• The Korean Journal of Pain
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• v.36 no.1
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• pp.113-127
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• 2023

Background: Resting-state functional connectivity (rs-FC) may aid in understanding the link between painmodulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the differences in rs-FC of the primary somatosensory cortex in responders and non-responders to the conditioned pain modulation test (CPM-test) are related to pain, sleep quality, central sensitization, and the impact of FM on quality of life. Methods: This cross-sectional study included 33 females with FM. rs-FC was assessed by functional magnetic resonance imaging. Change in the numerical pain scale during the CPM-test assessed the DPMS function. Subjects were classified either as non-responders (i.e., DPMS dysfunction, n = 13) or responders (n = 20) to CPM-test. A generalized linear model (GLM) and a receiver operating characteristic (ROC) curve analysis were performed to check the accuracy of the rs-FC to differentiate each group. Results: Non-responders showed a decreased rs-FC between the left somatosensory cortex (S1) and the periaqueductal gray (PAG) (P < 0.001). The GLM analysis revealed that the S1-PAG rs-FC in the left-brain hemisphere was positively correlated with a central sensitization symptom and negatively correlated with sleep quality and pain scores. ROC curve analysis showed that left S1-PAG rs-FC offers a sensitivity and specificity of 85% or higher (area under the curve, 0.78, 95% confidence interval, 0.63-0.94) to discriminate who does/does not respond to the CPM-test. Conclusions: These results support using the rs-FC patterns in the left S1-PAG as a marker for predicting CPM-test response, which may aid in treatment individualization in FM patients.

• KIPS Transactions on Software and Data Engineering
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• v.12 no.3
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• pp.141-148
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• 2023

Accurate overlay metrology is essential to achieve high yields of semiconductor products. Overlay metrology performance is greatly affected by overlay target design and measurement method. Therefore, in order to improve the performance of the overlay target, measurement methods applicable to various targets are required. In this study, we propose a new algorithm that can measure image-based overlay. The proposed measurement algorithm can estimate the sub-pixel position by using a motion vector. The motion vector may estimate the position of the sub-pixel unit by applying a quadratic equation model through polynomial expansion using pixels in the selected region. The measurement method using the motion vector can calculate the stacking error in all directions at once, unlike the existing correlation coefficient-based measurement method that calculates the stacking error on the X-axis and the Y-axis, respectively. Therefore, more accurate overlay measurement is possible by reflecting the relationship between the X-axis and the Y-axis. However, since the amount of computation is increased compared to the existing correlation coefficient-based algorithm, more computation time may be required. The purpose of this study is not to present an algorithm improved over the existing method, but to suggest a direction for a new measurement method. Through the experimental results, it was confirmed that measurement results similar to those of the existing method could be obtained.

• Journal of the Korean Geotechnical Society
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• v.26 no.1
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• pp.5-19
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• 2010

Geo-layer information is important to determine pile length and estimate residual settlement in the construction site. An overall spatial distribution of geo-layers in the entire construction site can be predicted using drill-log information. In this study, the geo-layer distribution at Song-do area was estimated by kriging and inverse distance weighting methods, and a cross validation was adopted to verify the reliability of estimation results. The analysis results indicate that the best fitted theoretical variogram model to the experimental variogram does not always provide the most reliable estimation in the kriging method. The proper $\alpha$ value of inverse distance weighting method must be determined by types of geo-layer, because the $\alpha$ value is affected by types of geo-layer. Results of the kriging method show more reliable results than those of inverse distance weighting method, and the structure of geo-layer distribution could be evaluated by variogram in the kriging method.

• Journal of the Korean Geotechnical Society
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• v.25 no.11
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• pp.27-38
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• 2009

In this study, a series of 1 g shaking table model pile tests were carried out in saturated dense and loose sand to evaluate dynamic p-y curves for various conditions of flexural stiffness of a pile shaft, acceleration frequency and acceleration amplitude for input loads. Dynamic p-y backbone curve which can be applied to pseudo static analysis for saturated dense sand was proposed as a hyperbolic function by connecting the peak points of the experimental p-y curves, which corresponded to maximum soil resistances. In order to represent the backbone curve numerically, empirical equations were developed for the initial stiffness ($k_{ini}$) and the ultimate capacity ($p_u$) of soils as a function of a friction angle and a confining stress. The applicability of a p-y backbone curve was evaluated based on the centrifuge test results of other researchers cited in literature, and this suggested backbone curve was also compared with the currently available p-y curves. And also, the scaling factor ($S_F$) to account for the degradation of soil resistance according to the excess pore pressure was developed from the results of saturated loose sand.

• Journal of the Korean Geotechnical Society
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• v.23 no.1
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• pp.23-37
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• 2007

Recently a concept of pile-tip enlarged PHC pile (Ext-PHC pile), for use in the auger-drilled construction method, has been developed and is being implemented in practice. A series of field axial load tests on both PHC and Ext-PHC piles were conducted at an experimental site. In addition, a parametric study on a number of influencing factors was made using a validated finite element model. The field axial load tests indicated an enhanced load-settlement characteristics for the Ext-PHC piles compared with the PHC piles, giving approximately 50% increase in the end bearing capacity. Also found in the results of the parametric study was that the increase in the end bearing capacity of Ext-PHC piles slightly varies with the mechanical properties of supporting ground as well as pile length, in the range of 1.25 to 1.4 time that of PHC. Overall, the results of the field tests as well as the numerical study confirmed that the end bearing capacity of PHC pile can be improved by the concept of.Ext-PHC pile.

• Journal of the Korea institute for structural maintenance and inspection
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• v.27 no.3
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• pp.38-46
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• 2023

In this study, a bearing test was performed and analytically evaluated to evaluate the bearing performance according to the application of the aluminum stiffener in round-end concrete. In the bearing strength test, the change in bearing performance due to the aluminum stiffener using the aluminum form for manufacturing concrete with round-end, and the steel anchor bolts for member movement and assembly was confirmed. The FE analysis model was identically configured to the experimental conditions, and the result was compared with the experiment. Also, the crack patterns and stress behavior were confirmed. In addition, the effect of strength change of the aluminum stiffener on the round-end concrete was also evaluated analytically. The bearing strength of the round-end concrete increased by about 20% due to the aluminum stiffener, and it was confirmed that the steel anchor bolt did not affect the bearing strength. The maximum load and crack patterns shown as a result of FE analysis were similar to those of the experiment. As a result of FE analysis according to the strength change of the aluminum stiffener, the maximum load change according to the increase and decrease of the strength of the aluminum stiffener by 10% and 20% was evaluated to have no significant effect at a maximum of about 4% compared to before the strength change.

• Journal of Veterinary Science
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• v.23 no.1
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• pp.2.1-2.18
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• 2022

Background: Co-infections of the porcine reproductive and respiratory syndrome virus (PRRSV) and the Haemophilus parasuis (HPS) are severe in Chinese pigs, but the immune response genes against co-infected with 2 pathogens in the lungs have not been reported. Objectives: To understand the effect of PRRSV and/or HPS infection on the genes expression associated with lung immune function. Methods: The expression of the immune-related genes was analyzed using RNA-sequencing and bioinformatics. Differentially expressed genes (DEGs) were detected and identified by quantitative real-time polymerase chain reaction (qRT-PCR), immunohistochemistry (IHC) and western blotting assays. Results: All experimental pigs showed clinical symptoms and lung lesions. RNA-seq analysis showed that 922 DEGs in co-challenged pigs were more than in the HPS group (709 DEGs) and the PRRSV group (676 DEGs). Eleven DEGs validated by qRT-PCR were consistent with the RNA sequencing results. Eleven common Kyoto Encyclopedia of Genes and Genomes pathways related to infection and immune were found in single-infected and co-challenged pigs, including autophagy, cytokine-cytokine receptor interaction, and antigen processing and presentation, involving different DEGs. A model of immune response to infection with PRRSV and HPS was predicted among the DEGs in the co-challenged pigs. Dual oxidase 1 (DUOX1) and interleukin-21 (IL21) were detected by IHC and western blot and showed significant differences between the co-challenged pigs and the controls. Conclusions: These findings elucidated the transcriptome changes in the lungs after PRRSV and/or HPS infections, providing ideas for further study to inhibit ROS production and promote pulmonary fibrosis caused by co-challenging with PRRSV and HPS.

• Journal of Convergence for Information Technology
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• v.12 no.3
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• pp.132-140
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• 2022

This study was conducted to identify the optimal lotion manufacturing conditions with decursin and decursinol angelate of Angelica gigas Nakai extraction. Lotion was confirmed that it had viscosity (5,208±112 cPs), assay (99.71±1.01%), and pH (5.62) for 3 months. The optimization of manufacturing conditions of mixing 4 for lotion formulation were made by 22+3 full factorial design. Mixing temperature (40-80℃) and mixing time (10-30 min) were used as independent variables with three responses(assay, pH, and weight variation) as critical quality attributes (CQAs). The model for assay and weight variation identified a proper fit having a determination coefficient of the regression equation (about 0.9) and a p-value less than 0.05. Estimated conditions for the optimal manufacturing process of lotion were 61.93℃ in mixing temperature and 15.85 min in mixing time. Predicted values at the mixing temperature (60℃) and mixing time (20 min) were 100.69% of assay, 5.57 of pH, and 98.07% of weight variation. In the verification of the actual measurement the obtained values showed 100.29±0.98% of assay, 5.57±0.02 of pH, and 98.27±0.89% of weight variation, respectively, in good agreement with predicted values.

• Composites Research
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• v.36 no.3
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• pp.199-204
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• 2023

A combination of a metallic mesh and an adhesive layer of metallic particle/epoxy composite was introduced as an intermediate layer to enhance the adhesion between cold-sprayed particles and fiber-reinforced composites (FRCs). Aluminum was considered for both the metallic particles in the adhesive and the metallic mesh. To predict the mechanical characteristics of the intermediate bond layer under a high strain rate, the properties of the adhesive layer needed to be calculated or measured. Therefore, in this study, the Al particle/epoxy adhesive was homogenized by using a rule of mixture. To verify the homogenization, the penetration depth, and the thickness decrease after the cold spray deposition from the undeformed surface, was monitored with FE analysis and compared with experimental observation. The comparison displayed that the penetration depth was comparable to the diameters of one cold spray particle, and thus the homogenization approach can be reasonable for the prediction of the stress level of particulate polymer composite interlayer under a high strain rate for cold spray processing.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.4A
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• pp.767-774
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• 2006

This study has focused on the possibility for recycling of tailings from the sangdong tungsten mine as powder (TA) of self-compacting concrete (SCC). The experimental tests for entrapped water ratio were carried out in accordance with the specified method by Okamura. The rheological measurements of cement paste were conducted by using a commercially digital Brookfield viscometer (Model LVDV-II+) equipped with cylindrical spindles, also tests for slump-flow, time required to reach 500 mm of slump flow (sec), time required to flow through V-funnel (sec) and filling height of U-box test (mm) were carried out in accordance with the specified by the Japanese Society of Civil Engineering (JSCE). The results of this study, entrapped water ratio was decreased with increasing replacement of TA. Thickness of pseudo water film was increased, and mean plastic viscosity was decreased with increasing replacement of TA. And slump-flow of SCC was decreased with increasing replacement of TA. But time required to reach 500 mm of slump flow (sec), time required to flow through V-funnel (sec) and filling height of U-box test (mm) were satisfied a prescribed range. The mechanical properties including compressive strength, splitting tensile strength and elastic modulus were checked with the requirements specified by Korean Industrial Standard (KS). The compressive strength of SCC was decreased with increasing replacement of TA, splitting tensile strength and elastic modulus were similar to those of normal concrete.