• 한국정보통신학회논문지
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• 제18권6호
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• pp.1441-1446
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• 2014

본 논문에서는 로봇군집이 미로 탈출을 위해 협력하는 방법에 대해 제안되었다. 로봇은 센서를 통해 필수적인 데이터를 수집하고 판단하여 자율적으로 움직일 수 있다. 하지만 미로 탈출을 위해 협력하기 위해서는 중앙 시스템이 여러 로봇들을 제어할 필요가 있다. 로봇들은 보이지 않는 미로를 탐색하며, 탈출 경로를 위한 분석과 지도를 만들기 위해 이동과 같은 정보를 중앙제어시스템에 전송한다. 여러 대의 로봇들이 미로를 효과적으로 탈출하기 위해서, 이 논문에서는 다음과 같은 문제를 고려하였다. 첫째, 로봇들이 미로 영역을 나누어서 탐색하기. 둘째, 벽으로 막혀 있는 막다른 골목을 찾아서 다른 로봇이 진입하지 못하도록 하기. 셋째, 목적지에 먼저 도착한 로봇이 최단 경로를 만들어 다른 로봇이 빨리 탈출할 수 있도록 하기. 위의 3가지를 고려하여 미로 동시 탈출을 위한 알고리즘을 구현하여 다양한 미로 크기별로 실험하였다.

• 한국게임학회 논문지
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• 제19권4호
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• pp.85-96
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• 2019

이 논문에서는 블록체인을 이용해 게임 변수들 (게임 난이도, 아이템 강화확률 등)을 사용자들이 직접 공정하고 투명하게 업데이트하는 게임 시스템을 제안한다. 일례로 소개하는 이더리움 기반 미로 탈출 게임은, 최초의 블록체인 기반 미로 게임이며 블록체인을 통해 난이도를 조절하는 최초의 시도이다. 이 시스템에서는 난이도 함수가 사용자들이 매매한 미로 벽의 수량을 반영해 난이도를 계산한다. 게임 관리에 블록체인을 사용하는 것은 인적 경제적 자원을 절약할 뿐 아니라, 난이도 및 아이템 강화확률을 일방적으로 조작하는 게임 개발자의 불공정한 관행도 방지된다. 누구도 비밀스럽게 미로, 승자, 난이도를 조작할 수 없기 때문이다.

• Archives of Pharmacal Research
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• 제18권5호
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• pp.346-350
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• 1995

To assess the behavior of the various chemicals, such as ethylcholine axiridinium (AF54A), scopolamine and morphine, the chemicals were administered into eitheer rat or mice. And water maze tests were performed before and during drug administration. In AF64A-treated groups (3 nmol/each ventricle), the latencies to escape was significantly increased in both of the pretraining-and posttraining groups. In scopolamine-treatment (2mg/kg, sc) to the pretrained group, the latency to escape was significantly shortened after the acute administration of scopolamine. However in subscute treatment group with scopolamine, the latency to escape was significantly increased. In morphine-treated groups (10 mg/kg, ip), the subacute treatmment with morphine, the latency to escape was not ahcnged. The results indicate that each chemical induces the learning impariment. However the chrmical-induced learning impairment may have different characteristics upon the exposed chemical. Also the results suggest that both the motivation and the retrieval of memory might be impaired by AF64A.

• Journal of Nutrition and Health
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• 제39권3호
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• pp.219-224
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• 2006

This study was performed to determine the effect of soy isoflavones on brain development and function in rats. Forty Sprague-Dawley male rats were provided diets containing different levels of soy isoflavones for 6 weeks; 0 ppm (control), 50 ppm (low isoflavone intake; LI), 250 ppm (medium isoflavone intake; MI) and 500 ppm (high isoflavone intake; HI). Learning ability was evaluated by a Y-shaped water maze and the activity of acetylcholinesterase in brain was assayed after decapitation. Food intake and body weights as well as weights of brain, liver, spleen, heart and kidney showed no significant difference among the four groups, which means 500 ppm of isoflavones is safe. In the water maze test, the frequency of error counted when rats entered one end of the alley without platform was significantly lower in the HI group than in the control group, and the escape latency as swim time taken to escape on the hidden platform was significantly shorter in the HI group than in the LI and control groups. The activity of acetylcholinesterase of the brain was significantly higher in the HI and MI groups than in the control group. Therefore, the results indicate that isoflavones may improve the cognitive function without adverse effects.

• Journal of Ginseng Research
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• 제32권4호
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• pp.341-346
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• 2008

백삼과 홍삼추출물 투여가 scopolamine으로 기억을 손상시킨 실험동물의 학습수행 개선과 뇌조직의 AChE 억제 및 ACh 함량을 평가하여 다음과 같은 결론을 얻었다. 1. 백삼과 홍삼추출물(200 mg/kg, p.o.) 투여는 scopolamine (2 mg/kg, i.p.)으로 유발된 기억손상 동물모델의 Morris water maze 시험에서 tacrine 투여군과 대조군처럼 인지훈련이 반복될수록 escape latency 시간이 현저히 감소하였다. probe test에서도 scopolamine 투여군보다 유의적으로 감소하여 인삼추출물이 장기기억(Long-term memory)과 working memory의 개선에 효과가 있음을 확인하였다. 2. Y-maze test를 통한 실험동물의 자발적 변동행동력은 실험군간 차이가 없었으며, 총 출입회수도 차이가 없어 인삼추출물은 실험동물의 일반적 운동성에 영향을 주지 않았다. 3. 해마조직의 AChE 활성은 인삼추출물 군에서 감소하는 경향을 보였으나 유의적 차이는 없었다. 대뇌피질과 혈청 AChE 활성은 홍삼추출물 투여군에서 유의적으로 감소하였다. 4. 인삼추출물 투여군의 뇌조직 ACh 함량은 대뇌피질과 해마조직에서 scopolamine 투여군보다 증가하는 경향을 보였으나 그룹간의 유의적인 차이는 없었다. 5. 이를 통하여 볼 때 인삼추출물 특히 홍삼추출물은 장기기억 활성촉진, AChE 억제, ACh 활성촉진으로 콜린성 신경계를 자극하여 기억 및 학습증진에 매우 효과적으로 작용하는 항치매 물질로 사료된다.

• Advances in Traditional Medicine
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• 제7권1호
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• pp.41-45
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• 2007

The roots of the plant Korean ginseng have been extensively used in the traditional Chinese herbal medicine. The effects of chronic administration of Korean ginseng extract (KGE) were investigated on two different anxiety models: the elevated T-maze (for inhibitory avoidance and escape measurements) and the open field test (OFT). Diazepam (1 mg/kg), KGE (10, 30 and 100 mg/kg) were administered orally for 15 days. On the 14th day, mice were previously exposed for 30 min to one of the open arms of the T-maze, 24 h before the test. On 15th day, mice had two exposures to the enclosed and open arm of the elevated T-maze followed by exposure to the open field apparatus. The number of line crossings in the apparatus was used to assess locomotor changes. Cumulative Concentration Response Curve of 5-HT was plotted using rat fundus which were pre-treated in a similar way. Treatment with Diazepam (1 mg/kg) and KGE (10, 30 and 100 mg/kg) significantly (P < 0.05) impaired inhibitory avoidance performance but did not impair escape latency. In OFT, diazepam facilitated locomotion as compared to vehicle and other treatment groups. KGE at any of the selected doses did not impair locomotion. Concentration response curve of 5-HT was shifted towards the right with suppression of maxima in rats treated with KGE. The results suggest that KGE exerts anxiolytic like behaviour in a specific subset of defensive behaviour, particularly those related to generalized anxiety disorder.

• 한국산학기술학회논문지
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• 제11권11호
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• pp.4167-4173
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• 2010

2005년에 개정된 ICT교육지침에는 전 학교급에 걸쳐서 알고리즘, 자료구조, 프로그래밍 내용과 같은 컴퓨터 과학 요소가 매우 강화되었다. 컴퓨터교육의 목표가 소프트웨어 활용보다 문제해결력 향상이기 때문이다. 그래서 본 논문에서는 이러한 요소에 대한 학습방법의 일환으로서 로봇들이 협동을 통하여 미로를 탈출하는 문제를 해결할 수 있는 방안을 제시하였다. 로봇이 해결해야하는 문제로서 우선탐색 문제와 역할바꿈 문제와 같이 2가지를 제시하였다. 우선탐색 문제는 첫 번째 로봇이 미로를 끝까지 탐색하면서 미로의 정보를 두 번째 로봇에게 실시간으로 전송한다. 그 후 슬레이브 로봇은 이 정보를 이용하여 탐색없이 미로를 탈출하게 된다. 역할바꿈 문제는 첫 번째 로봇이 미로를 탐색하는 도중 그 기능을 상실했을 때, 두 번째 로봇이 첫 번째 로봇의 역할을 이어받아 수행하는 것이다. 각 문제를 해결하기 위해서 문제분석, 알고리즘 기술, 순서도 작성, 프로그래밍의 4단계를 거치도록 하였다. 본 논문에서 제시한 내용의 부수적인 효과로는 로봇협동을 통한 학습자들의 협동학습 기회 제공, 로봇간 데이터 송수신을 위해서 큐(queue)라는 자료구조를 사용했다는 점이다. 향후에는 좀 더 일반적인 미로의 사용, 실제 현장에의 적용, 영재교육 과정에의 적용에 대한 연구가 필요하다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2014년도 춘계학술대회
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• pp.871-872
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• 2014

이 논문에서는 군집 로봇들이 미로 탈출을 위해 협력하는 방법에 대해 제안한다. 로봇들은 ZIGBEE로 서로 통신할 수 있으나 로봇들의 연산기능이 낮아 중앙제어 시스템이 로봇들에게 명령을 전달한다. 로봇들은 보이지 않는 미로를 탐색하며 지도를 만들기 위해 이동과 같은 정보를 중앙제어 시스템에 전송한다. 중앙제어시스템은 수신된 데이터를 분석하여 미로 탈출을 위한 경로를 찾는다.

• 동의생리병리학회지
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• 제22권3호
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• pp.624-629
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• 2008

Effects of Kyungohkgo Ga Nokyong(Yongohkgo) on growth development and learning ability were investigated growth and intellectual impairment rat with insufficient nutrition diet. We divided male Sprague-Dawley rats into 4 groups. They were Normal group, Growth deficiency rat with insufficient nutrition diet group, Growth deficiency rat with 0.1% Yongohkgo group and 0.2% Yongohkgo group. They were administered for 5 weeks. We measured body weight, and morris water maze test in escape distance, escape time and escape speed, serum growth hormone, insulin-like growth factor and thyroid stimulating hormone, RBC, concentration of Hb and PCV ratio, total WBC and its composition, the values of GOT and GPT activities. The results are as follows that Yongohkgo 0.1%, 0.2% groups were showed significantly different than control groups in body weight and the counts of RBC. In the morris water maze test, in escape distance and escape time, in concentration of Hb and PCV ratio, 0.2% Yongohkgo group were significantly different than control groups. Serum growth hormone, insulin- like growth factor and thyroid stimulating hormone showed a tendency to increase in Yongohkgo groups. The counts of total WBC and its composition, GOT, GPT activities showed no significantly different in all treatment groups. These results suggested that Yongohkgo have an effect of promoting growth and learning ability of rats and might be effect to treat various kinds of growth and learning ability delay in children.

• 대한한의학회지
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• 제20권4호
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• pp.39-49
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• 2000

This study was conducted to prove that there exists a relation between the spleen and learning and memory as Oriental medicine believesTo promote the function of the Spleen, Guibitang was administered to rats in this study. Rats were 250～300g Sprague-Dawley, and were divided into three groups. One was the normal group without any pretreatment. Another was the control group which was administered normal saline and the abdominal injection of L-NAME before learning and memory test. And the 3rd was the sample group, to which was administered Guibitang extract and (no 'the') abdominal injection of L-NAME before the learning and memory test. Each group was made up of 12 rats. Morris water maze and radial arm maze tasks were performed in the learning test and Morris water maze task in the memory test. For 2 days to evaluate the ability of learning in the Morris water maze, 16 trials were carried out and first latency(lapse time to find the escape platform for the first time) was measured. The next day, to evaluate the ability of memory, the escape platform was eliminated from the maze, and total path, target entry number, first latency and memory score were measured. 48hrs before the radial arm maze task was performed, bait was deprived from each group. After learning test, bait was permitted to each group. So 85% of the body weight was maintained for 6 days of the test. Each of the eight arms was baited; correct choice numer and error were counted; each trial was finished when the rat had entered each of the eight arms, or more than 10 minutes had elapsed. The results were as follows: In the learning test, the first latency of the sample group in the Morris water maze showed evident improvement of learning compared to control group at the 11th, 12th, 13th trial of 16 trials, and correct choice number in radial arm maze showed noticeable improvement compared to the control group at 3rd, 4th and 5th; In the memory test, the memory score of the sample group showed evident improvement compared to the control group. From the above results, the administration of Guibitang, which tonifies the function of the Spleen, could enhance the ability of learning and memory. So it was suggested that the Spleen has a relation with learning and memory.