• KSCE Journal of Civil and Environmental Engineering Research
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• v.14 no.6
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• pp.1365-1373
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• 1994

A Monte-Carlo simulation model, developed to predict size distribution of air bubbles in turbulent shear flow, is applied to a laboratory-scale problem. Sensitivity to various numerical and physical parameters of the model is analyzed. Practical applicability of the model is explored through comparisons of results with experimental measurements. Bubble size increases with air-water discharge ratio and friction factor. Bubble size decreases with increasing mean flow velocity, but the total bubble surface area in the aeration region remains fairly constant. The effect on bubble size distribution of the longitudinal length increment in the simulation model is negligible. A larger radial length increment yields more small and large bubbles and fewer in between. Bubble size distribution is significantly affected by its initial distribution and the location of air injection. Collision efficiency is introduced to explain the discrepancy between collisions with and without coalescence.

• Molecular & Cellular Toxicology
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• v.1 no.2
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• pp.73-77
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• 2005

Nickel is the one of potent environmental, the occupational pollutants and the classified human carcinogens. It is a serious hazard to human health, when the metal exposure. To prevent human diseases from the heavy metals, it is seemingly important that understanding of how nickel exerts their toxicity and carcinogenic effect at a molecular and a genomic level. The process of nickel absorption has been demonstrated as phagocytosis, iron channel and diffusion. Uptaked nickel has been suggested to induce carcinogenesis via two pathways, a direct DNA damaging pathway and an indirect DNA damaging pathway. The former was originated from the ability of metal to generate Reactive Oxygen Species (ROS) and the reactive intermediates to interact with DNA directly. Ni-generated ROS or Nickel itself, interacts with DNAs and histones to cause DNA damage and chromosomal abnormality. The latter was originated from an indirect DNA damage via inhibition of DNA repair, or condensation and methylation of DNA. Cells have ability to protect from the genotoxic stresses by changing gene expression. Microarray analysis of the cells treated with nickel or nickel compounds, show the specific altered gene expression profile. For example, HIF-I (Hypoxia-Inducible Factor I) and p53 were well known as transcription factors, which are upregulated in response to stress and activated by both soluble and insoluble nickel compounds. The induction of these important transcription factors exert potent selective pressure and leading to cell transformation. Genes of metallothionein and family of heat shock proteins which have been known to play role in protection and damage control, were also induced by nickel treatment. These gene expressions may give us a clue to understand of the carcinogenesis mechanism of nickel. Further discussions on molecular and genomic, are need in order to understand the specific mechanism of nickel toxicity and carcinogenicity.

• Journal of the Korea Society of Computer and Information
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• v.17 no.5
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• pp.127-136
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• 2012

This study empirically analyzed which influence the moderating effect of individual characteristics has on adolescents' perceived parenting attitude and school life adjustment. The results showed that parenting attitude positively affected social adjustment; particularly, affection and acceptance had significant effects on academic and social adjustment. As for influence of parenting attitude upon school life adjustment, women showed more significant result than men in schoolwork adjustment, social adjustment, and environmental/general adjustment when attachment factor is high. Also, it could be known that the birth placing moderates the influence upon social adjustment by democratic autonomous parenting attitude and attachment acceptance-based parenting attitude in the parenting attitude.

• Journal of the Korea Concrete Institute
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• v.25 no.5
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• pp.573-581
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• 2013

In this paper, an experimental investigation of bond properties between steel fiber reinforced concrete and glass fiber reinforced polymer reinforcements was performed. The experimental variables were diameter of reinforcements, volume fraction of steel fiber, cover thickness and compressive strength of concrete. Bond failure mainly occurred with splitting of concrete cover. Main factor for splitting of concrete is tension force occurred by the displacement difference between reinforcements and concrete. Therefore, in order to prevent the bond failure between reinforcements and concrete, capacity of tensile strength of concrete cover should be upgraded. As a results of test, volume fraction of steel fiber significantly increases the bond strength. Cover thickness changes the failure mode. Diameter of reinforcements also changes the failure mode. Generally, diameter of reinforcement also affects the bond properties but this effect is not significant as volume fraction of fiber. Increase of compressive strength increases the bond strength between concrete and reinforcement because compressive strength of concrete directly affects the tensile strength of concrete.

• Korean Institute of Interior Design Journal
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• v.24 no.2
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• pp.189-196
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• 2015

In case of Senior Hospitals, meticulous care is required in both amount and quality of natural lighting because of the semi-long term residence of patients. Natural lighting has a huge impact on the physical and psychological part for the seniors. Likewise, natural lighting is an important factor considered for hospital design because it can also effect hospitalization period of patients. Research subject was K Senior Hospital which was determined as the courtyard-type building made to provide healing environment through natural lighting. Analysis was performed by dividing the space of K Senior Hospital into Central Treatment Department directly used by patients, Outpatient Department(OPD), Ward Department, Common Use Department. Research was carried out in two ways of integration value analysis using SPACE SYNTAX and illumination intensity analysis using ECOTECT. K Senior Hospital intended to actively let in natural light through courtyard and to make patients exposed to natural light when they walk along the circuit corridor built around the courtyard. This environmental consideration affected the utilization rate of Common Use Department and residence time of patients raising the average of Common Use Department on every floor. As a resuit of this study presenting type C and type D, part of four types of illumination intensity, takes higher percentage of almost every spaces compare to the others therefore K Senior Hospital was designed on the assumption of healing environment composition through natural light. The result of this research would be used meaningfully in the space programming phase of Senior Hospitals in the future. Utilization rate can be adjusted using illumination intensity value in the space that integration rate should be planed to be high. The use(purpose) of space and integration rate can be used as a guideline to set illumination intensity of natural.

• Journal of Korean Society of Forest Science
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• v.101 no.4
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• pp.656-662
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• 2012

This study has been undertaken to research the characteristics of growth of Pinus thunbergii Parl., which were planted in Uljin-gun, Gyeongbuk, Coast Disaster Prevention Forest. The total amount of 3600 trees of 9 sand dune stabilizing hedges were monitored in the past 4 years. The relationship between tree growth with environmental factors such as wind speed, soil conditions and sand-accumulation fences has been compared and investigated. To increase the growth increment of coastal disaster prevention forests, the development of sand-accumulating fences is the most important factor in controlling wind speed effectively. The monitoring for the maximizing wind-break effect of the sand-accumulating fences should be investigated when building coastal disaster prevention forests.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.5589-5597
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• 2013

The aim of this review article was to evaluate the relationship and the possible etiological mechanisms between endometriosis, leiomyoma (LM) and adenomyosis and gynecological cancers, such as ovarian and endometrial cancer and leiomyosarcoma (LMS). MEDLINE was searched for all articles written in the English literature from July 1966 to May 2013. Reports were collected systematically and all the references were also reviewed. Malignant transformation of gynecologic benign diseases such as endometriosis, adenomyosis and LM to ovarian and endometrial cancer remains unclear. Hormonal factors, inflammation, familial predisposition, genetic alterations, growth factors, diet, altered immune system, environmental factors and oxidative stress may be causative factors in carcinogenesis. Early menarche, low parity, late menopause and infertility have also been implicated in the pathogenesis of these cancers. Ovarian cancers and endometriosis have been shown to have common genetic alterations such as loss of heterozygosity (LOH), PTEN, p53, ARID1A mutations. MicroRNAs have also been implicated in malignant transformation. Inflammation releases proinflammatory cytokines, and activates tumor associated macrophages (TAMS) and nuclear factor kappa b (NF-KB) signaling pathways that promote genetic mutations and carcinogenesis. MED12 mutations in LM and smooth muscle tumors of undetermined malignant potential (STUMP) may contribute to malignant transformation to LMS. A hyperestrogenic state may be shared in common with pathogenesis of adenomyosis, LM and endometrial cancer. However, the effect of these benign gynecologic diseases on endometrial cancer should be studied in detail. This review study indicates that endometriosis, LM, adenomyosis may be associated with increased risk of gynecological cancers such as endometrial and ovarian cancers. The patients who have these gynecological benign diseases should be counseled about the future risks of developing cancer. Further studies are needed to investigate the relationship between STUMPs, LMS and LM and characteristics and outcome endometrial carcinoma in adenomyotic patients.

• Mycobiology
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• v.47 no.4
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• pp.512-520
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• 2019

Statistical experimental methods were used to optimize the medium for mass production of a novel laccase3 (Lac3) by recombinant Saccharomyces cerevisiae TYEGLAC3-1. The basic medium was composed of glucose, casamino acids, yeast nitrogen base without amino acids (YNB w/o AA), tryptophan, and adenine. A one-factor-at-a-time approach followed by the fractional factorial design identified galactose, glutamic acid, and ammonium sulfate, as significant carbon, nitrogen, and mineral sources, respectively. The steepest ascent method and response surface methodology (RSM) determined that the optimal medium was (g/L): galactose, 19.16; glutamic acid, 5.0; and YNB w/o AA, 10.46. In this medium, the Lac3 activity (277.04 mU/mL) was 13.5 times higher than that of the basic medium (20.50 mU/mL). The effect of temperature, pH, agitation (rpm), and aeration (vvm) was further examined in a batch fermenter. The best Lac3 activity was 1176.04 mU/mL at 25 ℃, pH 3.5, 100 rpm, and 1 vvm in batch culture.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.4C
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• pp.159-167
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• 2012

In this study, laboratory model pile-load test and finite element analysis were carried out to compare and analyze the strain behaviour around the model pile tip. In order to simulate the pile load, both the LCM(load control method)and DCM(displacement control method) were introduced to determine which one is appropriate for the FE simulation. In contrast to the previous simulation method, two interface elements around the model pile were used to consider the slip effect in the finite element analysis and its results were compared to the model test. Through this study it was found that the degree of non-associated flow was a dominant factor in terms of numerical solution convergence. In addition, an improved FE mesh was required to obtain the symmetric distribution of the maximum shear strain contour.

• Toxicological Research
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• v.34 no.3
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• pp.241-247
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• 2018

Lactobacillus (LAB) have been reported to exert both harmful and beneficial effects on human and animal health. Recently, it has been reported that dysbiosis and bacterial translocation contribute to liver fibrosis. However, the role of Gram-positive LAB in the situation of chronic liver diseases has not been yet elucidated. Liver injury was induced by bile duct ligation (BDL) in LAB or control-administered mice. Liver fibrosis was enhanced in LAB-administered mice compared with control-treated mice as demonstrated by quantification of Sirius-red positive area, hydroxyproline contents and fibrosis-related genes ($Col1{\alpha}1$, Acta2, Timp1, Tgfb1). Moreover, LAB-administered mice were more susceptible to BDL-induced liver injury as shown by increased ALT and AST level of LAB group compared with control group at 5 days post BDL. Consistent with serum level, inflammatory cytokines ($TNF-{\alpha}$, IL-6 and $IL-1{\beta}$) were also significantly increased in LAB-treated mice. Of note, LAB-treated liver showed increased lipoteichoic acid (LTA) expression compared with control-treated liver, indicating that LAB-derived LTA may translocate from intestine to liver via portal vein. Indeed, responsible receptor or inflammatory factor (PAFR and iNOS) for LTA were upregulated in LAB-administered group. The present findings demonstrate that administration of LAB increases LTA translocation to liver and induces profibrogenic inflammatory milieu, leading to aggravation of liver fibrosis. The current study provides new cautious information of LAB for liver fibrosis patients to prevent the detrimental effect of LAB supplements.