• Reproductive and Developmental Biology
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• v.33 no.2
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• pp.77-83
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• 2009

Erythropoietin (EPO), a glycoprotein hormone produced from primarily cells of the peritubular capillary endothelium of the kidney, is responsible for the regulation of red blood cell production. We have been investigating the roles of glycosylation site added in the biosynthesis and function of recombinant protein. We constructed three EPO mutants ($\Delta$69, $\Delta$105 and $\Delta$69,105), containing an additional oligosaccharide chains. EPOWT and EPO$\Delta$69 were effectively expressed in transient and stably transfected CHO-K1 cell lines. But, it wasn't detected any protein in the culture medium of EPO$\Delta$105 and EPO$\Delta$69,105 mutants. The growth and differentiation of EPO-dependent human leukemic cell line (F36E) were used to measure the cytokine dependency and in vitro bioactivity of rec-hEPO. MTT assay values were increased by survival of F36E cells at 24h. To analysis biological activity in vivo, two groups of ICR-mice (7 weeks old) were injected subcutaneously with 10 IU per mice of rec-hEPO molecules on days 0 and 2. Red blood cell and hematocrit values were measured on 6 days after the first injection. The hematocrit values were remarkably increased in all treatment groups. The pharmacokinetic analysis was also affected in the mice injected with rec-hEPO molecules 2.5 IU by tail intravenous. Protein samples were detected by Western blotting. An EPO$\Delta$69 protein migrated as a broad band with an average apparent molecular and detected slightly high band. Enzymatic N-deglycosylation resulted in narrow band and was the same molecular size. The biological activity of EPO$\Delta$69 was enhanced to compare with wt-hEPO. The half-life was longer than wt-hEPO. The results suggest that hyperglycosyalted recombinant human erythropoietin (EPO$\Delta$69) may have important biological and therapeutic good points.

• The Journal of the Korea Contents Association
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• v.9 no.8
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• pp.1-8
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• 2009

With the development of IT convergence technology and the construction of master plan for the four rivers restoration of the government, the importance of the eco-friendly water pollution management is being spotlighted. In this paper, we proposed the effective water pollution management using the reservoir tank automatic classification for improving the water quality and on-line managing efforts of ceo-friendly reservoir tanks. The proposed method defined the seven factors of water pollution evaluation and managed the water pollution according to hydrogen ion concentration(pH), chemical oxygen demand(COD), suspend solid(SS), dissolved oxygen(DO), count of coliform group(MPN), total phosphorus(T-P), and total nitrogen(T-N) using the sensors. We measured the values for the seven factors from the reservoir tank and normalized to ranging from 1 to 9. To evaluate the performance of the water pollution management using the reservoir tank automatic classification, we conducted F-measure so as to verify usefulness. This evaluation found that the difference of satisfaction by the traditional system was statistically meaningful.

• Journal of Astronomy and Space Sciences
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• v.15 no.1
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• pp.139-150
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• 1998

We measured the terrestrial nightglow of OI $6300{\AA}$ in the thermosphere (~250km) using a ground-based Fabry-Perot interferometer at the King Sejong Station, Antarcticfrom March through September, 1997. The King Sejong Station is located at high latitude geographically ($62.22^{\circ}S,\;301.25^{\circ}E$) but at mid latitude geomagnetically ($50.62^{\circ}S,\;7.51^{\circ}E$). It is therefore the strategic location to measure the temperatures of the thermosphere in the Southern Hemisphere associated with both solar and geomagnetic activities. In this study, we analyzed the observed temperatures inrelation to F10.7 and Kp indices to examine the effect of the solar and the geomagneticactivities on high-latitude neutral thermosphere. During the observing period, the solaractivity was at its minimum. The measured temperatures are usually in the range between about 600~1000 K with some seasonal variation and are higher than those predicted by semi-empirical model, VSH (Vector Spherical Harmonics) and empirical model, MSIS (Mass-Spectrometer-Incoherent-Scatter)-86.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.3
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• pp.1153-1160
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• 2012

This study was intended to implement ankle joint dorsi flexion training against ankle muscule strength weakening that erodes stroke patients' gait performance to examine the effect of the training on stroke patients' plantar pressure and gait ability. In this study, 36 stroke patients diagnosed with stroke due to cerebral infarction or cerebral hemorrhage were divided to measure 10MWS which are stroke patients' gait variables maximum plantar pressure by area of the sole by collecting data using an F-scan system during gait. Given these results of the study, compared to other training groups, the ankle muscule strength reinforcing training group showed statistically significant increases of maximum plantar pressure in the great toe, the toe and the first metatasal areas too and thus it can be said that this training increases forward thrust during stroke patients' foot end taking off and positively affects stroke patients' ability to perform gait.

• Journal of Korea Multimedia Society
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• v.11 no.5
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• pp.597-609
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• 2008

Due to the recursive updating nature of background model, previous background modeling methods are often perturbed by crowd scenes where foreground pixels occurs more frequently than background pixels. To resolve this problem, an adaptive background modeling method, which is based on the well-known Gaussian mixture background model, is proposed. In the proposed method, the learning rate of background model is adaptively adjusted with respect to the crowdedness of the scene. Consequently, the learning process is suppressed in crowded scene to maintain proper background model. Experiments on real dataset revealed that the proposed method could perform background subtraction effectively even in crowd situation while the performance is almost the same to the previous method in normal scenes. Also, the F-measure was increased by 5-10% compared to the previous background modeling methods in the video of crowded situations.

• The KIPS Transactions:PartB
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• v.16B no.5
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• pp.427-434
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• 2009

With the rapid evolution of the Internet and mobile environments, text including spelling errors such as newly-coined words and abbreviated words are widely used. These spelling errors make it difficult to develop NLP (natural language processing) applications because they decrease the readability of texts. To resolve this problem, we propose a spelling error correction model using a spelling error correction dictionary and a newspaper corpus. The proposed model has the advantage that the cost of data construction are not high because it uses a newspaper corpus, which we can easily obtain, as a training corpus. In addition, the proposed model has an advantage that additional external modules such as a morphological analyzer and a word-spacing error correction system are not required because it uses a simple string matching method based on a correction dictionary. In the experiments with a newspaper corpus and a short message corpus collected from real mobile phones, the proposed model has been shown good performances (a miss-correction rate of 7.3%, a F1-measure of 97.3%, and a false positive rate of 1.1%) in the various evaluation measures.

• Perspectives in Nursing Science
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• v.17 no.2
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• pp.90-98
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• 2020

Purpose: This study examined the effects of breastfeeding education among preterm mothers. Methods: A nonequivalent control group, repeated measure, quasi-experimental study design was used. The participants comprised 46 preterm mothers recruited from the neonatal intensive care unit of a university hospital who were divided into two groups: 23 in the control group and 22 in the experimental group. The breastfeeding education program intervention to promote preterm mothers' self-efficacy used was devised based on the self-efficacy theory. The intervention program consisted of individual breastfeeding education with demonstrations and discharge education, and telephone follow-up education within one week after being discharged. The participants were surveyed before and after the intervention, and four weeks after being discharged from the newborn intensive care unit. Results: The intervention group showed a significant increase in breastfeeding self-efficacy compared with the control group (F=6.92, p=.003) and showed a significant increase in their breastfeeding attitude score (F=3.49, p=.039). Four weeks after discharge, the breastmilk volume of the intervention group increased significantly (t=-2.87, p=.006), and the same group continued to breastfeed more compared with the control group (χ²=4.50, p=.049). Conclusion: This study suggests that the preterm breastfeeding program had a positive effect on breastfeeding self-efficacy, breastfeeding attitude, and extending the breastfeeding period among preterm mothers.

• Journal of Korean Academy of Nursing
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• v.28 no.4
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• pp.1003-1012
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• 1998

The purpose of this research was to identify the effect of human potential seminars on the perceived stigma of adults with epilepsy. The research employed a quasi experimental design and unequivalent control group pre-post design. The test was conducted on 15 adults with epilepsy attending one psychiartric out-patient clinic in Masan City, Korea. The stigma questionnaire was used as a pre-test to these patients. HPS was done ten times for five weeks from May 6, to July 26, 1996. The stigma questionnaire was again given, but this time as a post test. The control group of 14 adults with epilepsy were receiving medication at the same clinic. The human potential seminars were structured by McHolland(1972) and translated by Lee, Hae Seung(1990). The stigma research tool was modified and revised to be appropriate to Korean culture. It consisted of 15 sentences. The internal consistency was 0.92 with Cronbach's α. Research results are as follows. 1) To determine the homogenity of the experimental and control groups, the pre-stigma results were used and democratic-sociologic characteristics, job characteristics and disease related variables were compared. There was no significant difference between the two groups. 2) To identify the relationship between stigma and patient characteristics a pre-test was done. The study used both Mann-Whitney U-test and ANOVA test for statistical analysis. The variables related to stigma were the reason of unemployment and age at onset of epilepsy. 3) The test results of the effect of the human potential seminars on stigma in the patients with epilepsy, showed that stigma in the experimental group was lower than in the control group. The statistical method used to determine the difference between pre and post stigma results was the Wilcoxon signed rank test. The test results were statistically significant at the one percent level. 4) As a follow-up evaluation ten more patients(66.7% of the total) were additionally tested. In order to investigate if the stigmas were different between the pre, post and follow-up, Repeated measure ANOVA was used. The test results showed that the stigma scores were statistically different between the three groups at the one percent level(F=10.06, d.f.=2, p=0.00).

• Journal of the Korea Society of Computer and Information
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• v.19 no.7
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• pp.113-130
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• 2014

In this paper, we propose BLOCS algorithm to find sequence of data that should be saved in cache device of hybrid storage system which uses SSD as a cache device. BLOCS algorithm which uses a sequence pattern mining scheme, creates a set of frequently requested sectors with respect to requested order of sectors. To compare the performance of the proposed scheme, we introduce Distance (DIST) based scheme, Request Frequency (FREQ) based scheme, and Frequency times Size (F-S) based scheme. We measure the hit ratio and I/O latency of different caching schemes using hybrid storage caching simulator. We acquired booting workload along with ten scenarios of launching applications and use the workloads as input to the cache simulator. After experiment with booting workload, we find that BLOCS scheme gives hit ratio of 61% which is about 15% higher than the least performing DIST scheme.

• Journal of the Institute of Electronics and Information Engineers
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• v.50 no.2
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• pp.174-184
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• 2013

For the successful R&D and deployment of LED-based green energy lighting systems, the real-time power quality measurement of both various non-linear power signals including pulse waveform, spike waveform, etc and the undesired-signals including harmonics, sag, swell, etc is required. In this paper, we propose a low-cost power quality measurement (PQM) method for low- (60Hz-several KHz) to high-frequency (several tens KHz) power signals, which are generated by green-energy lighting systems, and implement a PQM testbed using TI TMS320F28335 MCU. The proposed algorithm is programmed using C in the CCS (Code Composer Studio) 3.3 environment and is verified using test signals generated by an arbitrary signal generator, NF-WF1974. In the implemented testbed, we can measure various non-linear current signals that LED SMPS generates, analyze harmonics by fast Fourier transform, and test sag, swell, and interruption using wavelet transform.