확률강우량 산정(FARD2002), Huff분포법을 이용한 시간분포, ARF(Area Reduction Factor)적용, HEC-1내의 SCS단위도법, Snyder 단위도법, Clark의 유역추적법에 포함된 각각의 매개변수의 최적화를 시도하여 분석하고, 설계 홍수량 산정시 이용될 수 있는 지침 마련을 목적으로 하였다.

• Current Optics and Photonics
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• v.1 no.2
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• pp.150-156
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• 2017

A diffraction limited optical system for head mounted displays (HMDs) was designed. This optical system consists of four modules, including 1:5 mm and 5:30 mm beam expanders, polarization grating-polarization conversion system (PG-PCS) and refractive/diffractive projection optical module. The PG-PCS module transforms the unpolarized Gaussian beam to a linearly polarized beam and it simultaneously homogenizes the spatial intensity profile. The optical projector module has a $30^{\circ}$ field of view, a 22 mm eye relief, and a 10 mm exit pupil diameter with a compact structure. Common acrylic materials were utilized in the optical design process; therefore, the final optical system was lightweight. The whole optical system is suitable for a 0.7 inch liquid crystal on silicon microdisplay (LCOS) with HDTV resolution ($1920{\times}1080$) and $8.0{\mu}m$ pixel pitch.

• Transactions on Electrical and Electronic Materials
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• v.15 no.1
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• pp.12-15
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• 2014

At the moment of transformer energization by the supply voltage, a high current called transient inrush current, which may rise to ten times the transformer full load current, could be drawn by the primary winding. This paper discusses a microcontroller circuit with the intention of controlling and limiting the inrush current for a transformer, by the method of ramping up the supply voltage feeding to the transformer primary. Simulations and the experimental results show a significant reduction of inrush current, when the ramping up voltage is applied to the three-phase transformer load. The inrush current could be almost eliminated if the correct switching step rate is chosen.

• Structural Engineering and Mechanics
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• v.72 no.4
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• pp.525-540
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• 2019

The purpose of the present work was to study the dynamic instability of a three-layered, symmetric sandwich beam subjected to a periodic axial load resting on nonlinear elastic foundation. A higher-order theory was used for analysis of sandwich beams with soft core on elastic foundations. In the higher-order theory, the Reddy's third-order theory was used for the face sheets and quadratic and cubic functions were assumed for transverse and in-plane displacements of the core, respectively. The elastic foundation was modeled as nonlinear's type. The dynamic instability regions and free vibration were investigated for simply supported conditions by Bolotin's method. The results showed that the responses of the dynamic instability of the system were influenced by the excitation frequency, the coefficients of foundation, the core thickness, the dynamic and static load factor. Comparison of the present results with the published results in the literature for the special case confirmed the accuracy of the proposed theory.

• Advances in materials Research
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• v.12 no.1
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• pp.67-81
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• 2023

Basalt and poly-ester fibers along with epoxy resin were used to produce inter-ply, intra-ply and functionally gradient hybrid composites. In all of the composites, the relative content of basalt fiber to poly-ester fiber was equal to 50 percent. The flexural and charpy impact properties of the hybrid composites are presented with particular regard to the effects of the hybrid types, stacking sequence of the plies, loading direction and loading speed. The results show that with properly choosing the composition and the stacking sequence of the plies; the inter-ply hybrid composites can achieve better flexural strength and impact absorption energy compared to the intra-ply and functionally gradient composites. The flexural strength and impact absorption energy of the functionally gradient hybrid composites is comparable to, or higher than the intra-ply sample. Also, by increasing the loading speed, the flexural strength increases while the flexural modulus does not have any special trend.