• Nutrition Research and Practice
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• v.9 no.1
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• pp.71-78
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• 2015

BACKGROUND/OBJECTIVES: The purposes of this study were to compare total energy expenditure (including PAL and RMR) of Korean farmers between the farming season and off farming season and to assess the accuracy of estimated energy requirement (EER) prediction equation reported in KDRIs. SUBJECTS/METHODS: Subjects were 72 Korean farmers (males 23, females 49) aged 30-64 years. Total energy expenditure was calculated by multiplying measured RMR by PAL. EER was calculated by using the prediction equation suggested in KDRIs 2010. RESULTS: The physical activity level (PAL) was significantly higher (P < 0.05) in the farming season (male $1.77{\pm}0.22$, female $1.69{\pm}0.24$) than the off farming season (male $1.53{\pm}0.32$, female $1.52{\pm}0.19$). But resting metabolic rate was significantly higher (P < 0.05) in the off farming season (male $1,890{\pm}233kcal/day$, female $1,446{\pm}140kcal/day$) compared to the farming season (male $1,727{\pm}163kcal/day$, female $1,356{\pm}164kcal/day$). TEE ($2,304{\pm}497kcal/day$) of females was significantly higher in the farming season than that ($2,183{\pm}389kcal/day$) of the off farming season, but in males, there was no significant difference between two seasons in TEE. On the other hand, EER of male and female ($2,825{\pm}354kcal/day$ and $2,115{\pm}293kcal/day$) of the farming season was significantly higher (P < 0.05) than those ($2,562{\pm}339kcal/day$ and $1,994{\pm}224kcal/day$) of the off farming season. CONCLUSIONS: This study indicates that there is a significant difference in PAL and TEE of farmers between farming and off farming seasons. And EER prediction equation proposed by KDRI 2010 underestimated TEE, thus EER prediction equation for farmers should be reviewed.

• BMB Reports
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• v.48 no.12
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• pp.647-654
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• 2015

Energy homeostasis in our body system is maintained by balancing the intake and expenditure of energy. Excessive accumulation of fat by disrupting the balance system causes overweight and obesity, which are increasingly becoming global health concerns. Understanding the pathogenesis of obesity focused on studying the genes related to familial types of obesity. Recently, a rare human genetic disorder, ciliopathy, links the role for genes regulating structure and function of a cellular organelle, the primary cilium, to metabolic disorder, obesity and type II diabetes. Primary cilia are microtubule based hair-like membranous structures, lacking motility and functions such as sensing the environmental cues, and transducing extracellular signals within the cells. Interestingly, the subclass of ciliopathies, such as Bardet-Biedle and Alström syndrome, manifest obesity and type II diabetes in human and mouse model systems. Moreover, studies on genetic mouse model system indicate that more ciliary genes affect energy homeostasis through multiple regulatory steps such as central and peripheral actions of leptin and insulin. In this review, we discuss the latest findings in primary cilia and metabolic disorders, and propose the possible interaction between primary cilia and the leptin and insulin signal pathways which might enhance our understanding of the unambiguous link of a cell's antenna to obesity and type II diabetes.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.1
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• pp.1-9
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• 2019

This paper aims to present a model of obesity and leanness based on eum, yang, ki and blood metabolism of Korean medicine. I analyzed the theory of eum, yang, ki and blood metabolism, yang transforming ki and eum forming the body on Korean medicine, and compared them with energy homeostasis by anabolism and catabolism of modern medicine. In the eum and yang theory, the metabolic process of the human body is dominated by synergism and antagonism between eum force and yang force. When the balance of eum and yang collapses, all the pathological actions of the human body appear, and in the eum and yang metabolic process, an imbalance between yang transforming ki and eum forming the body occurs. The function of yang transforming ki is reduced to ki deficiency, and the function of eum forming the body is increased to blood excess. When blood excess and ki deficiency is given, energy intake increases, energy expenditure decreases, overweight and obesity occur. On the contrary, the function of yang transforming ki is increased to ki excess, and the function of eum forming the body is decreased to blood deficiency. When ki excess and blood deficiency is done, energy intake decreases and energy expenditure increases, the body becomes leanness. When the balance of eum, yang, ki and blood metabolism collapses and becomes blood excess and ki deficiency, overweight and obesity occur, and when ki excess and blood deficiency is done, the body becomes leanness. The energy homeostasis of the human body can be explained by eum, yang, ki and blood metabolism of Korean medicine and it contains the concept of anabolism and catabolism of modern medicine.

• Journal of mucopolysaccharidosis and rare diseases
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• v.2 no.2
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• pp.43-45
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• 2016

Whole body energy balance is achieved through the coordinated regulation of energy intake and energy expenditure in various tissues including liver, muscle and adipose tissues. A positive energy imbalance by excessive energy intake or insufficient energy expenditure results in obesity and related metabolic diseases. Although there have been many obesity treatment trials aimed at the reduction of energy intake, these strategies have achieved only limited success because of their associated adverse effects. Serotonin is among those traditional pharmacological targets for anti-obesity treatment because central 5-HT functions as an anorexigenic neurotransmitter in the brain. Thus, there have been many trials aimed at increasing the activity of 5-HT in the central nervous system, and some of the developed methods are already used in the clinical setting as anti-obesity drugs. However, recent studies suggest the new functions of peripheral serotonin in energy homeostasis ranging from the endocrine regulation by gut-derived serotonin to the autocrine/paracrine regulation by adipocyte-derived serotonin. Pharmacological inhibition of 5-HT synthesis leads to inhibition of lipogenesis in epididymal white adipose tissue (WAT), induction of browning in inguinal WAT and activation of adaptive thermogenesis in brown adipose tissue (BAT). Fat specific Tph1 knock-out (Tph1 FKO) mice exhibit similar phenotypes as mice with pharmacological inhibition of 5-HT synthesis, suggesting the localized effects of 5-HT in adipose tissues. In addition, Htr3a KO mice exhibit increased energy expenditure in BAT and Htr2a KO mice exhibit the decreased lipid accumulation in WAT. These data suggest the clinical significance of the peripheral serotonergic system as a new therapeutic target for anti-obesity treatment.

• Horticultural Science & Technology
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• v.32 no.1
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• pp.123-128
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• 2014

This study investigated the exercise intensity and energy expenditure involved in two gardening activities (planting transplants and sowing seeds in a garden plot) and four common physical activities (running, skipping rope, walking, and throwing a ball) in children. Eighteen children aged 11 to 13 years (mean age, $12.3{\pm}0.7$ years) participated in this study. The children made two visits to a high tunnel in Cheongju, Chungbuk, South Korea and performed randomly selected activities. Each activity was performed for 10 min, with a 5-min rest period between activities. The children wore a Cosmed $K4b^2$ (Cosmed $K4b^2$; Cosmed, Rome, Italy), which is a portable calorimetric monitoring system, to measure indicators of metabolic cost such as oxygen uptake and energy expenditure. The children's heart rates during the activities were measured by radiotelemetry (Polar T 31; FitMed, Kempele, Finland). We found that the two gardening and four physical activities performed by the 11-13 years old children in this study were moderate-to high-intensity physical activities [i.e.,$5.4{\pm}0.7$ to $9.1{\pm}1.4$ metabolic equivalents (METs)]. Running ($9.1{\pm}1.4$ METs) and skipping rope ($8.8{\pm}1.1$ METs) were high-intensity physical activities, whereas walking ($6.1{\pm}0.9$ METs), planting transplants ($5.8{\pm}1.1$ METs), throwing a ball ($5.6{\pm}1.1$ METs), and sowing seeds ($5.4{\pm}0.7$ METs) were moderate intensity physical activities. Running and skipping rope were significantly more intense than the other activities (P < 0.0001). The gardening tasks such as planting transplants and sowing seeds in a garden plot showed similar exercise intensities and energy costs as walking and throwing a ball. This study indicates that gardening can be used as a physical activity intervention to provide health benefits similar to more common physical activities such as walking and running.

• Korean Journal of Exercise Nutrition
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• v.15 no.4
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• pp.163-171
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• 2011

The effects of a high-fat diet and fasting on resting energy expenditure and energy substrate utilization were examined using the method of measuring whole body energy metabolism and oxygen uptake. Eight 4-week old male Sprague-Dawley rats were used for the high-fat diet experiment. Energy metabolism was measured using acrylic metabolic chambers over 24 hours. After 1-week of preliminary feeding, 4 rats were fed a chow diet, whereas the remaining 4 rats were fed a high-fat diet (HF) ad libitum, which contained 40% (w/w, calorie base 60%) more fat than that in the chow diet. The flow rate to measure energy metabolism inside the chamber was controlled at a mean of 3.5 L/min, and five chambers were subjected to measurement. One of the five chambers was used to correct errors by measuring the atmosphere. As a result of 5 weeks of control diet and high-fat diet feeding, body weight of the high-fat diet group tended to increase more than that in the control diet fed group, but the difference was not significant. Oxygen uptake and carbon dioxide production changed as time went on over the 24 hr. The respiratory exchange ratio also changed during the 24 hr, and the difference between the groups was significant. The control group showed significantly more carbohydrate oxidation than that of the high-fat diet fed group. A fasting experiment was conducted using six 7-week old Sprague-Dawley male rats. Energy metabolism measurements were performed using the same method as that used in the high-fat diet experiment; resting metabolism was measured prior to fasting, and a fasting condition began from 9:00 am the next day for 3 days to calculate energy metabolism. Both body weight and 24-hour oxygen uptake decreased significantly as a result of 3-day fasting. Total oxygen uptake in the first day decreased, and declined significantly on day 3 of fasting. Total 24-hour carbon dioxide production decreased significantly over the 3 days. The mean 24-hour respiratory exchange ratio decreased significantly. Additionally, energy expenditure during the dark period (20:00-08:00), which is the active period for rats, decreased significantly with fasting, whereas energy expenditure during the light period (08:00-20:00) did not increase by fasting.

• Journal of Yeungnam Medical Science
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• v.29 no.2
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• pp.73-76
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• 2012

More and more children are becoming obese and overweight due to several factors that include a high energy density in the diet (a high fat intake) and low energy expenditure. Consequently childhood obesity is becoming a significant health problem. Fat tissue releases many cytokines such as resistin, tumor necrosis factor-${\alpha}$, leptin, interleukin-6. These adipocytokines induce obesity-related insulin resistance. Insulin resistance is a key component of obesity-related metabolic problems such as hypertension, type 2 diabetes mellitus, dyslipidemia, non-alcoholic steatohepatitis, acanthosis nigricans and polycystic ovarian syndrome. This review article focused on insulin resistance and its related metabolic diseases.

• Journal of Nutrition and Health
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• v.54 no.2
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• pp.129-138
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• 2021

To set the estimated energy requirement (EER) in Dietary Reference Intakes for Koreans (KDRI), we need the coefficient by physical activity stage, as determined by the physical activity level(PAL). Thus, there has been demand for a tool to calculate PAL based on the physical activity diary. This study was undertaken to develop a physical activity (PA) classification table for Koreans, using the 2011 Compendium of physical activities in the United States. The PA classification table for Koreans contains 262 codes, and values of the metabolic equivalent of task (MET) for specific activities. Of these, 243 PAs which do not have Korean specific data or information, were selected from the 2011 Compendium of PAs that originated in the United States; another 19 PAs were selected from the previous research data of Koreans. The PA classification table is codified to facilitate the selection of energy values corresponding to each PA. The code for each PA consists of a single letter alphabet (activity category) and four numeric codes that display the activity type (2 digit number), activity intensity (1 digit number), and specific activities (1 digit number). In addition, the intensity (sedentary behavior, low, middle and high) of specific PA and its rate of energy expenditure in MET are presented together. The activity categories are divided into 4 areas: Daily Activity (A), Movement (B), Occupation (C), and Exercise and Sports (D). The developed PA classification table can be applied to quantify the energy cost of PA for adults in research or practice, and to assess energy expenditure and physical activity levels based on self-reported PA.

• Proceedings of the KSCN Conference
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• 2005.04a
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• pp.108-108
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• 2005

• Clinical and Experimental Pediatrics
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• v.48 no.2
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• pp.126-137
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• 2005

New insights in the complex metabolic pathways and its control mechanism for energy homeostasis have refined our understanding of the pathophysiology of obesity. It is now recognized that there are several additional regulatory mechanism such as peripheral signals including leptin, ghrelin, GLP-1 and PYY and cellular signals including uncoupling proteins and ${\beta}$ Adrenergic receptors, which contribute to the regulation of food intake and energy expenditure, respectively. In addition, the function of adipocyte as an endocrine organ in energy homeostasis has been recently emphasized. Recent findings suggest that elevated levels of adipokines, such as leptin, adiponectin, resistin and TNF-${\alpha}$, in addition to increased free fatty acid level could be related to the pathophysiology of insulin resistance in obesity. For effective treatments and prevention of obesity, further studies on the circuits of neural and endocrine interactions in the regulation of energy homeostasis are needed.