• Journal of Chest Surgery
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• 제32권3호
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• pp.310-314
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• 1999

심내막 심근섬유증은 비교적 드문 형태의 심근병증으로 섬유화와 혈전 등에 의해 심실충만의 제한과 심실강 유입부의 폐쇄를 가져온다. 병이 진행하면 심판막까지 침범해 방실판 역류를 일으킨다. 유일한 치료법은 심내막절제술과 판막대치술 등의 수술적 방법이다. 저자들은 수술적 치료를 시행했던 심내막 심근섬유증을 1례 치험하였다. 이에 관련된 문헌과 함께 보고하는 바이다.

• Investigative Magnetic Resonance Imaging
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• 제25권4호
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• pp.332-337
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• 2021

Behçet's disease is a chronic inflammatory disorder involving vessels of various sizes and organs, including the skin, joints, gastrointestinal tract, lungs, and cardiovascular system. The etiology of Behçet's disease is unclear, and clinical diagnosis is important in the absence of definitive laboratory or pathological findings diagnostic of Behçet's disease. Cardiac involvement is rare but might present as endocarditis, myocarditis, pericarditis, or intracardiac thrombosis. This report presents a case of Behçet's disease involving the heart in a 22-year-old man with unusual manifestations of right ventricular fibrosis and intracardiac thrombosis. Cardiac magnetic resonance imaging revealed multiple intracardiac thrombi and delayed diffuse subendocardial enhancement involving the right ventricle. No peripheral eosinophilia was detected. Endomyocardial biopsy showed mixed inflammatory cell infiltrates. Based on the patient's clinical history of oral ulcer and arthritis, a diagnosis of Behçet's disease was made considering the clinical, radiological, and histological findings. Intracardiac thrombi and endomyocardial fibrosis are rare manifestations of Behçet's disease, and the diagnosis is often a clinical challenge. Early diagnosis is important for appropriate management. Behçet's disease should be considered in the differential diagnosis of patients with intracardiac thrombosis and endomyocardial fibrosis of the right chamber.

• Journal of Chest Surgery
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• 제36권7호
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• pp.523-526
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• 2003

환자는 44세 남자로 호흡곤란과 동반된 복부팽만을 주소로 입원하였다. 심초음파상 우심방내의 종괴와 삼첨판막 협착증, 우심실내강의 감소를 관찰할 수 있었다 수술을 시행하여 우심방내의 종괴를 제거하였고 삼첨판막의 개구부를 확장시킴과 동시에 심실내부의 심내막절제술을 시행하였다. 또한 우심방의 용적부하를 낮추기 위해 심방중격결손을 만들어주었다. 술 후 환자는 증세의 호전을 보였고 별다른 문제없이 퇴원하였고 조직검사상 진단은 심근내막섬유증으로 내려졌다. 술 후 18개월 뒤 환자는 진행된 호흡곤란과 청색증으로 인해 다시 입원하였고 심초음파를 시행하여 우심실내강이 이전보다 더 좁아져 있으며 폐동맥의 혈류가 거의 없음을 확인하였다. 기능적 단 심실 상태였기 때문에 양 방향성 상대정맥폐동맥 단락수술을 시행하였고 술 후 호흡곤란과 청색증은 많은 호전을 보였다. 진행된 우심실의 심근내막섬유증에서 양 방향성 상대정맥-폐동맥 단락수술의 시행은 술 후 초기에 효과적인 증상완화를 제공하지만 장기간의 추적관찰이 요구된다.

• The Korean Journal of Physiology and Pharmacology
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• 제25권6호
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• pp.533-543
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• 2021

Myocardial fibrosis (MF) is the result of persistent and repeated aggravation of myocardial ischemia and hypoxia, leading to the gradual development of heart failure of chronic ischemic heart disease. Triptolide (TPL) is identified to be involved in the treatment for MF. This study aims to explore the mechanism of TPL in the treatment of MF. The MF rat model was established, subcutaneously injected with isoproterenol and treated by subcutaneous injection of TPL. The cardiac function of each group was evaluated, including LVEF, LVFS, LVES, and LVED. The expressions of ANP, BNP, inflammatory related factors (IL-1β, IL-18, TNF-α, MCP-1, VCAM1), NLRP3 inflammasome factors (NLRP3, ASC) and fibrosis related factors (TGF-β1, COL1, and COL3) in rats were dete cted. H&E staining and Masson staining were used to observe myocardial cell inflammation and fibrosis of rats. Western blot was used to detect the p-P65 and t-P65 levels in nucleoprotein of rat myocardial tissues. LVED and LVES of MF group were significantly upregulated, LVEF and LVFS were significantly downregulated, while TPL treatment reversed these trends; TPL treatment downregulated the tissue injury and improved the pathological damage of MF rats. TPL treatment downregulated the levels of inflammatory factors and fibrosis factors, and inhibited the activation of NLRP3 inflammasome. Activation of NLRP3 inflammasome or NF-κB pathway reversed the effect of TPL on MF. Collectively, TPL inhibited the activation of NLRP3 inflammasome by inhibiting NF-κB pathway, and improved MF in MF rats.

• Journal of Chest Surgery
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• 제20권3호
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• pp.489-497
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• 1987

Six hundred and twenty two cases of open heart surgery were performed at Sejong General Hospital in 1986. And also, 117 cases of non open heart cardiac surgery had been performed during same period. Among the 622 open heart cases, 548 were congenital cardiac diseases and 74 were acquired heart diseases. In congenital heart patients, 422 were acyanotic and 126 were cyanotic. There were 52 cases of infant open heart Surgery below 12 months. Acyanotic group were consisted of 314 VSD, 66 ASD, 13 AVSD, 9 PDA, 8 ASD + PS, 4 AS, and 8 other rare cardiac cases. And cyanotic group were consisted of 84 TOF, 15 DORV, 5 Trilogy, 4 Ebstein`s anomaly, 3 PS + TR, 3 TGA, 3 TAPVR, 3 Pulmonary atresia and 6 other rare cardiac diseases. Majority of the acquired heart cases were valvular heart diseases. And there were also 4 cardiac myxoma and one endomyocardial fibrosis in acquired heart disease group. The operative results were as follows: Overall operative mortality, 5.3%: acyanotic 2.4%: cyanotic 15.8% and acquired heart disease, 8.5%.

• Journal of Yeungnam Medical Science
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• 제29권2호
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• pp.118-120
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• 2012

Loeffler's endocarditis involves progressive eosinophilic infiltration of the endocardium, which leads to apical thrombotic obliteration of the ventricle and endomyocardial fibrosis, that may finally represent a characteristic feature of restrictive cardiomyopathy. This paper presents a case of a 44-year-old male with symptoms of dyspnea and peripheral hypereosinophilia, who was diagnosed with early stage Loeffler's endocarditis via multicardiac imaging modalities.