• Proceedings of the Korean Operations and Management Science Society Conference
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• 2004.05a
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• pp.425-428
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• 2004

Flexible assembly line (FAL) is a production system that assembles various parts in unidirectional flow line with many constraints and manufacturing flexibilities. In this research we deal with a FAL balancing problem with the objective of minimizing the maximum workload allocated to the stations. However, almost all the existing researches do not appropriately consider various constraints due to the problem complexity. Therefore, this thesis addresses a balancing problem of FAL with many constraints and manufacturing flexibilities, unlike the previous researches. To solve this problem we use a genetic algorithm (GA). To apply GA to FAL, we suggest a genetic representation suitable for FAL balancing and devise evaluation method for individual's fitness and genetic operators specific to the problem, including efficient repair method for preserving solution feasibility. The experimental results are reported.

• The Transactions of the Korea Information Processing Society
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• v.2 no.6
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• pp.823-830
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• 1995

A reactive piloting policy for Flexible Assembly Lines (FAL) is proposed, where the sequencing of the operations as well as the assignment of tasks to manipulators are not predetermined but driven by the actual state of the FAL For all work-in-process coming from a manipulator, the next destination is determined by minimizing a temporal criterion taking into account the time needed to reach the destination, the load of the manipulator to reach, the durati on of the operation to be completed in the destination manipulator, and the availability of product components in this manipulator. The purpose of proposed piloting policy is to manufacture a given quantity of products as rapidly as possible by balancing the amount of work allocated to manipulators and to reduce the efforts required for scheduling the production of short series of diversified products. After introducing the characteristics of assembly processes and FAL modelization, the proposed algorithm is evaluated by simulations. The simulations of the proposed algorithm showed satisfactory results.

• Journal of the Korean Operations Research and Management Science Society
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• v.30 no.1
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• pp.43-54
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• 2005

A flexible assembly line (FAL) is a production system that assembles various parts in unidirectional flow line with many constraints and manufacturing flexibilities. In this research we deal with a FAL balancing problem with the objective of minimizing the maximum workload allocated to the stations. However, almost all the existing researches do not appropriately consider various constraints due to the problem complexity. Therefore, this study addresses a balancing problem of FAL with many constraints and manufacturing flexibilities, unlike the previous researches. We use a genetic algorithm (GA) to solve this problem. To apply GA to FAL. we suggest a genetic representation suitable for FAL balancing and devise evaluation method for individual's fitness and genetic operators specific to the problem, including efficient repair method for preserving solution feasibility. After we obtain a solution using the proposed GA. we use a heuristic method for reassigning some tasks of each product to one or more stations. This method can improve workload smoothness and raise work efficiency of each station. The proposed algorithm is compared and analyzed in terms of solution quality through computational experiments.

• Natural Product Sciences
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• v.23 no.2
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• pp.103-107
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• 2017

Angelica koreana is an important medicinal plant for some locals in East Asia including Korea. A few reports have shown the efficacy of its phytochemical constituents. We have isolated and purified one compound falcarindiol (FAL) from the methanolic extract of A. koreana roots. At concentrations from to $1{\mu}M$ to $25{\mu}M$, the FAL isolated from the roots of A. koreana exerted no significant cytotoxicity and down-regulated LPS-stimulated pro-inflammatory cytokine IL-8 in colon epithelial cells, while up-regulating anti-inflammatory cytokine IL-10. In addition, the FAL decreased the expression of LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein by Western blot analysis. Colon epithelial cells play pivotal roles in regulating the colon immune system and thus FAL is expected to be candidate agent as therapeutic potential for the treatment of inflammatory bowel disease (IBD) by modulating LPS-induced inflammation in colon epithelial cells.

• Korean Journal of Organic Agriculture
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• v.10 no.3
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• pp.1-24
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• 2002

This study aims to provide quite recent information on the organic agriculture in developed countries such as German, UK, Switzerland and USA and on the current activities of international research institutions of organic agriculture. The establishment and activity of ENOF in EU and ARNOA in Asia, IIRNOA in IFOAM was introduced shortly. I stitute of Organic Agriculture in FAL/Germany and FiBL in Switzerland. OMRI in USA, HDRA in UK and Schweisfurth Foundation in Germany were described. Also the educations in European universities for organic agriculture and the research activities and technical education system for organic farming were described. All of these informations could be useful for the further development of the strategy for Korean organic agriculture in education and research.

• Korean Journal of Organic Agriculture
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• v.10 no.1
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• pp.1-18
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• 2002

The aim of this study was to introduce the history and development of German organic farming(Bio-dynamic Agriculture and organic agriculture) which has a worldwide reputation and initiative in organic agriculture. And also the organization of organic producer's or farmer's group such as AGOL, POB, OSL, ALOG & Schweisfurth Stiftung and its regional distribution, the basic standard of organic farming and certification system for organic food, an actual cultivated area for organic forming and organic livestock were also shortly reported. The government subsidizing programmes and Agenda 2000, the extension services for organic farming by government and private level, the research activities of organic agriculture by governmental research body(FAL) and universities, the education system for organic agriculture in the German universities(University of Bonn, Gesamthochschule Kassel, University of Hohenheim, University of Gie$\beta$en and etc) were also explained. In the conclusion it was suggested several issues what should be considered to facilitate an organic farming in Korea in the view of organic production, marketing, distributing, extension and organic processing.

• Tuberculosis and Respiratory Diseases
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• v.50 no.6
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• pp.668-675
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• 2001

Background : Non-smalll lung cancer(NSCLC) develops as a result of the accumulation of multiple genetic abnormalities. Loss of heterozygosity(LOH) is one of the most frequent genetic alterations that is found in NSCLC, and the chromosomal regions that display a high rate of LOH are thought to harbor tumor suppressor genes(TSGs). This study was done to determine the frequency of LOH in 21q with the aim of identifying potential TSG loci. Method : Thirty-nine surgically resected NSCLCs were analysed. Patients peripheral lymphocytes were used as the source of the normal DNA. Five microsatellite Inarkers of 21q were used to study LOH : 21q21.1(D21S1432, and D21S1994); 21q21.2-21.3(D21S1442) ; 21q22.1(21S1445) ; and 21q22.2-22.3(D21S266). The fractional allelic loss(FAL) in a tumor was calculated as the ratio of the number of markers showing LOH to the number of informative markers. Result : LOH for at least one locus was detected in 21 of 39 tumors(53.8%). Among the 21 tumors with LOH, 5(21.8%) showed LOH at almost all informative loci. Although statistically not significant, LOH was found more frequently in squamous cell carcinomas(15 of 23, 65.2%) than in adenocarcinomas(6 of 16, 37.5%). In the squamous cell carcinomas the frequency of LOH was higher in stage II-III (80.0%) than in stage I (53.8%). The FAL value in squamous cell carcinomas($0.431{\pm}0.375$) was significantly higher than that found in adenocarcinomas($0.l92{\pm}0.276$). Conclusion : These results suggest that LOH on 21q may be involved in the development of NSCLC, and that TSG(s) that contribute to the pathogenesis of NSCLC may exist on 21q.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.05a
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• pp.564-567
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• 2004

FAs and BAs indicated different chemical compositions and physical properties. Leaching of Pb in FAl and Cu in FA2 were 33.2mg/L and 5.92mg/L, these were high concentration above 30 and 2 times respectively in compared to permit level. Leaching of Hg and Cr were about 1/2 of permit level. When diatom was complexly mixed with portland cement, the 28 days compressive strength of mortar with FA2 was similar with that of control mortar. Furtherfore, leaching of heavy metal ions like as Pb, Cu, Hg, Cr was highly reduced.

• Journal of the Korean Institute of Intelligent Systems
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• v.11 no.3
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• pp.280-285
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• 2001

We introduce the new concepts of some fuzzy continuous and closed mappings and study their properties. Also we investigate the properties of fuzzy mildly normal spaces.

• Proceedings of the Korean Society of Crop Science Conference
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• 1994.10a
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• pp.44-45
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• 1994