• Nutrition Research and Practice
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• 제12권6호
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• pp.459-468
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• 2018

BACKGROUND/OBJECTIVES: The Dietary Reference Intakes for Koreans (KDRIs), a set of reference intake values, have served as a basis for guiding a balanced diet that promotes health and prevents disease in the general Korean population. In the process of developing DRIs, a systematic review has played an important role in helping the DRI committees make evidence-based and transparent decisions for updating the next DRIs. Thus, the 2015 KDRI steering committee applied the systematic review framework to the revision process of the KDRIs. The purpose of this article is to summarize the revision process for the 2015 KDRIs by focusing on the systematic review framework. MATERIALS/METHODS: The methods used to develop the systematic review framework for 2015 KDRIs followed the Agency for Healthcare Research and Quality and the Tufts Evidence-based Practice Center. The framework for systematic review of the 2015 KDRIs comprised of the 3 following steps: (1) development of an analytic framework and refinement of key questions and search terms; (2) literature search and data extraction; and, (3) appraisal of the literature and summarizing the results. RESULTS: A total of 203,237 studies were retrieved through the above procedure, with 2,324 of these studies included in the analysis. General information, main results, comments of reviewers, and results of quality assessment were extracted and organized by study design. The average points of quality appraisals were 3.0 (range, 0-5) points for intervention, 6.1 (0-9) points for cohort, 6.0 (3-9) points for nested case-control, 5.4 (1-8) points for case-control, 14.6 (0-22) points for cross-sectional studies, and 7.0 (0-11) points for reviews. CONCLUSIONS: Systematic review helped to establish the 2015 KDRIs as a useful tool for evidence-based approach. Collaborative efforts to improve the framework for systematic review should be continued for future KDRIs.

• Journal of Preventive Medicine and Public Health
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• 제55권5호
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• pp.415-423
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• 2022

Economic evaluations in the healthcare are used to assess economic efficiency of pharmaceuticals and medical interventions such as diagnoses and medical procedures. This study introduces the main concepts of economic evaluation across its key steps: planning, outcome and cost calculation, modeling, cost-effectiveness results, uncertainty analysis, and decision-making. When planning an economic evaluation, we determine the study population, intervention, comparators, perspectives, time horizon, discount rates, and type of economic evaluation. In healthcare economic evaluations, outcomes include changes in mortality, the survival rate, life years, and quality-adjusted life years, while costs include medical, non-medical, and productivity costs. Model-based economic evaluations, including decision tree and Markov models, are mainly used to calculate the total costs and total effects. In cost-effectiveness or costutility analyses, cost-effectiveness is evaluated using the incremental cost-effectiveness ratio, which is the additional cost per one additional unit of effectiveness gained by an intervention compared with a comparator. All outcomes have uncertainties owing to limited evidence, diverse methodologies, and unexplained variation. Thus, researchers should review these uncertainties and confirm their robustness. We hope to contribute to the establishment and dissemination of economic evaluation methodologies that reflect Korean clinical and research environment and ultimately improve the rationality of healthcare policies.

• 분석과학
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• 제19권6호
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• pp.512-518
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• 2006

화재원인물질을 규명하기 위해 화재현장에서 수거된 물을 포함한 증거물로부터 석유류를 용매추출하여 기체크로마토그래피법으로 분석하였다. 다량의 수분을 포함한 증거물에서 석유류를 추출하기 위해, HPLC 용 n-hexane을 10.0 mL를 가하여 30분간 흔들어준 다음 일정시간 방치한 후 n-hexane 층을 분리하고 기체크로마토그래피에 주입하여 크로마토그램을 얻었다. 얻어진 시료의 크로마토그램과 시너, 휘발유, 난방용 등유, 보일러 등유 및 경유를 n-hexane에 첨가하여 만든 인공시료의 크로마토그램과 비교하였다. 시료의 크로마토그램은 비교적 끓는점이 낮은 시너와 휘발유의 크로마토그램과 확연히 차이가 났으며, 난방용 등유와 보일러용 등유는 머무름 시간에 따라 다른 피크 패턴을 보였다. 이에 비해 경유의 크로마토그램과는 유사한 피크패턴을 보였고, 시료에 일정량의 경유를 첨가한 후 측정한 시료의 크로마토그램에서는 특징적인 피크의 면적이 증가하는 현상을 관찰할 수 있어 시료에 포함된 석유류가 경유라고 예측할 수 있었다.

• 한국산학기술학회논문지
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• 제22권2호
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• pp.76-84
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• 2021

품질보증활동은 양산단계에서 위험 식별을 기반으로 품질에 영향을 주는 인자를 확인할 수 있다. 위험 식별은 고장 분석을 통해 이루어지며, 회전익 항공기 착륙장치에 대한 고장 분석 방법은 고장 유형 영향 분석(FMEA)으로 선정하였다. FMEA는 고장 유형에 대해서 심각도, 발생도, 검출도에 대한 정보를 결합하여 품질에 영향을 미치는 인자를 확인하는 방법이다. FMEA 결과는 위험도를 통해 고장 우선순위를 결정한다. 하지만 심각도, 발생도, 검출도에 대한 중요도는 동일하게 구성된다. Dempster-Shafer 증거 이론은 경험과 주관이 반영된 의견에 대해서 불확실성 분석을 수행한다. 또한, Dempster-Shafer 증거 이론은 믿음 함수와 개연성 함수를 구성할 수 있으며, 믿음 함수와 개연성 함수를 통해 가설의 믿음 정도, 신뢰도를 확인할 수 있다. 회전익 항공기 착륙장치는 이륙 및 착륙 시 충격을 받는 구성품으로, 양산단계에서 고장 유형을 관리하는 것이 중요하다. 본 논문에서는 회전익 항공기 착륙장치의 고장 유형에 대한 위험도 분석을 위해 Dempster-Shafer 증거 이론을 이용한 FMEA를 제안하고, 고장 우선순위를 결정한다. 결과는 믿음 함수 및 개연성 함수 곡선을 통해 도출한다.

• 정보화정책
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• 제28권1호
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• pp.77-93
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• 2021

본 연구는 정책과정에서 다양한 증거가 활용되어 정책의 질을 높일 수 있다는 규범적 주장보다 실무적으로 증거의 바탕이 되는 정보가 정책과정에서 어떻게 활용될 수 있는가에 대한 고찰을 바탕으로, 이해관계자들 간 지속적인 상호 작용을 촉진할 수 있는 유용한 정보를 제공하기 위한 정보 분석 프레임워크와 분석된 정보를 통해 갈등을 조정할 수 있는 운영 절차를 제시하였다. 특히 국가경쟁력 제고 및 사회적·환경적 문제를 해결하기 위해 요구되는 과학기술 관련 지식의 창출을 촉진하는 연구개발(R&D) 정책과정 중 정책형성단계에서 수행되는 전략기획과정에 초점을 두고 있다. 국가 현안인 고령화를 사례로 국가R&D 전략기획에 참여하는 이해관계자들 간 대립적이고 갈등적인 상황을 운영절차를 통해 정책과정의 합리성을 확보하고, 제공된 정보를 기반으로 의사소통을 유도하여 갈등을 협상 진화적으로 전환 긍정적인 영향을 미치는 것을 확인하였다. R&D전략기획을 수립하는데 발생하는 갈등 관리를 위해, 본 연구에서 제시한 바와 같이 정보 분석 프레임워크와 이를 활용한 운영절차를 이해관계자들과 사전에 합의가 선행되어져야 할 것이다. 본 연구는 증거기반 정책의 본질을 환기시키고 있으며, 합리적 행위를 강화함으로써 증거기반 연구개발 정책에 기여하고 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9813-9815
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• 2014

Background: This analysis was conducted to evaluate the efficacy and safety of cisplatin based chemotherapy for treating patients with cutaneous squamous cell carcinoma. Methods: Clinical studies evaluating the efficacy and safety of cisplatin based regimens on response and safety for patients with cutaneous squamous cell carcinoma were identified using a predefined search strategy. Pooled response rates (RR) of treatment were calculated. Results: In cisplatin based regimens, 4 clinical studies which including 50 patients with advanced cutaneous squamous cell carcinoma were considered eligible for inclusion. Regimens included cisplatin, doxorubicin, or vindesine. Pooled analysis suggested that, in all patients, the pooled RR was 60% (30/50) in cisplatin based regimens. Nausea and vomiting were the main side effects. No grade III or IV renal or liver toxicity were observed. No treatment related death occurred with the cisplatin based treatments. Conclusion: Evidence based analysis suggests that cisplatin based regimens are associated with a good response rate and acceptable toxicity for treating patients with cutaneous squamous cell carcinoma.

• 대한소아치과학회지
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• 제33권4호
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• pp.728-737
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• 2006

연구 목적은 근거중심 소아치과학 연구의 기본이 되는 체계적 고찰의 방법과, 체계적 고찰의 통계적 방법이 되는 메타분석에 대하여 소개하는 것이었다. 연구 자료로서 Cochrane Handbook for Systematic Reviews of Interventions 등을 참고하였다. 체계적 고찰의 첫 단계이자 가장 중요한 것은 잘 규정된, 초점이 또렷한 질문을 만드는 것이고, 다음에 자료의 검색을 하고 선정된 자료에 대한 타당도 평가를 한 후, 변수의 종류에 따라 자료를 분석하고 결과를 해석하여 결론을 도출한다. 자료 분석의 통계학적 방법인 메타분석의 필요성과 원리 및 변수의 종류에 따른 자료별 메타분석 방법에 대하여 요약 기술하였다.

• 한국환경성돌연변이발암원학회지
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• 제22권2호
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• pp.70-75
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• 2002

Gly460Trp polymorphism of a-adducin gene has been reported to be associated with hypertension in some populations, and we, therefore, attempted to replicate this finding in Korean population. There were no significant differences in allele and genotype frequencies of Gly460Trp polymorphism in Korean normotensives and hypertensives, respectively. The meta-analysis revealed that the Mantel-Haenszel estimate of the odds ratio across the studies was 1.17 (95%CI 1.04-1.31), and that there was significant evidence against homogeneity of the odds ratio among the studies included (Breslow-Day test = 27.34, df = 9, p = 0.001). Although the meta- analysis appeared in favour of association between the Gly4601tf polymorphism of $\alpha$-adducin gene and hypertension, there was the considerable heterogeneity among the studies and the evidence is also rather borderline. Further comprehensive approaches are needed to resolve this debatable issue.

• 성인간호학회지
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• 제29권2호
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• pp.177-189
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• 2017

Purpose: A meta-analysis was conducted to identify the effect of cognitive improvement programs for the elderly with mild cognitive impairment (MCI) in Korea. Methods: Five databases, as well as relevant reference lists, of studies published from 2000 to 2016, were searched. Fourteen studies were identified. Quality assessments of included studies were conducted using the Scottish Intercollegiate Guidelines Network checklist. An R program was used to analyze effect sizes and to identify possible sources of heterogeneity among studies. The potential for publication bias was investigated using a funnel plot, Egger's regression test and sensitivity analysis. Results: The total effect size was large (Standardized Mean Difference [SMD]=1.44, 95% CI: 1.11~1.77), with cognition based intervention (SMD= 1.77, 95% CI: 1.26~2.29) and exercise intervention (SMD=1.13, 95% CI: 0.82~1.44). Statistically significant moderators were identified intervention type by meta-ANOVA analyses. Finally, no significant evidence of publication bias was found. Conclusion: There is clear evidence that cognitive improvement programs can greatly enhance cognition in elderly with MCI. Future research should examine the effects of non-pharmacological interventions targeting elderly populations with mild-to-severe cognitive impairment in order to develop and enhance the effectiveness of cognitive improvement programs in Korea.

• 보건교육건강증진학회지
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• 제31권1호
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• pp.71-83
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• 2014

Objectives: This study examined the trend of alcohol-related research, with a specific focus on adolescent problem drinking, to provide evidence for prevention and intervention for adolescent alcohol problems and alcohol policy in Korea. Methods: A total of 17 studies examining adolescent problem drinking were included for meta-analysis. Using CMA (Comprehensive Meta-Analysis) 2.0, the effect sizes of correlation coefficients of variables related to adolescent problem drinking were analyzed. Results: 176 variables were extracted under 4 higher categories and 20 sub-categories. Variables were extracted using the four higher categories, namely individual, family, environmental, and demographics, as the theoretical framework. Results showed that most studies on adolescent problem drinking focused mostly on individual factors followed by family factors. Variables including drinking motivation, drinking expectancy, and peer relations showed relatively higher effect size. Conclusions: Study findings suggest the importance of balance between individual and environmental factors in examining problem drinking among adolescents. In order to provide evidence for alcohol policy, more attention should be given to macro environment that are known to influence adolescent drinking.