• Water Engineering Research
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• v.1 no.1
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• pp.63-74
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• 2000

This paper presents a two- phase search scheme for optimal pipe expansion of expansion of existing water distribution systems. In pipe network problems, link flows affect the total cost of the system because the link flows are not uniquely determined for various pipe diameters. The two-phase search scheme based on stochastic optimization scheme is suggested to determine the optimal link flows which make the optimal design of existing pipe network. A sample pipe network is employed to test the proposed method. Once the best tree network is obtained, the link flows are perturbed to find a near global optimum over the whole feasible region. It should be noted that in the perturbation stage the loop flows obtained form the sample existing network are employed as the initial loop flows of the proposed method. It has been also found that the relationship of cost-hydraulic gradient for pipe expansion of existing network affects the total cost of the sample network. The results show that the proposed method can yield a lower cost design than the conventional design method and that the proposed method can be efficiently used to design the pipe expansion of existing water distribution systems.

• Journal of the Korean earth science society
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• v.36 no.5
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• pp.419-426
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• 2015

We investigated the high dispersion spectra that had been secured at the center of the planetary nebula NGC 7027 with the Bohyunsan Optical Echelle Spectrograph (BOES) on October, 20, 2009. We analyzed the forbidden lines of [OI], [SII], [OII], [NII], [ClIII], [ArIII], [OIII], [ArIV], [NeIII], [ArV], and [CaV] in the $3770-9225{\AA}$ wavelength region. The expansion velocities were derived from double Gaussian line profiles of the emission lines, after eliminating the subsidiary line broadening effects. The radial variations of the expansion velocities were obtained by projecting the derived expansion velocities: $19.56-31.93kms^{-1}$ onto the equatorial shell elements of the inner and the outer boundaries of the main shell of 2.5(2.1)" and 3.8(3.6)", according to the ionization potential of each ion. Analysis of equatorial shell spectra indicated that the equatorial shell generally expands in an accelerated velocity mode, but the expansion pattern deviates from a linear velocity growth with radial distance. NGC 7027, of which age is about 1000 years or less, might be still at its early stage. During the first few hundred years, plausibly in its early stage, the main shell of PN expands very slowly and, later, it gradually gain its normal expansion speed.

• The Journal of the Korean dental association
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• v.51 no.6
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• pp.330-336
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• 2013

Considering the high prevalence, transverse control in adult patients presenting relatively narrow maxillary width is a challenging issue. This study compared the pattern of arch expansion induced by either miniscrew-assisted rapid palatal expander (MARPE) or continuous archwire engaged on self-ligating brackets. Age-matched adults groups(N=15 each) were treated with respective appliance. In both groups, all intercanine, interpremolar, and intermolar widths increased, and significantly greater change was noted in the intermolar region. Buccal tipping was minimal in both groups. Subsequent arch length increase, lingual tipping of incisors and distal tipping of molars were also found in both groups. According to the results, it can be concluded that the MARPE induced generally more arch expansion, particularly in the intermolar width, indicating that the adults showing buccal crossbite of the molars may have to undergo expansion via MARPE prior to arch alignment using continuous archwire.

• Geomechanics and Engineering
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• v.18 no.3
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• pp.225-234
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• 2019

A numerical stepwise approach for cavity expansion problem in strain-softening rock or soil mass is investigated, which is compatible with Mohr-Coulomb and generalized Hoek-Brown failure criteria. Based on finite difference method, plastic region is divided into a finite number of concentric rings whose thicknesses are determined internally to satisfy the equilibrium and compatibility equations, the material parameters of the rock or soil mass are assumed to be the same in each ring. For the strain-softening behavior, the strength parameters are assumed to be a linear function of deviatoric plastic strain (${\gamma}p^*$) for each ring. Increments of stress and strain for each ring are calculated with the finite difference method. Assumptions of large-strain for soil mass and small-strain for rock mass are adopted, respectively. A new numerical stepwise approach for limited pressure and plastic radius are obtained. Comparisons are conducted to validate the correctness of the proposed approach with Vesic's solution (1972). The results show that the perfectly elasto-plastic model may underestimate the displacement and stresses in cavity expansion than strain-softening coefficient considered. The results of limit expansion pressure based on the generalised H-B failure criterion are less than those obtained based on the M-C failure criterion.

• The Korean Journal of Physiology and Pharmacology
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• v.9 no.1
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• pp.1-8
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• 2005

Myotonic Dystrophies type 1 and 2 (DM1/2) are neuromuscular disorders which belong to a group of genetic diseases caused by unstable CTG triplet repeat (DM1) and CCTG tetranucleotide repeat (DM2) expansions. In DM1, CTG repeats are located within the 3' untranslated region of myotonin protein kinase (DMPK) gene on chromosome 19q. DM2 is caused by expansion of CCTG repeats located in the first intron of a gene coding for zinc finger factor 9 on chromosome 3q. The CTG and CCTG expansions are located in untranslated regions and are expressed as pre-mRNAs in nuclei (DM1 and DM2) and as mRNA in cytoplasm (DM1). Investigations of molecular alterations in DM1 discovered a new molecular mechanism responsible for this disease. Expansion of un-translated CUG repeats in the mutant DMPK mRNA disrupts biological functions of two CUG-binding proteins, CUGBP and MNBL. These proteins regulate translation and splicing of mRNAs coding for proteins which play a key role in skeletal muscle function. Expansion of CUG repeats alters these two stages of RNA metabolism in DM1 by titrating CUGBP1 and MNBL into mutant DMPK mRNA-protein complexes. Mouse models, in which levels of CUGBP1 and MNBL were modulated to mimic DM1, showed several symptoms of DM1 disease including muscular dystrophy, cataracts and myotonia. Mis-regulated levels of CUGBP1 in newborn mice cause a delay of muscle development mimicking muscle symptoms of congenital form of DM1 disease. Since expansion of CCTG repeats in DM2 is also located in untranslated region, it is predicted that DM2 mechanisms might be similar to those observed in DM1. However, differences in clinical phenotypes of DM1 and DM2 suggest some specific features in molecular pathways in both diseases. Recent publications suggest that number of pathways affected by RNA CUG and CCUG repeats could be larger than initially thought. Detailed studies of these pathways will help in developing therapy for patients affected with DM1 and DM2.

• Journal of Cardiovascular Imaging
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• v.30 no.4
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• pp.292-304
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• 2022

BACKGROUND: Calcium is a determinant of paravalvular leakage (PVL) after transcatheter aortic valve implantation (TAVI). This is based on a fixed contrast attenuation value while X-ray attenuation is patient-dependent and without considering frame expansion and PVL location. We examined the role of calcium in (site-specific) PVL after TAVI using a patient-specific contrast attenuation coefficient combined with frame expansion. METHODS: 57 patients were included with baseline CT, post-TAVI transthoracic echocardiography and rotational angiography (R-angio). Calcium load was assessed using a patient-specific contrast attenuation coefficient. Baseline CT and post-TAVI R-angio were fused to assess frame expansion. PVL was assessed by a core lab. RESULTS: Overall, the highest calcium load was at the non-coronary-cusp-region (NCR, 436 mm³) vs. the right-coronary-cusp-region (RCR, 233 mm³) and the left-coronary-cusp-region (LCR, 244 mm³), p < 0.001. Calcium load was higher in patients with vs. without PVL (1,137 vs. 742 mm³, p = 0.012) and was an independent predictor of PVL (odds ratio, 4.83, p = 0.004). PVL was seen most often in the LCR (39% vs. 21% [RCR] and 19% [NCR]). The degree of frame expansion was 71% at the NCR, 70% at the RCR and 74% at the LCR without difference between patients with or without PVL. CONCLUSIONS: Calcium load was higher in patients with PVL and was an independent predictor of PVL. While calcium was predominantly seen at the NCR, PVL was most often at the LCR. These findings indicate that in addition to calcium, specific anatomic features play a role in PVL after TAVI.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 1994.11a
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• pp.21-23
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• 1994

By adding La₂O₃ to optical multicomponent glass composition, after making mother glass and core fiber that enable to enlarge the infrared transmittance region, then surveyed the optical properties. Through thermal analysis of the glass abstained by melt-quenching after selecting stable basic composition on devitrification and replace SiO₂ by 4-12wt% La₂O₃. As La₂O₃ increases up to l2wt% transition temperature, refractive index, density, deformation temperature increased, whereas thermal expansion coefficient decreased. As a result of inspectig transmittance in UV/VIS/IR region, visable region indicated the decrease of transmittance by increasing the La₂O₃ and transmittance region was enlarged by increasing the La₂O₃ in IR region. Also, fabricate core fiber at 820℃ and severy the optical loss we could fact that La₂O₃ composition added 12wt% showed the minimum optical loss.

• Journal of Energy Engineering
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• v.21 no.4
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• pp.362-372
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• 2012

The steam generator tubes of nuclear power plants are pressure boundaries, and if tubes are leaked, the coolant with the radioactive materials was flowed out from the primary system to the secondary system and polluted the plant and the air. Recently most crack defects of tubes are stress corrosion cracks and these defects are located in expansion transition area, sludge pile-up region, and U-bend area. The most effective one of crack initiation factors in expansion transition area and U-bend area is the residual stress. According to the experiences of Korea standard nuclear plants(Optimized Power Reactor-1000), they had the stress corrosion cracks at the tube expansion transition area in early operating stage and especially lots of circumferential cracks were occurred. Therefore in this study, the distributions and conditions of residual stresses by tube expansion methods were compared and the dominant reason of a specific direction was examined.

• Journal of the korean Society of Automotive Engineers
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• v.15 no.1
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• pp.45-54
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• 1993

The reattachment lengths of the Non-Newtonian fluid are investigated in the sudden expansion pipes whose ratios are 2.316 and 3.368, and the range of the Reynolds numbers is 100-30000. The reattachment lengths for the viscoelastic fluid in the laminar flow region are found to be much shorter than those of the Newtonian fluid, and decrease significantly with the increase of the concentration of viscoelastic fluid is two or three times longer than those of water, and gradually increases with the increase of the concentration of viscoelastic fluid.

• Journal of Institute of Control, Robotics and Systems
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• v.14 no.5
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• pp.444-452
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• 2008

This paper presents an overall image processing approach of defect inspection of patterned TFT-LCD panels for the real manufacturing process. A prototype of AOI(Automatic Optical Inspection) system which is composed of air floating stage and multi line scan cameras is developed. Adjacent pattern comparison algorithm is enhanced and used for pattern elimination to extract defects in the patterned image of TFT-LCD panels. New region merging algorithm which is based on border expansion is proposed to identify defects from the pattern eliminated defect image. Experimental results show that a developed AOI system has acceptable performance and the proposed algorithm reduces environmental effects and processing time effectively for applying to the real manufacturing process.