• Journal of Periodontal and Implant Science
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• 제34권3호
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• pp.607-622
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• 2004

Recently epidemiologic studies have indicated that the patients with periodontitis may have increased risk of ischemic cardiovascular events, and have suggested the important roles of blood cytokines and acute reactant proteins in the systemic infection and inflammatory response. Periodontitis and coronary heart disease (CHD) may share the common risk factors and the genetic mechanism associated with interleukin(IL)-1A, B and RA genotype may be involved in the production of IL-1. This study was aimed to investigate the relationship between angiographically defined CHD and periodontitis as chronic Gram-negative bacterial infection and to determine whether the IL-1 gene polymorphism is associated in both diseases. Patients under the age of 60 who had undergone diagnostic coronary angiography were enrolled in this study. Subjects were classified as positive CHD (+CHD, n=37) with coronary artery stenosis more than 50% in at least one of major epicardial arteries, and negative CHD (-CHD, n=30) without significant stenosis. After recording the number of missing teeth, periodontal disease severity was measured by means of plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), and radiographic bone loss around all remaining teeth. Gingival crevicular fluid (GCF) was collected from the 4 deepest periodontal pockets and assessed for cytokine ($IL-1{\beta}$, IL-6, IL-1ra, tumor necrosis $factor-{\alpha}$, and prostaglandin $E_2$). Additionally, blood CHD markers, lipid profile, and blood cytokines were analyzed. IL-1 gene cluster genotyping was performed by polymerase chain reaction and enzyme restriction using genomic DNA from buccal swab, and allele 2 frequencies of IL-1A(+4845), IL-1B(+3954), IL-B(-511), and IL-1RA(intron 2) were compared between groups. Even though there was no significant difference in the periodontal parameters between 2 groups, GCF level of $PGE_2$ was significantly higher in the +CHD group(p<0.05). Correlation analysis showed the positive relationship among PD, CAL and coronary artery stenosis(%) and blood $PGE_2$. There was also significant positive relationship between the periodontal parameters (PI, PD, CAL) and the blood CHD markers (leukocyte count, C-reactive protein, and lactic dehyrogenase). IL-1 gene genotyping showed that IL-1A(+3954) allele 2 frequency was significantly higher in the +CHD group compared with the -CHD group (15% vs. 3.3%, OR 5.118,p=0.043). These results suggested that periodontal inflammation is related to systemic blood cytokine and CHD markers, and contributes to cardiovascular disease via systemic inflammatory reaction. IL-1 gene polymorphism might have an influence on periodontal and coronary heart diseases in Korean patients.

• Journal of Microbiology and Biotechnology
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• 제25권6호
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• pp.837-844
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• 2015

Carob waste is a useful raw material for the second-generation ethanol because 50% of its dry weight is sucrose, glucose, and fructose. To optimize the process, we have studied the influence of the initial concentration of sugars on the fermentation performance of Saccharomyces cerevisiae. With initial sugar concentrations (S₀ ) of 20 g/l, the yeasts were derepressed and the ethanol produced during the exponential phase was consumed in a diauxic phase. The rate of ethanol consumption decreased with increasing S₀ and disappeared at 250 g/l when the Crabtree effect was complete and almost all the sugar consumed was transformed into ethanol with a yield factor of 0.42 g/g. Sucrose hydrolysis was delayed at high S₀ because of glucose repression of invertase synthesis, which was triggered at concentrations above 40 g/l. At S₀ higher than 250 g/l, even when glucose had been exhausted, sucrose was hydrolyzed very slowly, probably due to an inhibition at this low water activity. Although with lower metabolic rates and longer times of fermentation, 250 g/l is considered the optimal initial concentration because it avoids the diauxic consumption of ethanol and maintains enough invertase activity to consume all the sucrose, and also avoids the inhibitions due to lower water activities at higher S₀ .

• 천문학회보
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• 제39권2호
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• pp.57.2-57.2
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• 2014

Red active galactic nuclei (AGNs) are supposed to be transitional objects becoming normal AGNs in the galaxy evolution scenario. So far, ~200 red AGNs have been found by very red color in optical through NIR wavelength (e.g., r'-K >5 and J-K>1.3; Urrutia et al. 2009). Here, we compare nuclear activities of the red AGNs to those of normal AGNs to verify the evolutionary phase of the red AGNs. In order to study the nuclear activities of the red AGNs, we use broad emission lines of $P{\beta}$ ($1.28{\mu}m$) of which flux is less suppressed by a factor of 100 than the $H{\beta}$ line in the case of the red AGNs with a color excess of E(B-V)=2 mag. We use 16 red AGNs discovered in previous red AGN surveys by using SDSS, 2MASS, and FIRST (Glikman et al. 2007; Urrutia et al. 2009) at z ~0.7 for which $P{\beta}$ lines are redshifted to the sky window at ${\sim}2.2{\mu}m$. The mean Eddington ratio of the 16 red AGNs is 0.562, and that of the normal AGNs is 0.320, which indicates the red AGNs include more active black hole (BH) than the normal AGNs. To test how significantly the nuclear activities of the red AGNs and the normal AGNs are different, we perform a two-dimensional Kolmogorov-Smirnov test (K-S test) on their Eddington ratio distributions. The K-S test shows the maximum deviation between the cumulative distributions, D, is 0.48, and the probability of null hypothesis, p, is even less than 0.001. This result is consistent with a picture of that the red AGNs are in intermediate phase between the stage of merger-driven starburst galaxy and the normal AGN.

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2008년도 춘계학술발표대회 논문집
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• pp.43-48
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• 2008

Through simulations and field experiment on A.C. parallel operation of both Utility Interactive Photovoltaic System and Diesel Engine Revolving Field Type Synchronous Generator, following factors have been found. First, the inverter should be operated in three modes of frequency(mode.1: ${\pm}$0.3Hz, mode.2: ${\pm}$1Hz, mode.3: ${\pm}$2Hz) as default, considering properties of operating Synchronous Generator. Second, as a result of supplying 13.5kW of residual power, it has been found that Synchronous Generator takes the power input only as reactive power, because it was electrically stable with frequency of 60.14Hz and high voltage of 222.3V even when power factor was -0.94. Besides, it was mechanically stable, too, because the quake, noise, and temperature of Synchronous Generator in this case were 7.5mm/s, 97dB, and $6^{\circ}C$ respectively, which were lower than normal load connection of 145.6kW; 11.03mm/s. Thus, load share of Revolving Field Type Synchronous Generator reduces according to the supply of Photovoltaic System to the load power. In this experiment, 200kW of Synchronous Generator and 40kW of Photovoltaic System were operated in parallel. The load share was 20% in maximum. and 11.1lit/hr of fuel was saved.

• 미생물학회지
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• 제49권2호
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• pp.105-111
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• 2013

Erm 단백질은 23S rRNA의 특정 아데닌 잔기 $N_6$ 위치에 methylation을 일으켜 임상적으로 중요하게 사용되는 macrolide-lincosamide-streptogramin B계 항생제에 내성을 유발시킨다. 최근 ErmC'에서 N-말단 catalytic domain과 C-말단 substrate binding domain를 연결하는 오목한 홈 형성부위에 존재하는 잘 보존된 아미노산 잔기가 기질과 상호작용하는 것으로 제안되었다. 우리는 ErmSF에서 두 domain의 연결 부위의 오목한 홈에 위치하여 기질과의 상호작용이 예상되며 또한 Erm 단백질들 사이에서 매우 높게 보존되어있는 237번 아르지닌 잔기를 치환하여 그 기능을 in vivo, in vitro상에서 검색하여 분석하였다. R237A 변이 단백질을 발현하는 세균은 야생형 단백질을 발현하는 세균과 비교하여 in vivo 상에서는 차이를 나타내지 않았으나 순수분리 한 후 in vitro에서의 효소 활성은 야생형에 비하여 51%만을 나타내어 그 잔기가 기질 부착 기능을 수행하고 있다고 제안할 수 있었다.

• 한국결정성장학회:학술대회논문집
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• 한국결정성장학회 1996년도 The 9th KACG Technical Annual Meeting and the 3rd Korea-Japan EMGS (Electronic Materials Growth Symposium)
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• pp.422-448
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• 1996

Low-temperature epitaxial growth of Si and SiGe layers of Si is one of the important processes for the fabrication of the high-speed Si-based heterostructure devices such as heterojunction bipolar transistors. Low-temperature growth ensures the abrupt compositional and doping concentration profiles for future novel devices. Especially in SiGe epitaxy, low-temperature growth is a prerequisite for two-dimensional growth mode for the growth of thin, uniform layers. UHV-ECRCVD is a new growth technique for Si and SiGe epilayers and it is possible to grow epilayers at even lower temperatures than conventional CVD's. SiH and GeH and dopant gases are dissociated by an ECR plasma in an ultrahigh vacuum growth chamber. In situ hydrogen plasma cleaning of the Si native oxide before the epitaxial growth is successfully developed in UHV-ECRCVD. Structural quality of the epilayers are examined by reflection high energy electron diffraction, transmission electron microscopy, Nomarski microscope and atomic force microscope. Device-quality Si and SiGe epilayers are successfully grown at temperatures lower than 600℃ after proper optimization of process parameters such as temperature, total pressure, partial pressures of input gases, plasma power, and substrate dc bias. Dopant incorporation and activation for B in Si and SiGe are studied by secondary ion mass spectrometry and spreading resistance profilometry. Silicon p-n homojunction diodes are fabricated from in situ doped Si layers. I-V characteristics of the diodes shows that the ideality factor is 1.2, implying that the low-temperature silicon epilayers grown by UHV-ECRCVD is truly of device-quality.

• Steel and Composite Structures
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• 제22권1호
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• pp.141-159
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• 2016

Commonly in steel frames, steel beam and concrete slab are connected together by shear keys to work as a unit member which is called composite beam. When a composite beam is subjected to positive bending, flexural strength and stiffness of the beam can be increased due to "composite action". At the same time despite these advantages, composite action increases the strain at the beam bottom flange and it might affect beam plastic rotation capacity. This paper presents results of study on the rotation capacity of composite beam connected to Rectangular Hollow Section (RHS) column in the steel moment resisting frame buildings. Due to out-of-plane deformation of column flange, moment transfer efficiency of web connection is reduced and this results in reduction of beam plastic rotation capacity. In order to investigate the effects of width-to-thickness ratio (B/t) of RHS column on the rotation capacity of composite beam, cyclic loading tests were conducted on three full scale beam-to-column subassemblies. Detailed study on the different steel beam damages and concrete slab damages are presented. Experimental data showed the importance of this parameter of RHS column on the seismic behavior of composite beams. It is found that occurrence of severe concrete bearing crush at the face of RHS column of specimen with smaller width-to-thickness ratio resulted in considerable reduction on the rate of strain increase in the bottom flange. This behavior resulted in considerable improvement of rotation capacity of this specimen compared with composite and even bare steel beam connected to the RHS column with larger width-to-thickness ratio.

• 한국통신학회논문지
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• 제37B권9호
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• pp.806-813
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• 2012

클라우드 컴퓨팅 환경에서 Infrastructure as a Services (IaaS), Platform as a Services (PaaS), Software as a Services (SaaS), Desktop as a Services (DaaS) 등 다양한 솔루션들이 지속적으로 제공되고 있다. 현재는 사용자 단말이 클라우드 서비스를 제공받으면서 이동성을 보장하기 위한 솔루션으로 Mobile as a Services(MaaS)가 가장 많은 주목을 받고 있다. 사용자는 이동을 하면서도 클라우드에 있는 데이터 및 어플리케이션에 대한 접근과 이용이 가능해야 한다. 다시 말해 모바일 Thin-Client 환경에서 클라우드와 통신, 이동성 지원은 필수 요소이다. 모바일 단말의 이동성을 지원하기 위해 MobileIPv6 (MIPv6) 및 Proxy Mobile IPv6 (PMIPv6)가 소개되면서 많은 연구가 진행되고 있다. 또한, PMIPv6에 대한 연구는 도메인 내에 패킷 손실을 우려한 최적 경로 설정, 빠른 핸드 오버 등의 개선방안이 많이 제시된 바 있다. 본 논문은 모바일 Thin-Client 지원을 위해 PMIPv6 및 클라우드 연동 시스템을 제안한다. 제안한 시스템에서 모바일 Thin-Client가 서비스를 지원받기 위해 Replica서버를 이용하여 원활한 서비스를 제공하는 기법을 제안하며 성능평가를 통하여 기존 PMIPv6에서 핸드오버에 대한 데이터 비용을 비교 분석할 것이다.

• 한국항해항만학회지
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• 제44권4호
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• pp.275-282
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• 2020

최근 선박의 전복사고는 무게중심의 부적절한 관리, 기상악화 또는 과도한 조타사용 등으로 인한 선체운동이 발생하면서 화물 또는 중량물이 이동하여 복원력 저하 또는 상실 등이 주된 원인으로 분석되고 있다. 따라서 전복사고를 예방하기 위해서는 위험한 횡경사가 발생하더라도 직립 상태로 되돌아오려는 복원성 확보가 이루어져야 한다. GM은 복원성을 판단하는 중요한 평가요소이며, 항해사는 GM을 복원성 검토에 좋은 척도로 활용한다. 본 연구에서는 5년간 운항 중인 선박으로부터 수집한 복원성 자료를 바탕으로 운항 상태에 따른 선종별 GM을 선박 길이, 폭, 총톤수 등 선박제원으로 분석하였다. 선박 길이에 따른 GM 분포의 특징을 확인하였고, 선박 폭과 GM의 상관분석을 수행한 후 선폭대비 GM의 비율을 산출한 후 과거의 비율과 비교하여 최근 경향을 검토하였다. 또한 선박 대형화 추세를 반영하기 위하여 총톤수(GT)/선폭(B)을 이용하여 GM을 회귀분석하여 선종별 GM 추정을 위한 간이근사식 및 최소 GM을 제안하였다. 연구의 결과는 선박에서 항해사가 안정적인 GM 확보의 검토를 위한 자료로 이용되길 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.5773-5777
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• 2015

Background: Oral squamous cell carcinoma (OSCC) is thought to develop from precancerous dysplastic lesions through multistep processes of carcinogenesis involving activation of oncogenes and loss of tumor suppressor genes. The human epidermal growth factor receptor 2 (Her-2/neu [erbB-2]), a cell membrane glycoprotein, is a growth factor receptor that has receptor tyrosine kinase activity. Her2/neu activation plays a central role in cell proliferation and survival. It has been shown that overexpression of Her2/neu increases the rate of cell division and growth, leading to precancerous changes. The aim of the present study was to compare the serum and salivary Her2/neu levels between cases with premalignant and malignant oral lesions. Materials and Methods: Fasting blood samples and unstimulated saliva by passive drooling were collected from three groups of healthy control (n=20), premalignant disorder (PMD) (n=20) and OSCC (n=25) subjects. The HER2 extracellular domain (HER2 ECD) levels were measured using ELISA. Results: The levels of serum Her2/neu showed no significant differences between any of the groups but on the other hand salivary Her2/neu levels were found to be significantly (p<0.05) higher when compared between control (median 68.7 pg/ml, range: 21.5 - 75.8) and OSCC (median 145.6 pg/ml, range: 45.1-191.1). A similar trend was observed when comparing between PMD (median 43.3, range: 22.1 -94.7) and OSCC with a statistical significance of p<0.05. Conclusions: Our study provided evidence of increased salivary Her2/neu in OSCC when compared to PMD and control which was not the case for serum levels. This suggests that probably Her2/neu is not highly amplified as in breast cancer so as to be reflected in serum. Since saliva is in local vicinity of the OSCC, even a mild increase might be mirrored. On the whole, this study proposes Her2/neu as marker for distinguishing premalignant and malignant conditions.