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The Effect of Sihosogansangagambang (SS) on Melanin Synthesis and gene expression in B16F10 Mouse Melanoma Cell (시호소간산가감방(柴胡疎肝散加減方)이 멜라닌 생성 및 유전자발현에 미치는 영향)

  • Kim, Ju-Young;Lim, Hyun-Jung;Shin, Sun-Mi;Yoo, Dong-Youl
    • The Journal of Korean Obstetrics and Gynecology
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    • v.22 no.1
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    • pp.95-109
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    • 2009
  • Purpose: This study was performed to determine the inhibitory effect of Sihosogansangagambang (SS) on melanin synthesis in B16F10 melanoma cells (B16F10). Methods: The inhibitory effects of Sihosogansangagambang on melanin synthesis were used by in vitro assay. To elucidate inhibitory effects of SS on melanin synthesis, we determined the melanin release in B16F10. And to investigate the mechanism of inhibitory effect of SS, we assessed the gene expression of tyrosinase, TRP-1, TRP-2 and ERK-1 in B16F10. Results: 1. SS decreased the release of melanin in B16F10 melanoma cells. 2. SS inhibited mushroom tyrosinase activity in vitro. 3. SS decreased the expression of tyrosinase, TRP-2 in B16F10 melanoma cells, but did not decreased the expression of TRP-1 in B16F10 melanoma cells. 4. SS decreased the expression of ERK-1 in B16F10 melanoma cells. Conclusion: From these results, it may be suggested that SS is possesed of the antimelanogenetic effects.

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The Effect of Mibaeksan(MB) on Melanin Synthesis and Gene Expression (미백산(美白散)이 멜라닌 생성 및 유전자 발현에 미치는 영향)

  • Kim, Soo-Min;Yoo, Dong-Youl
    • The Journal of Korean Obstetrics and Gynecology
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    • v.22 no.4
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    • pp.1-18
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    • 2009
  • Purpose: This study was performed to elucidate the inhibitory effect of Mibaeksan (MB) on melanin synthesis in B16F10 mouse melanoma cell. Methods: To demonstrate the inhibitory effects of MB on melanin synthesis, we measured the amount of released and produced melanin in B16F10 melanoma cell. Also, we evaluated tyrosinase-activity in vitro as well as in B16F10 melanoma cell. And to investigate the action mechanism, we assessed the gene expression of tyrosinase, TRP-1, TRP-2, MMP-2, PKA, $PKC{\beta}$, ERK-1 ERK-2, AKT-1 and MITF in B16F10 melanoma cells. Results: 1. MB decreased the release and production of melanin in B16F10 melanoma cells. 2. MB decreased tyrosinase activity in vitro and in B16F10 melanoma cells. 3. MB decreased the expression of tyrosinase, TRP-1, TRP-2, PKA, $PKC{\beta}$ and MMP-2 in B16F10 melanoma cells. 4. MB increased the expression of ERK-1, ERK-2 and AKT-1 in B16F10 melanoma cells. 5. MB decreased the expression of MITF in B16F10 melanoma cells. Conclusion: From these results, it may be concluded that MB has the antimelanogenetic effects.

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A Study on the Visual Effects According to the Lines in Cloth Designing (의복 디자인 선에 따른 시각적 효과에 관한 연구)

  • 이경희
    • Journal of the Korean Home Economics Association
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    • v.28 no.4
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    • pp.1.1-13
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    • 1990
  • Authors have performed the sensory evaluation tests according to each given items after selecting various lines in order to assess the visual effects by the lines in cloth designing. The evaluations were done by means of ranking tests followed by paired comparison tests. The results obtained were as follows : 1. In the item in than "Shoulder width looks wide", the design C3 showed the best visual effect, and then B1, F8, and A5 comes in order. In "Shoulder width looks narrow", they were A2, F5, F7, and B2 in order. 2. In "Bust looks big", the effect was best in F9, and then B1, F5, C3, and A5 and order. "Bust looks small" item showed A3, C1, and F1 in order. 3. In "Waist looks thick", they were B2, D1, and F7 while in "Waist looks thin", they were B3, F8, and D6 in order. 4. In the item in that "Hip looks big", the best effect was in F9, and then E3, C2, and B4 in order. In "Hip looks small", the best one was C1, and then comes. E1, F6, and F8. 5. In "Upper body looks thick", they were D2, D4, F8, C3 and A5 in order whild in "Upper body looks thin", they were A1, F5, and D7 in order. 6. In the item "Lower body lookds thick", they were F9, C2, E3, B3, and D3 in order. In "Lower body looks thin", the best one was C1, and then D1, E2, F6, and F8 comes in order. 7. In "whole body looks thick", they were F9, F3, D3, and A5, and in "Whole body looks thin", they were F5, A1, C1, and D6 in order. 8. In "Height looks tall", the effects were in order of A4, D6, E1, and F7 while in "Height looks short", they were E3, F9, B4, D2, and D1. 8. In "Height looks tall", the effects were in order of A4, D6, E1, and F7 while in "Height looks short", they were E3, F9, B4, D2, and D1. F9, B4, D2, and D1.

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THE RADIAL DERIVATIVES ON WEIGHTED BERGMAN SPACES

  • Kang, Si-Ho;Kim, Ja-Young
    • Communications of the Korean Mathematical Society
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    • v.18 no.2
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    • pp.243-249
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    • 2003
  • We consider weighted Bergman spaces and radial derivatives on the spaces. We also prove that for each element f in B$\^$p, r/ there is a unique f in B$\^$p, r/ such that f is the radial derivative of f and for each f$\in$B$\^$r/(i), f is the radial derivative of some element of B$\^$r/(i) if and only if, lim f(tz)= 0 for all z$\in$H.

ZERO DISTRIBUTION OF SOME DELAY-DIFFERENTIAL POLYNOMIALS

  • Laine, Ilpo;Latreuch, Zinelaabidine
    • Bulletin of the Korean Mathematical Society
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    • v.57 no.6
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    • pp.1541-1565
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    • 2020
  • Let f be a meromorphic function of finite order ρ with few poles in the sense Sλ(r, f) := O(rλ+ε) + S(r, f), where λ < ρ and ε ∈ (0, ρ - λ), and let g(f) := Σkj=1bj(z)f(kj)(z + cj) be a linear delay-differential polynomial of f with small meromorphic coefficients bj in the sense Sλ(r, f). The zero distribution of fn(g(f))s - b0 is considered in this paper, where b0 is a small function in the sense Sλ(r, f).

The Effect of Yukmijihwangtanghapyijihwangagambang on Melanin Synthesis and Related Gene Expressions in B16F10 Mouse Melanoma Cell (육미지황탕합이지환가감방(六味地黃湯合二至丸加減方)이 멜라닌 생성과 관련 유전자 발현에 미치는 영향)

  • Shin, Sun-Mi;Yoo, Dong-Youl
    • The Journal of Korean Obstetrics and Gynecology
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    • v.22 no.4
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    • pp.28-45
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    • 2009
  • Purpose: This study was performed to elucidate the inhibitory effect of Yukmijihwangtanghapyijihwangagambang (YM) on melanin synthesis in B16F10 melanoma cells. Methods: To demonstrate the inhibitory effects of YM on melanin synthesis, we measured the amount of released and produced melanin in B16F10 melanoma call. Also, we evaluated tyrosinase-activity in vitro as well as in B16F10 melanoma call. And to investigate the action mechanism, we assessed the gene expression of tyrosinase, TRP-1, TRP-2, PKA, $PKC{\beta}$, ERK-1 ERK-2, AKT-1 and MITF in B16F10 melanoma call. Results: 1. YM decreased the release and production of melanin in B16F10 melanoma cells. 2. YM decreased tyrosinase activity in vitro and in B16F10 melanoma cells. 3. YM decreased the expression of tyrosinase, TRP-1, TRP-2 in B16F10 melanoma cells. 4. YM decreased the expression of PKA, $PKC{\beta}$ in B16F10 melanoma cells. 5. YM increased the expression of ERK-1, ERK-2 and AKT-1 in B16F10 melanoma cells. 6. YM decreased the expression of MITF in B16F10 melanoma cells. Conclusion: From these results, it may be concluded that YM has antimelanogenetic effects.

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Functional Analysis of the marB gene of Escherichia coli K-12

  • Lee, Chang-Mi;Park, Byung-Tae
    • Biomedical Science Letters
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    • v.10 no.2
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    • pp.153-161
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    • 2004
  • Antibiotic resistance is often associated with the production of inner membrane proteins (for example, AcrAB/TolC efflux pump) that are capable to extrude antibiotics, detergents, dyes and organic solvents. In order to evaluate the unknown MarB function of Escherichia coli, especially focused on the function of OmpF porin, several mutants were construted by T4GT7 transduction. MarA plays a major roles in mar (multiple antibiotic resistance) phenotype with AcrAB/TolC efflux pump in E. coli K-12. Futhermore, MarA decreases OmpF porin expression via micF antisense RNA. Expression of acrAB is increased in strains containing mutation in marR, and in those carrying multicopy plasmid expressing marA. MarB protein of E. coli K-12 showed its activity at OmpF porin & TolC protein as target molecule. Some paper reported MarB positively regulates OmpF function. MarA shows mar phenotype, and MarB along with MarA show decreased MIC through OmpF function. By this experiment, MarB could decrease MIC through the OmpF porin & TolC protein as target.

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NOTE ON CONNECTED (g, f)-FACTORS OF GRAPHS

  • Zhou, Sizhong;Wu, Jiancheng;Pan, Quanru
    • Journal of applied mathematics & informatics
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    • v.28 no.3_4
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    • pp.909-912
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    • 2010
  • In this note we present a short proof of the following result by Zhou, Liu and Xu. Let G be a graph of order n, and let a and b be two integers with 1 $\leq$ a < b and b $\geq$ 3, and let g and f be two integer-valued functions defined on V(G) such that a $\leq$ g(x) < f(x) $\leq$ b for each $x\;{\in}\;V(G)$ and f(V(G)) - V(G) even. If $n\;{\geq}\;\frac{(a+b-1)^2+1}{a}$ and $\delta(G)\;{\geq}\;\frac{(b-1)n}{a+b-1}$,then G has a connected (g, f)-factor.

Cloning and Sequence Analysis of the trpB, trpA and 3' trpC(F) Gens of Vibrio metschnikovii Strain RH530 (Vibrio metschnikovii 균주 RH530의 trpB, trpA 그리고 3' trpC(F) 유전자의 클로닝 및 염기서열 결정)

  • Kwon, Yong-Tae;Kim, Jin-Oh;Yoo, Young-Dong;Rho, Hyune-Mo
    • Korean Journal of Microbiology
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    • v.32 no.2
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    • pp.120-125
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    • 1994
  • The genes, trpB, trpA and 3’ trpC(F) of Vibrio metschnikovii strain RH530 were cloned and sequenced. The trpB and trpA genes had open reading frames of 1,173 bp and 804 bp encoding 391 and 268 amino acids, respectively. The trpB and trpA genes had conventional ribosome-binding sequences and overlapped with each other by one nucleotide, suggesting that these two genes are translationally coupled. 115 nucleotide upstream the trpB start codon, tjere was an incomplete open reading frame of the 3’-end of the trpC(F). The amino acid sequences of trpB, trpA and trpC(F) of V. metschnikovii RH530 had identities of 64.2%, 82.4% and 73.7% respectively, for those of V. parahaemolyticus; 58.7%, 72.3% and 54.9%, respectively, for Salmonella typhimurium; and 42.6%. 54.1% and 12.5%, respectively, for brevibacterium lactofermentum. The genetic organization of these genes, especially in the noncoding region between trpC(F) and trpB, was distinct from that of Enterobacteriaceae.

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NONCONSTANT WARPING FUNCTIONS ON EINSTEIN WARPED PRODUCT MANIFOLDS WITH 2-DIMENSIONAL BASE

  • Lee, Soo-Young
    • Korean Journal of Mathematics
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    • v.26 no.1
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    • pp.75-85
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    • 2018
  • In this paper, we study nonconstant warping functions on an Einstein warped product manifold $M=B{\times}_{f^2}F$ with a warped product metric $g=g_B+f(t)^2g_F$. And we consider a 2-dimensional base manifold B with a metric $g_B=dt^2+(f^{\prime}(t))^2du^2$. As a result, we prove the following: if M is an Einstein warped product manifold with a 2-dimensional base, then there exist generally nonconstant warping functions f(t).