• Title/Summary/Keyword: Endogenous development

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Cost Driver Analysis in General Hospitals Using Simultaneous Equation Model and Path Model (연립방정식모형과 경로모형을 이용한 종합병원의 원가동인 분석)

  • 양동현;이원식
    • Health Policy and Management
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    • v.14 no.1
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    • pp.89-120
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    • 2004
  • The purpose of this empirical study is to test hypotheses in order to identify the cost drivers that drive indirect costs in general hospitals in Korea. In various cases' studies, it has been suggested that overhead costs are driven by volume and complexity variables, how they are structurally related and how the cost impacts of these variables can be A unique feature of the research is the treatment of complexity as an endogenous variable. It is hypothesized that level of hospital complexity in terms of the number of services provided(i.e., “breath" complexity) and the intensity of individual estimated in practice. overhead services(ie., “depth" complexity) are simultaneous determined with the level of costs needed to support the complexity. Data used in this study were obtained from the Database of Korean Health Industry Development Institute, Health Insurance Review Agency and analyzed using simultaneous equation model, path model. The results found those volume and complexity variables are all statistically signi-ficance drivers of general hospital overhead costs. This study has documented that the level of service complexity is a significant determinant of hospital overhead costs, caution should be exercised in interpreting this as supportive of the cost accounting procedures associated with ABC. with ABC.

Growth Regulators Prolong Bract Longevity of Potted Bougainvillea

  • Liu, Fang-Yin;Chang, Yu-Sen
    • Horticultural Science & Technology
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    • v.29 no.4
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    • pp.326-335
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    • 2011
  • When bougainvilleas are subjected to indoor low-light conditions, flower bracts regularly abscise. This study elucidates the effects of plant growth regulators on bract longevity of potted bougainvillea. Potted 'Taipei Red' bougainvillea in four different bract development stages were treated with 1-MCP (1-methylcyclopropene), NAA (1-naphthaleneacetic acid), SNA (sodium salt of naphthaleneacetic acid), IBA (indolebutyric acid), BA (6-benzylaminopurine), $KH_2PO_4$ (potassium dihydrogen phosphate), Put (diamine putrescine), SA (salicylic acid), or STS (silver thiosulfate) and were moved to indoor low-light conditions after treatments. Experimental results indicate that 1-MCP, NAA, SNA, BA, Put, and SA prolonged bract longevity, and this effect increased as bract stage increased. The effect of STS was significant in early bract stages and decreased as bract stages increased. Additionally, 1-MCP, NAA, SNA, BA, Put, SA, and STS treatment significantly reduced endogenous ACC (1-aminocyclopropene-1-carboxylate) content and ACC oxidase activity, suggesting that the inhibition of ethylene production was achieved via physiological metabolism. However, treatment with IBA or $KH_2PO_4$ had no effect on the bract longevity at any stage. In the combined chemical treatments, NAA + STS or NAA + SA were effectively for prolonging bract longevity and contained less protein or chlorophyll degradation, decrease ACC oxidase or ethylene production than the control. In conclusion, we propose that combined chemical treatment significantly prolonged the bract longevity and more effectively than single chemical treatment at any stage.

Effects of Light on the Expression of 1-Aminocyclopropane-1-Carboxylic Acid Synthase and Oxidase Genes in Mung Bean Hypocotyls

  • Song, Ju-Dong;Lee, Dong-Hee;Rhew, Tae-Hyong;Lee, Choon-Hwan
    • Journal of Photoscience
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    • v.10 no.2
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    • pp.189-193
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    • 2003
  • The effects of light on the regulation of ethylene biosynthesis during development of mung bean seedlings were investigated by monitoring the differential expression of seven 1-aminocyclopropane-l-carboxylate (ACC) synthase and two ACC oxidase genes. Among them, only the expression of VR-ACS1, VR-ACS6, VR-ACS7, VR-ACO1 and VR-AC02 was observable in etiolated mung bean hypocotyls. When the seedlings were de-etiolated for 1 d under a light/dark cycle of 16 h/8 h, the expression of VR-ACS6, VR-ACS7 and VR-ACO2 was controlled negatively by light. The expression of VR-ACS1 showed a tendency to increase until 6 h after a dark-to-light transition and then decreased at 12 h. On the other hand, the expression of VR-ACO1 was mostly constitutive up to 12 h after the dark-to-light transition. The opening of hypocotyl hooks during de-etiolation in the light was stimulated by the inhibition of the action of endogenous ethylene in the presence of 1-MCP. These results suggest that the negative regulation of light on the expression of ACC synthase and ACC oxidase genes eventually results in the inhibition of ethylene production with an acceleration of the opening of apical hooks.

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Evaluation of Lactic Acid Bacteria for the Resistance to Endocrine Disruptors

  • Kim, Su-Won;Min, Byung-Tae;Yoo, Min
    • Biomedical Science Letters
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    • v.8 no.2
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    • pp.95-99
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    • 2002
  • Endocrine disruptors are chemicals which can be found in our normal daily life. They can be easily ingested through plastic food containers, pesticides, etc. They include DDT, bisphenol A, benzophenone and phenylphenol, etc. Endocrine disruptor can be very harmful and toxic because it disrupts the normal function of the endogenous endocrine system. It has been reported that endocrine disruptor can cause the fatal strike in reproductive system central nervous system and the other part of the body. We have examined if the growth of lactic acid bacteria could be resistant to the endocrine disruptor. We have used Lactobacillus delbruekii as an experimental strain and benzophenone and phenylphenol for the comparison purpose. Experiments included the evaluation of turbidity, absorbance and actual cell counts. Although Lactobacillus delbruekii showed the higher resistance to benzophenone than phenylphenol it was still resistant to both benzophenone and phenylphenol. Because the experimental concentrations of benzophenone and phenylphenol were so high to compare with the actual concentration we meet in daily life, Lactobacillus delbruekii was considered to be sufficient to survive in the environmental concentration of these endocrine disruptors. This study should contribute to the development of fermented beverage with beneficial effect by lactic acid bacteria.

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A Study on the Developmental Direction with Reference to User's Satisfaction of Urban Park -Cases study of Daeshin Natural Park in Pusan City- (도시공원 이용만족도에 기초한 도시공원의 개발방향에 관한 연구 - 부산시 대신자연공원을 사례로-)

  • 임승범
    • Journal of the Korean Institute of Landscape Architecture
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    • v.19 no.3
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    • pp.87-97
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    • 1991
  • The primary purpose of this study is to investigate factors and variables which have significant effects on user's satisfaction with recreational activities in Daeshin Natural Park, thereby establishing directions of development of urban parks. To test the causal models of this research, the data were gathered by self-administered questionnaires form 627 households in Pusan City which were selected by the multi-stage probability sampling method. The analysis of the data primarily consists of two-phase: The first analysis dealt exploratory factor analysis which identified major factors involved in satisfaction with recreational activities in Daeshin Natural Park and the second analysis tested the fit of the causal models of this research by employing LISREL methodology. The factor analysis identified that three factors are involved in satisfaction with recreational actitives. The three factors of satisfaction with recreational activities are facilities for health and phisical exercise, group recreational activity, maintenance activity. The second phase analysis tested the fit of the causal models for satisfaction with recreational activity to the data and identified statistically significant causal linkage among overall satisfaction with Daeshin Natural Park, other endogenous factors and exogenous variables.

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Protective Activity of Seolitae Chungkukjang Added with Green Tea against Cellular Oxidative Stress induced by AAPH

  • Park, Hyun-Young;Lee, Hee-Seob;Cho, Eun-Ju
    • Preventive Nutrition and Food Science
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    • v.14 no.1
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    • pp.37-42
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    • 2009
  • The protective activity of seolitae chungkukjang added with green tea against oxidative stress was investigated under the cellular systems using LLC-$PK_1$ cells. The treatment of 2,2'-azobis(2-aminopropane) dihydrochloride (AAPH) showed increase in lipid peroxidation, and decrease in endogenous antioxidant enzymes activity and cell viability. However, the methanol extract of seolitae chungkukjang inhibited lipid peroxidation by 58.3%, and increased cell viability up to more than 60%. In addition, it enhanced superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities. Seolitae chungkukjang improved oxidative stress-induced cellular injury through the radical scavenging activities. In particular, the addition of green tea in seolitae chungkukjang showed stronger effect against oxidative stress induced by AAPH. The more addition of green tea resulted in the greater antioxidative effect through elevation in activities of SOD and GSH-Px, and inhibition of lipid peroxidation, eventually leading to increase in cell viability. Theses results suggested that seolitae chungkukjang added with green tea have protective effects from cellular oxidative damage and could be considered as an application for the development of chungkukjang with functionality.

Heat Shock Proteins as Molecular Chaperons in Neuropsychiatry (열충격 단백질의 신경정신의학적 의의와 중요성)

  • Oh, Dong-Hoon;Yang, Byung-Hwan;Choi, Joonho
    • Korean Journal of Biological Psychiatry
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    • v.14 no.4
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    • pp.221-231
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    • 2007
  • Recent researches have shown that important cellular-based autoprotective mechanisms are mediated by heat-shock proteins(HSPs), also called 'molecular chaperones'. HSPs as molecular chaperones are the primary cellular defense mechanism against damage to the proteome, initiating refolding of denatured proteins and regulating degradation after severe protein damage. HSPs also modulate multiple events within apoptotic pathways to help sustain cell survival following damaging stimuli. HSPs are induced by almost every type of stresses including physical and psychological stresses. Our nervous system in the brain are more vulnerable to stress and damage than any other tissues due to HSPs insufficiency. The normal function of HSPs is a key factor for endogenous stress adaptation of neural tissues. HSPs play an important role in the process of neurodevelopment, neurodegeneration, and neuroendocrine regulation. The altered function of HSPs would be associated with the development of several neuropsychiatric disorders. Therefore, an understanding of HSPs activities could help to improve autoprotective mechanism of our neural system. This paper will review the literature related to the significance of HSPs in neuropsychiatric field.

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Expression level and glycan dynamics determine the net effects of TIMP-1 on cancer progression

  • Kim, Yong-Sam;Kim, Sun-Hee;Kang, Jeong-Gu;Ko, Jeong-Heon
    • BMB Reports
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    • v.45 no.11
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    • pp.623-628
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    • 2012
  • Tissue inhibitor of metalloproteinases (TIMPs; TIMP-1, -2, -3 and -4) are endogenous inhibitor for matrix metalloproteinases (MMPs) that are responsible for remodeling the extracellular matrix (ECM) and involved in migration, invasion and metastasis of tumor cells. Unlike under normal conditions, the imbalance between MMPs and TIMPs is associated with various diseased states. Among TIMPs, TIMP-1, a 184-residue protein, is the only N-linked glycoprotein with glycosylation sites at N30 and N78. The structural analysis of the catalytic domain of human stromelysin-1 (MMP-3) and human TIMP-1 suggests new possibilities of the role of TIMP-1 glycan moieties as a tuner for the proteolytic activities by MMPs. Because the TIMP-1 glycosylation participate in the interaction, aberrant glycosylation of TIMP-1 presumably affects the interaction, thereby leading to pathogenic dysfunction in cancer cells. TIMP-1 has not only the cell proliferation activities but also anti-oncogenic properties. Cancer cells appear to utilize these bilateral aspects of TIMP-1 for cancer progression; an elevated TIMP-1 level exerts to cancer development via MMP-independent pathway during the early phase of tumor formation, whereas it is the aberrant glycosylation of TIMP-1 that overcome the high anti-proteolytic burden. The aberrant glycosylation of TIMP-1 can thus be used as staging and/or prognostic biomarker in colon cancer.

Photodynamic Action by Endogenous Non-Chlorophyll Sensitizer As a Cause of Photoinhibition

  • Suh, Hwa-Jin;Kim, Chang-Sook;Jin Jung
    • Journal of Photoscience
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    • v.7 no.3
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    • pp.87-95
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    • 2000
  • As sunlight not always optimized for every terrestrial plant in terms of light quality, quantity and duration, some plants suffer detrimental effects of sunlight exposure under certain conditions. Photoinhibition of photosynthesis is a typical phenomenon representing harmful light effects, commonly observed in many photosynthetic organisms. It is generally accepted that functional, structural loss of photosystem II complex(PSII) is the primary event of photoinhibition. Accumulating data also suggest that singlet oxygen($^1$O$_2$) is the main toxic species directly involved in it. There are two different views on the specific site and mechanism of $^1$O$_2$ production in the photosynthetic membrane. One of them favors the PSII reaction center, where the primary charge pairs recombination occurs as a prerequisite for the generation of $^1$O$_2$, and the other inclines to photosensitized $^1$O$_2$ formation by a substance located outside PSII. This article describes how we, as the advocators of the latter concept, have arrived at the conclusion that $^1$O$_2$ immediately involved in PSII photodamage is largely generated from the Rieske center of the cytochrome b$_{6}$/f complex and diffuses into PSII, attacking the reaction center subunits.s.

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Light-Dark and Food Restriction Cycles in Red sea bream, Pagrus major: Effect of Zeitgebers on Demand-feeding Rhythms

  • Choe Yong-Gwon;Choi Jae-Eun;Roh Duk-Whan;Bae Bong-Seong;Choi Cheol-Young
    • Fisheries and Aquatic Sciences
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    • v.4 no.3
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    • pp.138-143
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    • 2001
  • Red sea bream, Pagrus major a fish species characterized by its dualistic feeding pattern, was investigated to study the synchronizing effect of light and food on the demand-feeding rhythm. Nocturnal and diurnal red sea bream, both in groups and individually, were exposed to restricted-feeding and Light-Dark cycles of different periods. The phase relationship between both zeitgebers was also studied. In some cases, food availability restricted to the light or dark phase contrary to that of the previous feeding phase changed a diurnal feeding pattern into nocturnal and vice versa, suggesting that food can be one of the switching factors that decides whether the circadian system of red sea bream is diurnal or nocturnal. However, the fact that the feeding pattern of some fish was unrelated with the phase in which food was available suggests that other internal and/or external-factors could be involved in the temporal flexibility of red sea bream.

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