• Journal of Veterinary Clinics
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• v.32 no.3
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• pp.235-238
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• 2015

This study aimed to investigate the epidemiology of canine ophthalmic diseases in Seoul, Korea using data for new canine patients examined from January 2009 through December 2013 at an ophthalmic referral center (WooSung Animal Medical Center, Seoul). The study included 1253 dogs with an average age of 7.93 years (SD, 4.06). Shih Tzu (29.4%) was the most common breed, followed by Maltese, Yorkshire Terrier, Cocker Spaniel, and toy Poodle (P < 0.01). Lens diseases (28.3%) were the most common, followed by eyelid, corneal, retinal, and glaucomatous diseases (P < 0.01). Lens, eyelid, retinal, nasolacrimal, uveal, vitreous, and neuro-ophthalmic diseases more frequently showed a bilateral occurrence (P < 0.01) than a unilateral occurrence. In the Shih Tzu breed, corneal disease was the most frequent, followed by lens, eyelid, retinal, and glaucomatous diseases. The most frequent diseases in the Maltese breed were lens, eyelid, retinal, and corneal diseases. In the Yorkshire Terrier, Cocker Spaniel, and toy Poodle breeds, lens disease was the most common (P < 0.01). The most frequent ophthalmic patients belonged to small breeds such as Shih Tzu, Maltese, and Yorkshire Terrier. Moreover, the most common ophthalmic diseases were not traumatic diseases, but breed-inherited diseases such as lens diseases.

• Archives of Plastic Surgery
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• v.45 no.3
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• pp.222-228
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• 2018

Background The most common surgical treatment for paralytic lagophthalmos is the placement of a weight implant in the upper eyelid; however, this technique confers the risks of implant visibility, implant extrusion, and entropion. In this study, we present a new technique of placing platinum weight implants between the levator aponeurosis and inner septum to decrease such complications. Methods A total of 37 patients with paralytic lagophthalmos were treated between March 2014 and January 2017 with platinum weight placement (mean follow-up, 520.1 days). After dissecting through the orbicularis oculi muscle, the tarsal plate and levator aponeurosis were exposed. The platinum weights (1.0-1.4 g) were fixed to the upper margin of the tarsal plate and placed underneath the orbital septum. Results Five patients could partially close their eye after surgery. The average distance between the upper eyelid and the lower eyelid when the eyes were closed was 1.12 mm. The rest of the patients were able to close their eye completely. Three patients patient developed allergic conjunctivitis after platinum weight insertion, which was managed with medication. None of the patients complained of discomfort in the upper eyelid after surgery. Visibility or extrusion of the implant were observed in three patients. Conclusions Postseptal weight placement is a safe and reproducible method in both primary and secondary upper eyelid surgery for patients with paralytic lagophthalmos. It is a feasible method for preventing implant visibility, implant exposure, and entropion. Moreover, platinum is a better implant material than gold because of its smaller size and greater thinness.

• Development and Reproduction
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• v.12 no.2
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• pp.183-194
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• 2008

A variety of stem cells has been emerging as therapeutic cells that can replace organ transplantation in human liver diseases. The present study focused on whether human eyelid adipose-derived stem cells (HAD) might differentiate into functional hepatocyte-like cells in vitro. HAD were isolated from human eyelid adipose tissue. Effect of dimethyl sulfoxide (DMSO), fibroblast growth factor (FGF)-2 and FGF-4 on the hepatic differentiation of HAD have been examined in vitro. Immunocytochemical analysis and PAS staining showed that HAD cultured in both DMSO and FGF-4 exhibited the most intense staining than HAD of the other experimental groups. These HAD expressed numerous hepatocyte-related genes. Immunoblotting analyses showed that HAD cultured in the presence of DMSO and FGF-4 secreted higher amount of human albumin than HAD cultured in other conditions. Urea analysis also demonstrated that these HAD produced higher amount of urea than any other groups of HAD. In conclusion, combined treatment of DMSO and FGF-4 could effectively induce the functional differentiation of HAD into hepatocyte-like cells.

• Parasites, Hosts and Diseases
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• v.54 no.6
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• pp.787-792
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• 2016

Cutaneous leishmaniasis (CL) is a protozoan disease which is endemic in Iran. It is transmitted by the Phlebotomus sand fly. The eyelid is rarely involved possibly because the movement of the lids impedes the sand fly from biting the skin in this region. Here, we report 6 rare cases of eyelid CL. The patients were diagnosed by skin scraping, culture, and PCR from the lesions. Skin scraping examination showed Leishmania spp. amastigotes in the cytoplasm of macrophages. Culture examination was positive for Leishmania spp. PCR was positive for Leishmania major and Leishmania tropica. The lesions were disguised as basal cell carcinoma, chalazion, hordeolum, and impetigo. The patients were treated with intramuscular meglumine antimoniate (20 mg/kg/day) for at least 3 weeks. They showed a dramatic response, and the lesions almost completely disappeared. We emphasized the importance of clinical and diagnostic features of lesions, characterized the phylogenetic relationship of isolated parasites, and reviewed the literature on ocular leishmaniasis.

• Korean Journal of Head & Neck Oncology
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• v.36 no.2
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• pp.21-25
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• 2020

Sebaceous carcinoma is a relatively rare and aggressive malignant tumor. Periocular area (especially eyelid) is the most common lesion to occur, and the most common extraocular lesion is the parotid gland. Because the lesion also mimic other benign inflammatory diseases, this leads to delayed diagnosis or misdiagnosis. Here, we report a 58-year-old male patient who presented with a non-tender painless left parotid mass after wide excision of sebaceous carcinoma in the left eyelid two years ago. When he was diagnosed with sebaceous carcinoma of left eyelid, there was a small left parotid tumor on the computed tomography. But no further examination and treatment were performed. Two years later, physical examination revealed growing parotid tumor and multiple neck nodes on the left side. After radical parotidectomy and neck dissection, histological examination showed a sebaceous carcinoma and neck node metastasis. Considering the aggressiveness of sebaceous carcinoma, further evaluation for parotid glands should be considered when sebaceous carcinoma of the eyelid was discovered. Postoperative chemoradiotherapy was performed for disease control. Follow up after two years, and computed tomography showed no sign of recurrence.

• Journal of Veterinary Clinics
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• v.14 no.2
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• pp.141-146
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• 1997

This study was performed to investigate the ophthalmic diseases in 269 Holstein dairy cattle of 10 farms in Kyunggido, Korea. The acerage prevalence rate of ophthalmec diseases was 25.7%, ranging of from 4.8% to 47.6%. The highest incidence age was between 3 and 4 years old, 41.9% and then in order of between 5 and 6 years, between 2 and 3 years, over 6 years, between 4 and 5 years, between 1 and 2 years, and up to 1 year were shown the incidence of 33.3%, 29.4%, 27.7%, 23.8%, 19.8% and 12.5%, respectively. The prevalence rate of cataracts was higher than any other ophthalmic diseases, 10.4% and then in order of chorioretinitis, iris posterior synechiae, corneal scar, conjunctivitis, blindness, third eyelid carcinoma and globe anomaly were diagnosed as the incidence of 4.1%, 3.0%, 1.7%, 1.3%, 0.4%, 0.2% and 0.2%, respectively.

• Korean Journal of Veterinary Research
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• v.41 no.1
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• pp.113-121
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• 2001

Beagle is one of the most popular laboratory animal in a dog. We investigated the incidence of spontaneous ophthalmic disease in Beagles in order to make basic data for quality control of Beagles in Korea. We surveyed 389 beagles from 3 different farms. The average prevalence rate of ophthalmic diseases was 19.3%. The prevalence rate of cataracts was higher than any other ophthalmic diseases, 7.5% and then in order of corneal scar(2.1%), retinal hemorrhage(1.5%), post-inflammatory retinal change(1.5%), cherry eye(1.0%), distichiasis(0.8%), entropion(0.8%), hypoplastic optic disc(0.8%), conjunctivitis(0.5%), retinal dysplasia(0.5%), asteroid hyalosis(0.3%), congenital eye anomaly(0.3%), corneal lipidosis(0.3%), conjunctival hemorrhage(0.3%), lens capsule pigmentation(0.3%), persistent hyperplastic primary vitreous (0.3%), posterior synechia(0.3%), eyelid tumor(0.3%) and uveal cyst(0.3%) were diagnosed. There was a slight difference between male(24.8%) and female(17.4%) in prevalence rate of ophthalmic disease. The incidence of spontaneous ophthalmic disease was increased with age. These data would be useful for using Beagles as laboratory animals and standard reference for quality control of dogs.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.33 no.2
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• pp.1-11
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• 2020

Objectives : The purpose of this study was to analyze and report status of Korean Medicine Ophthalmology patients who did funduscopy examination. Through this, we hope that the development of our diagnosis and treatment. Methods : From June 1, 2010 to May 31, 2019, Based on the electronic medical records of patients who had funduscopy examination at Korean Medicine Ophthalmology, Busan University Korean Medicine Hospital, the gender, age, visiting motives and paths, diagnosis, examination number of years, other eye examinations and treatments method were summarized and analyzed. Results : 463 patients were able to check the electronic medical records. They were 283 females and 180 males. The mean age of the patients was 51.5 years and elderly patients who 50s and 60s were 49.3% of whole patients. The most common motives for Korean Medicine Ophthalmology visitation was 'combination treatment with other department in Korean Medicine Hospital'. Outer eye diseases were 283 cases, inner eye diseases were 198 cases. Dry eye syndrome, asthenopia, visual discomfort, conjunctivitis, and eye discomfort were most common in the outer eye diseases. Cataracts, Vitreous floater, Macular Degeneration, Glaucoma and Ocular Pain were most common in the inner eye disease. The most common parts of outer eye diseases were Conjunctival, lacrimal gland, paralytic, corneal, eyelid and front uveal, scleral disease and then in inner eye diseases parts, Retinal, lens, vitreous, glaucoma, optic nerve, behind uveal, choroid disease were most common. The number of funduscopy examination was ups and downs. Herbal medicine was the most common used. Conclusions : The funduscopy examination is essential for diagnosis and treatment of eye disease. We hope that the use of fundus examination and other ophthalmologic examination will be expanded soon in Korean Medicine Ophthalmology.

• The Journal of Korean Medical History
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• v.24 no.2
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• pp.69-76
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• 2011

This study focuses on the origin and the literature of eyelid-acupuncture, nunchim therapy in Korea and its present clinical usage in modern Korea. The therapy is called nunchim at local area of Korea and has been transmitted as folk remedy because its real practice has been fallen into oblivion in the regular medical institution in modern Korea. On the contrast, some old women called nunchim-halmae, still know its practice and give medical therapy in a certain irregular way. While many kinds of eye clinics are prevalent in Korea, some patients with chronic eye diseases still go to get the nunchim therapy from nunchim-halmae. Moreover some oriental medical doctors have learned the therapy from nunchim-halmae and performed that medical service in their clinics in spite of absence of medical insurance coverage. Nunchim has unique historic origin and transmission linage in Korea, which was shed light on by this research. We present concise structure of the essence of nunchim therapy and 80 year old woman case of dramatic eye curing with the therapy.

• The Journal of Pediatrics of Korean Medicine
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• v.16 no.2
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• pp.23-37
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• 2002

We have plenty of study of adults diseases, but not much has been said about children. 79 children who had visited in the weak children of Dongeui Oriental Medical Hospital from March, 2002 to October, 2002, were the respondents of the Weak Child Questionnaire. The results obtained were as follows: 1. Their symptoms have been observed with sequences of respiratory diseases, Digestive diseases, Psycho-neurological diseases. 2. Distribution of sex and ages : male 38 cases, female 41 cases. $0{\sim}6$ years 60 cases, $7{\sim}12$ years 17 cases, $13{\sim}18$ years 2 cases. 3. The texture of complexion was resulted in face color and the region of the face : whitish-2/ cases. yellowish-27 cases, darkish-22 cases, blue-2 cases, flushed face-l case. Sangeun(山根)-blue : 59 cases, a lower eyelid- dark or light brown : 54 cases. the rests of color on face region didn't mean. 4. The texture of tongue was ended in tongue state : tongue form-not plump not haggard patten(57 cases), a pricky patten(12), a map patten(7), a fissured patten(3). tongue color- pink (57 cases), red(16), light white(6). coating color- thin white(61 cases), thin yellow(l0), lack(6), deep and white(2). tongue coating substance-thin(72 cases), moisten(5), dry(1), deep(1).