• 약학회지
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• 제33권4호
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• pp.229-236
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• 1989

Even though two different preparations are chemically equivalent, the variance of bioavailability differenciates the clinical effect of preparations, so that the preparations need to be evaluated by comparing bioavailability in vivo as well as chemical equivalence. In this study, bioequivalence tests of commercially available isoniazid tablets A, B, C and D (standard) were performed to give some guidelines to bioequivalence test. The bioavailability parameters obtained by drug administeration were statistically analyzed. Statistical evaluation of the data involved an analysis of variance for a cross over design. Cross over design was employed with 8 healthy volunteers. The results were within 20% difference of mean value in the AUC, Cmax, Tmax and amount of urinary excretion (Au) between standard and isoniazid tablets. The results of ANOVA showed no significant differences for 'group or sequence', but almost not for 'between subjects'. The tablet. A, B and D were within 20 min, but tablet C was within 50 min. Tablet A was biologically equivalent in the Au. tablet B biologically equivalent in the Au and AUC. Tablet C was biologically equivalent in the Au. The relationship between the dissolution rate and Au was significant.

• 전력전자학회논문지
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• 제26권3호
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• pp.167-175
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• 2021

Reusing electric vehicle batteries after they have been retired from mobile applications is considered a feasible solution to reduce the demand for new material and electric vehicle costs. However, the evaluation of the value and the performance of second-life batteries remain a problem that should be solved for the successful application of such batteries. The present work aims to estimate the remaining useful life of Li-ion batteries through the neuro-fuzzy system with the equivalent circuit parameters obtained by Electrochemical Impedance Spectroscopy (EIS). To obtain the impedance spectra of the Li-ion battery over the life, a 18650 cylindrical cell has been aged by 1035 charge/discharge cycles. Moreover, the capacity and the parameters of the equivalent circuit of a Li-ion battery have been recorded. Then, the data are used to establish a neuro-fuzzy system to estimate the remaining useful life of the battery. The experimental results show that the developed algorithm can estimate the remaining capacity of the battery with an RMSE error of 0.841%.

• Smart Structures and Systems
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• 제29권3호
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• pp.485-498
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• 2022

In near-fault earthquake prone areas, the velocity pulse-like seismic waves often results in excessive horizontal displacement for structures, which may result in severe structural failure during large or near-fault earthquakes. The recently developed isolator-gap damper (IGD) systems provide a solution for the large horizontal displacement of long period base-isolated structures. However, the hysteresis characteristics of the IGD system are significantly different from the traditional hysteretic behavior. At present, the hysteretic behavior is difficult to be reflected in the structural analysis and performance evaluation especially under random earthquake excitations for lacking of effective analysis models which prevent the application of this kind of IGD system. In this paper, we propose a mathematical hysteretic model for the IGD system that presents its nonlinear hysteretic characteristics. The equivalent linearization is conducted on this nonlinear model, which requires the variances of the IGD responses. The covariance matrix for the responses of the structure and the IGD system is obtained for random earthquake excitations represented by the Kanai-Tajimi spectrum by solving the Lyapunov equation. The responses obtained by the equivalent linearization are verified in comparison with the nonlinear responses by the Monte Carlo simulation (MCS) analysis for random earthquake excitations.

• Journal of Radiation Protection and Research
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• 제24권3호
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• pp.143-154
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• 1999

Panasonic UD-809P 알비도 중성자 열형광선량계를 팬텀에 장착시켜 원자력발전소에서 중성자 개인선량당량을 측정하였다. 측정된 판독값으로부터 Panasonic 사의 사용자 매뉴얼에 제시되어 있는 방법을 이용하여 열중성자와 초열중성자 및 속중성자로 인한 개인선량당량을 평가하였다. 그 결과 열중성자 성분의 비율이 높은 원자력발전소에서는 속중성자로 인한 개인선량당량을 적절하게 평가할 수 없는 것으로 확인되었는데, 이는 열중성자로 인한 알비도 성분이 열형광선량계로 재입사 되는 양이 이론적인 값과 상당한 차이가 나기 때문인 것으로 추정되었다. 따라서 원자력발전소와 같이 열중성자 성분의 비율이 높은 조건에서 속중성자로 인한 중성자 개인선량당량을 평가하기 위하여 중성자 성분을 열중성자와 속중성자로 구분한 새로운 중성자 선량계산 알고리즘을 제안하였으며, 각각의 성분에 대한 개인선량당량과 교정인자, 민감도 인자 평가공식을 유도하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제32권10호
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• pp.1591-1602
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• 2019

Objective: The present study was conducted to evaluate the antioxidant potential of paneer, a soft cheese supplemented with various water soluble date extracts during storage. Further, the whey obtained from all the paneer samples was also investigated for its antioxidant potential. Methods: The date cultivars were evaluated for their physico-chemical characteristics and date extracts were assessed for their antioxidant potential. Physico-chemical evaluation, microbiological quality and further antioxidant potential of the prepared paneer were carried out during storage period (0 to 8 days, $5^{\circ}C$). Results: All the date extracts were found to have considerable antioxidant activity due to presence of total phenolics and flavonoids. Owing to the presence of phenolics and flavoinds in date extracts, supplemented paneer showed higher trolox equivalent antioxidant capacity, reducing power and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity than control paneer. Paneer supplemented with Rabi extracts had the highest total phenolics ($190.7{\mu}g$ gallic acid equivalent/g paneer), DPPH radical scavenging activity ($928.1{\mu}mol$ equivalent of Trolx/g paneer) and trolox equivalent antioxidant capacity ($9.2{\mu}mol$ equivalent of Trolx/g paneer). The whey obtained from control paneer showed lower values of total phenolics, total flavonoids, DPPH, trolox equivalent antioxidant capacity and reducing power as compared to the values of whey obtained from paneer supplemented with date extracts. Conclusion: Paneer supplemented with date extracts and its whey may offer potent antioxidant activity.

• 대한건축학회논문집:구조계
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• 제36권3호
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• pp.121-128
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• 2020

In this paper, the ASCE 7 equivalent static approach for seismic design of non-structural elements is critically evaluated based on the measured floor acceleration data, theory of structural dynamics, and linear/nonlinear dynamic analysis of three-dimensional building models. The analysis of this study on the up-to-date database of the instrumented buildings in California clearly reveals that the measured database does not well corroborate the magnitude and the profile of the floor acceleration as proposed by ASCE 7. The basic flaws in the equivalent static approach are illustrated using elementary structural dynamics. Based on the linear and nonlinear dynamic analyses of three-dimensional case study buildings, it is shown that the magnitude and distribution of the PFA (peak floor acceleration) can significantly be affected by the supporting structural characteristics such as fundamental period, higher modes, structural nonlinearity, and torsional irregularity. In general, the equivalent static approach yields more conservative acceleration demand as building period becomes longer, and the PFA distribution in long-period buildings tend to become constant along the building height due to the higher mode effect. Structural nonlinearity was generally shown to reduce floor acceleration because of its period-lengthening effect. Torsional floor amplification as high as 250% was observed in the building model of significant torsional irregularity, indicating the need for inclusion of the torsional amplification to the equivalent static approach when building torsion is severe. All these results lead to the conclusion that, if permitted, dynamic methods which can account for supporting structural characteristics, should be preferred for rational seismic design of non-structural elements.

• 치과방사선
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• 제29권2호
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• pp.423-433
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• 1999

Purpose : To assess the methods for the clinical evaluation of the longitudinal bone changes after implantation of tooth ash-plaster mixture into the defect area of human jaws. Materials and methods : Tooth ash-plaster mixtures were implanted into the defects of 8 human jaws. 48 intraoral radiograms taken with copper step wedge as reference at soon, 1st, 2nd, 4th, and 6th week after implantation of mixture were used. X-ray taking was standardized by using Rinn XCP device customized directly to the individual dentition with resin bite block. The images inputted by Quick scanner were digitized and analyzed by NIH image program. Cu­equivalent values were measured at the implanted sites from the periodic digital images. Analysis was performed by the bidirectional subtraction with color enhancement and the surface plot of resliced contiguous image. The obtained results by the two methods were compared with Cu­equivalent value changes. Results : The average determination coefficient of Cu-equivalent equations was 0.9988 and the coefficient of variation of measured Cu values ranged from 0.08~0.10. The coefficient of variation of Cu-equivalent values measured at the areas of the mixture and the bone by the conversion equation ranged from 0.06 ~0.09. The analyzed results by the bidirectional subtraction with color enhancement were coincident with the changes of Cu-equivalent values. The surface plot of the resliced contiguous image showed the three dimensional view of the longitudinal bone changes on one image and also coincident with Cu-equivalent value changes after implantation. Conclusion : The bidirectional subtraction with color enhancement and the surface plot of the resliced contiguous image was very effective and reasonable to analyze clinically and qualitatively the longitudinal bone change. These methods are expected to be applicable to the non-destructive test in other fields.

• 한국지진공학회논문집
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• 제8권1호
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• pp.39-58
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• 2004

성능에 기초한 내진설계 분야에서 구조물의 내진성능평가를 위해서는 비탄성 지진거동을 보다 정확하게 예즉할 필요가 있다. 성능기초 설계기준에 반영되어 있는 내진성능 평가 방법 가운데 하나인 pushover해석을 이용한 방법은 몇몇 연구자들에 의하여 다양한 해석 방법론이 개발되었다. 이 방법을 사용하여 비탄성 전체 또는 국부적 지진응답을 보다 정확하게 평가하기 위해서는 사용되는 횡하중 분배가 구조시스템과 지반운동의 동적특성에 부합되도록 반영되어야 한다. 그리고 구조물의 변형능력을 합리적으로 평가하여 성능점을 보다 정확하게 산정해야 한다. 본 연구에서는 개선된 적응적 횡하중 분배방법과 건물의 등가응답을 이용하여 비탄성 지진응답을 정확하고 효율적으로 평가할 수 있는 방법을 제안하였다. 제안된 방법은 건물의 전체 비탄성 거동에 대한 내진성능을 평가하고 국부적인 비탄성 지진응답을 정확하게 산정하는데 사용될 수 있다. 또한 제안된 방법의 정확성과 타당성을 검증하기 위해서 비탄성 시간이력해석과 기존의 다른 해석방법들에 의한 비탄성 지진응답과 비교하였다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2002년도 춘계학술대회 논문집
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• pp.446-451
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• 2002

Honeycomb structures have advantages in weight reduction with stiffness increment. As far as noise is concerned, however a light aluminum structure, instead of a steel frame, should have an equivalent mass density in order to maintain sound insulation performance. In this paper, an evaluation of a material effect on noise has been examined.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2007년도 추계학술대회논문집
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• pp.421-424
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• 2007

Currently domestic criteria for the aircraft noise is being adapted WECPNL(weighted equivalent continuous perceived noise level), while internationally preferred method is $L_{dn}$ which is based on from $L_{eq}$ and can also evaluate environmental noise. WECPNL used in domestic as an evaluation metric is only for the aircraft noise. It is, therefore, not adequate for the evaluation of residents' injury, moreover, it is very difficult to measure the aircraft noise by WECPNL due to the complicated calculating procedures as long as automatic measuring system is not used. Accordingly, this study aims to propose alternative evaluation metric for the aircraft noise. To achieve this purpose, WECPNL, $L_{eq}$, $L_{dn}$, other metrics and criteria were compared and analyzed.