• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2101-2107
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• 2012

Treatment responses of $N_0$ stage nasopharyngeal carcinoma were firstly analyzed comprehensively to evaluate long term outcomes of patients and identify prognostic factors. A total of 610 patients with $N_0$ NPC, undergoing definitive radiotherapy to their primary lesion and prophylactic radiation to upper neck, were reviewed retrospectively. Concomitant chemotherapy was administrated to 65 out of the 610. Survival rates of the patients were calculated using the Kaplan-Meier method and compared by log-rank test. Prognostic factors were identified by the Cox regression model. The study revealed the 5-year and 10-year overall, disease-free, disease-specific, local failure-free, regional failure-free, locoregional failure-free and distant metastasis-free survival rates to be 78.7% and 66.8%, 68.8% and 55.8%, 79.9% and 70.4%, 81.2% and 72.5%, 95.8% and 91.8%, 78.3% and 68.5%, 88.5% and 85.5%, respectively. There were 192 patients experiencing failure (31.5%) after radiotherapy or chemoradiotherapy. Of these, local recurrence, regional relapse and distant metastases as the first event of failure occurred in 100 (100/610, 16.4%), 15(15/610, 2.5%) and 52 (52/610, 8.5%), respectively. Multivariate analysis showed that T stage was the only independent prognostic factor for patients with $N_0$ NPC (P=0.000). Late T stage (P=0.000), male (P=0.039) and anemia (P=0.007) were independently unfavorable factors predicting disease-free survival. After treatment, satisfactory outcome wasgenerally achieved in patients with $N_0$ NPC. Local recurrence represented the predominant mode of treatment failure, while T stage was the only independent prognostic factor for overall survival. Late T stage, male gender, and anemia independently predicted lower possibility of the disease-free survival.

• Journal of Environmental Impact Assessment
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• v.24 no.5
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• pp.407-419
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• 2015

The unit load of paddy field was estimated by several methods and compared in this study. Four year field study was conducted at the paddy fields located in Yeongsan river and Sumjin river basins. The unit load was estimated by four methods; (1) averaging field monitored load; (2) NIER (National Institute of Environmental Research) method which use EMC(Event Mean Concentration) and runoff ratio of rainfall groups with rainfall weighting factors; (3)method using EMC determined by best fit probability distribution; (4)method using arithmetic mean EMC and runoff ratio. The result of this study showed that the unit loads of water quality constituents by field monitoring was similar to those of NIER method whereas those by probability distribution(log-normal, gamma) method were less than unit loads of NIER method. The unit loads by arithmetic mean EMC and runoff ratio were larger than those by NIER method. The unit load by NIER method showed higher BOD, COD, SS, lesser T-N, and similar T-P values when compared to unit loads determined by MOE in 1995.

• Journal of Preventive Medicine and Public Health
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• v.22 no.3 s.27
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• pp.355-367
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• 1989

This study examined the physical and mental health factors affecting the industrial accidents of 142 injured and 1,212 uninjured workers in the shipbuilding industry from 1986 to 1988. The results acquired from the Todai Health Index (THI) and from analysis of the health examination were as follows: 1. Among the personal characteristics of the workers, the educational level of injured workers was significantly lower than that of the uninjured workers. 2. Among the physical characteristics, vision and $R\ddot{o}hrer$ Index of the injured workers were lower than those of the uninjured workers, and the difference was statistically significant. On the other hand, the differences in height, weight, hearing function, hematocrit, blood pressure, urine test, and X-ray findings were not statistically significant between the injured and uninjured workers. 3. The score of the THI questionnaire on the physical and mental health of the injured workers was higher than that of the uninjured workers, and the difference was statistically significant. 4. Form the THI score, the industrial workers had complained more about mental health than physical health and there was a statistically singinficant relation with the industrial accidents. 5. The relative risk expressed in terms of the odds ratio was 2.9 for poorer vision, 2.7 for a lower educational level, 2.2 for a higher THI score and 1.6 for overdrinking. 6 Educational level, vision, and the THI score were selected as significant factors influencing industrial accidents based on a log-linear model. According to the results of this model by logistic analysis, the odds ratio of industrial accidents was 1.8 for a lower educational level, 1.7 for poorer vision, and 1.6 for a higher THI score. 7 By event history analysis with the dependent variable as the duration of work at the time of the industrial accident, educational level, age, $R\ddot{o}hrer$ Index and THI score were the statistically significant variables selected, and the hazard rate of industrial accident occurrence was 0.24 for a lower educational level, 0.92 for age, 0.99 for a lower $R\ddot{o}hrer$ Index and 2.72 for a higher THI score. As we have seen, educational level and THI score were the most significant factors affecting the hazard rate of industrial accidents. Vision, $R\ddot{o}hrer$ Index, age, and drinking behavior were also statistically significant variables influencing industrial accidents. Therefore, in order to prevent industrial accidents, it is necessary to establish a health management plan for industry which can objectively evaluate not only the physical but also the mental health of the workers. If we use this type of study as a prospective study design, we can determine the relative risk of physical and mental health factors on industrial accidents. Furthermore, it is expected that this type of study will provide workers at high risk with more precise basic data for a health managment plan for industrial accident prevention.

• Journal of Internet Computing and Services
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• v.17 no.6
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• pp.123-131
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• 2016

Process mining in big data environment utilize a number of data were generated from the business process. It generates lots of knowledge and insights regarding implementation and improvement of the process through the event log of the company's enterprise resource planning (ERP) system. In recent years, various research activities engaged with the audit work of company organizations are trying actively by using the maximum strength of the mining process. However, domestic studies on applicable sales auditing system for the process mining are insufficient under big data environment. Therefore, we propose process-mining methods that can be optimally applied to online and traditional auditing system. In advance, we propose continuous monitoring information system that can early detect and prevent the risk under the big data environment by monitoring risk factors in the organizations of enterprise. The scope of the research of this paper is to design a pre-verification system for risk factor via practical examples in sales auditing. Furthermore, realizations of preventive audit, continuous monitoring for high risk, reduction of fraud, and timely action for violation of rules are enhanced by proposed sales auditing system. According to the simulation results, avoidance of financial risks, reduction of audit period, and improvement of audit quality are represented.

• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.340-340
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• 2021

가뭄의 특성상 시점과 종점을 명확하게 정의하기 어렵기 때문에 기준수문량을 설정하고 부족량과 지속기간을 정의하는 것이 일반적이다. 대상 수문량은 강우나 유출량을 사용할 수 있지만, 두 성분간 지체와 감쇄효과로 인하여 빈도해석의 결과는 차이를 보일 수 밖에 없어, 사용 목적에 따라 선별적으로 적용해야 한다. 가뭄빈도해석은 강우를 기반으로 지속기간과 심도를 정의하여 빈도를 해석하는 연구가 선행되어왔지만, 기본적으로 강우의 간헐적 발생특성과 체감도의 한계가 문제로 지적되고 있다. 본 연구에서는 댐 유입량의 Run 시계열 특성을 이용하여 다양한 유황을 기준유량으로 활용하여 가뭄의 시점과 종점에 대한 가뭄사상을 추출하고 지속기간과 누적부족량을 계산하여 가뭄빈도해석의 변수로 설정하였다. 두 변수간의 복잡한 상호 관계를 해석하기 위해 Copula 함수를 이용한 이변량 가뭄빈도해석을 진행하였다. 먼저 소양강댐('74-'19) 유입량, 충주댐('86-'19) 유입량을 연구대상지역으로 설정하여, 두 유역의 유입량의 추세분석을 통해 시간의존성을 파악하였다. 유황분석에 사용되는 분위량중 평수량을 기준값으로 사용하여 각 년별 최대 지속기간과 누적부족량을 추출하였다. Copula 가뭄빈도해석을 수행하기 전에 지속기간에는 GEV, 누적 부족량에는 Log-normal 분포를 적용해 단변량 누적확률분포를 계산하여 재현기간을 도출하였다. 이변량 빈도해석에 Clayton Copula 함수를 적용하여 가뭄빈도해석을 진행하였고, Copula 이변량 재현기간과 SDF곡선을 도출하였다. Clayton Copula를 이용한 이변량 가뭄빈도해석의 결과로 소양강댐의 가장 극심한 가뭄은 1996년으로 단변량 재현기간은 지속기간 기준 9.11년, 누적부족량 기준 17.26년, Copula 재현기간은 141.19년 이며 충주댐의 가장 극심한 가뭄은 2014년으로 단변량 재현기간은 지속기간 기준 17.76년, 누적부족량 기준 18.72년, Copula 재현기간은 184.19년으로 단변량 가뭄빈도해석을 통한 재현기간보다 Copula 재현기간이 높은 결과가 도출되었다. Run 시계열을 바탕으로 한 기준유량의 임계값 기준 Event 산정과 Copula를 이용한 빈도해석은 가뭄분석에 이용되는 자료의 상관관계와 분포특성을 재현하는데 효과적인 특징이 있다. 이를 미루어 보아 Copula 함수를 이용한 가뭄빈도해석의 재현기간은 보다 현실적인 재현기간을 도출할 수 있는 것으로 판단된다. 임계값의 조정을 통해 가뭄빈도해석의 변수의 양이 늘어나면, 보다 정확도 높은 재현기간을 도출하여 수문학적 가뭄을 정의할 수 있을 것이라고 사료된다.

• Journal of Chest Surgery
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• v.19 no.1
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• pp.35-42
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• 1986

Prevention of thrombombolism after rosthetic cardiac valve replacement is essential for the patients. About 90% of patients are free of major and minor thromboembolic complications 5 year after replacement of cardiac valves with prosthetic devices when they are under control of anticoagulant therapy. Ticlopidine is a drug that alter platelet function to have an antithrombotic effect. It is an antiaggregating agent which inhibits primary platelet function to have an antithrombotic effect. It is an antiaggregating agent which inhibits primary platelet aggregation induced by ADP and increases the production of prostaglandin $D_{2}$. Aspirin in small doses inhibits platelet synthesis of prostaglandins by irreversibly blocking the enzyme cyclo-oxygenase. Platelet secretion and aggregation are impaired with Ticlopidine and Aspirin. the thromboembolic event sof 54 patient s who were treated with Ticlopidine and Aspirin after cardiac valve replacement were evaluated and compared with that of 79 patients who were treated with Wafarin and Aspirin after the same type of operation. The follow-up period ranged from 4 to 110 months (mean of 48 months). there were 11 major thromboembolic episodes including three deaths in the warfarin goup during mean follow-up period of 56 months. two cases of CVA and one hemoarthrosis were noted due to overdose of Warfarin. Inticlopidine group, there was only one fatal thromboembolic epdisode three month after mitral valve replacement during mean follow-up period of 18 months. Two episodes of hypermenorrhea resulting anemia ere noted in the ticlopidine group. We measured the parameters of platelet function in aggreagation curve of platelet with platelet aggregometer (chrono-log Aggregometer, Model No. 430) Aggregation test was performed with three final concentrations of epinephrine in 10 uM/L, ADP in 5uM/L. 28 patients with prosthetic cardiac valves and 35 healthy volunteers were subgrouped as follows to analyze the effect of antithrombotic drugs used. Group I ; 11 patients treated with 250-500 mg of ticlopidine and 0.5gm of Aspirin as a daily single dose after cardiac valve replacement (14 St. Jude Medical and 1 Carpentier-Edwards, 9 patients with atrial fibrillation among them) Group II ; 10 patients treated with 3-5 mg of Warfarin and 0.75 gm of Aspirin daily to prolong prothrombin time around 20 seconds for more than 6 months and single Aspirin dose was maintained afterward as a life-long regimes(3 St. Jude Medical, 1 Hall-Kaster and 7 Carpentier-Edwards valve, 9 patients in atrial fibrilation). Group III ; 7 patients who quit anticoagulant treatment (Warfarin + Aspirin) 6-12 months after the regime as group II (3 St. Jude Medical. 1 bjork-Shiley, 1 Hall-Kaster, 3 Carpentier-Edwards valve, 2 of them are with atrial fibrillation). Group IV ; 35 healthy vounteers (28 males and 7 females). The following results were obtained. 1. The mean maximal platelet aggregability in Group I induced by 10uM/L epinephrine was 15.6%, and 17.5 and 18.7% in BM in proportion to the induction by 5 and 10 uM/L ADP. 2. The mean maximal platelet aggregability in Group II induced by 10uM/L epinephrine was 16.5%, and 27.4 and 44.7% in BM in proportion to the induction by 5 and 10uM/L ADP. 3. The mean maximal platelet aggregability in group III induced by 10uM/L epinephrine was 65%, and 56.5 and 51.8% in BM in proportion to the induction by 5 and 10 uM/L ADP. 4. The mean maximal platelet aggregability in the normal subjects induced by 10 uM/L epinephrine was 64%, and 65 and 69% in Bm inproportion to the induction by 5 and 10 uM/L ADP. 5. Reversible change of platelet aggregation curve induced by 5 and 10uM/L was noted all of the patients in Group I. conclusion : Ticlopidine is an antiaggregating agent which inhibits primary platelet aggregation induced by ADP, and increases the production of prostaglandin $D_{2}$. Ticlopidine and Aspirin produced a significant inhibition of platelet in the presence of ADP and epinephrine in our study. Acccording to our brief experience, 250 mg of ticlopidine and low dose of Aspirin resulted synergistic superior effect to each drug alone in prevention of thromboembolism after prosthetic cardiac valve replacement.