• Korean Journal of Radiology
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• 제22권1호
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• pp.63-71
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• 2021

Objective: To identify the CT findings associated with treatment failure after antibiotic therapy for acute appendicitis. Materials and Methods: Altogether, 198 patients who received antibiotic therapy for appendicitis were identified by searching the hospital's surgery database. Selection criteria for antibiotic therapy were uncomplicated appendicitis with an appendiceal diameter equal to or less than 11 mm. The 86 patients included in the study were divided into a treatment success group and a treatment failure group. Treatment failure was defined as a resistance to antibiotic therapy or recurrent appendicitis during a 1-year follow-up period. Two radiologists independently evaluated the following CT findings: appendix-location, involved extent, maximal diameter, thickness, wall enhancement, focal wall defect, periappendiceal fat infiltration, and so on. For the quantitative analysis, two readers independently measured the CT values at the least attenuated wall of the appendix by drawing a round region of interest on the enhanced CT (HU_post) and non-enhanced CT (HU_pre). The degree of appendiceal wall enhancement (HU_sub) was calculated as the subtracted value between HU_post and HU_pre. A logistic regression analysis was used to identify the CT findings associated with treatment failure. Results: Sixty-four of 86 (74.4%) patients were successfully treated with antibiotic therapy, with treatment failure occurring in the remaining 22 (25.5%). The treatment failure group showed a higher frequency of hypoenhancement of the appendiceal wall than the success group (31.8% vs. 7.8%; p = 0.005). Upon quantitative analysis, both HU_post (46.7 ± 21.3 HU vs. 58.9 ± 22.0 HU; p = 0.027) and HU_sub (26.9 ± 17.3 HU vs. 35.4 ± 16.6 HU; p = 0.042) values were significantly lower in the treatment failure group than in the success group. Conclusion: Hypoenhancement of the appendiceal wall was significantly associated with treatment failure after antibiotic therapy for acute appendicitis.

• 한국음향학회지
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• 제40권6호
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• pp.649-659
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• 2021

벽면 흡음 처리는 잔향의 제어에는 효과적이나, 잔향이 큰 공간의 경우에는 넓은 면적에 대한 적용이 필요하며, 각 벽면의 흡음은 음성 명료도에 다르게 영향을 미친다. 본 연구에서는 실내 음성 명료도의 관점에서 빔포밍 수음장치에 대한 잔향 제어를 위해 흡음 처리가 가장 효과적인 벽을 선택하는 모사 방법을 제안한다. 고정된 위치의 빔포밍 수음어레이에 대해, 화자 혹은 스피커에서 방출된 음향이 각 벽면과 충돌하는 변수를 이용해 벽면 중요도 계수를 정의하고, 이를 이용해 흡음 처리에 따른 수음부의 음성개선 효과를 예측하는 방법을 제시했다. 검증을 위해 체적이 107 m³, 잔향 시간이 1.1 s인 직육면체형 실내공간에 대해 모사 실험을 진행했다. 중요도 계수가 가장 높은 벽면에 헬름홀츠 흡음기를 적용할 때 수정된 음성 명료도는 500 Hz, 1 kHz에서 각각 5.1 dB와 4.8 dB, 또 음성전달 지수는 0.06만큼의 향상이 예측되었는데, 이는 상용코드의 계산 결과와 차이인지 역치(Just-Noticeable Difference, JND) 이내의 차이로 일치했다. 분석결과, 벽면 중요도가 가장 높은 곳에 흡음 처리한 결과는 면적이 가장 넓은 천장에 같은 흡음률을 적용할 때보다 음성 명료도 지수가 JND 이상으로 더 개선되는 것을 알 수 있었다.

• 한국균학회소식:학술대회논문집
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• 한국균학회 2015년도 추계학술대회 및 정기총회
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• pp.23-23
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• 2015

Rice blast disease caused by M. oryzae is the most devastating fungal disease in rice. During the infection process, M. oryzae secretes a large number of glycosyl hydrolase (GH) proteins into the apoplast to digest host cell wall and assist fungal ingress into host tissues. In this study, we identified a novel M. oryze arabinofuranosidase B (MoAbfB) which is secreted during fungal infection. Live-cell imaging exhibited that fluorescent labeled MoAbfB was highly accumulated in fungal invasive structures such as appressorium, tips of penetration peg, biotrophic interfacial complex (BIC), as well as invasive hyphal tip. Deletion of MoAbfB mutants extended biotrophic phase followed by enhanced disease severity, whereas, over-expression of OsMoAbfB mutant induced rapid defense responses and enhanced rice resistance to M. oryzae infection. Furthermore, exogenous treatment of MoAbfB protein showed inhibition of fungal infection via priming of defense gene expression. We later found that the extract of MoAbfB degraded rice cell wall fragments could also induce host defense activation, suggesting that not MoAbfB itself but oligosaccharides (OGs) derived from MoAbfB dissolved rice cell wall elicited rice innate immunity.

• Asian-Australasian Journal of Animal Sciences
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• 제6권2호
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• pp.259-264
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• 1993

Rice straw treated with anhydrous ammonia and/or sulphur dioxide was incubated with rumen liquor for 24 hours and 48 hours to investigate the changes in cell wall structure caused by the treatments and bacterial degradation using scanning electron microscopy (SEM). A less significant tissue loss of untreated rice straw was inspected after incubated for 24 hours and 48 hours. Sulphuration decreased the thickness of sclerenchyma and apparently removed parenchyma tissues. Ammoniation degraded the phloem, and the lignified inner portion of the cell wall was completely, however, little collapsed epidemis and vascular bundles. Ammonia and Sulphur dioxide combined treatment removed the inner layer from outer layer. The extent of apparent degradability following combination treatment was the largest due to the enhanced microbial degradation of sclerenchyma and parenchyma cells.

• 국제초고층학회논문집
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• 제11권4호
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• pp.331-346
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• 2022

Reproducing the horizontally homogeneous atmospheric boundary layer in computational wind engineering is essential for predicting the wind loads on structures. One of the important issues is to use fully developed inflow conditions, which will lead to the consistence problem between inflow condition and internal roughness. Thus, by analyzing the previous results of computational fluid dynamic modeling turbulent horizontally homogeneous atmospheric boundary layer, we modify the past hypotheses, detailly derive a new type of inflow condition for standard k-ε turbulence model. A group of remedial approaches including formulation for wall shear stress and fixing the values of turbulent kinetic energy and turbulent dissipation rate in first wall adjacent layer cells, are also derived to realize the consistence of inflow condition and internal roughness. By combing the approaches with four different sets of inflow conditions, the well-maintained atmospheric boundary layer flow verifies the feasibility and capability of the proposed inflow conditions and remedial approaches.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2002년도 International Meeting on Information Display
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• pp.692-693
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• 2002

Well-aligned multi-wall carbon nanotubes (MWNTs) were fabricated by utilizing a radio frequency plasma-enhanced chemical vapor deposition (rf-PECVD) system from Ni particles at the bottom of anodic alumina nanoholes (AAN). To remove the amorphous graphite layers on the AAN surface and to eliminate the protrusion of MWNT tips, the AAN surface with MWNTs were treated by external rf plasma source. As a result, the AAN surface almost became flat without having any protrusion of MWNT tips. The diameter, length of MWNTs and AAN were investigated by using a scanning electron microscopy (SEM). Raman spectroscopy was also used to characterize wall structure of the carbon nanotube. And the emission properties of the MWNTs were measured for the application of field emission display (FED) in near future.

• Investigative Magnetic Resonance Imaging
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• 제20권1호
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• pp.75-79
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• 2016

We report a case of perivalvular abscess in a 66-year-old man with infective endocarditis, diagnosed by late gadolinium-enhanced (LGE) cardiovascular magnetic resonance (CMR) imaging. No clinical features suspicious of infective endocarditis were noted, however, transthoracic echocardiography revealed non-specific echogenic focal wall thickening at mitral-aortic intervalvular fibrosa. Perivalvular abscess in the aortic valve was demonstrated as focal wall thickening between the anterior mitral leaflet and the non-coronary cusp of the aortic valve with peripheral enhancement and central low signal intensity on LGE CMR imaging. Other features suggestive of infective endocarditis, such as neither vegetation nor valvular perforation were present. The perivalvular abscess did not grow after intensive intravenous antibiotics therapy, and the patient was discharged without surgical treatment. CMR with LGE provided an early accurate diagnosis of perivalvular abscess. The diagnosis of perivalvular abscess using LGE CMR imaging was not previously reported in Korea.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2002년도 International Meeting on Information Display
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• pp.689-691
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• 2002

Well-aligned multi-wall carbon nanotubes (MWCNTs) have been grown on both Coming glass and silicon substrates at about 400 $^{\circ}C$ by a modified plasma - enhanced chemical vapor deposition system. We have investigated laser irradiation effect on carbon nanotube surface by using an ultra - violet laser. The laser operated to modify structural defect of was carbon nanotube and to ablate possible contamination of carbon nanotube surface. The morphology and surface transformation of MWCNTs as analyzed by a SEM. In addition, the field emission measurement was also carried out in a vacuum chamber with a $10^{-7}$ Torr base pressure by applying bias voltages up to 1000V.

• Journal of Microbiology and Biotechnology
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• 제16권2호
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• pp.247-255
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• 2006

Yeast cell wall matrix particles are composed entirely of mannoprotein and ${\beta}-glucan$. The mannoproteins of yeast cell wall can systemically enhance the immune system. We previously purified and analyzed alkali-soluble ${\beta}-glucans$ [${\beta}$-(1,3)- and ${\beta}$-(1,6)-glucans] [10]. In the present study, a wild-type strain was first mutagenized with ultraviolet light, and the cell wall mutants were then selected by treatment with 1.0 mg/ml laminarinase (endo-${\beta}$-(1,3)-D-glucanase). Mannoproteins of Saccharomyces cerevisiae were released by laminarinase, purified by concanavalin-A affinity and ion-exchange chromatography. The results indicated that the mutants yielded 3-fold more mannoprotein than the wild-type. The mannoprotein mass of mutant K48L3 was 2.25 mg/100 mg of yeast cell dry mass. Carbohydrate analysis revealed that they contained mannose, glucose, and N-acetylglucosamine. Saccharomyces cerevisiae cell wall components, mannoproteins, are known to interact with macrophages through receptors, thereby inducing release of tumor necrosis factor alpha ($TNF-{\alpha}$) and nitric oxide. Mannoprotein tractions in the present study had a higher macrophage activity of secretion of $TNF-{\alpha}$ and nitric oxide and direct phagocytosis than positive control ($1{\mu}g$ of lipopolysaccharide). In particular, F1 and F3 fractions in mannoproteins of K48L3 enhanced and upregulated the activity of nitric oxide secretion and macrophage phagocytosis by approximately two- and four-fold, respectively.

• 한국식품영양학회지
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• 제23권2호
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• pp.141-146
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• 2010

Cisplatin(cis-diamminedichloroplatium) is one of the most effective anti-cancer drugs being clinically used in the treatment of solid tumors. Despite its therapeutic benefits, its use in clinical practice is often limited because of dose related toxicity. It is known that yeast cell wall beta-glucans possess immuno-modulating properties, which allows for their application in antitumor therapy. IS2 is a kind of beta-glucan derived from the cell wall of mutated Saccharomyces cerevisiae, which exhibits anti-cancer activity in vitro and in vivo. The present study explored the possibility of combination therapy of IS2 with cisplatin. In experimental metastasis of colon26-M3.1 cells, prophylactic intravenous administration of IS-2 in combination with cisplatin effectively inhibited tumor metastasis compared with cisplatin alone or IS-2 treatment in vivo. IS-2 effectively enhanced Th1 type cytokines including IFN-$\gamma$, IL-2, IL-12 and GM-CSF. Simultaneously, this combined treatment inhibited production of Th2 type cytokines compared with control. These results suggested that IS-2 can be applied in combination therapy with anti-cancer drugs to minimize their side effects.