• Proceedings of the SCSK Conference
• /
• 2003.09a
• /
• pp.352-373
• /
• 2003

Rhamnose-rich (RROP-s) and fucose-rich (FROP-s) oligo-and polysaccharides were prepared and extensively characterised by physical and chemical procedures [1,2] and compared to L-fucose. Their biological properties were then studied on human skin fibroblast cell cultures, human skin explant cultures and on hairless rat skin, using a variety of cell-biological, biochemical and computerised morphometrical procedures. Among the most important properties we could establish, the following are of particular interest for the tretment and prevention of age-dependent modifications of human skin (loss of skin-tissue, cells and matrix, wrinkle formation and others) : stimulation of cell proliferation (by $^3$[H]-thymidine incorporation and the MTT test), scavenging of reactive oxygen species (ROS) using several different procedures, and protease (MMP-2 and MMP-9) down-regulation. A topical preparation, using RROP-s and FROP-s, and/or L-fucose, was shown to increase cell proliferation, dermal matrix synthesis, efficient scavenging of ROS-s and to increase also the thickness of dermal tissue when applied for 4 weeks on hairless rat skin, accompanied by the densification of collagen bundles as well as by an increase of elastin synthesis. Using fluorescent labeled FROPs, it could be shown that these oligosaccharides react with cell-membrane receptors and especially with the elastin-laminin-receptor and the fucose-mannose receptor, but they penetrate also in the cell nucleus, suggesting the possibility of a direct action on the regulation of gene expression. When applied to the human skin of a team of voluntary women encompassing all age-groups, the efficiency of FROP-containing preparation could be confirmed using indentometry and computerised evaluation of skin micro-relief, as well as evaluation of periorbital wrinkles. It appears therefore that these preparations correspond to all the requirements of active anti-aging principles.

• Journal of Periodontal and Implant Science
• /
• v.38 no.3
• /
• pp.437-444
• /
• 2008

Purpose: A number of techniques and materials have been used for periodontal regeneration and bone graft procedures with guided tissue regeneration(GTR) have been suggested as alternatives to osseous surgery in the management of local infra-bony defects. However, the long-term stability and treatment outcome following bone graft procedure of infra-bony defects is poorly documented. The purpose of this study was to assess radiographic change in infra-bony defects over 2 years after bone graft procedures with various graft materials. Material and Methods: Patients attending the department of periodontics of Kyungpook National University Hospital were studied. Patients showed clinical and radiographic evidence of infra-bony defect(s). 44 sites of 34 patients aged 31 to 69 (mean age 48.3) were treated by bone graft procedure with a bone graft material. Baseline and 2-year follow-up radiographs were collected and evaluated for this study. Radiographic assessment includes a bone fill, bone crest change, defect resolution, and % of defect resolution. Pre- and post-treatment differences between variables (maxilla and mandible, defect depth, defect angle, bone graft materials) using the paired t-test were examined. Result: We observed $1.15{\pm}1.95\;mm$ of bone fill, $0.40{\pm}1.19\;mm$ of crestal resorption, $1.55{\pm}1.77\;mm$ of defect resolution, and $40{\pm}44%$ of percentage of defect resolution. Deeper initial defect depth, narrower initial defect angle showed significantly greater bone fill, defect resolution, and % of defect resolution. But no significant difference was observed in graft sites and graft materials. Conclusion: If good oral hygiene maintenance and periodic recall check of patients is assured, bone graft procedure using various graft materials is one of the appropriate treatment modality for regenerative therapy of infra-bony defects.

• Korean Journal of Clinical Pharmacy
• /
• v.31 no.2
• /
• pp.153-159
• /
• 2021

Background: With increasing economic evaluation studies on the treatment of or screening tools for liver diseases that cause hepatocellular carcinoma (HCC), interest in the analysis of the medical utilization and costs of HCC treatment is increasing. Therefore, we aimed to estimate the medical utilization and costs of HCC patients, and calculate the cost of main procedures for HCC treatment, including liver transplant (LT), hepatic resection (HR), radiofrequency ablation (RFA), and transarterial chemoembolization (TACE). Methods: We analyzed claim data from January to December 2018 from the Health Insurance and Review and Assessment Service-National Patient Sample (HIRA-NPS-2018) dataset, including data of patients diagnosed with HCC (Korean Standard Classification of Diseases code C22.0) who had at least one inpatient claim for HCC. Results: A total of 715 HCC patients were identified. In 2018, the yearly average medical cost per HCC patient was ₩18,460K (thousand), of which ₩14,870K was attributed to HCC. Among the total medical costs of HCC patients, the inpatient cost accounted for the largest portion of both the total medical and HCC-related costs. The major procedures of HCC treatment occurred most frequently in the order of TACE, RFA, HR, and LT. The average medical cost per treatment episode was the highest for LT (₩87,280K), followed by HR (₩10,026K), TACE (₩4,047K), and RFA (₩2,927K). Conclusion: By identifying the medical costs of HCC patients and the costs of the main procedures of HCC treatment, our results provide basic information that could be utilized for cost estimation in liver disease-related economic evaluation studies.

• Journal of Applied Reliability
• /
• v.15 no.4
• /
• pp.222-232
• /
• 2015

Purpose : The purpose of this study is to analyse affecting factors of Test and Evaluation and to improve the institution of Test and Evaluation in the Domestic purchase program. Methods : The domestic acquisition program is currently small in terms of size, but it is gradually increasing every year. Still, the domestic purchase program has insufficient regulations and procedures compared to the other procurement methods including research & development. Various problems are likely to occur between test and evaluation group, and defense industries regarding the regulations during Test & Evaluation. Therefore, the regulations and methods need to be amended to upgrade the current domestic purchase program into an effective and flawless one. In this paper, six variables have been chosen by the help of experts working in Ministry of National Defense (MND), Joint Chiefs of Staff (JCS), Army Headquarters and DAPA. Results : The six variables are effectiveness of proposal evaluation, fairness of test and evaluation, sufficiency of operational capabilities, seasonal period of test and evaluation, fulfillment in Integrated Logistics Support (ILS) of the industries, and guaranteeing appropriate environment for related enterprises' participation. Conclusion : This paper can help defense industries to enhance their development capabilities, and to perform tests more fairly and effectively considering the key factors identified in this research.

• Journal of the Korean Society for Precision Engineering
• /
• v.19 no.11
• /
• pp.174-182
• /
• 2002

The integrity evaluation of pressure tube is essential for the safety of CANDU reactor, and integrity must be assured when flaws or contacts between pressure tube and surrounding calandria tube are found. In order to complete the integrity evaluation, not only complicated and iterative calculation procedures but also a lot of data and knowledge are required. For this reason, an integrity evaluation system, which provides an efficient way of the evaluation with the help of attached databases, was developed. The developed system was built on the basis of ASME Sec.？ and FFSG issued by the AECL, and applicable for the evaluation of blister, sharp flaw and blunt notch. Delayed hydride cracking and blister evaluation modules are included in the general flaw and notch evaluation module. In order to verify the developed system, several case studies have been performed and the results were compared with those from AECL. A good agreement was observed between those two results.

• Journal of Korean Society of Rural Planning
• /
• v.13 no.2
• /
• pp.17-26
• /
• 2007

This study aims to develop a rational evaluation system which consists of the selection of evaluation items and the estimation of its weight for the Enhancement Program of the Quality of Life for Farmers and Fishermen and Rural Development. This system has two hierarchical steps. The first step shows the evaluation goals which are relevance, efficiency and effectiveness of the program. The second step stands for the evaluation items which have 11 sub-items such as necessity and externalization for the program, rationality of procedures, feedback and monitoring system, budgetary allocations, information activities, impacts on the program, achievements of the goals and so on. A tentative evaluation system was proposed by brainstorming and Delphi method of expert-group. Weighting values of evaluation items were calculated through pair-comparison works of expert group using stepwise matrix sheets by AHP(Analytic Hierarchy Process).

• Proceedings of the KSME Conference
• /
• 2000.11a
• /
• pp.843-848
• /
• 2000

The pressure tube is a major component of the CANDU reactor, which supports nuclear fuel bundle and it's containment vessel. If a flaw is found during the periodic inspection from the pressure tubes, the integrity evaluation must be carried out, and the safety requirements must be satisfied for continued service. In order to complete the integrity evaluation, complicated and iterative calculation procedures are required. Besides, a lot of data and knowledge for the evaluation are required for the entire integrity evaluation process. For this reason, an integrity evaluation system, which provides efficient way of evaluation with the help of attached databases, was developed. The developed system was built on the basis of ASME Sec. XI and FFSG(Fitness For Service Guidelines for zirconium alloy pressure tubes in operating CANDU reactors) issued by the AECL, and covers the delayed hydride cracking(DHC). Various analysis methods are provided for the integrity evaluation of pressure tube. In order to verify the developed system, several case studies have been performed and the results were compared with those from AECL. A good agreement was observed between those two results.

• Journal of the Korean Society for Library and Information Science
• /
• v.45 no.2
• /
• pp.309-324
• /
• 2011

The purpose of this study is to develop evaluation indicators for academic libraries in Korea. The evaluation model developed in this research consists of three elements:(1) Confirmation of evaluation methods, procedures and criteria,(2) Development of qualitative and quantitative evaluation indicators, and(3) Assessment of the applicability and feasibility of those indicators. Evaluation indicators were developed to measure a basic state, a common use of library resources, specialized services, and user satisfaction for academic libraries. To test the feasibility and applicability of those evaluation indicators, a pilot assessment of academic libraries was conducted in 2010.

• Health Policy and Management
• /
• v.25 no.3
• /
• pp.185-196
• /
• 2015

Background: Issues concerning with the classification accuracy of Korean Outpatient Groups (KOPGs) have been raised by providers and researchers. The KOPG is an outpatient classification system used to measure casemix of outpatient visits and to adjust provider risk in charges by the Health Insurance Review & Assessment Service in managing insurance payments. The objective of this study were to refine KOPGs to improve the classification accuracy and to evaluate the refinement. Methods: We refined the rules used to classify visits with multiple procedures, newly defined chemotherapy drug groups, and modified the medical visit indicators through reviews of other classification systems, data analyses, and consultations with experts. We assessed the improvement by measuring % of variation in case charges reduced by KOPGs and the refined system, Enhanced KOPGs (EKOPGs). We used claims data submitted by providers to the HIRA during the year 2012 in both refinement and evaluation. Results: EKOPGs explicitly allowed additional payments for multiple procedures with exceptions of packaging of routine ancillary services and consolidation of related significant procedures, and discounts ranging from 30% to 70% were defined in additional payments. Thirteen chemotherapy drug KOPGs were added and medical visit indicators were streamlined to include codes for consultation fees for outpatient visits. The % of variance reduction achieved by EKOPGs was 48% for all patients whereas the figure was 40% for KOPGs, and the improvement was larger in data from tertiary and general hospitals than in data from clinics. Conclusion: A significant improvement in the performance of the KOPG was achieved by refining payments for visits with multiple procedures, defining groups for visits with chemotherapy, and revising medical visit indicators.

• IE interfaces
• /
• v.9 no.2
• /
• pp.191-202
• /
• 1996

A variety of approaches on performance evaluation modeling have appeared in the technical literature for flexible manufacturing systems(FMS) which can be evaluated only through computer simulation. This study represents a comparative approach for FMS performance evaluation modeling based on reliability, availability and maintainability, and life cycle cost. The methodology proposed in this research includes the following three-step generative approaches. First, a static model to find the initial system configuration is considered under the assumption that the system availability is given as one (failure and maintenance are not considered), and in second step, a stochastic simulation is proposed to serve as a performance evaluation model for FMS with stochastic failure and repair time. In the last step, we developed a simulation modeling using a simulator, FACTOR/AIM to consider a variety of performance factors and dynamic behavior of FMS. Also the applicability and validity of the proposed approaches has been tested and compared through the results of a sample problem using computer programs and procedures developed in each step.