• Carbon letters
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• 제7권3호
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• pp.196-200
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• 2006

Graphite has hexagonal closed packing structure with two bonding characteristics of van der Waals bonding between the carbon layers at c axis, and covalent bonding in the carbon layer at a and b axis. Graphite has high tolerant to the extreme conditions of high temperature and neutron irradiations rather than any other materials of metals and ceramics. However, carbon elements easily react with oxygen at as low as 400C. Considering the increasing production of today of hydrogen and electricity with a nuclear reactor, study of oxidation characteristics of graphite is very important, and essential for the life evaluation and design of the nuclear reactor. Since the oxidation behaviors of graphite are dependent on the shapes of testing specimen, critical care is required for evaluation of nuclear reactor graphite materials. In this work, oxidation rate and amounts of the isotropic graphite (IG-110, Toyo Carbon), currently being used for the Koran nuclear reactor, are investigated at various temperature. Oxidation process or principle of graphite was figured out by measuring the oxidation rate, and relation between oxidation rate and sample shape are understood. In the oxidation process, shape effect of volume, surface area, and surface to volume ratio are investigated at $600^{\circ}C$, based on the sample of ASTM C 1179-91.

• 한국정밀공학회지
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• 제24권8호통권197호
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• pp.58-66
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• 2007

In order to improve the recyclability and to reduce the recycling cost and time, the disassembly technology should be systemized because the worn out products can be reused or recycled after disassembly processes. This paper attempts to propose the integrated CATIA-based DfD (Design for Disassembly) support system to promote the disassemblability of products. The system is composed of two modules; evaluation of disassemblability, generation of DfD alternatives. The disassemblability of current vehicle is evaluated to identify the weak point in terms of disassembly using the DELMIA and developed evaluation system. Furthermore a new expert system is developed to propose the optimal redesign rule and principle for generating the DfD alternatives. In order to generate the DfD alternatives, a CATIA-based design support system is implemented. The system can provide quick results and ensure consistency and completeness of the redesign alternatives.

• 상하수도학회지
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• 제25권3호
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• pp.325-334
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• 2011

Market Environment around water work industry is rapidly changing. ISO, International Organization for Standardization, announced the international water work service standard for comparison and evaluation between nations and businesses. And developed countries in water work are introducing market principle for growth of nation's water industry and reinforcement of its competitiveness. Also, some local governments entrusted their water utilities for improvement of competitiveness of water work. However, as some failure cases from overseas came out with emphasis, there are many refuting perspective about entrusted operation achievements of domestic water market. Hence, this paper evaluated competitiveness of domestic local water utilities from the perspective of productivity. After evaluating productivity using Malmquist productivity index, the authors compared and analyzed whether there is a difference of productivity between two different operating types by using Mann-Whitney test. As a result of analysis, it has shown that local water utilities achieved higher productivity at entrusted operation type rather than direct operation type. The local water utilities which chose entrusted operation had increased the productivity 13.9% on total factor productivity(TFP) during experimenting period, while the local water utilities which chose direct operation had increased 0.2%. The background of achieving this high productivity in entrusted operation was analyzed as a result of the higher technological effectiveness of a special water company. The result of this study can be referred when local government needs to decide on what operating types they will use.

• Journal of Biosystems Engineering
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• 제40권1호
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• pp.1-9
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• 2015

Purpose: The objective of this study was to understand the operating mechanism of the rock-drill drifter, to explain how to setup an experimental test system and measure the strain of the drifter's rod, and to evaluate the drifter's performance with respect to the impact energy and blow frequency. Methods: The structure of the rock-drill drifter and its operating principle regarding the impact process were analyzed. Static calibration was carried out to calculate the correction factor using a drifter rod as the first step of the experimental test. The impact energy and blow frequency were then calculated based on strain measurements of the drifter's rod. Results: Experimental results showed that the tested drifter elicited a blow frequency of 3330 BPM (Blows Per Minute) and generated impact energy of 170 J/blow. This indicates that the drifter elicits a higher percussion speed and results in a lower impact energy compared to the hydraulic breaker at the same input power. Conclusions: The study proposed methodologies that deal with the experimental setup and the evaluation of the performance of the rock-drill drifter. These methodologies can be extensively used for validating and improving the percussion performance of the drilling equipment.

• 한국경영과학회지
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• 제27권4호
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• pp.41-65
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• 2002

We study a multi-component production/inventory system in which individual components are made to meet various demand types. We assume that the demands arrive according to a Poisson process, but there is a fixed probability that a demand requests a particular kit of different components. Each component is produced by a flow line with several stations in which the processing times of each station follow a two-stage Coxian distribution. The production of each component is operated by an independent base-stock policy with blocking. We assume that the time needed to assemble final products follows a general distribution and the capacity of an assembling facility is sufficiently large. The objective of this study is to obtain key performance measures such as the distribution of the number of each orders for each final product and the mean time of fulfilling a customer order. The basic principle of the proposed approximation method is to decompose the original system into a set of subsystems, each subsystem being associated with a flow line. Each subsystem is analyzed in isolation using a Marie's method. An iterative procedure is then used to determine the unknown parameters of each subsystem. Numerical results show that the accuracy of the approximation method is acceptable.

• 한국소음진동공학회논문집
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• 제15권5호
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• pp.550-557
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• 2005

Korean 'Law of Aviation' and 'Test Method of Measuring Noise and Vibration' designate to use WECPNL metric based on $L_{max}$ measurement for the accessment of aircraft noise in Korea. However, time duration of noise event can not be considered in $L_{max}$ metric in principle, compensation on the duration has been utilized. A study was done recently to evaluate appropriate duration compensation for the accessment of military aircraft noise under current metric of WECPNL and $L_{max}$. This study was carried out to evaluate what metric is the most appropriate to express aircraft noise including time duration of single noise event, computing and comparing noise exposure with 1 second noise measurement data of military aircraft in $L_{max}$, $L_{Aeq,\;T}$ and SEL. This study shows SEL is the most appropriate noise metric for the evaluation of noise exposure with time duration such as aircraft noise without compensation. It is suggested to use SEL noise metric instead of $L_{max}$ noise metric with duration compensation for the aircraft noise accessment either military aircraft or civilian aircraft.

• 한국실내디자인학회논문집
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• 제23권1호
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• pp.162-171
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• 2014

This study aimed to evaluate how universal design principles are embodied in the village community center. It will provide preliminary data on constructing a physical space of village community center as small community space in agricultural districts. To achieving the purpose in this study, the research conducted inspection using checklist to 25 village community centers at Hwasoon, Jeonnam province. The conclusion of this study is as follows: Living room and kitchen/dining room by supportive design urgently need installation of Western Style furniture and solutions of stair gap by accessible design, and also the evaluation is unsuited on a fire-gas alarm system and prevention of electric shook system on safety-oriented design. Entrance evaluated in principle for insufficient on safety handle by supportive design and spare chair by adaptable design, and also it unsuited on the solutions of door sill by accessible design and non-skid by safety-oriented design. Bathroom is insufficient lever handle and safety grip by supportive design, sink isn't suitable by adaptable design. Outdoor space information legislation staircase ramp installation and horizontal installation of the staircase was not built.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2006년도 하계학술발표대회 논문집
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• pp.95-98
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• 2006

Filtration by fibrous filter is one of the Principle methods used for removing pollutant particles in the liquid. Because of the increasing need to protect both human health and valuable devices from exposure to fine particles, filtration has become more important. Filters have been developed with modified surface charge characteristics to capture and adsorb particles by electrokinetic interaction between the filter surface and particles contained in water. The main purposes of this study are to develop and evaluate the performance evaluation of the apparatus for making a positively charged porous filter media and to analyze the surface characteristics of the filter media for capturing negavitely charged contaminants mainly bacteria and virus from water. The experimental apparatus consists of a mixing tank, a vacuum pumping system, a injection nozzle, a roller press and a controller. The filter media is composed of glass fiber(50-750 nm), cellulose($10-20{\mu}m$) and colloidal charge modifier. The characteristics of filter media is analyzed by SEM(Scanning Electron Microscopy), AFM(Atomic Force Microscopy) and quantified by measuring the zeta potential values.

• The Korean Journal of Physiology and Pharmacology
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• 제27권3호
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• pp.267-275
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• 2023

Cardiotoxicity, particularly drug-induced Torsades de Pointes (TdP), is a concern in drug safety assessment. The recent establishment of human induced pluripotent stem cell-derived cardiomyocytes (human iPSC-CMs) has become an attractive human-based platform for predicting cardiotoxicity. Moreover, electrophysiological assessment of multiple cardiac ion channel blocks is emerging as an important parameter to recapitulate proarrhythmic cardiotoxicity. Therefore, we aimed to establish a novel in vitro multiple cardiac ion channel screening-based method using human iPSC-CMs to predict the drug-induced arrhythmogenic risk. To explain the cellular mechanisms underlying the cardiotoxicity of three representative TdP high- (sotalol), intermediate- (chlorpromazine), and low-risk (mexiletine) drugs, and their effects on the cardiac action potential (AP) waveform and voltage-gated ion channels were explored using human iPSC-CMs. In a proof-of-principle experiment, we investigated the effects of cardioactive channel inhibitors on the electrophysiological profile of human iPSC-CMs before evaluating the cardiotoxicity of these drugs. In human iPSC-CMs, sotalol prolonged the AP duration and reduced the total amplitude (TA) via selective inhibition of I_Kr and I_Na currents, which are associated with an increased risk of ventricular tachycardia TdP. In contrast, chlorpromazine did not affect the TA; however, it slightly increased AP duration via balanced inhibition of I_Kr and I_Ca currents. Moreover, mexiletine did not affect the TA, yet slightly reduced the AP duration via dominant inhibition of I_Ca currents, which are associated with a decreased risk of ventricular tachycardia TdP. Based on these results, we suggest that human iPSC-CMs can be extended to other preclinical protocols and can supplement drug safety assessments.

• Toxicological Research
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• 제28권2호
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• pp.73-79
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• 2012

While the ability to develop nanomaterials and incorporate them into products is advancing rapidly worldwide, understanding of the potential health safety effects of nanomaterials has proceeded at a much slower pace. Since 2008, Korea Food and Drug Administration (KFDA) started an investigation to prepare "Strategic Action Plan" to evaluate safety and nano risk management associated with foods, drugs, medical devices and cosmetics using nano-scale materials. Although there are some studies related to potential risk of nanomaterials, physical-chemical characterization of nanomaterials is not clear yet and these do not offer enough information due to their limitations. Their uncertainties make it impossible to determine whether nanomaterials are actually hazardous to human. According to the above mention, we have some problems to conduct the human exposure risk assessment currently. On the other hand, uncertainty about safety may lead to polarized public debate and to businesses unwillingness for further nanotechnology investigation. Therefore, the criteria and methods to assess possible adverse effects of nanomaterials have been vigorously taken into consideration by many international organizations: the World Health Organization, the Organization for Economic and Commercial Development and the European Commission. The object of this study was to develop risk assessment principles for safety management of future nanoproducts and also to identify areas of research to strengthen risk assessment for nanomaterials. The research roadmaps which were proposed in this study will be helpful to fill up the current gaps in knowledge relevant nano risk assessment.