• Journal of Ocean Engineering and Technology
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• v.28 no.4
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• pp.294-305
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• 2014

In offshore structures, fire is one of the most important hazardous events. The concern of fires has recently been reflected in the rules and quantified risk assessment based design practice. Within the framework of quantified risk assessment and the management of offshore installations, therefore, more refined computations of the consequences or hazardous action effects due to fire are required. To mitigate fire risk, passive fire protection(PFP) is widely used on offshore structures. This study presents methods for a nonlinear structural response analysis considering the PFP effects under fires. It is found that a structural response analysis is most likely to use valuable technology for the optimization and design of offshore structures with PFP. Thermal and structural response analyses have been performed using LS-DYNA and FAHTS/USFOS. The results of these structural response analyses are compared with each other.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7583-7587
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• 2015

Epstein-Barr virus (EBV) is an extremely common herpesvirus that may cause asymptomatic infection or various diseases, including infectious mononucleosis, certain lymphoproliferative diseases and several types of neoplasms. Vaccine development is an important strategy to reduce the burden of EBV-associated diseases and the timing of vaccinations should be before primary infection occurs. In the past, more than 90% of Thai children were infected with EBV in early childhood. Now, due to the improved healthcare system in Thailand, we aim to determine current prevalence of EBV infection among people in different age groups. A total of 538 sera were collected from residents of Khon Kaen province in northeastern Thailand for detecting anti-EBV IgG. Sera of infants under 2-years-old were also tested for anti-EBV IgM and EBV-DNA. The prevalence of anti-EBV IgG was 47.1% (95% CI: 23.3-70.8) in infants aged 0-6 months, 34.9% (95% CI: 23.1-46.7) in those aged 6-24 months, 87.9% (95% CI: 79.5-96.3) in children aged 3-5 years and then maintained at above 95% through adulthood. These seropositivity rates among Thai children remain similar to those found in a previous study conducted 20 years ago. Thai children are still exposed to EBV from an early age. Therefore, a prophylactic vaccine should be given within the first two years of life.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4487-4490
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• 2016

Background: Methylation at cg 16941656 of FRY is exclusively found in normal pancreatic tissue and has been proven to be specific for pancreatic-in-origin among several adenocarcinomas. Here, we investigated methylated DNA in the bile as a biomarker to differentiate the cause of obstruction between pancreatic cancer and benign causes. Materials and Methods: Bile samples of 45 patients with obstructive jaundice who underwent ERCP were collected and classified into pancreatic cancer (group 1) and benign causes (group 2) in 24 and 21 patients, respectively. DNA was extracted from bile and bisulfite modification was performed. After, methylation in cg 16941656 of FRY was identified by real-time PCR, with beta-actin used as a positive control. Results: Methylated DNA was identified in 10/24 (41.67%) and 1/21 (4.8%) of cases in groups 1 and 2, respectively (P= 0.012). The sensitivity, specificity, positive predictive value and negative predictive value to differentiate pancreatic cancer from benign causes were 42%, 95%, 91%, and 59%, respectively. Conclusions: Detecting a methylation at cg 16941656 of FRY in bile has high specificity, with an acceptable positive likelihood rate, and may therefore be helpful in distinguish pancreatic cancer from benign strictures.

• International Commerce and Information Review
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• v.16 no.2
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• pp.221-249
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• 2014

This study analyzed the sufficient conditions for Korean firm's foreign subsidiaries in order to evolve into a center of excellence for knowledge creation and diffusion. In this respect, the purpose of this study is to develop a new framework based on literatures related to subsidiary knowledge creation and a center of excellence. Specifically, we created seven decisive factors for subsidiary knowledge creation: two general factors, two strategic important factors, and three excellent factors. Each factor can be a necessary condition or sufficient condition according to research purpose. For example, the decentralized organizational structure belonging to general factors become a sufficient factor for facilitating subsidiary's knowledge creation but it become a necessary condition for a center of excellence because all subsidiaries with decentralized organizational structure cannot be strategically important subsidiaries. By using seven decisive factors, this study examines the determinants' validity theoretically and practically.

• Journal of the Society of Naval Architects of Korea
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• v.51 no.4
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• pp.283-290
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• 2014

Environmental changes, especially global climate change, are creating new routes to reduce a shipping service distance in Arctic area. The Arctic routes are shorter than 60% of existing ways Panama or Suez canal). For this reason, ship owners prefer to navigate in Arctic area and a transportation of goods though the Arctic area is increasing. But the low temperature in Arctic condition changes the material properties. Especially, the material will be brittle and strength will increase. And an ultimate strength analysis of ship stiffened panels is changed depending on temperatures. In present study, the ultimate strength analysis of stiffened panels in double hull oil tankers is performed under various low temperatures with the material properties obtained by tensile coupon test. The analytical method as named ALPS/ULSAP was used for analysis method and 6 kinds of temperature (20, 0, -20, -40, -60 and $-80^{\circ}C$) were considered to investigate the effect of Arctic conditions.

• International Journal of Control, Automation, and Systems
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• v.3 no.4
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• pp.648-648
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• 2005

• Proceedings of the Korean Magnestics Society Conference
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• 2007.05a
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• pp.285.2-285.2
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• 2007

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.175.2-175.2
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• 2008

• Genomics & Informatics
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• v.20 no.4
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• pp.44.1-44.13
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• 2022

Brugada syndrome (BS) is an autosomal dominant inheritance cardiac arrhythmia disorder associated with sudden death in young adults. Thailand has the highest prevalence of BS worldwide, and over 60% of patients with BS still have unclear disease etiology. Here, we performed a new viral metagenome analysis pipeline called VIRIN and validated it with whole genome sequencing (WGS) data of HeLa cell lines and hepatocellular carcinoma. Then the VIRIN pipeline was applied to identify viral integration positions from unmapped WGS data of Thai males, including 100 BS patients (case) and 100 controls. Even though the sample preparation had no viral enrichment step, we can identify several virus genes from our analysis pipeline. The predominance of human endogenous retrovirus K (HERV-K) viruses was found in both cases and controls by blastn and blastx analysis. This study is the first report on the full-length HERV-K assembled genomes in the Thai population. Furthermore, the HERV-K integration breakpoint positions were validated and compared between the case and control datasets. Interestingly, Brugada cases contained HERV-K integration breakpoints at promoters five times more often than controls. Overall, the highlight of this study is the BS-specific HERV-K breakpoint positions that were found at the gene coding region "NBPF11" (n = 9), "NBPF12" (n = 8) and long non-coding RNA (lncRNA) "PCAT14" (n = 4) region. The genes and the lncRNA have been reported to be associated with congenital heart and arterial diseases. These findings provide another aspect of the BS etiology associated with viral genome integrations within the human genome.

• Proceedings of the Korean Information Science Society Conference
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• 2007.06c
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• pp.466-470
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• 2007

보안첨단화의 필요성 증대로 인하여 복합적이고 고기능의 보안 감시 시스템의 수요가 급속도로 확대되면서 보안은 안전하고 행복한 생활을 만드는데 없어서는 안될 중요한 역할을 하게 되었다. 최근, 디지털 영상기술의 급속한 발달과 보급은 이러한 보안 감시 시스템을 가능하도록 하였다. 본 논문은 다수의 카메라로부터 사람들의 움직임을 연속적으로 식별하고 추적할 수 있는 향상된 지능화 방법을 제안한다. 이 방법을 통해 카메라들 간의 위상이 자동으로 구성되고 객체의 움직임을 기반으로 학습하여 카메라들간의 거리, 객체와 카메라와의 거리, 카메라의 각도를 자동적으로 연산할 수 있도록 하였다. 이러한 자가 구성 단계 이후에 사람의 움직임을 추적하게 된다. 추적에서 사람들을 식별하는 단계가 선행되어야 하며, 이를 위해 머리, 몸, 손, 다리로 분리하여 각각의 정보들을 식별자로 사용하였다. 이러한 외형 식별자와 객체의 출몰간의 시간차를 이용해 다수의 카메라들로부터 객체를 연속적으로 추적하였다.