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Emulsification of Natural Sunscreen with Green Tea Extract : Optimization Using CCD-RSM (녹차추출물이 함유된 천연 자외선차단 크림의 제조: CCD-RSM을 이용한 최적화)

  • Lee, Seung Bum;Zuo, Chengliang;Xu, Yang;Hong, In Kwon
    • Applied Chemistry for Engineering
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    • v.31 no.5
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    • pp.532-538
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    • 2020
  • In this study, emulsification process were conducted to manufacture the natural sunscreen from raw materials such as shea butter, olive emulsifier wax, and green tea extract. The emulsification was optimized by using the central composite design model-response surface methodology (CCD-RSM) where the response values were established as the mean droplet size (MDS) and emulsion stability index (ESI) after 7 days in addition to UV absorbance at 300nm. The amount of emulsifier and additives and emulsification time were established as operating variables and the optimal conditions of sunscreen emulsification were accepted as 3.70, 2.47 wt.%, and 15.42 min, respectively according to the result of CCD-RSM. On the other hand, the response values were estimated as 1173.80 nm and 99.56% for MDS and ESI, respectively, after 7 days, in addition to UV absorbance at 300 nm (2.47). The average error from actual experiments was a low level as about 3.0 ± 1.5%, which is mainly due to the fact that the optimization using CCD-RSM applied in this study was in the relatively high significant level.

Effect of YGF251 on Secretion Of IGF-1 in Human Blood (YGF251 투여에 의한 인체내 혈중의 IGF-1 분비량 변화 효과)

  • 김재수;박준홍;조한성;박점석;홍억기
    • KSBB Journal
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    • v.17 no.4
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    • pp.403-408
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    • 2002
  • For stimulating the in vivo secretion of IGF-1 (insulin-like growth factor-1) which is well known to promote the various physiological actions in human body, the natural herbal extract, YGF251 (young growth factor 251), was developed and evaluated for its effect as IGF-1 secretagogue in this study. The clinical study was peformed as double blind test, and 31 adult female and male volunteers between the age of 40 and 70 were investigated for their changes of concentration of IGF-1 , insulin level, weight, blood pressure, and liver and kidney functions. As the result of paired sample test on the change of the concentration of IGF-1, in YGF251 treated group, it was 245.6 ng/mL before dosing. The concentration of IGF-1 was increased to 269.3 ng/mL after a month and to 275.6 ng/mL after two months, and both were statistically significant (p〈0.05). While in control group, the concentration of IGF-1 was 280.0 ng/mL before dosing, but decreased to 239.2 ng/mL after a month and to 230.2 ng/mL after two months, and both were also statistically significant (p〈0.05). In YGF251 treated group, the concentration of insulin in blood increased about 2 times after a month dosing as an average level, but in control group, it showed a decrease of 36% compared with before dosing. And there were little changes regarding to the measured weight and blood pressure. Various measured data in order to observe the alteration in liver and kidney functions by the administration of YGF251 showed a little change within measuring error range.

The Correlations among the Categorized Quality Cost Factors on SMEs (Small & Medium-sized Enterprises) (중소 제조기업의 품질비용 행태에 관한 실증 연구)

  • Lee, Sang-Choon;Koo, Il-Seob
    • Proceedings of the Safety Management and Science Conference
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    • 2011.04a
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    • pp.731-746
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    • 2011
  • The successful and sustainable growth of SMEs depends on their ability of strengthen their competitiveness in quality and cost and service more than anything else as a fundamental of operation. Among these key competitive factors of SMEs, quality is the most critical factor in manufacturing business fields. Because quality strongly influence cost and service performance on this manufacturing business field. There are many different ways to improve the quality performance but it needs proper management decision to choose the best way what can maximize outputs with minimum inputs. And it needs effective measurement methods and some indicators to analysis the quality performance properly. The quality cost is one of the simplest key indicators to measure the quality performance and the effectiveness of quality related management decisions. The major purpose of this study is to diagnose the categorized current level of actual quality cost of local SMEs to maximize their quality management effectiveness through comparing their level with others what's expressed in early studies. In this study, through survey on local SMEs, we found that their average annual quality cost ratio versus turnover - Total amount of annual quality cost divided by annual turnover - is around 3.69% excluded some SME's performances what have different quality control measures with others. And we found some results what corresponded with the early studies on the correlations between those categorized quality costs factors and some discrepancies between some of the literature model and the early case study results as follows. There were negative correlations between the Prevention costs and the External failure costs, and the Appraisal costs and the External failure costs, and there was positive correlation between the Appraisal costs and Internal failure costs same as early studies. But, we couldn't found any strong negative correlations between the Cost of control - Preventive costs & Appraisal costs - and the Cost of Failure of control - Internal & External failure costs -. It reveals not only the lack of effectiveness on their preventive or appraisal activities but also it can reveal there were so many effective ways to prevent the failure costs properly such as some innovative investment on Factory automation includes Error Proofing and more preventive actions to improve the effectiveness of the typical management methods likes CE (Concurrent Engineering), APQP (Advanced Product Quality Planning), FMEA (Failure Mode & Effect Analysis) etc.

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A Study for how a CEO's moral management influences on his employees' absorbing into their business in a Stock company (증권회사 CEO의 윤리경영이 조직몰입에 미치는 영향 연구)

  • Kang, Chang-Won
    • Journal of Distribution Science
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    • v.6 no.1
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    • pp.63-77
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    • 2008
  • The source of a business competition is man and the core of a business success depends on people's ability, efforts and cooperation. Therefore, modern managers are making varied efforts to perform the ethical management for the organization immersion and job satisfaction of the employees. The managers of the financial agencies including the enterprises competing in the global market, face numerous ethical issues and problems. Considering the reality that financial institutions are actively asked to perform the responsibility and duties sincerely, the tasks how the head of financial agency will accept the social study of the level of ethics and change the level of recognition, and how he will settle it as the natural feature in the institution, become an important management target. In addition, it is necessary to figure out how the ethical management of the head of the financial agency will affect the organizational immersion of the employees. Based on the objective of this study, we attempted to confirm how the ethical management will of the head of the financial institution would affect the organizational immersion, the employees' mental result variables. Through this study, it became necessary for the directors of the financial institutions to search for the methods to improve the system of management and enhance the observance will of the business ethics so that they may not cause the disposition of the violation of the business ethics owing to the enforcement to achieve the target of the results of the business or the error recognition of the norm. Further, the heads of banks will have to set a management policy focused on the democratic management and the ethical justice based on the participating methods to induce the cooperative commitment of the stock company employees not to be shifted from the globalization and the competitive society.

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A Study on the Architecture Modeling of Information System using Simulation (시뮬레이션을 이용한 정보시스템 아키텍쳐 모델링에 관한 연구)

  • Park, Sang-Kook;Kim, Jong-Bae
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2013.10a
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    • pp.455-458
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    • 2013
  • The conventional design of the information system architecture based on the personal experience of information systems has been acted as a limit in progress utilizing appropriate resource allocation and performance improvements. Architecture design depending on personal experience makes differences in variance of a designer's experience, intellectual level in related tasks and surroundings, and architecture quality according to individual's propensity. After all these problems cause a waste of expensive hardware resources. At working place, post-monitoring tools are diversely developed and are running to find the bottleneck and the process problems in the information operation. However, there are no simulation tools or models that are used for expecting and counteracting the problems at early period of designing architecture. To solve these problems we will first develop a simulation model for designing information system architecture in a pilot form, and will verify validity. If an error rate is found in the permissible range, then it can be said that the simulation reflects the characteristic of information system architecture. After the model is developed in a level that can be used in various ways, more accurate performance computation will be able to do, getting out of the old way relying on calculations, and prevent the existence of idle resources and expense waste that comes from the wrong design of architecture.

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Crystal Structure of Fully Dehydrated Partially Cs+-Exchanged Zeolite X, Cs52Na40-X (The Highest Cs+-Exchanged Level Achieved by Conventional Method and Confirmation of Special Site Selectivity)

  • Bae, Myung-Nam
    • Bulletin of the Korean Chemical Society
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    • v.28 no.2
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    • pp.251-256
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    • 2007
  • The crystal structure of fully dehydrated partially Cs+-exchanged zeolite X, [Cs52Na40Si100Al92O384], a = 24.9765(10) A, has been determined by single-crystal X-ray diffraction techniques in the cubic space group Fd3 at 21 °C. The crystal was prepared by flow method for 5 days using exchange solution in which mole ratio of CsOH and CsNO3 was 1 : 1 with total concentration of 0.05 M. The crystal was then dehydrated at 400 °C and 2 × 10-6 Torr for 2 days. The structure was refined to the final error indices, R1 = 0.051 and wR2 (based on F2) = 0.094 with 247 reflections for which Fo > 4σ (Fo). In this structure, about fifty-two Cs+ ions per unit cell are located at six different crystallographic sites with special selectivity; about one Cs+ ion is located at site I, at the centers of double oxygen-rings (D6Rs), two Cs+ ions are located at site I', and six Cs+ ions are found at site II'. This is contrary to common view that Cs+ ions cannot pass sodalite cavities nor D6Rs because six-ring entrances are too small. Ring-opening by the formation of ?OH groups and ring-flexing make Cs+ ions at sites I, I', and II' enter six-oxygen rings. The defects of zeolite frameworks also give enough mobility to Cs+ ions to enter sodalite cavities and D6Rs. Another six Cs+ ions are found at site II, thirty-six are located at site III, and one is located at site III' in the supercage, respectively. Forty Na+ ions per unit cell are located at two different crystallographic sites; about fourteen are located at site I, the centers of D6Rs and twenty-six are also located at site II in the supercage. Cs+ ions and Na+ ions at site II are recessed ca. 0.34(1) A and 1.91(1) A into the supercage, respectively. In this work, the highest exchange level of Cs+ ions per unit cell was achieved in zeolite X by conventional aqueous solution methods and it was also shown that Cs+ ion could pass through the sixoxygen rings.

Generation of Ionospheric Delay in Time Comparison for a Specific GEO Satellite by Using Bernese Software

  • Jeong, Kwang Seob;Lee, Young Kyu;Yang, Sung Hoon;Hwang, Sang-wook;Kim, Sanhae;Song, Kyu-Ha;Lee, Wonjin;Ko, Jae Heon
    • Journal of Positioning, Navigation, and Timing
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    • v.6 no.3
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    • pp.125-133
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    • 2017
  • Time comparison is necessary for the verification and synchronization of the clock. Two-way satellite time and frequency (TWSTFT) is a method for time comparison over long distances. This method includes errors such as atmospheric effects, satellite motion, and environmental conditions. Ionospheric delay is one of the significant time comparison error in case of the carrier-phase TWSTFT (TWCP). Global Ionosphere Map (GIM) from Center for Orbit Determination in Europe (CODE) is used to compare with Bernese. Thin shell model of the ionosphere is used for the calculation of the Ionosphere Pierce Point (IPP) between stations and a GEO satellite. Korea Research Institute of Standards and Science (KRISS) and Koganei (KGNI) stations are used, and the analysis is conducted at 29 January 2017. Vertical Total Electron Content (VTEC) which is generated by Bernese at the latitude and longitude of the receiver by processing a Receiver Independent Exchange (RINEX) observation file that is generated from the receiver has demonstrated adequacy by showing similar variation trends with the CODE GIM. Bernese also has showed the capability to produce high resolution IONosphere map EXchange (IONEX) data compared to the CODE GIM. At each station IPP, VTEC difference in two stations showed absolute maximum 3.3 and 2.3 Total Electron Content Unit (TECU) in Bernese and GIM, respectively. The ionospheric delay of the TWCP has showed maximum 5.69 and 2.54 ps from Bernese and CODE GIM, respectively. Bernese could correct up to 6.29 ps in ionospheric delay rather than using CODE GIM. The peak-to-peak value of the ionospheric delay for TWCP in Bernese is about 10 ps, and this has to be eliminated to get high precision TWCP results. The $10^{-16}$ level uncertainty of atomic clock corresponds to 10 ps for 1 day averaging time, so time synchronization performance needs less than 10 ps. Current time synchronization of a satellite and ground station is about 2 ns level, but the smaller required performance, like less than 1 ns, the better. In this perspective, since the ionospheric delay could exceed over 100 ps in a long baseline different from this short baseline case, the elimination of the ionospheric delay is thought to be important for more high precision time synchronization of a satellite and ground station. This paper showed detailed method how to eliminate ionospheric delay for TWCP, and a specific case is applied by using this technique. Anyone could apply this method to establish high precision TWCP capability, and it is possible to use other software such as GIPSYOASIS and GPSTk. This TWCP could be applied in the high precision atomic clocks and used in the ground stations of the future domestic satellite navigation system.

Comparative Analysis of Export Behaviors of Pyeongtaek-Dangjin Port and Daesan Port (평택.당진항과 대산항의 수출행태의 비교분석)

  • Mo, Soowon
    • Journal of Korea Port Economic Association
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    • v.29 no.3
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    • pp.25-37
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    • 2013
  • This study investigates the export behavior of port of Pyeongtaek-Dangjin and Daesan. The monthly data cover the period from January 2002 to December 2012. This paper tests whether the exchange rate and the industrial production are stationary or not, rejecting the null hypothesis of a unit root in each of the level variables and of a unit root for the residuals from the cointegration at the 5 percent significance level. The error-correction model is estimated to find that Daesan port is faster than Pyeongtaek-Dangjin in adjusting the short-run disequilibrium. This paper finds that the exchange rate coefficient of Daesan port is higher than that of Pyeongtaek-Dangjin port, while the industrial production coefficient of the former is much smaller than that of the latter. The industrial production coefficient is, however, much higher than the exchange rate coefficient in both ports. The rolling regression shows that the influence of exchange rate and industrial production tends to increase in Pyeongtaek-Dangjin port but tends to decrease in Daesan. The impulse response functions indicate that export volumes respond much greater to the positive shocks in industrial production than in exchange rate, and the exchange rate shock decays very fast, while the industrial production shock lasts very long.

Effective PPG Signal Processing Method for Detecting Emotional Stimulus (감성 자극 판단을 위한 효과적인 PPG 신호 처리 방법)

  • Oh, Dong-Gi;Min, Byung-Seok;Kwon, Sung-Oh;Kim, Hyun-Joong
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.37 no.5C
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    • pp.393-402
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    • 2012
  • In this study, we propose a signal processing algorithm to measure the arousal level of a human subject using a PPG(Photoplethysmography) sensor. From the measured PPG signals, the arousal level is determined by PPI(Pulse to Pulse Interval) and discrete-time signal processing. We ran psychophysical experiments displaying visual stimuli on TV display while measuring PPG signal from a finger, where the nature landscape scenes were used for restorative effect, and the urban environments were used to stimulate the stress. However, the measured PPG signals may include noise due to subject movement and measurement error, which results in incorrect detections. In this paper, to mitigate the noise impact on stimulus detection, we propose a detecting algorithm using digital signal processing methods and statistics of measured signals. A filter is adopted to remove a high frequency noise and adaptively designed taking into account the statistics of the measured PPG signals. Moreover we employ a hysteresis method to reduce the distortion of PPI in decision of emotional. Via experiment, we show that the proposed scheme reduces signal noise and improves stimulus detection.

A Study on Real-Time Loudness Metering Algorithm for Digital Broadcasting (디지털 방송용 오디오 레벨 계측 알고리즘의 실시간화 연구)

  • Park Seong-Gyoon
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.16 no.4 s.95
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    • pp.427-437
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    • 2005
  • In this paper, the perceived audio level metering algorithm of digital audio sound to be able to operate in real-time is proposed. Through analyzing a conventional recommendation ITU-RBS1387-I for objective audio quality analysis, FFT-based loudness metering algorithm is implemented and the real-time method of that algorithm was advised and proved. The proposed method is based on look-up table. In order to prove the proved method, using 23 pure tones and 30 preselected digital audio samples, its performance and operation time is evaluated. Its performance, compared with an original algorithm's, have a good figure of less than $2\;\%$ error even if look-up table related with spectral spreading have large level resolution of $10\;\cal{dB}$. The proposed algorithm take only 1/21 of original algorithm's measuring time. Also, in the proposed algorithm auditory pitch group energy calculation take 1/450 of original algorithm's and excitation calculation take 1/3.57. In conclusion, the proposed algorithm is expected to be implemented into DSP-based real-time loudness meter.