• 한국독성학회:학술대회논문집
• /
• 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
• /
• pp.154-154
• /
• 2002

Several lines of epidemiological and experimental evidence support that chronic ethanol consumption is implicated in pathophysiology of a variety of human disorders, including cancer. However, the association between chronic ethanol consumption and an increased risk of gastric cancer is not clearly defined.(omitted)

• Nutritional Sciences
• /
• 제8권2호
• /
• pp.89-96
• /
• 2005

To determine the deleterious effects of chronic alcohol consumption on bone especially in adolescents or young adults, 8 week-old Sprague Dawley male rats were fed with Lieber-Decarli ethanol liquid diet, containing $36\%$ of energy as ethanol, ad libitum (ethanol group) or isocaloric normal liquid diet (control group) for 7 weeks. Body weight was significantly lower in ethanol group than that in control group after 1 week of feeding to the end. liver weight and the ratio of liver or kidney weight to body weight in ethanol group were significantly increased when compared to those in control group. Ethanol group showed significantly lower serum protein and albumin levels (p<0.05), higher total cholesterol and HDL-cholesterol levels (p<0.05), and AST, ALT and BUN activities than control group, but serum triglyceride, Ca and phosphate levels were not different. Ethanol group had significantly lower tibial trabecular bone area and serum osteocalcin level than control group (p<0.05), but urinary Ca and NTx (cross-linked N-telopeptide of type I collagen) concentrations and serum testosterone and parathyroid hormone levels were not different. In conclusion, chronic alcohol consumption in growing young male rats may result in osteopenia through the reduction of bone formation as well as liver malfunction.

• Journal of Biosystems Engineering
• /
• 제6권2호
• /
• pp.1-8
• /
• 1982

The objective of this study was to find out the technical feasibility of ethanol-diesel fuel blends as a diesel engine fuel. Fuel properties essential to the proper operation of a diesel engine were determined for blends containing several concentrations of ethanol in No. 2 diesel fuel. A single-cylinder diesel engine for a power tiller was used for the engine tests, in which load, speed and fuel consumption rate were measured. The fuels used in tests were No. 2 diesel fuel and a blend containing 10-percent ethanol and 90-percent No. 2 diesel fuel. The results of the study are summarized as follows. 1. It was not possible to blend ethanol and No. 2 diesel fuel as a homogeneous solution even though anhydrous ethanol was used. The problem of blending ethanol in No. 2 diesel fuel could be solved by adding butanol about 5% of the amount of ethanol in the blends. 2. Because ethanol had a much lower boiling point ($78.3^{\circ}C$ under atmospheric pressure) than a diesel fuel, it was necessary to store ethanol-diesel fuel blends airtight in order to prevent them from evaporation losses of ethanol. 3. The addition of ethanol to No. 2 diesel fuel lowered the fuel viscosity and the cetane rating, but a blend of 10% ethanol and 90% diesel fuel had a viscosity and a cetane rating well above the KS minimum values for No. 2 diesel fuel. 4. At the rated speed, the specific fuel consumption of No.2 diesel fuel was lower than that of the 10% ethanol blend for the almost entire range of load. However, under the overload condition the specific fuel consumption was lower for the 10% ethanol blend. 5. Under the variable-speed full-load tests, both fuels produced approximately the same torque and power. At the speeds of 1600rpm or below, the specific fuel consumption of No. 2 diesel fuel was lower than that of the 10% ethanol blend. At the speeds of 1600rpm or above, however, the specific fuel consumption was lower for the 10% ethanol blend. 6. At the ambient temperature above $15^{\circ}C$, the use of the 10% ethanol blend in the engine created a vapor lock in the fuel injection pump and stalled the engine. The vapor locking problem was overcome by chilling the surroundings of the fuel injection pump and the cylinder head with water.

• Journal of Biosystems Engineering
• /
• 제7권1호
• /
• pp.53-61
• /
• 1982

As an attempt to reduce the consumption of petroleum resources and to improve the performance of a kerosene engine, a series of experiments was conducted using several kinds of ethanol-kerosene blends under the various compression ratios. The engine used in this study was a single-cylinder, four-cycle kerosene engine having a compression ratio of 4.5. To investigate the feasibility of ethanol-kerosene blends in the original engine, kerosene and blends of 5-percent, 10-percent, and 20-percent-ethanol, by volume, with kerosene were used. And to investigate the feasibility of improving the performance of the kerosene engine, a portion of the cylinder head was cut off to increase the compression ratio up to 5.0 by reducing the combustion chamber volume. Kerosene and blends of 30-percent and 40-percent-ethanol, by volume, with kerosene were used for the modified engine with an increased compression ratio. Variable speed tests at wide-open throttle were also conducted at five speed levels in the range of 1000 to 2200 rpm for each compression ratio and fuel type. Volumetric efficiency, engine torque, and brake specific fuel consumption were determined, and brake thermal efficiency based on the lower heating values of kerosene and ethanol was calculated. The results obtained in the study are summarized as follows: A. Test with the original engine: (1) No abnormal conditions were found when burning ethanol-kerosene blends in the original engine. (2) Volumetric efficiency increased with ethanol concentration in blends. When burning blends of 5-percent, 10-percent, and 20-percent ethanol, by volume, with kerosene, average volumetric efficiency increased 1.6 percent, 2.6 percent, and 4.1 percent respectively, than when burning kerosene. (3) Mean engine torque increased 5.2 percent for 5-percent-ethanol blend, 9.3 percent for 10-percent-ethanol blend, and 11.5 percent for 20-percent-ethanol blend than for kerosene. Increase in engine torque when using ethanol-kerosene blends was due to the improved combustion characteristics of ethanol as well as an increase in volumetric efficiency. (4) Up to ethanol concentration of 20 percent, mean brake specific fuel consumption was nearly constant inspite of the difference in heating value between ethanol and kerosene. (5) Brake thermal efficiency increased 0.3 percent for 5-percent-ethanol blend, 3.8 percent for 10-percent-ethanol blend, and 6.8 percent for 20-percent-ethanol blend than for kerosene. B. Test with the modified engine with an increased compression ratio: (1) When burning kerosene, mean volumetric efficiency, engine torque, and brake thermal efficiency were somewhat lower than for the original engine. (2) Engine torque increased 15.1 percent for 30-percent-ethanol blend and 18.4 percent for 40-percent-ethanol blend than for kerosene. (3) There was no significant difference in brake specific fuel consumption regardless of ethanol concentration in blends. (4) Brake thermal efficiency increased 15.0 percent for 30-percent-ethanol blend and 19. 5 percent for 40-percent-ethanol blend than for kerosene.

• Journal of Nutrition and Health
• /
• 제32권4호
• /
• pp.376-383
• /
• 1999

The effects of $\beta$-carotene substitutionl for vitamin A and the chronic consumption of ethanol of ethanol on hepatic folate metabolism were studied it rats. The substitution of $\beta$-carotene for vitamin A depressed hepatic 10-formyl-tetreahydrofolate dehydrogenase(10-formyl-tetrahydrofolate : NADP oxidoreductase, E.C. 1.5. 1.6)activity to 65% of controls(p<0.001) and enhanced hepatic 5, 10-methy-lenetetrahydrofolate reductase(E. C. 6.3.3.2)activity by 56% with respect to control levels(p<0.001). Hepatic activity of 10-formyltertrahydrofolate dehydrogenase was depressed to about half that of control levels by ethanol administration to rats(36% ethanol diet, p<0.001). The activity of 5, 10-methyleneterahydrofolate reductase was not changed by ethanol consumption. The increased activity of 5, 10-methyleneterahydrofolate reductase and the decreased activity of 10-formyltetrahydrofolate dehydrogenase appeared to decrease the level of nonmethyl folate conezyme and the rate of one-carbon metabolism. Plasma homocysteine concentrations were significantly higher in rats fed ethanol(p<0.01) o $\beta$-carotene(p<0.001) than in controls, which suggests that increased activity of 5, 10-methylenetetrahydrofolate reductase can depress homocysteine metabolism. We concluded that dietary substitution of $\beta$-carotene for vitamin A or chronic administration of ethanol resulted in changes in the activity of hepatic folate-dependent enzymes, which could affect the distribution of folate derivatives, plasma homocysteine levels and one-carbon metabolism.

• Journal of Advanced Marine Engineering and Technology
• /
• 제29권7호
• /
• pp.722-728
• /
• 2005

In this paper, the effects of ethanol blended gasoline on emissions and their catalytic conversion efficiency characteristics were investigated in a multiple-point EFI gasoline engine, The results show that with the increase of ethanol concentration in the blended fuels, THC emissions were drastically reduced by up to thirty percent, And brake specific fuel consumption was increased, but brake specific energy consumption could be improved. However, unburned ethanol and acetaldehyde emissions increased. Pt/Rh based three-way catalysts were effective to reduce acetaldehyde emissions, but had low catalytic conversion efficiency for unburned ethanol. The effect of ethanol on CO and NOx emissions and their catalytic conversion efficiency had close relation to the engine's speed, load and air/fuel ratio. Furthermore fuels blended with thirty percent ethanol by volume could dramatically reduced THC CO and NOx emissions at idle speed.

• Toxicological Research
• /
• 제11권2호
• /
• pp.267-271
• /
• 1995

A single large dose of ethanol as well as chronic ethanol consumption produces alcoholic fatty liver in human and experimental animals. We examined the effects of YH439, a potential hepatoprotective agent, on alcoholic fatty liver generation in adult female rats. In rats treated with YH439 (250 mg/kg, po) 4 hr prior to a single dose of ethanol (6 g/kg, po), a significant decrease in hepatic triglyceride accumulation was observed. YH439 also has an inhibitory effect on hepatic triglyceride and cholesterol accumulation induced by repeated ethanol treatments for one week. Because it has been known that induction of alcoholic fatty liver is associated with lipid peroxidation and/or hepatic glutathione depression, the effect of YH439 on these parameters was determined in the livers of rats treated with ethanol. Coadministration with YH439 inhibited MDA formation and gIutathione depression induced by acute or repeated ethanol administration. In order to determine the effect of YH439 on ethanol metabolism in vivo, disappearance of ethanol from blood was measured. In rats treated with a single dose of ethanol (6 g/kg, po), the ethanol concentration in blood reached a peak approximately 120 min following the treatment which declined linearly for 18 hrs. YH439 had no effect on the decline of blood ethanol concentration regardless of the dose of ethanol given to rats. These results in this study suggest that YH439 has an inhibitory effect on fatty liver generation induced by acute or repeated ethanol consumption through a mechanism not directly related to the rate of ethanol metabolism in vivo.

• Journal of Advanced Marine Engineering and Technology
• /
• 제28권3호
• /
• pp.516-521
• /
• 2004

In this paper, the effects of ethanol blended gasoline on emissions and their catalytic conversion efficiencies characteristics were investigated in gasoline engine with an electronic fuel injection. The results showed that the increase of ethanol concentration in the blended fuels brought the reduction of THC and $CO_2$ emissions from the gasoline engine. THC emissions were drastically reduced up to thirty percent. And brake specific fuel consumption was increased. but brake specific energy consumption was similar level. However. unburned ethanol and acetaldehyde emissions increased. The conversion efficiency of Pt/Rh based three-way catalysts and the effect of ethanol on CO and NOx emissions were investigated by the change of engine speed. load and air/fuel ratio. Furthermore, the ethanol blended fuel results in the reduction effect of THC. CO and NOx emissions at idle speed.

• Journal of Nutrition and Health
• /
• 제25권7호
• /
• pp.578-585
• /
• 1992

This study was undertaken to investigate effects of alcohol and dietary protein levels on serum lipids and enzyme activities in 15 week-old male rats given a normal diet. Rats were divided into 8 groups : control group (16% protein 16PC) and 8%(8PE) 16%(16PE) and 24% protein groups(24PE) to which was given 5% ethanol mixed into their drinking water after 4 weeks and 10 weeks. Body weight organ weight and various blood components were determined at 4 and 10 weeks. Body weight gain organ weight hemoglobin concentration and hematocrit value were not influenced by ethanol and dietary protein levels. The levels of total cholesterol HDL-cholesterol and phospholipid in serum were not affected by ethanol consumption. Serum triglyceride concen-trations after 10 weeks were significnatly increased ethanol-treated group compared with that of control group and the effect was greater in low protein group than control group. Serum ALP activity was significantly higher in 8PE group than other group but there was no influence by ethanol consumption.

• 대한기계학회논문집B
• /
• 제32권8호
• /
• pp.582-588
• /
• 2008

An experimental investigation was conducted to investigate the effect of Bio-ethanol fuel on the engine performance and exhaust emission characteristics under various engine operating conditions. To investigate the effect of bio-ethanol fuel, the commercial 1.6L SI engine equipped with 4 cylinder was tested on EC dynamometer. The engine performance including brake torque, brake specific fuel consumption, and barke specific energy consumption of bio-ethanol fuel was compared to those obtained by pure gasoline. Furthermore, the exhaust emissions were analyzed in terms of regulated exhaust emissions such as unburned hydrocarbon, oxides of nitrogen, and carbon monoxide.Result of this work shows that the effect of blending of ethanol to gasoline caused drastic decrease of emissions under various operating conditions. Also, improved engine performance such as brake torque and brake power were indicated for bio-ethanol fuel.