• 대한두경부종양학회지
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• 제22권2호
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• pp.167-170
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• 2006

Extramedullary plasmacytoma is rare tumor of plasma cell tumor, which involve soft tissue without any signs of systemic spread and occurs predominantly in the head and neck, especially the nasal cavity and the paranasal sinuses. Ten to twenty percent of extramedullary plasmacytoma have regional lymph metastasis at the time of diagnosis and approximately one third of patients with extramedullary plasmacytoma will subsequently develop multiple myeloma during long-term follow-up. Primary treatment modality is moderate-dose radiation and surgery is rarely used. Extramedullary plasmacytoma has good prognosis, but requires long-term systemic evaluation and follow-up. We report a case of extramedullary plasmacytoma of the sinonasal cavity with a review of literature.

• 대한골관절종양학회지
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• 제15권1호
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• pp.75-80
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• 2009

골수외 형질세포종은 아주 드물게 발생하는 종양으로, 전체 형질 세포 종양의 3~5 %를 차지하며 상부 호흡기관에서 주로 발생한다. 그 외 드물게 위장관, 방광, 중추 신경계, 유방, 갑상선, 고환, 타액선, 임파선, 피부 등에서 발생한 증례보고가 있다. 저자들은 49세 남자의 대둔근에서 발생한 골수외 형질세포종 1예를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다.

• Journal of Korean Neurosurgical Society
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• 제64권2호
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• pp.316-319
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• 2021

Extramedullary plasmacytoma and solitary plasmacytoma are localized neoplasms. Solitary plasmacytoma of bone consists about 4% of malignant plasma cell tumors. A plasmacytoma involving the frontal bone is unusual, and a limited number of cases have been reported. We present a rare case of a solitary plasmacytoma of the frontal bone manifesting as a forehead lump.

• Journal of Korean Neurosurgical Society
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• 제46권2호
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• pp.156-160
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• 2009

Solitary extramedullary plasmacytomas are isolated plasma cell tumors of soft tissue that typically do not metastasize. They are rare and account for 4% of all plasma cell tumors. To our knowledge, only 14 cases of solitary extramedullary plasmacytomas in the sphenoid sinus have been reported. A 32-year-old man presented to our department with complaint of ocular pain in the right eyeball and diplopia. Physical and neurological examinations revealed intact and prompt direct and indirect light reflexes in both pupils and limitation of extraocular muscle movement seen with the lateral gaze of the right eyeball. Magnetic resonance imaging suggested the presence of mucocele or mycetoma, therefore surgical resection was performed with endoscopic endonasal transsphenoidal approach. Histopathology was consistent with plasmacytoma. Systemic work-up did not show any evidence of metastasis and the sphenoid sinus was the sole tumor site, and therefore the diagnosis of solitary extramedullary plasmacytoma was confirmed. We report a rare case of solitary extramedullary plasmacytoma in the sphenoid sinus with successful treatment using the endoscopic endonasal transsphenoidal resection and adjuvant radiotherapy.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제32권3호
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• pp.235-240
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• 2006

Solitary plasmacytoma is a rare malignant neoplasm that originate in immunoglobulin-producing plasma cell. Solitary bone plasmacytoma can be found at any site throughout the skeleton and in most cases eventually progresses to multiple myeloma, of which it is thought to be an unusual presentation. On the other hand, extramedullary plasmacytoma has a tendency to occur in the head and neck region, mainly in association with the upper air passages. Incisional biopsy is the primary approach to make a definitive diagnosis, and immunohistochemical staining can be very helpful in understanding the nature of these tumors. We report a 66 years old patient with solitary bone plasmacytoma and a 36 years old patient with solitary extramedullary plasmacytoma with literatures review.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제36권6호
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• pp.543-547
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• 2010

Plasmacytoma is a rare malignant neoplasm in the head and neck region and comprises approximately 3% of all plasma cell tumors. This lesion is a unifocal, monoclonal, neoplastic proliferation of plasma cells that usually arises within the bone. Infrequently, it is observed in soft tissue, in which case, the term extramedullary plasmacytoma is used. Approximately 80-90% of extramedullary plasmacytomas involve the mucos-Associated-Lymphoid Tissue of the upper airways with 75% of these involving the nasal and paranasal regions. The plasmacytoma is usually detected in adult males, with an average age at diagnosis of 55 years. The male-to-female ratio is 3:1.Radiographically, the lesion may be seen as a well-defined, unilocularradioluceny with no evidence of a sclerotic border. Some investigators believe that this lesion represents the least aggressive part of the spectrum of plasma cell neoplasms that extend to multiple myeloma.Therefore, plasma cytoma is believed to have clinical importance. We report a case of extramedullary plasmacytoma in the right maxillary sinus of a 59-year-old male with review of the relevant literature.

• 한국임상수의학회지
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• 제41권1호
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• pp.18-23
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• 2024

A 13-year-old spayed female Golden Retriever with clinical signs of weight loss and lethargy presented with two esophageal masses and one sessile polyp on computed tomography and esophagoscopy. Endoscopic snare resection was performed, and histopathological examination was requested. Based on histopathology and immunohistochemistry of multiple myeloma oncogene 1 staining, the patient was diagnosed with esophageal extramedullary plasmacytoma. The patient remained clinically well without any clinical signs during a follow-up period of 12 months. Herein, we report the successful diagnosis and management of esophageal extramedullary plasmacytoma in a dog using endoscopy.

• 한국임상수의학회지
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• 제29권4호
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• pp.356-359
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• 2012

암컷, 8년령, 3.2 kg의 시츄견이 간헐적인 구토를 주증으로 내원하였다. 기본 혈액검사 및 방사선 검사에서 특별한 이상 소견은 관찰되지 않았다. 복부 초음파 검사에서 위벽에서 유래한 것으로 생각되는 저에코의 둥근 종괴가 관찰되었다. 위 내시경 검사에서 둥근 종괴가 유문동 벽에서 내강으로 돌출되어 있고, 종괴 및 주변 점막의 비정상적인 소견은 관찰되지 않았다. 이에 위 종괴 절제술을 실시하였고, 면역 염색을 포함한 조직학적 검사에서 extramedullary plasmacytoma로 진단되었다. 환자는 임상 증상이 개선되었으며, 약 2년 동안 재발 및 전이 소견 없이 건강한 상태이다.

• 대한수의학회지
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• 제64권3호
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• pp.25.1-25.5
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• 2024

A 7-year-old castrated male Persian cat presented with a cutaneous mass and an increase in serum amyloid A concentration. Fine needle aspirates of the mass indicated lymphoma, which was also the top differential diagnosis on histopathologic examinations. Immunohistochemically, neoplastic cells tested negative for anti-CD3, PAX5, CD20, and c-Kit, but positive for MUM1, CD79α, and CD138, suggesting extramedullary plasmacytoma. There were tumor-infiltrating non-neoplastic CD3⁺ T and PAX5⁺ B cells. Practitioners should be aware of feline plasmacytoma characterized by lymphoma-like cytologic and histologic features. The present study is valuable in providing the first clinical evidence that proves the immunogenicity of feline plasmacytoma.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제18권1호
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• pp.109-114
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• 1996

수질의 형질세포종(extramedullary plasmacytoma)은 극히 드물게 나타나는 형질세포 악성종양(plasma cell malignancy)중 하나이며 치은에 발생한 경우는 거의 보고된바 없다. 다발성 골수종과의 감별진단은 조직학적 검사 후에도 여러 혈액검사 및 병이화학 검사가 필요하며 초기진단에 확실한 검사는 어렵다. Pahor등에 의하면 수질외 형질세초종의 5년생존률이 60%인 것에 비해 다발성 골수종에서는 5.7%를 보여 예후에 있어서 현저한 차이를 보이고 보든 수질외 형질세포종환자에 있어서 전신질환으로의 진행 가능성은 배제할 수 없으므로 장기간의 관찰이 필수적이라고 할 수 있다. 저자 등은 신장이식 수술 후 면역억제제를 사용한 15세 환자에서 치은에 발생한 형질세포을 치험하였기에 문헌 고찰과 함께 진단, 예후, 치료 및 면역 억제제와의 연관성에 관하여 보고하는 바이다.