• 한국산업보건학회지
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• 제29권3호
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• pp.358-367
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• 2019

Objectives: This study aimed to review model algorithms and input parameters applied to some exposure models and to compare the simulated estimates using an exposure scenario from each model. Methods: A total of five exposure models which can estimate inhalation exposure were selected; the Korea Ministry of Environment(KMOE) exposure model, European Centre for Ecotoxicology and Toxicology of Chemicals Targeted Risk Assessment(ECETOC TRA), SprayExpo, and ConsExpo model. Algorithms and input parameters for exposure estimation were reviewed and the exposure scenario was used for comparing the modeled estimates. Results: Algorithms in each model commonly consist of the function combining physicochemical properties, use characteristics, user exposure factors, and environmental factors. The outputs including air concentration ($mg/m^3$) and inhaled dose(mg/kg/day) are estimated applying input parameters with the common factors to the algorithm. In particular, the input parameters needed to estimate are complicated among the models and models need more individual input parameters in addition to common factors. In case of CEM, it can be obtained more detailed exposure estimates separating user's breathing zone(near-field) and those at influencing zone(far-field) by two-box model. The modeled exposure estimates using the exposure scenario were similar between the models; they were ranged from 0.82 to $1.38mg/m^3$ for concentration and from 0.015 to 0.180 mg/kg/day for inhaled dose, respectively. Conclusions: Modeling technique can be used for a useful tool in the process of exposure assessment if the exposure data are scarce, but it is necessary to consider proper input parameters and exposure scenario which can affect the real exposure conditions.

• Environmental Analysis Health and Toxicology
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• 제14권4호
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• pp.203-216
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• 1999

This paper describes a set of multi-pathway models for estimating health risk to lead. The models link concentrations of an environmental contaminant (lead) in air, water and food to human exposure through inhalation, ingestion, and dietary routes. Exposure is used as the foundation for predicting risk of health detriment within the population. The process of estimating exposure using often limited data and extrapolating to a large diverse population requires many assumption, inferences, and simplification. This paper is divided into four section. The first section provides lead contaminant levels on obtaining environmental concentration of air, tap water, and foods. The second section provides a discussion of exposure parameters and uncertainty associated predicting human health risk of contaminants. The third and fourth section illustrate lifetime average daily exposure (LADE) and excess cancer risk (ECR) based on exposure parameters. The relationship between concentration of lead in an environmental medium and human exposure is determined with pathway exposure factors (PEFs). The calculation of LADE and ECR is carried out using Monte-Carlo simulation with probability density function of exposure parameters. Examination of the result reveals that, for lead exposure, ingestion (food) is the dominant route of exposure rather than inhalation (air), and ingestion (tap eater).

• 한국산업보건학회지
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• 제22권3호
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• pp.191-199
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• 2012

Objectives: The study aim was to evaluate the application of a chemical exposure assessment tool for the Korean workplace. The Ministry of Employment and Labor in Korea (KMOEL) introduced the need for workplace risk assessments in 2011, requiring the Korean chemical industry to consider both domestic and international chemical regulation policies (e.g., estimations of exposure scenarios). Exposure scenarios are required in the European Union as part of material safety data sheets (MSDS) under the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) system. Methods: Although many programs for the estimation of exposure have been developed worldwide, to date there is no standard for the Korean workplace. To develop programs suitable for the Korean workplace, we examined the applicability of the European Center for Ecotoxicology and Toxicology of Chemicals target risk assessment (ECETOC TRA), which is recommended by the European Chemical Agency (ECHA). Results: To investigate the applicability of the ECETOC TRA to Korean industry, this study simulated 15 industrial processes. The predicted respiratory exposures for four processes using origin input parameters were underestimated compared to the measured respiratory exposure. Using calibrated input parameters, results for two processes were underestimated compared to the measured respiratory exposure. This result suggests that the use of calibrated input parameters reduces the differences between predicted and measured respiratory exposure. Conclusions: we developed applicable exposure estimating method by modifying the ECETOC TRA program; one suggested the development of exposure estimating program that explains Korea domestic workplace exposure scenario.This study will support the introduction of exposure scenario in MSDS system and protect health of worker from hazardous chemical.

• Fisheries and Aquatic Sciences
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• 제22권5호
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• pp.9.1-9.7
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• 2019

The study investigated the changes in growth performance, hematological parameters, plasma components, and stress indicators of juvenile starry flounder, Platichthys stellatus, depending on varying exposure to hexavalent chromium. P. stellatus was exposed to waterborne chromium at 0, 50, 100, 200, and 400 ppb for 4 weeks. The result showed that Cr exposure resulted in decreased daily length gain (DLG), daily weight gain (DWG), condition factor (CF), and hepatosomatic index (HIS) in P. stellatus. In terms of hematological parameters, red blood cell (RBC) count, hematocrit (Ht), and hemoglobin (Hb) significantly decreased at 400 ppb after 2 weeks. In terms of plasma components, inorganic analysis was unchanged and cholesterol, an organic component, considerably increased at 400 ppb after 4 weeks. Plasma enzyme components including glutamic oxalate transaminase (GOT) and glutamic pyruvate transaminase (GPT) were significantly increased. Stress indicators such as cortisol and glucose were notably increased over 100 ppb after 4 weeks with increasing chromium concentration. The results indicate that exposure to waterborne Cr induced toxic effects on growth, hematological parameters, plasma components, and stress indicators.

• Applied Microscopy
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• 제45권3호
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• pp.150-154
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• 2015

Negative staining electron microscopy facilitates the visualization of small bio-materials such as proteins; thus, many electron microscopists have used this conventional method to visualize the morphologies and structures of biological materials. To achieve sufficient contrast of the materials, a number of imaging parameters must be considered. Here, we examined the effects of one of the fundamental imaging parameters, electron beam exposure time, on electron densities generated using transmission electron microscopy. A single site of a negatively stained biological sample was illuminated with the electron beam for different times (1, 2, or 4 seconds) and sets of micrographs were collected. Computational image processing demonstrated that longer exposure times provide better electron densities at the molecular level. This report describes technical procedures for testing parameters that allow enhanced evaluations of the densities of electron microscopy images.

• 한국환경과학회지
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• 제1권1호
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• pp.47-51
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• 1992

수중에 존재하는 휘발성 유기화합물은 샤워를 하는동안 공기로 방출되고 공기농도는 샤워 변수에 따라 달라지는데, 이는 휘발성 유기화합물의 호기농도의 변화를 야기 시킨다. 본 연구에서는 샤워를 하는 동안 공기중의 클로로포픔 노출에 영향을 미치는 주요한 샤워변수(물온다 및 노출시간)를 클로로포픔 호기농도를 측정하여 검토 하였다. 크롤로포름 호기농도는 물의 온도와 노출 시간이 증가함에 따라 증가 하였다. 가장 큰 클로로포름 호기농도 차이를 나타내는 두개의 흡기 노출 조건은 미지근한 물을 이용한 5분 동안의 노출과 더운 물을 이용한 15분 동안의 노출이었다. 클로로포름 호기농도는 후자의 노출후에 전자의 경우보다 거의 3배 정도 높았다. 주요 샤워변수와 수중농도로 조정된 호기농도 사이의 수학모델은 0.0001의 확률에서의 데이타와 훌륭한 일치되는 결과를 나타내었다.

• Environmental Analysis Health and Toxicology
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• 제24권2호
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• pp.95-105
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• 2009

Chemical Ranking and Scoring (CRS) system is a useful tool to screen priority chemicals of large body of substances. The relative ranking of chemicals based on CRS system has served as a decision-making support tools. Exposure potential and toxicity are significant parameters in CRS system, and there are differences in evaluating those parameters in each CRS system. In this study, the parameters of exposure potential, human toxicity, and ecotoxicity were extensively compared. In addition the scoring methods in each parameter were analyzed. The CRS systems considered in this study include the CHEMS-1 (Chemical Hazard Evaluation for Management Strategies), SCRAM (Scoring and Ranking Assessment Model), EURAM (European Union Risk Ranking Method), ARET (Accelerated Reduction/Elimination of Toxics), and CRS-Korea. An comparative analysis of the several CRS systems is presented based on their assessment parameters and scoring methods.

• 한국멀티미디어학회논문지
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• 제24권11호
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• pp.1461-1471
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• 2021

This paper presents a light exposure correction algorithm for less pleasant images, acquired with a light metering failure. Since conventional tone mapping and gamma correction methods adopt a function mapping with the same range of input and output, the results are pleasurable for almost symmetric distributions to their intensity average. However, their corrections gave insufficient outputs for asymmetric cases at either bright or dark regions. Also, histogram modification approaches show good results on varied pattern images, but these generate unintentional noises at flat regions because of the compulsive shift of the intensity distribution. Therefore, in order to sufficient corrections for both bright and dark areas, the proposed algorithm calculates the gamma coefficients using primary parameters extracted from the global distribution. And the fusion weights are adaptively determined with complementary parameters, considering the classification information of a binary segmentation. As the result, the proposed algorithm can obtain a good output about both the symmetric and the asymmetric distribution images even with severe exposure values.

• Annals of Occupational and Environmental Medicine
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• 제35권
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• pp.39.1-39.14
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• 2023

Background: Diseases affecting the lungs and airways contribute significantly to the global burden of disease. The problem in low- and middle-income countries appears to be exacerbated by a shift in global manufacturing base to these countries and inadequate enforcement of environmental and safety standards. In Ghana, the potential adverse effects on respiratory function associated with occupational wood dust exposure have not been thoroughly investigated. Methods: Sixty-four male sawmill workers and 64 non-woodworkers participated in this study. The concentration of wood dust exposure, prevalence and likelihood of association of respiratory symptoms with wood dust exposure and changes in pulmonary function test (PFT) parameters in association with wood dust exposure were determined from dust concentration measurements, symptoms questionnaire and lung function test parameters. Results: Sawmill workers were exposed to inhalable dust concentration of 3.09 ± 0.04 mg/m³ but did not use respirators and engaged in personal grooming habits that are known to increase dust inhalation. The sawmill operators also showed higher prevalence and likelihoods of association with respiratory symptoms, a significant cross-shift decline in some PFT parameters and a shift towards a restrictive pattern of lung dysfunction by end of daily shift. The before-shift PFT parameters of woodworkers were comparable to those of non-woodworkers, indicating a lack of chronic effects of wood dust exposure. Conclusions: Wood dust exposure at the study site was associated with acute respiratory symptoms and acute changes in some PFT parameters. This calls for institution and enforcement of workplace and environmental safety policies to minimise exposure at sawmill operating sites, and ultimately, decrease the burden of respiratory diseases.

• 한국광학회지
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• 제33권6호
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• pp.324-330
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• 2022

포토레지스트의 노광 및 현상 특성을 각각 결정하는 Dill 및 Mack 모델 파라미터들을 측정하였다. 먼저, 노광량을 변화시켜가며 포토레지스트 샘플을 준비하였고, 노광량에 따른 투과율 변화를 측정하였다. 이 결과를 바탕으로 Dill 모델의 A, B, C 파라미터를 결정하였는데, 특히 C 파라미터를 결정하기 위하여 Dill 모델 방정식의 완전해를 사용하였다. 또한, 노광량별로 현상 시간에 따른 포토레지스트의 두께 변화를 측정하였고, 이 결과를 사용하여 Mack 모델의 R_min, R_max, a, n 파라미터를 결정하였다. 모델 파라미터 R_min, R_max, n만을 사용하는 간략화된 Mack 모델에 대해서도 파라미터값들을 결정해 보았는데, 네 개의 파라미터를 사용하는 본래 Mack 모델의 경우와 비교했을 때 측정결과와의 오차가 다소 커짐을 알 수 있었다.