• 대한기계학회논문집B
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• 제32권6호
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• pp.446-454
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• 2008

The purpose of this paper is to analyze two-phase flows of the hydrogen recirculation system. Two-phase flow modeling is one of the great challenges in the classical sciences. As with most problems in engineering, the interest in two-phase flow is due to its extreme importance in various industrial applications. In hydrogen recirculation systems of fuel cell, the changes in pressure and temperature affect the phase change of mixture. Therefore, two-phase flow analysis of the hydrogen recirculation system is very important. Two-phase computation fluid dynamics (CFD) calculations, using a commercial CFD package FLUENT 6.2, were employed to calculate the gas-liquid flow. A two-phase flow calculation was conducted to solve continuity, momentum, energy equation for each phase. Then, the mass transfer between water vapor and liquid water was calculated. Through an experiment to measure production of liquid water with change of pressure, the analysis model was verified. The predictions of rate of condensed liquid water with change of pressure were within an average error of about 5%. A comparison of experimental and computed data was found to be in good agreement. The variations of performance, properties, mass fraction and two-phase flow characteristic of mixture with resepct to the fuel cell power were investigated.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2004년도 제22회 춘계학술대회논문집
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• pp.848-853
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• 2004

Regarding to the project SUAV (Smart Unmanned Aerial Vehicle) in KARI (Korea Aerospace Research Institute), several engine configurations has been evaluated. However it's not an easy task to collect all the necessary data of each engine for the analysis. Usually, some kind of modeling technique is required in order to determine the unknown data. In the present paper a qualitative method for reverse engineering is proposed, in order to identify some design patterns and relationships between parameters. The method can be used to estimate several parameters that usually are not provided by the manufacturer. The method consists of modeling an existing engine and through a simulation, compare its transient behavior with its operating envelope. In the simulation several parameters such as thermodynamics, performance, safety and mechanics concerning to the definition of operation-envelope, have been discussed qualitatively. With the model, all engine parameters can be estimated with acceptable accuracy, making possible the study of dependencies among different parameters such as power-turbine total inertia, TIT, take-off time and part load, in order to check if the engine transient performance is within the design criteria. For more realistic approach and more detailed design requirements, it will be necessary to enhance the compressor map first, and more realistic estimated values must be taken into account for intake-loss, bleed-air and auxiliary power extraction. The relative importance of these “unknown” parameters must be evaluated using sensitivity analysis in the future evaluation. Moreover, fluid dynamics, thermal analysis and stress analysis necessary for the resulting life assessment of en engine, will not be addressed here but in a future paper. With the methodology presented in the paper was possible to infer the relationships between operation-envelope and engine parameters.

• Genomics & Informatics
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• 제14권2호
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• pp.53-61
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• 2016

Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. T. gondii invades the host cell by forming a moving junction (MJ) complex. This complex formation is initiated by intermolecular interactions between the two secretory parasitic proteins-namely, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2) and is critically essential for the host invasion process. By this study, we propose two potential leads, NSC95522 and NSC179676 that can efficiently target the AMA1 hydrophobic cleft, which is a hotspot for targeting MJ complex formation. The proposed leads are the result of an exhaustive conformational search-based virtual screen with multilevel precision scoring of the docking affinities. These two compounds surpassed all the precision levels of docking and also the stringent post docking and cumulative molecular dynamics evaluations. Moreover, the backbone flexibility of hotspot residues in the hydrophobic cleft, which has been previously reported to be essential for accommodative binding of RON2 to AMA1, was also highly perturbed by these compounds. Furthermore, binding free energy calculations of these two compounds also revealed a significant affinity to AMA1. Machine learning approaches also predicted these two compounds to possess more relevant activities. Hence, these two leads, NSC95522 and NSC179676, may prove to be potential inhibitors targeting AMA1-RON2 complex formation towards combating toxoplasmosis.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2009년도 춘계학술대회 논문집 에너지변화시스템부문
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• pp.29-31
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• 2009

Optimal efficiency control of synchronous reluctance motor(SynRM) is very important in the sense of energy saving and conservation of natural environment because the efficiency of the SynRM is generally lower than that of other types of AC motors. This paper is proposed an efficiency optimization control for the SynRM which minimizes the copper and iron losses. The design of the speed controller based on fuzzy-neural networks (FN)-PI controller that is implemented using fuzzy control and neural networks. There exists a variety of combinations of d and q-axis current which provide a specific motor torque. The objective of the efficiency optimization control is to seek a combination of d and q-axis current components, which provides minimum losses at a certain operating point in steady state. It is shown that the current components which directly govern the torque production have been very well regulated by the efficiency optimization control scheme. The proposed algorithm allows the electromagnetic losses In variable speed and torque drives to be reduced while keeping good torque control dynamics. The control performance of the proposed controller is evaluated by analysis for various operating conditions. Analysis results are presented to show the validity of the proposed algorithm.

• Nuclear Engineering and Technology
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• 제48권6호
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• pp.1349-1359
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• 2016

Alternative control schemes for an Advanced High Temperature Reactor system consisting of a reactor, an intermediate heat exchanger, and a secondary heat exchanger (SHX) are presented in this paper. One scheme is designed to control the cold outlet temperature of the SHX ($T_{co}$) and the hot outlet temperature of the intermediate heat exchanger ($T_{ho2}$) by manipulating the hot-side flow rates of the heat exchangers ($F_h/F_{h2}$) responding to the flow rate and temperature disturbances. The flow rate disturbances typically require a larger manipulation of the flow rates than temperature disturbances. An alternate strategy examines the control of the cold outlet temperature of the SHX ($T_{co}$) only, since this temperature provides the driving force for energy production in the power conversion unit or the process application. The control can be achieved by three options: (1) flow rate manipulation; (2) reactor power manipulation; or (3) a combination of the two. The first option has a quicker response but requires a large flow rate change. The second option is the slowest but does not involve any change in the flow rates of streams. The third option appears preferable as it has an intermediate response time and requires only a minimal flow rate change.

• 대한기계학회논문집B
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• 제41권2호
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• pp.109-115
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• 2017

전산유체해석(CFD) 기법을 이용하여 음극 지지체형 고체산화물 연료전지(SOFC)에 대한 수치해석을 수행하였다. 평판형 구조의 SOFC 에서 가스채널과 리브폭 변화에 따른 성능과 온도균일성에 관한 연구가 이루어졌다. 전산해석 툴로서는 공개소스 전산유체해석 툴박스인 OpenFOAM 을 이용하였다. 수치해석결과, 산소고갈이 일어나지 않는 범위 내에서 가스채널과 리브폭의 증가는 성능과 온도 균일성에 크게 영향을 미치지 않음을 알 수 있었다. 하지만 넓은 리브폭의 사용과 고전류밀도에서의 작동은 산소고갈로 인한 성능저하의 가능성이 있음을 확인하였다.

• Biomolecules & Therapeutics
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• 제27권6호
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• pp.530-539
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• 2019

Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and less on astrocytes which are the most abundant cells in the brain known to be in charge of various functions including the maintenance of brain physical formation, ion homeostasis, and secretion of various extracellular matrix proteins. Altered mitochondrial dynamics, defective mitophagy or mitochondrial damages are causative factors of mitochondrial dysfunction, which is linked to age-related disorders. Etoposide is an anti-cancer reagent which can induce DNA stress and cellular senescence of cancer cell lines. In this study, we investigated whether etoposide induces senescence and functional alterations in cultured rat astrocytes. Senescence-associated ${\beta}$-galactosidase (SA-${\beta}$-gal) activity was used as a cellular senescence marker. The results indicated that etoposide-treated astrocytes showed cellular senescence phenotypes including increased SA-${\beta}$-gal-positive cells number, increased nuclear size and increased senescence-associated secretory phenotypes (SASP) such as IL-6. We also observed a decreased expression of cell cycle markers, including PhosphoHistone H3/Histone H3 and CDK2, and dysregulation of cellular functions based on wound-healing, neuronal protection, and phagocytosis assays. Finally, mitochondrial dysfunction was noted through the determination of mitochondrial membrane potential using tetramethylrhodamine methyl ester (TMRM) and the measurement of mitochondrial oxygen consumption rate (OCR). These data suggest that etoposide can induce cellular senescence and mitochondrial dysfunction in astrocytes which may have implications in brain aging and neurodegenerative conditions.

• 한국기계가공학회지
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• 제18권10호
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• pp.83-92
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• 2019

A pump is considered to be submersible when a motor and a pump are integrated and operate while submerged in water. Submersible pumps mainly function as rejection pumps to prevent foods in densely populated areas, as cold water circulation pumps in large power plants, as pumps to supply irrigation water, as drainage pumps to prevent flooding of agricultural lands, as water supply intake pumps, and as inflow pumps for sewage treatment. The flow in such turbomachines (submersible pumps) inevitably involves various eddy currents. Since it is almost impossible to accurately grasp the complex three-dimensional flow structure and characteristics of a rotating turbomachine through actual testing, three-dimensional numerical analysis using computational fluid dynamics techniques measuring the flow field, velocity, and the pressure can be accurately predicted. In this study, the shape of the impeller was developed to reduce vibration and noise. This was done by increasing the efficiency of the existing submersible pump and reducing turbulence. In order to evaluate the pump's efficiency and turbulence reduction, we tried to analyze the flow using ANSYS Fluent V15.0, a commercial finite element analysis program. The results show that the efficiency of the pump was improved by 4.24% and the Reynolds number was reduced by 15.6%. The performance of a developed pump with reduced turbulence, vibration, and noise was confirmed.

• Smart Structures and Systems
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• 제13권2호
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• pp.177-201
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• 2014

With the increased size and flexibility of the tower and blades, structural vibrations are becoming a limiting factor towards the design of even larger and more powerful wind turbines. Research into the use of vibration mitigation devices in the turbine tower has been carried out but the use of dampers in the blades has yet to be investigated in detail. Mitigating vibrations will increase the design life and hence economic viability of the turbine blades and allow for continual operation with decreased downtime. The aim of this paper is to investigate the effectiveness of Semi-Active Tuned Mass Dampers (STMDs) in reducing the edgewise vibrations in the turbine blades. A frequency tracking algorithm based on the Short Time Fourier Transform (STFT) technique is used to tune the damper. A theoretical model has been developed to capture the dynamic behaviour of the blades including the coupling with the tower to accurately model the dynamics of the entire turbine structure. The resulting model consists of time dependent equations of motion and negative damping terms due to the coupling present in the system. The performances of the STMDs based vibration controller have been tested under different loading and operating conditions. Numerical analysis has shown that variation in certain parameters of the system, along with the time varying nature of the system matrices has led to the need for STMDs to allow for real-time tuning to the resonant frequencies of the system.

• Nuclear Engineering and Technology
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• 제42권4호
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• pp.339-364
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• 2010

Following a joint OECD/NEA-IAEA-sponsored meeting to define the current role and future perspectives of the application of Computational Fluid Dynamics (CFD) to nuclear reactor safety problems, three Writing Groups were created, under the auspices of the NEA working group WGAMA, to produce state-of-the-art reports on different aspects of the subject. The work of the second group, WG2, was to document the existing assessment databases for CFD simulation in the context of Nuclear Reactor Safety (NRS) analysis, to gain a measure of the degree of quality and trust in CFD as a numerical analysis tool, and to take initiatives to extend the existing databases. The group worked over the period of 2003-2007 and produced a final state-of-the-art report. The present paper summarises the material gathered during the study, illustrating the points with a few highlights. A total of 22 safety issues were identified for which the application of CFD was considered to potentially bring real benefits in terms of better understanding and increased safety. A list of the existing databases was drawn up and synthesised, both from the nuclear area and from other parallel, non-nuclear, industrial activities. The gaps in the technology base were also identified and discussed. In order to initiate new ways of bringing experimentalists and numerical analysts together, an international workshop -- CFD4NRS (the first in a series) -- was organised, a new blind benchmark activity was set up based on turbulent mixing in T-junctions, and a Wiki-type web portal was created to offer online access to the material put together by the group giving the reader the opportunity to update and extend the contents to keep the information source topical and dynamic.