• Biomolecules & Therapeutics
• /
• v.20 no.2
• /
• pp.171-176
• /
• 2012

HaCaT cells are the immortalized human keratinocytes and have been extensively used to study the epidermal homeostasis and its pathophysiology. T helper cells play a role in various chronic dermatological conditions and they can affect skin barrier homeostasis. To evaluate whether HaCaT cells can be used as a model cell system to study abnormal skin barrier development in various dermatologic diseases, we analyzed the gene expression profile of epidermal differentiation markers of HaCaT cells in response to major T helper (Th) cell cytokines, such as $IFN{\gamma}$, IL-4, IL-17A and IL-22. The gene transcriptional profile of cornified envelope-associated proteins, such as filaggrin, loricrin, involucrin and keratin 10 (KRT10), in HaCaT cells was generally different from that in normal human keratinocytes (NHKs). This suggests that HaCaT cells have a limitation as a model system to study the pathophysiological mechanism associated with the Th cell cytokine-dependent changes in cornified envelope-associated proteins which are essential for normal skin barrier development. In contrast, the gene transcription profile change of human ${\beta}2$-defensin (HBD2) in response to $IFN{\gamma}$, IL-4 or IL-17A in HaCaT cells was consistent with the expression pattern of NHKs. $IFN{\gamma}$ also up-regulated transglutaminase 2 (TGM2) gene transcription in both HaCaT cells and NHKs. As an alternative cell culture system for NHKs, HaCaT cells can be used to study molecular mechanisms associated with abnormal HBD2 and TGM2 expression in response to $IFN{\gamma}$, IL-4 or IL-17A.

• Wind and Structures
• /
• v.16 no.1
• /
• pp.61-91
• /
• 2013

An analytical model of internal pressure response of a leaky and quasi-statically flexible building with a dominant opening is provided by including the effect of the envelope external pressure fluctuations on the roof, in addition to the fluctuating external pressure at the dominant opening. Wind tunnel experiments involving a flexible roof and different building porosities were carried out to validate the analytical predictions. While the effect of envelope flexibility is shown to lower the Helmholtz frequency of the building volume-opening combination, the lowering of the resonant peak in the internal and net roof pressure coefficient spectra is attributed to the increased damping in the system due to inherent background leakage and envelope flexibility. The extent of the damping effects of "skin" flexibility and background leakage in moderating the internal and net pressure response under high wind conditions is quantified using the linearized admittance functions developed. Analytical examples provided for different combinations of background leakage and envelope flexibility show that alleviation of internal and net pressure fluctuations due to these factors by as much as 40 and 15% respectively is possible compared to that for a nominally sealed rigid building of the same internal volume and opening size.

• KIEAE Journal
• /
• v.16 no.1
• /
• pp.5-10
• /
• 2016

Purpose: The energy consumption in buildings has continuously increased in some countries and it reaches almost 25% of the total energy use in korea. Therefore there are various efforts to minimize energy consumption in buildings, and the regulations on building envelope insulation have been tightened up gradually. To satisfy the building regulation, the use of vacuum insulation panels(VIPs) is increasing. VIP is a high performance insulation materials, so that it can be thinner than conventional insulation material. When VIP is applied in a building, it may cause thermal bridge, which occurs due to very low thermal conductivity compared to other building materials and the envelope of VIPs. Method: This study designed the capsulized VIPs using conventional insulation for reduction of the thermal bridge. Then designed VIPs were applied to a wall. The linear thermal transmittance and the effective thermal conductivity were analyzed by HEAT2 simulation program for two dimensional steady-state heat transfer. The result compared with a wall with non-capsulized VIPs. Result: It analyzed that the wall with capsulized VIPs had lower linear thermal transmittance and reduced the difference of the effective thermal transmittance with one dimensional thermal transmittance compared to that of the wall with non-capsulized VIPs.

• Wind and Structures
• /
• v.18 no.6
• /
• pp.669-691
• /
• 2014

Since low-rise residential buildings are the most common and vulnerable structures in coastal areas, a reliable prediction of their performance under hurricanes is necessary. The present study focuses on developing a refined finite element model that is able to more rigorously represent the load distributions or redistributions when the building behaves as a unit or any portion is overloaded. A typical 5:12 sloped low-rise residential building is chosen as the prototype and analyzed under wind pressures measured in the wind tunnel. The structural connections, including the frame-to-frame connections and sheathing-to-frame connections, are modeled extensively to represent the critical structural details that secure the load paths for the entire building system as well as the boundary conditions provided to the building envelope. The nail withdrawal, the excessive displacement of sheathing, the nail head pull-through, the sheathing in-plane shear, and the nail load-slip are found to be responsible for the building envelope damage. The uses of the nail type with a high withdrawal capacity, a thicker sheathing panel, and an optimized nail edge distance are observed to efficiently enhance the building envelope performance based on the present numerical damage predictions.

• Architectural research
• /
• v.11 no.2
• /
• pp.1-8
• /
• 2009

In contemporary architecture, glass is being used less as a single piece for the exterior envelope, due to a variety of influences such as increased performance regulations, the market environment and technical developments. An architectural exterior wall today is usually installed as a 'ystem' wall, not as a single plane glass wall. That brings up the necessity to question the appropriateness of the materiality of an individual piece of glass for the exterior envelope in urban settings. Therefore, in many cases it is appropriate to examine materiality of glass as a system. A new examination of materiality can be carried out by analyzing the interactions between layers that constitute a system. This paper examines the experimental use of glass systems in contemporary architecture, and analyzes them to interpret the relationship between the layers of each system in order to establish the diversified materiality of glass in contemporary architecture.

• Proceedings of the IEEK Conference
• /
• 2003.11c
• /
• pp.297-301
• /
• 2003

The binary clipping PW/CDMA system is considered. This system can be constructed with effective cost. leading to reduce the influence of the non-linear amplifier because of converting multi-level signals into constant envelope signals. In addition, the clipping method which is to clip out signal amplitude at some level when multi-level signals are converted into constant envelope signals is used. The multi-level signals are clipped at 1 and -1 to limit the extension of bandwidth and to maintain the bandwidth after clipping. In this paper, the performance of the binary clipping PW/CDMA system with the non-linear amplifier analyzed by simulation over AWGN and flat fading channels respectively. The binary clipping PW/CDMA system with the non-linear amplifier is 2.2dB and 0.9dB better than conventional DS/CDMA system over the flat fading channels when the number of users are 9 and 17 respectively.

• Journal of the Korean Society of Safety
• /
• v.25 no.3
• /
• pp.1-6
• /
• 2010

Ball bearings are one of main components that support the rotational shaft in high speed rotary machinery. So, it is very important to detect the incipient faults and fault growth of bearing since the damage and failure of bearing can cause a critical failures or accidents of machinery system. In the past, many researchers mainly performed to detect the bearing fault using traditional method such as wavelet, statistics, envelope etc in vibration signals. But study on the detection technique for bearing fault growth has a little been performed. In this paper, we verified the possibility for monitoring of fault growth and detection of fault size in bearing outer-race by using the envelope powerspectrum and probabilistic density function from measured vibration signals.

• 한국태양에너지학회:학술대회논문집
• /
• 2008.11a
• /
• pp.251-256
• /
• 2008

Nowaday, The Sustainable Development about global environment is the most important subject. In urban environment, a variety of the nature energy utilization such as the solar energy are the most efficient solution to solve this issue. One of these efficient solutions, a photovoltaic system using sunlight has been introduced to the building with an advantage such as cost-effective, safe for using and good for environment friendly in light with energy utilization. The BIPV is one of the most interesting and promisingly possibilities of an active use of solar energy at the building. Therefore the goal of this study is to get securing the application information of BIPV as finished envelope. The purpose of this study is to investigate the current performance measurement methods of BIPV module and to measure the performance of BIPV module by mock-up tests.

• Journal of electromagnetic engineering and science
• /
• v.15 no.2
• /
• pp.63-75
• /
• 2015

The CMOS power amplifier (PA) is a promising solution for highly-integrated transmitters in a single chip. However, the implementation of PAs using the CMOS process is a major challenge because of the inferior characteristics of CMOS devices. This paper focuses on improvements to the efficiency and linearity of CMOS PAs for modern wireless communication systems incorporating high peak-to-average ratio signals. Additionally, an envelope tracking supply modulator is applied to the CMOS PA for further performance improvement. The first approach is enhancing the efficiency by waveform engineering. In the second approach, linearization using adaptive bias circuit and harmonic control for wideband signals is performed. In the third approach, a CMOS PA with dynamic auxiliary circuits is employed in an optimized envelope tracking (ET) operation. Using the proposed techniques, a fully integrated CMOS ET PA achieves competitive performance, suitable for employment in a real system.

• The Bulletin of The Korean Astronomical Society
• /
• v.44 no.1
• /
• pp.33.1-33.1
• /
• 2019

Protostars grow their mass by the accretion of disk material, which is infalling from the envelope. This accretion process is important to the physical and chemical conditions of the disk and envelope, and thus, the planets yet to be formed from the disk material. Therefore, if we map the physical and chemical properties of disks and envelopes, we can study indirectly the accretion process in star formation. In particular, the chemical distribution in the disk and the inner envelope of a young stellar object is greatly affected by the thermal history, which is mainly determined by the accretion process in the system. In my talk, I will review the episodic accretion model for the low mass star formation and observational efforts to find the evidence of episodic accretion. Finally, I will present our recent ALMA detection of several complex organic molecules associated directly with the planet formation in V883 Ori, which is in the burst accretion phase.