• 원예과학기술지
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• 제29권1호
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• pp.1-9
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• 2011

본 연구는 한지형 마늘인 '의성마늘'을 이용하여 장일과 단일 조건에서 재배하여 마늘의 인경 분화 및 비대에 미치는 식물 생장 물질의 역할에 대해서 조사하였다. 한지형 마늘의 인경 분화기(4월 16)부터 인경 비대기(4월 24일, 5월 18일)에 엽신과 엽초내 식물내생호르몬 abscisic acid (ABA), jamonic acid(JA) 및 당 함량변화는 장일조건에서 ABA 함량이 단일조건에서 ABA 함량보다 높았고, 엽초내 ABA 함량이 엽신내 ABA 함량보다 높은 것으로 조사되었다. 마늘생육시기별 ABA 함량은 인편 분화기에서 인경 비대개시기까지는 큰 변화가 없다가 인경 비대개시기(5월 2일) 이후부터 인경이 비대 되는(5월 18일) 동안 그 함량이 현저히 증가하는 것으로 조사되었다. 반면 단일조건에서는 내생 JA 함량은 변화가 없었으나, 장일조건에서는 인편 분화기(4월 16일)부터 인경 비대개시기(5월 2일)까지 JA 함량은 증가되었다. 엽초내 JA 함량($30.19-53.19ng{\cdot}g^{-1}$ DW)은 엽신내 JA 함량($12.82-20.41ng{\cdot}g^{-1}$ DW)보다 높은 것으로 조사되어 엽초 내 JA 함량에 의해 마늘의 인경 비대가 유도되는 것으로 조사되었다. 장일 조건에서 엽신내 당 함량은 인편 분화기(4월 16일)부터 인경 비대개시기(5월 4일)까지 증가되었고, 인경 비대기(5월 4일에서 5월 8일) 동안 감소하였으나, 엽초내 당 함량은 인편 분화기(4월 16일)부터 인경 비대기(5월 18일)까지 서서히 증가되었다. 결론적으로 한지형 의성마늘 생장양상에 따라 엽초내 호르몬도 변화하는 경향을 보여 호르몬 변화가 마늘 생장과 밀접한 연관이 있음을 보여주었다.

• Molecules and Cells
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• 제41권12호
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• pp.1072-1080
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• 2018

A plant-specific B3 domain and AP2 domain-containing transcription factor, RAV1 acts as a negative regulator of growth in many plant species and its transcription was down-regulated by BR and ABA. In this study, we found that RAV1-overexpressing transgenic plants showed abnormally developed ovules, resulting in reduced seed size, weight, and number in a silique. Interestingly, the endogenous expression of RAV1 fluctuated during seed development; it remained low during the early stage of seed development and sharply increased in the seed maturation stage. In plants, seed development is a complex process that requires coordinated growth of the embryo, endosperm, and maternal integuments. Among many genes that are associated with endosperm proliferation and embryo development, three genes consisting of SHB1, MINI3, and IKU2 form a small unit positively regulating this process, and their expression was regulated by BR and ABA. Using the floral stage-specific RNAs, we found that the expression of MINI3 and IKU2, the two downstream genes of the SHB1-MINI3-IKU2 cascade in the seed development pathway, were particularly reduced in the RAV1-overexpressing transgenic plants. We further determined that RAV1 directly binds to the promoter of MINI3 and IKU2, resulting in their repression. Direct treatment with brassinolide (BL) improved seed development of RAV1-overexpressing plants, but treatment with ABA severely worsened it. Overall, these results suggest that RAV1 is an additional negative player in the early stages of seed development, during which ABA and BR signaling are coordinated.

• World Technopolis Review
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• 제6권2호
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• pp.148-158
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• 2017

Sejong City, which has been chosen as a new administrative capital of South Korea, has completed the first phase of its development plan with the construction of the facilities needed to accommodate central administrative organizations and the required accompanying population. Now, it is undergoing the second phase of development with a focus on strengthening the region's innovation capacity to catalyze endogenous development. The strategy for phase II is to establish a regional innovation system including building necessary infrastructure and attracting innovation agents such as universities, businesses, and research institutes. The first step for this is developing a research complex, tentatively named Tech Valley, that includes universities, research institutes, and businesses, and building infrastructure comprising a science complex, a knowledge industry center, and support facilities. Phase II of the city's development initiative includes the establishment of a joint university campus, which is to serve as a center to promote cooperation among industry actors, universities, and research institutes. The concept of a joint campus has been drawn from a need to enhance capacity for innovation and specialization in the region's industries and to maximize synergy among participating universities through the sharing of research equipment, facilities, and programs. The joint campus is expected to play a key role in creating an innovation system in the region by enhancing research capacity for strategic industries, cultivating highly skilled human resources, and leading industry-academia-research cooperation. In order to ensure the sustainable development of the new city, there is a growing need to have a main player in place that could lead the region's economic development. The joint campus will propel industrial specialization and serve as a catalyst to attract competent universities to the region. This paper will examine the concept, major functions, and the establishment and operation of the joint campus.

• BMB Reports
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• 제43권7호
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• pp.480-484
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• 2010

The Bombyx mori Microarray Database (BmMDB; http://silkworm.swu.edu.cn/microarray) provides information for tissue-specific gene expression by using the whole-genome oligonucleotide microarray in the silkworm. We analyzed the tissue-specific expression patterns in the silk gland, fat body, and midgut five days of fifth instar larvae during the development of B. mori. To verify the tissue-specific expression, analysis was conducted using quantitative Real-time RT-PCR and the highly expressed endogenous Actin RNA as an intrinsic reference. Finally, we confirmed five genes, (sw15872, sw00692, sw20990, sw05300,and sw2250), out of 18 candidates expressed in two different tissues, which was consistent with the data published by Dr. Xiang's group, thereby supporting the BmMDB. Further studies for promoter regions of candidate genes can be applied in creating transgenic silkworms as biomedical insects for use in producing biomaterials, and to serve as well-characterized models for understanding the mechanism for the genetic regulation of tissue-specific development.

• Journal of Plant Biotechnology
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• 제5권3호
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• pp.149-155
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• 2003

Metabolic engineering for production of isoflavones in nonlegume plants could distribute the health benefits of these phytoestrogens in more widely-consumed grains. Series of investigation to check the ability of the heterologous isoflavone synthase enzyme to interact with the endogenous phenylpropanoid pathway have been conducted. Overall, results provide possibility of production of isoflavonoids in several plant tissue systems including soybean and nonlegumes. In tissue that undergoes naturally enhanced synthesis of anthocyanins, genistein production was enhanced. In a monocot cell system, introduced expression of a transcription factor regulating genes of the anthocyanin pathway was effective in conferring the ability to produce genistein in the presence of the isoflavone synthase gene. However, in this case the intermediate accumulated to high levels indicating an inefficiency in its conversion. Introduction of a third gene, chalcone reductase, provided the ability to synthesize an additional substrate of isoflavone synthase resulting in production of the isoflavone daidzein. These research efforts provide insight into requirements for metabolic engineering for isoflavone production in nonlegume dicot and monocot tissues.

• STI Policy Review
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• 제2권2호
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• pp.45-54
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• 2011

This paper develops a recursive multinomial probit model and describes its estimation method. The recursive multinomial probit model is an extension of a recursive bivariate probit model. The main difference between the two models is that a single decision among two or more alternatives can be considered in each choice equation in the proposed model. The recursive multinomial probit model is developed based on a standard framework of the multinomial probit model and a Bayesian approach with a Gibbs sampling is adopted for the estimation. The simulation exercise with artificial data sets is showed that the model performed well. Since the recursive multinomial probit model can be applied to analyze the causal relationship between discrete dependent variables with more than two outcomes, the model can play an important role in extending the methodology of the causal relationship analysis in innovation research.

• Genomics & Informatics
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• 제17권4호
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• pp.36.1-36.6
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• 2019

The incidence and mortality rate of cancer continues to gradually increase, although considerable research effort has been directed at elucidating the molecular mechanisms underlying biomarkers responsible for tumorigenesis. Accumulated evidence indicates that the long non-coding RNAs (lncRNAs), which are transcribed but not translated into functional proteins, contribute to cancer development. Recently, linc00152 (an lncRNA) was identified as a potent oncogene in various cancer types, and shown to be involved in cancer cell proliferation, invasiveness, and motility by sponging tumor-suppressive microRNAs acting as a competing endogenous RNA, binding to gene promoters acting as a transcriptional regulator, and binding to functional proteins. In this review, we focus on the oncogenic role of linc00152 in tumorigenesis and provided an overview of recent clinical studies on the effects of linc00152 expression in human cancers.

• 한국산림과학회지
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• 제97권2호
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• pp.140-143
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• 2008

This study compared the plywood demand prediction accuracy of econometric and vector autoregressive models using Korean data. The econometric model of plywood demand was specified with three explanatory variables; own price, construction permit area, dummy. The vector autoregressive model was specified with lagged endogenous variable, own price, construction permit area and dummy. The dummy variable reflected the abrupt decrease in plywood consumption in the late 1990's. The prediction accuracy was estimated on the basis of Residual Mean Squared Error, Mean Absolute Percentage Error and Theil's Inequality Coefficient. The results showed that the plywood demand prediction can be performed more accurately by econometric model than by vector autoregressive model.

• Journal of Oral Medicine and Pain
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• 제25권4호
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• pp.365-369
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• 2000

Oral mucositis or stomatitis produced by stomatotoxic chemotherapy and/or radiation therapy are painful, restrict oral intake and, importantly, act as sites of secondary infection and potals of entry for the endogenous oral microflora often leading to bacteremias or sepsis. A number of clinical observations and studies of animal model suggests a pathophysiological complexity in the development of mucositis. The condition appears to represent a sequential interaction of the oral mucosal cells and tissues, pro-inflammatory cytokines, and local environmental factors in the mouth. This article discussed and reviewed biological process of the mucositis and, the role of cytokines as initiators and amplifiers of the process. The recognition that the pathophysiology of mucositis is a multifactorial process has presented opportunities for intervention based upon biological attenuation.

• 한국산림과학회지
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• 제95권2호
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• pp.203-208
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• 2006

This study compared the roundwood demand prediction accuracy of econometric and time-series models using Korean data. The roundwood was divided into softwood and hardwood by species. The econometric model of roundwood demand was specified with four explanatory variables; own price, substitute price, gross domestic product, dummy. The time-series model was specified with lagged endogenous variable. The dummy variable reflected the abrupt decrease in roundwood demand in the late 1990's in the case of softwood roundwood, and the boom of plywood export in the late 1970's in the case of hardwood roundwood. On the other hand, the prediction accuracy was estimated on the basis of Residual Mean Square Errors(RMSE). The results showed that the softwood roundwood demand prediction can be performed more accurately by econometric model than by time-series model. However, the hardwood roundwood demand prediction accuracy was similar in the case of using econometric and time-series model.