• 한국콘텐츠학회논문지
• /
• 제17권3호
• /
• pp.212-221
• /
• 2017

본 연구는 노인의 주관적 삶의 질에 미치는 영향요인을 파악하여 노인의 삶의 질 향상을 위한 기초자료를 마련하고자 2015년 10월 4일 B광역시 소재 일 병원의 1004day 행사에 참여한 노인 201명을 대상으로 설문지를 배부하여 자료를 수집하였다. 수집된 자료는 SPSS 20.0 프로그램을 이용하여 빈도와 백분율, t-검증, 일원분산분석, 사후검증(Scheffe's-test), Pearson's correlation, 단계적 다중회귀분석을 실시하였다. 본 연구의 결과 대상자의 일반적 특성에 따른 주관적 삶의 질은 학력(F=5.87, p=.001), 동거형태(F=4.39, p=.005), 지각된 경제상태(F=16.25, p<.001)에 따라 유의한 차이를 보였으며, 주관적 건강상태(r=.22), 사회활동(r=.25), 가족지지(r=.20)와 정적 상관관계를 보였다. 대상자의 주관적 삶의 질에 영향을 미치는 요인은 지각된 경제상태, 동거형태, 가족지지, 사회활동으로 확인되었으며, 총 23.6%를 설명하였다(R2= .236, p<.001). 이를 바탕으로 노인의 주관적 삶의 질을 높이기 위하여 가족지지 향상 프로그램 및 다양한 사회활동 프로그램을 개발하여 적용할 것을 제안한다.

• 한국생물정보학회:학술대회논문집
• /
• 한국생물정보시스템생물학회 2003년도 제2차 연례학술대회 발표논문집
• /
• pp.3-3
• /
• 2003

With biomedical literature expanding so rapidly, there is an urgent need to discover and organize knowledge extracted from texts. Although factual databases contain crucial information the overwhelming amount of new knowledge remains in textual form (e.g. MEDLINE). In addition, new terms are constantly coined as the relationships linking new genes, drugs, proteins etc. As the size of biomedical literature is expanding, more systems are applying a variety of methods to automate the process of knowledge acquisition and management. In my talk, I focus on the project, GENIA, of our group at the University of Tokyo, the objective of which is to construct an information extraction system of protein - protein interaction from abstracts of MEDLINE. The talk includes (1) Techniques we use fDr named entity recognition (1-a) SOHMM (Self-organized HMM) (1-b) Maximum Entropy Model (1-c) Lexicon-based Recognizer (2) Treatment of term variants and acronym finders (3) Event extraction using a full parser (4) Linguistic resources for text mining (GENIA corpus) (4-a) Semantic Tags (4-b) Structural Annotations (4-c) Co-reference tags (4-d) GENIA ontology I will also talk about possible extension of our work that links the findings of molecular biology with clinical findings, and claim that textual based or conceptual based biology would be a viable alternative to system biology that tends to emphasize the role of simulation models in bioinformatics.

• 대한토목학회논문집
• /
• 제29권2B호
• /
• pp.155-162
• /
• 2009

단변량 빈도해석법은 수공구조물 설계에 널리 사용되고 있다. 하지만 호우사상은 강우량, 최대강우강도, 강우지속기간과 같은 특성으로 표현되기 때문에 단변량 빈도해석법으로는 그 특성을 종합적으로 표현하는데 한계가 있을 수 있다. 이러한 호우사상의 특성들을 함께 표현해 줄 수 있는 이변량 빈도해석법의 사용이 수공구조물의 설계에 필요하다. 본 연구는 서울 강우관측소의 46개년(1961~2006) 시 강우자료를 Gumbel 혼합모형에 적용하여 빈도해석을 수행하였다. 이변량 강우빈도해석을 통해 결합누적분포함수를 산정한 후, 결합재현기간, 그리고 조건부 재현기간을 산정하였다. 이와 같은 이변량 강우빈도해석은 다양한 호우특성들에 대한 확률적 거동에 대한 예측정보를 제공함으로써 수공구조물의 계획 및 설계 그리고 위험도 평가 등의 문제 해결에 유용하게 사용될 수 있다.

• 한국터널지하공간학회 논문집
• /
• 제24권6호
• /
• pp.539-552
• /
• 2022

열차 정거장의 경우 연기배출이 제한된 지하공간이라는 특수성으로 인해 적절한 제연 설비가 갖추어지지 않는다면 화재 발생시 화재연기로 인한 피해가 확대될 우려가 있다. 이에 지하 정거장의 대피 안전성을 확보하기 위한 대책의 필요성이 부각되었으며, 화재시 승강장 이용객의 안전한 대피를 위한 연구가 국내외에서 지속적으로 수행되고 있다. 하지만 현재 열차 승강장에는 제연 경계벽과 PSD (Platform Screen Door)등에 의해 제연구역을 구획하여 제연설비를 설치하고 있으나, 화재시 제연구역별 제연방법(급기 또는 배기) 즉, 제연모드에 관한 기준은 제시되어 있지 않은 실정이다. 본 연구에서는 열차 정거장 화재시 제연모드에 따른 화재위험을 정량적으로 평가하기 위해서 화재해석 및 대피해석을 수행하여 사망자수를 추정하고 F/N선도를 도출하였으며, 이를 통해 최적 제연모드를 검토한 결과, 화재 구역 배기 및 인접구역 급기인 경우에 총 위험도가 가장 낮은 것으로 분석됐다.

• 한국물환경학회지
• /
• 제33권1호
• /
• pp.1-7
• /
• 2017

식생체류지는 도시 강우유출수 관리를 위한 저영향개발 및 그린인프라 기술이며, 개발이전의 상태를 최대한 유지하는 강우유출수 관리기술로 자연을 모방하면서 생태계의 다양성을 향상시키는 기술이다. 본 연구는 식생체류지의 물순환 능력과 비점오염물질의 저감효율에 영향을 끼치는 인자를 도출하기 위하여 4개의 식생체류지 시스템에 대하여 연구를 수행하였다. 2개의 식생체류지, 즉 Type A-C와 Type A-FC에는 국화와 매발톱꽃이 식재되었으며, Type B-A와 Type B-JM식생체류지에는 진달래 및 조팝나무와 같은 관목식물이 식재되었다. 연구결과 식생체류지의 유출저감, 저류량 및 오염물질 저감에 영향을 끼치는 인자로는 TV, 침투기작, 여과재의 두께와 식생 종류로 나타났다. Type B-A와 Type B-JM식생체류지 설계시에는 유출저감, 지하수 충진, 긴 체류시간과 첨두유출량 저감과 비점오염물질 저감을 고려하여 설계가 필요한 것으로 나타났다. 반면에 Type A-C와 Type A-FC 식생체류지 설계시에는 지하수 오염 저감을 중요하게 고려하여야 하는 것으로 나타났다.

• Journal of Photoscience
• /
• 제7권3호
• /
• pp.87-95
• /
• 2000

As sunlight not always optimized for every terrestrial plant in terms of light quality, quantity and duration, some plants suffer detrimental effects of sunlight exposure under certain conditions. Photoinhibition of photosynthesis is a typical phenomenon representing harmful light effects, commonly observed in many photosynthetic organisms. It is generally accepted that functional, structural loss of photosystem II complex(PSII) is the primary event of photoinhibition. Accumulating data also suggest that singlet oxygen($^1$O$_2$) is the main toxic species directly involved in it. There are two different views on the specific site and mechanism of $^1$O$_2$ production in the photosynthetic membrane. One of them favors the PSII reaction center, where the primary charge pairs recombination occurs as a prerequisite for the generation of $^1$O$_2$, and the other inclines to photosensitized $^1$O$_2$ formation by a substance located outside PSII. This article describes how we, as the advocators of the latter concept, have arrived at the conclusion that $^1$O$_2$ immediately involved in PSII photodamage is largely generated from the Rieske center of the cytochrome b$_{6}$/f complex and diffuses into PSII, attacking the reaction center subunits.s.

• Nuclear Engineering and Technology
• /
• 제44권8호
• /
• pp.855-870
• /
• 2012

The paper deals with three main topics: a) the definition of System Thermal-Hydraulics (SYS TH), b) a historical outline for SYS TH and, c) the description of elements for reflection when planning research projects or improvement activities, this last topic being the main reason for the paper. Distinctions between basic thermal-hydraulics and computational Fluid-Dynamics (CFD) on the one side and SYS TH on the other side are considered under the first topic; stakeholders in the technology are identified. The proposal of Interim Acceptance Criteria for Emergency Core Cooling Systems in 1971 by US NRC (AEC at the time) is recognized as the starting date or the triggering event for SYS TH (second topic). The complex codes and the main experimental programs (list provided in the paper) constitute the pillars for SYS TH. Caution or warning statements are introduced in advance when discussing the third topic: a single person (or a researcher) has little to no possibility, or capability, of streamlining the forthcoming investments or to propose a roadmap for future activities. Nevertheless, the ambitious attempt to foresee developments in this area has been pursued without constraints connected with the availability of funds and with industrial benefits or interests. Demonstrating the acceptability of current SYS TH limitations and training in the application of those codes are mentioned as the main challenges for forthcoming research activities.

• Nuclear Engineering and Technology
• /
• 제48권1호
• /
• pp.114-128
• /
• 2016

The development of operational performance indicators is of utmost importance for nuclear power plants, since they measure, track, and trend plant operation. Leading indicators are ideal for reducing the likelihood of consequential events. This paper describes the operational data analysis of the information contained in the Corrective Action Program. The methodology considers human error and organizational factors because of their large contribution to consequential events. The results include a tool developed from the data to be used for the identification, prediction, and reduction of the likelihood of significant consequential events. This tool is based on the resilience curve that was built from the plant's operational data. The stress is described by the number of unresolved condition reports. The strain is represented by the number of preventive maintenance tasks and other periodic work activities (i.e., baseline activities), as well as, closing open corrective actions assigned to different departments to resolve the condition reports (i.e., corrective action workload). Beyond the identified resilience threshold, the stress exceeds the station's ability to operate successfully and there is an increased likelihood that a consequential event will occur. A performance indicator is proposed to reduce the likelihood of consequential events at nuclear power plants.

• International Journal of Advanced Culture Technology
• /
• 제9권2호
• /
• pp.72-79
• /
• 2021

This study is to develop a strategy to prepare an improvement strategy according to the environmental change of the hotel. Currently, domestic hotels are implementing marketing through food and beverage as a countermeasure against the sales decrease, and in order to develop effective marketing plan, 5 Force Model environmental analysis and STP analysis are analyzed. 5 Force Model Environmental Analysis showed that domestic hotels are facing various difficulties such as the expansion of accommodation sharing system, the decrease of Chinese tourists due to the THAAD problem, the increase of hotels, the introduction of PMS, the increase of minimum wage, the introduction of 52 hours work week, and the increase in product preference As an STP response strategy to correspond these difficulties, it is necessary to develop products for the main customers of the hotel food and beverage, such as those in the 20s-30s, the workers, smartphones and SNS users. And also hotels should seek ways to lower price of the product to the level desired by the user to compete against substitutes. In conclusion we suggest that hotels are committed to fulfilling their role by meeting guest safety and COVID-19 compliance requirements, but a focus on immediate cleanliness and quarantine against infectious diseases, like Airbnb, will enable greater growth.

• Molecular Medicine Reports
• /
• 제20권4호
• /
• pp.3301-3307
• /
• 2019

c-Myc is a characteristic oncogene with dual functions in cell proliferation and apoptosis. Since the overexpression of the c-Myc proto-oncogene is a common event in the development and growth of various human types of cancer, the present study investigated whether oncogenic c-Myc can alter natural killer (NK) cell-mediated immunity through the expression of associated genes, using PCR, western blotting and flow cytometry assays. Furthermore, whether c-Myc could influence the expression levels of natural killer group 2 member D (NKG2D) ligands, which are well known NK activation molecules, as well as NK cell-mediated immunity, was investigated. c-Myc was inhibited by 10058-F4 treatment and small interfering RNA transfection. Upregulation of c-Myc was achieved by transfection with a pCMV6-myc vector. The inhibition of c-Myc increased MHC class I polyeptide-related sequence B and UL16 binding protein 1 expressions among NKG2D ligands, and the overexpression of c-Myc suppressed the expression of all NKG2D ligands, except MHC class I polyeptide-related sequence A. Furthermore, the alteration of c-Myc activity altered the susceptibility of K562 cells to NK cells. These results suggested that the overexpression of c-Myc may contribute to the immune escape of cancer cells and cell proliferation. Combined treatment with NK-based cancer immunotherapy and inhibition of c-Myc may achieve improved therapeutic results.