• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제19권2호
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• pp.116-122
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• 2016

Purpose: We aimed to investigate the efficacy and safety of adalimumab in pediatric-onset Crohn's disease patients who had failed treatment with infliximab. Methods: In this retrospective study, patients included were those who had been diagnosed with Crohn's disease before 18 years old, and had received treatment with adalimumab after infliximab failure. The efficacy of adalimumab treatment was investigated at 1 month and 1 year, and adverse events that had occurred during treatment with adalimumab were explored. Results: Ten patients were included in this study. The median duration from diagnosis to adalimumab treatment was 5.5 years (range: 2.4-7.9 years). At 1 month after adalimumab initiation, 80% (8/10) of patients showed clinical response, and 40% (4/10) achieved clinical remission. At 1 year, 71% (5/7) of patients showed clinical response, and 43% (3/7) were under clinical remission. Among the total included patients, 5 patients (50%) showed clinical response at 1 year. Primary non-response to adalimumab was observed in 2 patients (20%), and secondary failure to adalimumab was observed in 3 patients (30%) during 1 year treatment with adalimumab. No serious adverse event had occurred during adalimumab treatment. Conclusion: Adalimumab was effective for 1 year without serious adverse events in half of pediatric-onset Crohn's disease patients who had failed treatment with infliximab.

• 한국수자원학회논문집
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• 제40권7호
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• pp.545-554
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• 2007

본 연구에서는 조선왕조실록의 문헌 기록 호우사상의 특성을 파악하고 구조적으로 간단한 강우모형인 구형펄스모형을 이용하여 평가하였다. 전체적으로 '큰비'에서와 같이 강우에 대한 언급만이 있는 경우가 '큰물', '홍수', '폭우'와 같이 홍수유출 및 이에 따른 피해가 설명되어 있는 경우보다 강우의 재현기간이 작게 나타나는 것을 파악할 수 있었다. 기본적으로 기록된 호우사상은 모두 극치사상이 아닌 것으로 파악되었다. 일관되게 어느 정도 이상의 재현기간을 갖고 있는 것도 아니다. 또 하나 주목할만한 점은 기록된 호우사상이 강우의 총량보다는 강우의 지속기간에 보다 민감하다는 점이다. 즉, 일시에 많은 비가 온 경우보다는 장기간에 걸쳐 내린 호우사상에 보다 초점이 맞추어져 있다는 점이다. 즉, 홍수유출의 크기 및 이에 따른 피해의 정도가 실제 이들 호우사상이 기록으로 남게 되는 원인으로 파악된다.

• Journal of Chest Surgery
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• 제46권4호
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• pp.256-264
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• 2013

Background: Surgical treatment of infective endocarditis (IE) remains a challenge, especially in cases of multiple valve surgery. We evaluated the clinical outcomes of native valve IE and compared the outcomes of single valve surgery with those of multiple valve surgery. Materials and Methods: From 1997 to 2011, 90 patients underwent surgery for native valve IE; 67 patients with single valve surgery (single valve group) and 23 patients with multiple valve surgery (multiple valve group). The mean follow-up duration was $73.1{\pm}47.4$ months. Results: The surgical mortality in the total cohort was 4.4%. The overall survival (p=0.913) and valve-related event-free survival (p=0.204) did not differ between the two groups. The independent predictor of postoperative complications was New York Heart Association class (p=0.001). Multiple valve surgery was not a significant predictor of surgical mortality (p=0.225) or late mortality (p=0.936). Uncontrolled infection, urgent or emergency surgery, and postoperative complications were identified as independent predictors of valve-related morbidity, excluding multiple valve surgery (p=0.072). Conclusion: In native valve IE, multiple valve surgery as a factor was not an independent predictor of mortality and morbidity. The number of surgically corrected valves in native IE seems to be unrelated to perioperative and long-term outcomes.

• 한국농공학회논문집
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• 제62권1호
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• pp.17-27
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• 2020

The objective of this study was to assess the flood probability based on temporal distribution of forecasted-rainfall in Cheongmicheon watershed. In this study, 6-hr rainfalls were disaggregated into hourly rainfall using the Multiplicative Random Cascade (MRC) model, which is a stochastic rainfall time disaggregation model and it was repeated 100 times to make 100 rainfalls for each storm event. The watershed runoff was estimated using the Clark unit hydrograph method with disaggregated rainfall and watershed characteristics. Using the peak discharges of the simulated hydrographs, the probability distribution was determined and parameters were estimated. Using the parameters, the probability density function is shown and the flood probability is calculated by comparing with the design flood of Cheongmicheon watershed. The flood probability results differed for various values of rainfall and rainfall duration. In addition, the flood probability calculated in this study was compared with the actual flood damage in Cheongmicheon watershed (R² = 0.7). Further, this study results could be used for flood forecasting.

• 한국자동차공학회논문집
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• 제14권1호
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• pp.100-108
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• 2006

Time-resolved current and voltage measurements for an inductive automotive spark system were made. Also presented are measurements of the total energy delivered to the spark gap. The measurements were made in air for a range of pressures from 1-18atm, at ambient temperatures. The measured voltage and current characteristics were found to be a function of many ignition parameters; some of these include: spark gap distance, internal resistance of the spark plug and high tension wire, and pressure. The voltages presented were measured either at the top of the spark plug or at the spark gap. The measurements were made at different time resolutions to more accurately resolve the voltage and current behavior throughout the discharge process. This was necessary because the breakdown event occurs on a time scale much shorter than the arc and glow phases. The breakdown, are, and glow voltages were found to be functions of spark plug resistance, gas density, and spark plug gap as expected from the literature. Spark duration was found to decrease as either pressure or gap was increased. The transition from the arc to glow phase is usually distinguished by a sudden rise in the voltage across the gap. At pressures above about 7atm this transition was not observed suggesting that a glow phase was not present. Energy delivered to the gap increased with increasing pressure. The effective resistance of the spark gap during discharge was about twice as large for the glow phase as the arc phase.

• Clinics in Shoulder and Elbow
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• 제23권3호
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• pp.144-151
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• 2020

Background: This study was designed to evaluate characters of the rotator cuff tear (RCT) recognized after primary shoulder dislocation in patients older than 40. Methods: From 2008 to 2019, patients who visited two hospitals after dislocation were retrospectively reviewed. Inclusion criteria were patients over 40 who had dislocation, with magnetic resonance imaging (MRI) undergone. Exclusion criteria were patients who lost to follow-up, combined with any proximal humerus fracture, brachial plexus injury, and previous operation or dislocation history in the ipsilateral shoulder. Also patients who had only bankart or bony bakart lesion in MRI were excluded. We evaluated RCTs that were recognized by MRI after the primary shoulder dislocation with regard to tear size, degree, involved tendons, fatty degeneration, the age when the first dislocation occurred, and the duration until the MRI was evaluated after the dislocation. Results: Fifty-five RCTs were included. According to age groups, the tear size was increased in coronal and sagittal direction, the number of involved tendons was increased, and the degree of fatty degeneration was advanced in infraspinatus muscle. Thirty-two cases (58.2%) conducted MRI after 3 weeks from the first shoulder dislocation event. This group showed that the retraction size of the coronal plane was increased significantly and the fatty accumulation of the supraspinatus muscle had progressed significantly. Conclusions: Age is also a strong factor to affect the feature of RCT after the shoulder dislocation in patients over 40. And the delay of the MRI may deteriorate the degree of tear size and fatty degeneration.

• 대기
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• 제30권3호
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• pp.221-236
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• 2020

The Gangneung region has the complicated geographical characteristics being adjacent to East Sea and Taeback mountains, and thus sea breeze could play an important role in local weather in various aspects. This study aims to understand overall characteristics of sea breeze largely based on long-term (2009~2018) ground-based observation data. We also propose a selection criteria of sea breeze occurrence day; 1) daily precipitation is less than 10 mm, 2) surface wind direction is 0~110° (northerly to easterly) for more than 3 hours during the daytime, 3) wind direction is 110~360° for more than 3 hours during the nighttime, and 4) land and sea temperature difference is positive during the daytime, 5) sea and land sea-level pressure difference is more than 0.5 hPa. As a result, a total of 595 days was selected for the past 10 years. The occurrence of sea breeze is the highest in late Spring to early Summer (May to June). The passage time of sea breeze at the inland station (1.6 km farther inland) is one hour later than the coastal station. On the typical sea breeze event of April 12, 2019, the passage speed and duration of sea breeze was 15 km hr^-1 and about 9 hours, respectively, with its depth of about 500 m and its head swelling. The current results emphasize the critical role of sea breeze in forecasting surface temperature and wind, and contribute to relieve heat wave especially in summer in the Yeongdong region.

• 한국지반공학회논문집
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• 제21권8호
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• pp.45-53
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• 2005

강우에 의한 표면파괴는 세계적으로 흔히 볼 수 있는 사면파괴의 형태이다. 본 연구에서는 침투가 사면 표면의 안정에 미치는 영향을 평가하기 위해 일차원 침투모델을 이용한 무한사면 해석법을 연구하였다. 2층으로 구성된 지반에서 임의의 강우에 의해 유발되는 얕은 사면파괴의 가능성을 평가하기 위해서 Green-Ampt모델에 바탕을 둔 수정 GAML(Green-Ampt-Mein-Larson) 모델을 확장하여 재현기간에 따른 강우강도와 지속시간이 고려되는 침투거동을 예측하였다. 예측된 침투거동과 비교하기 위하여 일련의 수치해석이 수행되었다. 그 결과에 의하면 적절하게 선택된 입력값을 사용하면 제안된 간략법이 더욱 엄밀한 해석법인 유한요소해석과 근사한 합리적인 결과를 줌을 알 수 있다.

• 대한토목학회논문집
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• 제37권1호
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• pp.231-238
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• 2017

용수공급시설의 설계 및 운영에 기준이 되는 이수안전도는 용수공급안전도의 평가를 위한 중요한 지표이지만, 이수안전도에 대한 일관된 지침이 없어 댐 설계 과정에서 저마다 사용된 자료기간과 평가 방법이 서로 상이한 문제점이 있다. 따라서 본 연구에서는 다목적댐의 용수공급능력을 일관성 있게 평가하기 위해 가뭄의 심도와 지속기간을 동시에 고려할 수 있는 이변량 가뭄빈도해석을 수행하였다. 확률론적 개념을 바탕으로 가뭄사상을 평가하여 댐유역의 가뭄특성을 분석하였으며, 우리나라의 5개 다목적댐(소양강, 충주, 안동, 대청, 섬진강)을 대상으로 특정 가뭄상황에서의 용수공급능력을 평가하였다. 그 결과 여름과 가을에는 자체 유입량만으로 안정적인 용수공급이 가능하지만, 강수량이 적은 봄과 겨울에는 1년 빈도의 작은 가뭄에도 용수부족이 발생하는 것으로 나타났다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제40권
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• pp.41.1-41.4
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• 2018

Background: Free fibular flap is one of the most useful methods in the hard tissue reconstruction of the maxillamandible. Free fibular flap presents some advantages in which the reconstruction of both soft and hard tissues can be done at the same time. It also provides a safe and successful bone graft for the reconstruction, along with a low rate of complications. Despite these advantages and the rarity of a postoperative complication, particularly in oral and maxillofacial surgery procedures, a prolonged operation might exhibit some complications related with rhabdomyolysis. We experienced the rare event of rhabdomyolysis after oral cancer surgery. Case presentation: In this article, we report the case of a patient who developed rhabdomyolysis after undergoing free fibular flap surgery. Conclusions: Despite the advantages of the free fibular flap operation, clinicians must be aware of the risk of complications because there are multiple factors that could result in rhabdomyolysis, such as duration of operation, position of the subject, and pre-existing conditions of diabetes and hypertension. Once the diagnosis of rhabdomyolysis is confirmed, a prompt treatment plan should be made and applied as soon as possible. This will increase the chance of a full recovery for the patient who is exhibiting symptoms of rhabdomyolysis.