• 제목/요약/키워드: External Q

검색결과 141건 처리시간 0.024초

Topomer CoMFA Analysis of Xanthine Oxidase inhibitors

  • Santhosh Kumar, N
    • 통합자연과학논문집
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    • 제10권4호
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    • pp.192-196
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    • 2017
  • Xanthine Oxidase is an enzyme, which oxidizes hypoxanthine to xanthine, and xanthine to uric acid. It is widely distributed throughout various organs including the liver, gut, lungs, kidney, heart, brain and plasma. It is involved in gout pathogenesis. Hence, in the present study, topomer based Comparative Molecular Field Analysis (topomer CoMFA) was performed on a series of Xanthine oxidase antagonist named 2-(indol-5-yl) thiazole derivatives. The best topomer CoMFA model was obtained with significant cross-validated correlation coefficient ($q^2$ = 0.572) and non cross-validated correlation coefficients ($r^2$ = 0.937). The model was evaluated with six external test compounds and its $r^2{_{pred}}$ was found to be 0.553. The steric and electrostatic contribution map show that presence of bulky and electropositive group in indole thiazole ring is necessary for improving the biological activities of the compounds. The generated topomer CoMFA model could be helpful for future design of novel and structurally related xanthine oxidase antagonists.

자동진폭조절 기능을 갖는 CMOS IF VCO 설계 (Design of a CMOS W VCO with Automatic Amplitude Control)

  • 김유환;문요섭;이종렬;박종태;유종근
    • 대한전자공학회:학술대회논문집
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    • 대한전자공학회 2002년도 하계종합학술대회 논문집(2)
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    • pp.145-148
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    • 2002
  • In this paper, a voltage controlled oscillator (VCO) with automatic amplitude control is designed using a 0.35${\mu}{\textrm}{m}$ CMOS process. A cross-coupled PMOS pair is used for a negative resistance to compensate for the losses in the LC resonator, and an automatic\ulcorner amplitude control function is adapted to provide constant output power independent of the Q-factor of the LC resonator. The designed VCO operates in the 200MHz to 550MHz frequency range using different external resonators. The simulated phase noise is -128 dBc/Hz at 100KHz offset from the carrier frequency of 260MHz. It dissipates 0.㎽ from a 3V power supply. The area is 300${\mu}{\textrm}{m}$ x1201${\mu}{\textrm}{m}$.

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Resonance Frequency and Quality Factor Tuning in Electrostatic Actuation of Nanoelectromechanical Systems

  • Kim, Dong-Hwan
    • Journal of Mechanical Science and Technology
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    • 제19권9호
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    • pp.1711-1719
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    • 2005
  • In an electro statically actuated nanoelectromechanical system (NEMS) resonator, it is shown that both the resonance frequency and the resonance quality (Q) factor can be manipulated. How much the frequency and quality factor can be tuned by excitation voltage and resistance on a doubly-clamped beam resonator is addressed. A mathematical model for investigating the tuning effects is presented. All results are shown based on the feasible dimension of the nanoresonator and appropriate external driving voltage, yielding up to 20 MHz resonance frequency. Such parameter tuning could prove to be a very convenient scheme to actively control the response of NEMS for a variety of applications.

진동형 미세구조 각속도 센서의 공진 특성 해석 및 설계 (design and Resonant Characteristics Analysis of a Vibrating Angular Rate Senser of Microstructure)

  • 홍윤식
    • 한국정밀공학회:학술대회논문집
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    • 한국정밀공학회 1996년도 춘계학술대회 논문집
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    • pp.156-160
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    • 1996
  • A vibrating angular rate sensor with tuning fork type resonator of microstructure (940*820 .mu. m$^{2}$) was designed and will be fabricated by polysilicon surface micromaching. The angular rate sensor is driven in a lateral direction by electrostatic force of comb drive electrodes, and vertical vibrations of the sensor, thich is detected capacitively, are produced by Coriolis forces due to an external angular rate. Mechanical Q factors and a difference between the frequencies of the two resonant modes, the driving mode and detecting mode, play a great role in increasing the sensitivity of the sensor. To be a highly sensitive sensor, it was designed to have as small frequency discrepancy of the two resonant modes as possible. Finite element method was used for the modal analysis. Several design parameters were selected and their contributions to the modal frequencies were investigated. A method was presented for tuning the detecting mode frequency by DC bias on the drive electrodes.

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Molecular Docking, 3D QSAR and Designing of New Quinazolinone Analogues as DHFR Inhibitors

  • Yamini, L.;Kumari, K. Meena;Vijjulatha, M.
    • Bulletin of the Korean Chemical Society
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    • 제32권7호
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    • pp.2433-2442
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    • 2011
  • The three dimensional quantitative structure activity relationship (3D QSAR) models were developed using Comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA) and docking studies. The fit of Quinazolinone antifolates inside the active site of modeled bovine dihydrofolate reductase (DHFR) was assessed. Both ligand based (LB) and receptor based (RB) QSAR models were generated, these models showed good internal and external statistical reliability that is evident from the $q^2_{loo}$, $r^2_{ncv}$ and $r^2_{pred}$. The identified key features enabled us to design new Quinazolinone analogues as DHFR inhibitors. This study is a building bridge between docking studies of homology modeled bovine DHFR protein as well as ligand and target based 3D QSAR techniques of CoMFA and CoMSIA approaches.

RF-MEMS 스위치용 마이크로 외팔보의 감쇠특성 (Damping Characteristics of a Microcantilever for Radio Frequency-microelectromechanical Switches)

  • 이진우
    • 한국소음진동공학회논문집
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    • 제21권6호
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    • pp.553-561
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    • 2011
  • A theoretical approach is carried out to predict the quality factors of flexible modes of a microcantilever on a squeeze-film. The frequency response function of an inertially-excited microcantilever beam is derived using an Euler-Bernoulli beam theory. The external force due to squeeze-film phenomenon is developed from the Reynolds equation. Slip boundary conditions are employed at the interfaces between the fluid and the structure to consider the gas rarefaction effect, and pressure boundary condition at both ends of fluid analysis region is enhanced to increase the exactness of predicted quality factors. To the end, an approximate equation is derived for the first bending mode of the microcantilever. Using the approximate equation, the quality factors of the second and third bending modes are calculated and compared with experimental results of previously reported work. The comparison shows the feasibility of the current approach.

Profile Control Using RF Wave Heating in KT-2 Tokamak

  • Ju, M.H.;Hong, B.G.;Kim, S.K.
    • 한국원자력학회:학술대회논문집
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    • 한국원자력학회 1996년도 춘계학술발표회논문집(4)
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    • pp.443-448
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    • 1996
  • In this paper, the 100 % non-inductive current drive scenarios are addressed for the steady-state operation on KT-2 tokamak, with the profile control using fast wave and lower hybrid wave as the external tools. Considering the stability, the well-aligned current profiles with a reversed-shear and $q_{min}$ > 2.0 has been favor-able in high ${\beta}_{p}$ plasma, together with a possibly higher bootstrap current fraction. Therefore, the effects of the auxiliary heating power profile on the control of MHD favorable current profile are evaluated in detail.

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한국산 유각변형충목 (Arcellinida) 및 유각사상근족충목 (Gromiida)의 계통분류학적 연구 (Systematic Study on the Marine Hydroids (Cnidaria: Hydrozoa) in Korea ll. The Families Sphaerocorynidae, Eudendriidae, Haleciidae and Lafofidae)

  • 박정희
    • 한국동물학회지
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    • 제34권4호
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    • pp.541-547
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    • 1991
  • Some Korean marine hvdroids of the families Sphaerocorynidae, Eudendriidae, Haleciidae and Lafoeidae were observed based on the external features. Thev were collected from the coasts and islands of Korea during the years 1971-1990 by the author and others. As a result12 species and subspecies are identified, of which 6 species: Sphaerocowne bedoti, Eudendrium insigne, Eudendrium cumeum, Hydrodendron gordineri, Acwptolaria confena austrolis and Crammaria obi'etinQ tuned out to be new to the Korean fauna, which are redescribed briefly. For already known species in Korean fauna, the materials examined for this work and previous rdcore given, and not examined but already known species in Korean waters the only previous records are given for definition of the hydroid taxa. So that the Korean hvdroids of four families identified so far consist of ten genera and 19 species.

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벡터제어에 의한 자립식 유도발전기의 여자특성 해석 (Excitation Characteristics Analysis of an Isolated Induction Generator by applying Vector Control)

  • 이규민;구태만
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2004년도 하계학술대회 논문집 B
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    • pp.896-898
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    • 2004
  • The lagging reactive power should be supplied for the excitation of isolated squirrel-cage induction generators by external circuit. This paper deals with a technique to drive the equations for analysis of the excitation characteristics and performance of an isolated squirrel-cage induction generator from the conventional equivalent circuit of induction machine, transform the equations into d-q coordinates to use vector control technique, and carry out the simulation of an induction generator system with various conditions using MATLAB. The results of the simulation indicate that moderate reactive power can be controlled effectively to maintain constant voltage over a wide range of the rotor speeds and loads.

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집단지성의 품질, 그 결정요인, 유용성의 관계: 수용자 관점에서 한국의 위키서비스와 Q&A 서비스의 비교 (Relationships between Collective Intelligence Quality, Its Determinants, and Usefulness: A Comparative Study between Wiki Service and Q&A Service in Perspective of Korean Users)

  • 주재훈;이스마틸라 노르마토프
    • Asia pacific journal of information systems
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    • 제22권4호
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    • pp.75-99
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    • 2012
  • Innovation can come from inside or outside organizations. Recently, organizations have begun turning to external knowledge more often, through various forms of collective intelligence (CI) as collaborative platform to solve complex problems. Several factors facilitate this CI utilization phenomenon. First, with the rapid development of Internet and social media, numerous web applications have become available to millions of the Internet users over the past few decades. Web 2.0 and social media have become innovative web applications that provide an environment for human social interaction and collaboration. Second, the diffusion of simple and easy-to-use technologies that enable users to interact and design web applications without programming skills have led to vast, previously unknown amounts of user-generated content. Finally, the Internet has enabled communities to connect and collaborate, creating a virtual world of CI. In this study, web enabled CI is defined as a composed ability of individuals who are acting as a single cognitive unit to achieve common goals, think reasonably, solve problems, make decisions, carry out complex tasks, and develop creative ideas collectively through participation and collaboration on the web. Although CI plays a critical role in organizational innovation and collaboration, the dubious quality of CI is still problem that is difficult to solve. In general, the quality level of content collected from the crowd is lower than that from professionals. Thus, it is important to identify determinants of CI quality and to analyze the relationship between CI quality and its usefulness. However, there is a lack of empirical study on the quality factors of web-enabled CI. There exist a variety of web enabled CI sites such as Threadless, iStockphoto or InnoCentive, Wikipedia, and Youtube. One of the most successful forms of web-enabled CI is the Wikipedia online encyclopedia, accessible all over the world. Another one example is Naver KnowledgeiN, a typical and popular CI site offering question and answer (Q&A) services. It is necessary to study whether or not different types of CI have a different effect on CI quality and its usefulness. Thus, the purpose of this paper is to answer to following research questions: ${\bullet}$ What determinants are important to CI quality? ${\bullet}$ What is the relationship between CI quality factors and the usefulness of web-enabled CI? ${\bullet}$ Does CI type have a moderating effect on the relationship between CI quality, its determinants, and CI usefulness? Online survey using Google Docs with email and Kakao Talk was conducted for collecting data from Wikipedia and Naver KnowledgeiN users. A totoal of 490 valid responses were collected, where users of Wikipedia were 220 while users of Naver KnowledgeiN were 270. Expertise of contributors, community size, and diversity of contributors were identified as core determinants of perceived CI quality. Perceived CI quality has significantly influenced perceived CI usefulness from a user's perspective. For improving CI quality, it is believed that organizations should ensure proper crowd size, facilitate CI contributors' diversity and attract as many expert contributors as possible. Hypotheses that CI type plays a role of moderator were partially supported. First, the relationship between expertise of contributors and perceived CI quality was different according to CI type. The expertise of contributors played a more important role in CI quality in the case of Q&A services such as Knowledge iN compared to wiki services such as Wikipedia. This implies that Q&A service requires more expertise and experiences in particular areas rather than the case of Wiki service to improve service quality. Second, the relationship between community size and perceived CI quality was different according to CI type. The community size has a greater effect on CI quality in case of Wiki service than that of Q&A service. The number of contributors in Wikipeda is important because Wiki is an encyclopedia service which is edited and revised repeatedly from many contributors while the answer given in Naver Knowledge iN can not be corrected by others. Finally, CI quality has a greater effect on its usefulness in case of Wiki service rather than Q&A service. In this paper, we suggested implications for practitioners and theorists. Organizations offering services based on collective intelligence try to improve expertise of contributeros, to increase the number of contributors, and to facilitate participation of various contributors.

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