• Korean Journal of Clinical Pharmacy
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• v.26 no.4
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• pp.312-317
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• 2016

Objective: Midazolam is mainly metabolized by cytochrome P450 (CYP) 3A. Inhibition or induction of CYP3A can affect the pharmacological activity of midazolam. The aims of this study were to develop a population pharmacokinetic (PK) model and evaluate the effect of CYP3A-mediated interactions among ketoconazole, rifampicin, and midazolam. Methods: Three-treatment, three-period, crossover study was conducted in 24 healthy male subjects. Each subject received 1 mg midazolam (control), 1 mg midazolam after pretreatment with 400 mg ketoconazole once daily for 4 days (CYP3A inhibition phase), and 2.5 mg midazolam after pretreatment with 600 mg rifampicin once daily for 10 days (CYP3A induction phase). The population PK analysis was performed using a nonlinear mixed effect model ($NONMEM^{(R)}$ 7.2) based on plasma midazolam concentrations. The PK model was developed, and the first-order conditional estimation with interaction was applied for the model run. A three-compartment model with first-order elimination described the PK. The influence of ketoconazole and rifampicin, CYP3A5 genotype, and demographic characteristics on PK parameters was examined. Goodness-of-fit (GOF) diagnostics and visual predictive checks, as well as bootstrap were used to evaluate the adequacy of the model fit and predictions. Results: Twenty-four subjects contributed to 900 midazolam concentrations. The final parameter estimates (% relative standard error, RSE) were as follows; clearance (CL), 31.8 L/h (6.0%); inter-compartmental clearance (Q) 2, 36.4 L/h (9.7%); Q3, 7.37 L/h (12.0%), volume of distribution (V) 1, 70.7 L (3.6%), V2, 32.9 L (8.8%); and V3, 44.4 L (6.7%). The midazolam CL decreased and increased to 32.5 and 199.9% in the inhibition and induction phases, respectively, compared to that in control phase. Conclusion: A PK model for midazolam co-treatment with ketoconazole and rifampicin was developed using data of healthy volunteers, and the subject's CYP3A status influenced the midazolam PK parameters. Therefore, a population PK model with enzyme-mediated drug interactions may be useful for quantitatively predicting PK alterations.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.1
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• pp.129-134
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• 2018

Research on the technique for estimating the indoor position has been actively carried out. In particular, the WiFi fingerprint method, which does not require any additional infrastructure, is being partially used because of its high economic efficiency. The KNN method which estimates similar points to the corresponding points by comparing intensity information of the WLAN reception signal measured at various points in advance with intensity information measured at a specific point in the future is simple but has a good performance. However, in the conventional KNN scheme, since the number K of average candidate positions is constant, there is a problem that the position estimation error is not optimized according to a specific point. In this paper, we proposed an algorithm that adaptively changes the K value for each point and applied it to experimental data and evaluated its performance.

• Atmosphere
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• v.24 no.1
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• pp.101-110
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• 2014

This study estimates and evaluates the daily January temperature from 2003 to 2012 with 30 m-resolution over South Korea, using a modified Parameter-elevation Regression on Independent Slopes Model (K-PRISM). Several factors in K-PRISM are also adjusted to 30 m grid spacing and daily time scales. The performance of K-PRISM is validated in terms of bias, root mean square error (RMSE), and correlation coefficient (Corr), and is then compared with that of inverse distance weighting (IDW) and hypsometric methods (HYPS). In estimating the temperature over Jeju island, K-PRISM has the lowest bias (-0.85) and RMSE (1.22), and the highest Corr (0.79) among the three methods. It captures the daily variation of observation, but tends to underestimate due to a high-discrepancy in mean altitudes between the observation stations and grid points of the 30 m topography. The temperature over South Korea derived from K-PRISM represents a detailed spatial pattern of the observed temperature, but generally tends to underestimate with a mean bias of -0.45. In bias terms, the estimation ability of K-PRISM differs between grid points, implying that care should be taken when dealing with poor skill area. The study results demonstrate that K-PRISM can reasonably estimate 30 m-resolution temperature over South Korea, and reflect topographically diverse signals with detailed structure features.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.11
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• pp.2021-2032
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• 1992

A redundant sensor system, which consists of two incremental encoders and a gyro sensor, has been proposed for the estimation of the posture of mobile robots. A hardware system was built for estimating the heading angle change of the mobile robot from outputs of the gyro sensor. The proposed hardware system of the gyro sensor produced an accurate estimate for the heading angle change of the robot. A sensor data fusion algorithm has been developed to find the optimal estimates of the heading angle change based on the stochastic measurement equations of our readundant sensor system. The maximum likelihood estimation method is applied to combine the noisy measurement data from both encoders and gyro sensor. The proposed fusion algorithm demonstrated a satisfactory performance, showing significantly reduced estimation error compared to the conventional method, in various navigation experiments.

• The Journal of the Acoustical Society of Korea
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• v.16 no.6
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• pp.94-99
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• 1997

This paper describes a technique of probabilistic spectral subtraction which uses the knowledge of both noise and speech so as to reduce automatic speech recognition errors in noisy environments. Spectral subtraction method estimates a noise prototype in non-speech intervals and the spectrum of clean speech is obtained from the spectrum of noisy speech by subtracting this noise prototype. Thus noise can not be suppressed effectively using a single noise prototype in case the characteristics of the noise prototype are different from those of the noise contained in input noisy speech. To modify such a drawback, multiple noise prototypes are used in probabilistic subtraction method. In this paper, the probabilistic characteristics of noise and the knowledge of speech which is embedded in hidden Markov models trained in clean environments are used to suppress noise. Futhermore, dynamic feature parameters are considered as well as static feature parameters for effective noise suppression. The proposed method reduced error rates in the recognition of 50 Korean words. The recognition rate was 86.25% with the probabilistic subtraction, 72.75% without any noise suppression method and 80.25% with spectral subtraction at SNR(Signal-to-Noise Ratio) 10 dB.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.2166-2178
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• 2010

The Korea Transportation Database (KTDB) is used to obtain data on the origin and destination (OD) of inter-city travel, which are currently used in railroad planning when estimating traffic demand. The KTDB employs the trip assignment method, whereby the total traffic volume researched for inter-city travel in Korea is divided into road, rail and air traffic, etc. However, as regards rail travel, the railroad stations are not identical to the existing zones or the connector has not been established because there are several stations in one zone as such, certain problems with the applicable methods have been identified. Therefore, estimates of the volume of railroad traffic using the KTDB display low reliability compared to other modes of transportation. In this study, these problems are reviewed and analyzed, and use of the aggregate model method to estimate the direct demand for rail travel is proposed in order to improve the reliability of estimation. In addition, a method of minimizing error in traffic demand estimation for the railroad field is proposed via an analysis of the relationship between the aggregate model and various social-economic indicators including population, distances, numbers of industrial employees, numbers of automobiles, and the extension of roads between cities.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.10 no.5
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• pp.20-30
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• 2007

Environmental Conservation Value Assessment Map (ECVAM) is the class map to divide the national land into conservation areas and development areas based on legal and ecological assessment criteria. It contributes to enhancements of the efficiency and the scientificity when framing a policy in various fields including the environment. However, it is impossible to understand the multiphase vegetation structure as data on judging the national forest class in ECVAM are restricted to areal information of Ecological Nature Status, Degree of Green Naturality and Forest Map. This point drops the reliability of ECVAM. Therefore we constructed vegetation information using LiDAR (Light Detection And Raging) technology. We generated Biomass Class Maps as final results of this study, to introduce the new forest assessment criterion in ECVAM that alternates or makes up for existing forest assessment criteria. And then, we compared these with Forest Map and Landsat TM NDVI image. As a result, biomass classes are generally higher than stand age classes and DBH classes of Vegetation Map, and lower than NDVI of Landsat TM image because of the difference of time on data construction. However distributions between these classes are mostly similar. Therefore we estimates that it is possible to apply the biomass item to the new forest assessment criterion of ECVAM. The introduction of the biomass in ECVAM makes it useful to detect the vegetation succession, to adjust the class of the changed zone since the production of Vegetation Map and to rectify the class error of Vegetation Map because variations on tree heights, forest area, gaps between trees, vegetation vitality and so on are acquired as interim findings in process of computing biomass.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.40 no.4
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• pp.1-9
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• 2003

Many CDMA systems provide pilot channels in order to help channel estimation process. Especially in wideband CDMA systems, the number of receive diversity paths can be large due to small chip duration and high multi-path resolution capability. Hence, the received signal power of each path is small for a given total SNR (signal-to-noise ratio) and the pilot power of each path may not be sufficiently large for accurate channel estimation. When the pilot power is small, one can use decision-directed channel estimation to utilize more energy of the received data. However, the decision errors can deteriorate the quality of decision-directed channel estimation. This paper proposes a novel channel estimation method that optimally utilizes receiver decisions as well as pilot symbols with the help of estimated SER (symbol error rate) and SNR. The proposed method computes two channel estimates using the pilot and the data channel filters and optimally combines them. The simulation results show that the proposed method is robust and outperforms the conventional pilot-symbol-aided channel estimation method.

• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.8
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• pp.18-26
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• 2015

Measuring the heart rate during exercise is important to properly control the amount of exercise. With the recent advent of smart device usage, there is a dramatic increase in interest in devices for the real-time measurement of the heart rate during exercise. During intensive exercise, accurate heart rate estimation from wrist-type photoplethysmography (PPG) signals is a very difficult problem due to motion artifact (MA). In this study, we propose an efficient algorithm for an accurate estimation of the heart rate from wrist-type PPG signals. For the twelve data sets, the proposed algorithm achieves the average absolute error of 1.38 beat per minute (BPM) and the Pearson correlation between the estimates and the ground-truth of heart rate was 0.9922. The proposed algorithm presents the strengths in an accurate estimation together with a fast computation speed, which is attractive in application to wearable devices.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.9
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• pp.1407-1414
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• 2018

Objective: The aim of this study was to estimate (co) variance components and genetic parameters for categorical carcass traits using Bayesian inference via mixed linear and threshold animal models in Anglonubian goats. Methods: Data were obtained from Anglonubian goats reared in the Brazilian Mid-North region. The traits in study were body condition score, marbling in the rib eye, ribeye area, fat thickness of the sternum, hip height, leg perimeter, and body weight. The numerator relationship matrix contained information from 793 animals. The single- and two-trait analyses were performed to estimate (co) variance components and genetic parameters via linear and threshold animal models. For estimation of genetic parameters, chains with 2 and 4 million cycles were tested. An 1,000,000-cycle initial burn-in was considered with values taken every 250 cycles, in a total of 4,000 samples. Convergence was monitored by Geweke criteria and Monte Carlo error chain. Results: Threshold model best fits categorical data since it is more efficient to detect genetic variability. In two-trait analysis the contribution of the increase in information and the correlations between traits contributed to increase the estimated values for (co) variance components and heritability, in comparison to single-trait analysis. Heritability estimates for the study traits were from low to moderate magnitude. Conclusion: Direct selection of the continuous distribution of traits such as thickness sternal fat and hip height allows obtaining the indirect selection for marbling of ribeye.