• Korean Management Science Review
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• v.17 no.2
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• pp.75-86
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• 2000

In evolutionary algorithm, there exist various models for the evolution of the population with respect to schemes and strategies for reproduction. In the application of the algorithm to a specific problem, one model suitable to the problem is to be properly chosen and a program expert or a software is needed to help implement and test a designed algorithm. In this study, abject oriented modeling and the class library for simple evolutionary algorithms(SEA) with one population is developed. The library proposed here can be used as a generalized tool for solving problems in a wide range of domains.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1995.10a
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• pp.894-897
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• 1995

This paper focuses on self-organization of fuzzy rules for performance management of computer communication networks serving manufacturing systems. The performance management aims to improve the network performance in handling various types of messages by on-line adjustment of protocol parameters. The principle of fuzzy logic has been used in representing the knowledge of human expert on the performance management and in deriving management decisions. In this paper, we present applications of genetic algorithm, simulated annealing, and evolution strategies to find a better set of rules for various network conditions. The efficacy of this self-organization is demonstrated by discrete simulation of an IEEE 802.4 network.

• Clinical and Experimental Pediatrics
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• v.50 no.9
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• pp.835-840
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• 2007

Any infant noted to be jaundiced at 2 weeks of age should be evaluated for cholestasis with measurement of total and direct serum bilirubin. With the insight into the clinical phenotype and the genotype-phenotype correlations, it is now possible to evaluate more precisely the neonate who presents with conjugated hyperbilirubinemia. Testing should be performed for the specific treatable causes of neonatal cholestasis, specifically sepsis, galactosemia, tyrosinemia, citrin deficiency and endocrine disorders. Biliary atresia must be excluded. Low levels of serum gamma-glutamyl transferase in the presence of cholestasis should suggest progressive familial intrahepatic cholestasis type 1, 2, or arthrogryposis- renal dysfunction-cholestasis syndrome. If the serum bile acid level is low, a bile acid synthetic defect should be considered. Molecular genetic testing and molecular-based diagnostic strategies are in evolution.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.33.1-33
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• 2001

We address a novel approach to identify a nonlinear dynamic system for Wiener models, which are composed of a linear dynamic system part followed by a nonlinear static part. The aim of system identification here is to provide the optimal mathematical model of both the linear dynamic and the nonlinear static parts in some appropriate sense. Assuming the nonlinear static part is invertible, we approximate the inverse function by a piecewise linear function. We estimate the piecewise linear inverse function by using the evolutionary computation approach such as genetic algorithm (GA) and evolution strategies (ES), while we estimate the linear dynamic system part by the least squares method. The results of numerical simulation studies indicate the usefulness of proposed approach to the Wiener model identification.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2003.05a
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• pp.1048-1055
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• 2003

This paper proposes a new method of solving integrated problems that consist of several sub-problems in a symmetric multi-layered structure, and also demonstrate the applicability of the method. The proposed method is named Symmetric Multi-layered Coevolutionary Algorithm (SMCA). The SMCA imitates partly the natural process of endosymbiotic evolution, which is a special type of coevolution. The SMCA is applied to the process planning problem in flexible manufacturing system (FMS), taking account of the flexibility of machine, tool, process, and sequence. To do this, SMCA's components are studied and its strategies are developed to improve the performance. The proposed algorithm is compared with the existing ones in terms of solution quality. The experimental results confirm the effectiveness of our approach.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.29 no.3
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• pp.33-42
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• 2006

From middle of 90's, SCM had emphasized the importance of connection of all companies which participate to a market, and outsourcing has emphasizes the slim structure of companies for pursing cost reduction and service improvement. But outsourcing as '2-1=1' and integration as '1+1=2' not adapt to the advanced market but return to the former state. Besides, it is impossible of subcontractors and logistics companies to execute these strategies which are win-win strategy and outsourcing. So many logistics companies have sharp competition in price recently. Therefore logistics companies have increased the need for a profitable business model and strategy. This paper researches the limitations of logistics market and redefines the role of logistics through the evolution of logistics. Also this paper proposes new role(Logister) and structure(Velcro structure) for not maker-oriented logistics but market-oriented logistics. The introductory case study will help to understand 2 terms(logister and velcro structure).

• Archives of Plastic Surgery
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• v.41 no.3
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• pp.231-240
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• 2014

Cartilage has a limited regenerative capacity. Faced with the clinical challenge of reconstruction of cartilage defects, the field of cartilage engineering has evolved. This article reviews current concepts and strategies in cartilage engineering with an emphasis on the application of nanotechnology in the production of biomimetic cartilage regenerative scaffolds. The structural architecture and composition of the cartilage extracellular matrix and the evolution of tissue engineering concepts and scaffold technology over the last two decades are outlined. Current advances in biomimetic techniques to produce nanoscaled fibrous scaffolds, together with innovative methods to improve scaffold biofunctionality with bioactive cues are highlighted. To date, the majority of research into cartilage regeneration has been focused on articular cartilage due to the high prevalence of large joint osteoarthritis in an increasingly aging population. Nevertheless, the principles and advances are applicable to cartilage engineering for plastic and reconstructive surgery.

• Biomolecules & Therapeutics
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• v.21 no.6
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• pp.423-434
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• 2013

The adoption of oligonucleotide aptamer is well on the rise, serving an ever increasing demand for versatility in biomedical field. Through the SELEX (Systematic Evolution of Ligands by EXponential enrichment), aptamer that can bind to specific target with high affinity and specificity can be obtained. Aptamers are single-stranded nucleic acid molecules that can fold into complex three-dimensional structures, forming binding pockets and clefts for the specific recognition and tight binding of any given molecular target. Recently, aptamers have attracted much attention because they not only have all of the advantages of antibodies, but also have unique merits such as thermal stability, ease of synthesis, reversibility, and little immunogenicity. The advent of novel technologies is revolutionizing aptamer applications. Aptamers can be easily modified by various chemical reactions to introduce functional groups and/or nucleotide extensions. They can also be conjugated to therapeutic molecules such as drugs, drug containing carriers, toxins, or photosensitizers. Here, we discuss new SELEX strategies and stabilization methods as well as applications in drug delivery and molecular imaging.

• 한국HCI학회:학술대회논문집
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• 2006.02b
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• pp.789-794
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• 2006

UI (User Interface)는 끊임없이 진화한다. 사용자의 새로운 요구 사항을 만족시키기 위해, 기존 UI에 대한 불편 사항을 해결하기 위해, 경쟁 제품의 더 좋은 UI를 따라 잡기 위해, 그리고 새로운 기술로 기존에는 불가능했던 것이 가능해 짐으로 인해, UI는 지속적으로 더 좋은 방향으로 변화하고 있다. 특히 휴대폰과 같이 라이프사이클이 짧은 제품의 UI는 매 제품마다 UI를 변화시킬 수 없기 때문에 기업 입장에서의 전략적인 접근이 중요해 진다. 더욱이 충분한 검증 없이 이루어진 진화의 방향은 사용자가 원하는 방향과 일치하지 않게 되어 오히려 퇴화하는 문제도 발생할 수 있다. 본 논문은 UI가 생성, 유지, 융합, 소멸되어 가는 진화론적 발전 속성 및 그러한 속성에 영향을 주는 요소들을 살펴보고, 라이프사이클이 짧은 제품의 UI를 개선할 때 어떤 전략을 취하는 것이 기업 차원에서 좋은지를 설명한다. UI 진화 전략은 크게 점진적 개선을 추구하는 구릉식 전략과 한번에 도약하는 계단식 전략으로 나눌 수 있다. 위 두 전략들은 사용자 만족도, 개선에 필요한 비용과 그 가치, 개선 후의 리스크 (Risk)에 따라 장단점을 가진다. 결론적으로 본 논문에서는 두 전략 모두 서로 상반되는 장단점을 가지므로, 어느 한 전략을 취하기 보다는 UI 요소의 특성 및 변화의 규모에 따라 두 전략을 혼용하는 전략이 기업 입장에서 최적의 전략임을 주장한다.

• Management Science and Financial Engineering
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• v.12 no.2
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• pp.19-35
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• 2006

We use the hierarchical Bayesian approach to describe the transition probabilities of a binary nonhomogeneous Markov chain. The Markov chain is used for describing the transition behavior of emotionally disturbed children in a treatment program. The effects of covariates on transition probabilities are assessed using a logit link function. To describe the time evolution of transition probabilities, we consider two modeling strategies. The first strategy is based on the concept of exchangeabiligy, whereas the second one is based on a first order Markov property. The deviance information criterion (DIC) measure is used to compare models with two different time dependent structures. The inferences are made using the Markov chain Monte Carlo technique. The developed methodology is applied to some real data.