• BMB Reports
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• v.45 no.12
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• pp.719-723
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• 2012

A close association between the obesity hormone leptin and breast cancer progression has been suggested. The present study investigated the molecular mechanism for enhanced leptin expression in breast cancer cells and its functional significance in breast cancer aggressiveness. We examined whether leptin expression level is affected by the oncoprotein human epidermal growth factor receptor2 (HER2), which is overexpressed in ~30% of breast tumors. Here, we report, for the first time, that HER2 induces transcriptional activation of leptin in MCF10A human breast epithelial cells. We also showed that p38 mitogen-activated protein kinase signaling was involved in leptin expression induced by HER2. We showed a crucial role of leptin in the invasiveness of HER2-MCF10A cells using an siRNA molecule targeting leptin. Taken together, the results indicate a molecular link between HER2 and leptin, providing supporting evidence that leptin represents a target for breast cancer therapy.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.29 no.2
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• pp.39-48
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• 2023

Background: The position of pitcher requires a lot of repetitive motion, and because of this, it is known that not only professional baseball players, but also middle and high school players are frequently exposed to injuries in baseball. The purpose of this study is to examine the differences in upper extremity muscle activity during repeated pitching and the activity of each muscle during repeated pitching by analyzing middle and high school pitchers, divided into groups by age. Methods: Twenty participants (10 middle school male students and 10 high school male students) were recruited for this research. The outcome measures included neuromuscular motor control, including the upper trapezius (UT), triceps brachii (TB), deltoid (DT), latissimus dorsi (LD), biceps brachii (BB), pectoralis major(PM), extensor carpi radialis(ER), and flexor carpi radialis (FR). Results: The two-way analysis of varaince (ANOVA) was used to compare the muscle activity variables between the middle school and high school students. The one-way ANOVA was used to compare the muscle activity variables within time differences each groups. Conclusion: Our results provided promising clinical evidence that guide for upper extremity muscles to increase pitching efficiency in middle and high school base ball players.

• Journal of Animal Science and Technology
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• v.65 no.4
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• pp.838-855
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• 2023

The highly pathogenic avian influenza (HPAI) virus triggers infectious diseases, resulting in pulmonary damage and high mortality in domestic poultry worldwide. This study aimed to analyze miRNA expression profiles after infection with the HPAI H5N1 virus in resistant and susceptible lines of Ri chickens.For this purpose, resistant and susceptible lines of Vietnamese Ri chicken were used based on the A/G allele of Mx and BF2 genes. These genes are responsible for innate antiviral activity and were selected to determine differentially expressed (DE) miRNAs in HPAI-infected chicken lines using small RNA sequencing. A total of 44 miRNAs were DE after 3 days of infection with the H5N1 virus. Computational program analysis indicated the candidate target genes for DE miRNAs to possess significant functions related to cytokines, chemokines, MAPK signaling pathway, ErBb signaling pathway, and Wnt signaling pathway. Several DE miRNA-mRNA matches were suggested to play crucial roles in mediating immune functions against viral evasion. These results revealed the potential regulatory roles of miRNAs in the immune response of the two Ri chicken lines against HPAI H5N1 virus infection in the lungs.