• 한국임상약학회지
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• 제11권2호
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• pp.49-56
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• 2001

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is a naturally existing molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioefuivalence of two ALC tablets, $Nicetile^{TM} (Dong-A Pharmaceutical Co.) and $L-Cartin^{TM}$ (Kuhn Il Pharmaceutical Co.), according to the guidelines of Korea Food and Drug Administration (KFDA). The ALC release from the two ALC tablets in vitro was tested using KP VII Apparatus II method in various dissolution media (pH 1.2, 6.0 and 6.8). Twenty six normal male volunteers, $24.46\pm3.67$ years in age and $64.45\pm5.54$ kg in body weight, were divided into two groups and a randomized $2\times2$cross-over study was employed. After one tablet containing 500 mg of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. The dissolution profiles of the two ALC tablets were similar in all the dissolution media. The pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets were $0.35\%,\;0.93\%\;and\;2.34\%$ respectively, when calculated against the $Nicetile^{TM} tablet. The powers $(1-\beta)\;for\;AUC_t$ , and Cmax were $98.72\%\;and\;85.48\%$, respectively. Minimum detectable differences $(\Delta)\;at\;\alpha=0.05\;and\;1-\beta=0.8$ were less than $20\%,\;(e.g.,\;13.21\%\;and\;18.42\%\;for\;AUC_t,\;and\;C_{max}$ respectively). The $90\%$ confidence intervals were within $\pm20\%\;(e.g.,\;-7.38\sim8.09\;and\;-9.86\sim11.72\;for\;AUC_t,\;and\;C_{max}$, respectively). These two parameters met the criteria of KFDA for bioequivalence, indicating that $L-Cartin^{TM}$ tablet is bioequivalent to $Nicetile^{TM} tablet.

• 지역연구
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• 제6권2호
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• pp.123-147
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• 1990

This paper examines the changing geography of producer service industries in the 1980s. The foci of this study are to analyze the regional distribution of each producer services, and to reveal the spatial linkage of producer services. Further this paper asserts the potential role of producer services for reducing the potential endogenous development in the periphery. During the 1981-86 period, producer service industries grew more rapidly than other service sectors and manufacturing sector. The main reason of the raid growth of producer services is attributable to an increase in demand for intermediate services from manufacturing firms. In order to compete an increasingly complex business environment, firms have expanded the amount of effort devoted to activities such as planning, coordination and control, and consequently have increased their use of producer services. The most distinctive feature of the location of producer services is spatial concentration into Seoul and surrounding region. Especially the degree of the concentration o business services into the Capital Region has been accelerating during the 1990s. The pattern of employment growth and regional distribution of producer services show a clear core / periphery disparity. Much of the regional inequality in producer services is largely due to variation in demand associated with the pattern of corporation headquarters with the pattern of corporation headquarters and branch plants location with large manufacturing firms. The analysis of spatial division of labor reflects that producer services are related to the location of headquarters in manufacturing industry. Headquarters in manufacturing firms and business service firms tend to cluster each other. Most of the headquarters spatially separated from branch offices are clustered heavily in Seoul. Especially headquarters of business services and insurance services are overwhelmingly concentrated into Seoul. The firms whose headquarters are located in Seoul have a linkage pattern on a nationwide scale. It is viewed have little potential for generating local multiplier effects and regional development. In the light of the result of this study, producer services are not likely to disperse soon to peripheral regions. Consequently the absence of policies directed at enhancing producer sevice in the periphery, concentration tendency would continue to reinforce the core's dominance at the expense of peripheral regions. From a regional perspective, the quality of a region's producer service sector is a key determinant of economic growth, since manu industrial location decisions are influenced by the differential availability of producer services among regions. Poor performance of producer services in peripheral regions seemed to be linked to the region's manufacturing base. Low-wage, standardized branch plants are not likely to induce the growth in knowledge intensive services associated with high-technology corporate headquarters. Producer services may help to create and attract new business including manufacturing firms, and also to enhance the productivity and competitiveness of local firms. Therefore the provision of service producing activities would be lead not only to generate and retain endogenous development but also to attract external firms, especially small and medium sized firms which have a lower propensity of internalized services. Hence, it may be more efficient to create and expanse new locally owned producer services rather than to attract branch plants of mult-locational firms in order to make indigenous economic development.

• 농촌계획
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• 제20권2호
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• pp.23-43
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• 2014

This study aims to analyze the affecting factors-construction of collaborative planning process and effect on Comprehensive Rural Village Development Project. To this end, targeting the 36 districts which were selected for 2004 Comprehensive Rural Village Development Project and completed their 2010 5-year projects, components of collaborative planning process and planning effect will be drawn and the affecting factors-construction of collaborative planning and effect on Comprehensive Rural Village Development Project will be analyzed below. According to the results of this study, the affecting factors of collaborative planning process of Comprehensive Rural Village Development Project on planning effect, The level of effect of individual component on endogenous variable appeared greatest mostly in the upper groups. In terms of the level of individual component effect, social learning process and interaction among participants affected greatest. The process of Comprehensive Rural Village Development Project is evaluated that it reflected collaborative planning theory of Healey enough. Therefore, in the course of Comprehensive Rural Village Development Project progress, collaborative planning model must pass social learning process and interaction among participants which are the most important components out of collaborative planning process as we saw in the upper groups. And in order to maximize the performance and results of Comprehensive Rural Village Development Project, the following sequential affecting factors model as Figure 7 must be suggested as optimal collaborative planning models of Comprehensive Rural Village Development Project. Based on the results of the study, the policy implication was drawn as follows. First, systematic supplementations in the form of a consultative body are required to perform Comprehensive Rural Village Development Project efficiently. Second, network needs to be built among different participants in Comprehensive Rural Village Development Project process. Third, systematic mechanism is required to improve social learning among different participants. Fourth, systematic rearrangement is required to guarantee the residents' realistic participation in the course of Comprehensive Rural Village Development Project process.

• 아동학회지
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• 제8권2호
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• pp.17-44
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• 1987

The study examined the characteristics of the relationship of home environment variables and children's social development. Two studies were conducted ; Study I examined (1) the correlation of home environment variables and children's social ability and (2) the predictability of home environment variables for children's social ability by children's age. Study II investigated the causal relationship among the variables which are supposed to affect children's social ability. The subjects of this study were 240 children at age four, six and eight attending nursery schools, kindergartens and elementary schools and their mothers. Instruments included the Inventory of Home Stimulation (HOME), the Inventory of Sociodemographic Variables, social maturation scale, and the social-emotional developmental rating scale. The results obtained from this study were as follows : 1) Home environment variables had a positive correlation with children's social development at age four and six, but at age eight, only HOME variables had a significant positive correlation with children's social development. 2) The home environmental variables that significantly predicted children's social development differed according to children's age. That is, play materials, economic status of the home, and parent education were predictive of children's social development at age four, while parent's education, fostering maturity and independence, and play materials were predictive at age six. Fostering maturity and independence, aspects of physical environment, and economic status of the home were predictive at age eight. 3) The causal model of home environment effect on children's social development was formulated by exogenous variables (parent education and economic status of the home) and endogenous variables (direct stimulation, indirect stimulation and the emotional climate of the home). 4) The results of the analysis of the causal model showed that the variables that have a direct effect on children's social development differed according to children's age. That is, direct stimulation had more effect on children's social development at earlier ages, and indirect stimulation had more effect on children's social development at later ages. Among socio-demographic variables, parent's education was most closely related to children's social development. The amount of variance that explained children's social development decreased with increase in children's age.

• 대한지리학회지
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• 제51권6호
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• pp.819-836
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• 2016

근대화 이론과 경제성장 위주로 진행된 과거의 개발 패러다임이 1980년대 교착상태에 빠지게 되면서 이에 대한 대안과 돌파구로 개발을 경제성장을 넘어서 총체적인 사회발전으로 바라보는 관점이 등장했고 이를 실현시키기 위한 개발의 접근법으로서 또 수단으로서 문화에 대한 관심이 고조되었다. 포스트개발 이론들은 유럽중심주의의 개발 개념을 파괴하고 동시에 포스트식민사회의 문화 회복, 지역 자체의 내생적 개발과 다양성을 강조하는 대안적 개발 개념을 제시하였고, 공동체, 여성, 개발주권, 참여를 강조하는 신포퓰리즘개발의 움직임도 등장하였다. 국제기구 역시 유네스코를 중심으로 문화와 발전 관계에 대한 논의를 발전시켜나갔다. 본 논문은 개발학과 포스트개발, 국제기구에서의 문화와 발전 논의의 전개 양상을 살펴봄으로써 문화 개념이 이전시기와 질적으로 다르게 변화됐긴 했지만, 본질적으로 문화를 구별되고 경계가 지워진 특수한 것으로 본다는 한계가 있음을 지적한다. 이에 대한 대안으로 지리학의 관계적 장소관을 적용하여 재개념화함으로써 항상 외부와의 관계를 통해 내부적 혼종성과 다양성을 가진 것으로 인식할 필요가 있음을 주장한다.

• KDI Journal of Economic Policy
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• 제34권1호
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• pp.87-133
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• 2012

본 논문은 경제의 개방화 진전이 고용구조에 어떠한 영향을 미치는지에 대한 주제를 다루고 있다. 이를 위해 본 논문은 경제주체의 이질성(heterogeneity)을 가미하여 Romer(1990)의 내생적 성장모형을 확장하였다. 이와 같은 이질성에 기반하여 본 모형은 한 경제의 고용구조(숙련 및 미숙련 부문의 상대적 고용의 크기)가 숙련노동의 수요 및 공급 조건에 따라 어떻게 결정되는지를 설명한다. 본 모형은 폐쇄경제에 기반하고 있으나 개방경제의 경우로 확장 가능하다. 개방경제의 경우로 확장된 모형에 따르면, 경제의 개방화 진전은 다음과 같은 두 가지 경로를 통해 고용구조에 영향을 미친다. 하나는 생산특화(specialization)를 통한 경로로서 개방 경제하에서 각국은 비교우위에 기반하여 부문별 생산량을 결정하는데, 이에 따라 부문별 노동수요가 결정되고 이는 고용구조에 영향을 미치게 된다. 다른 하나는 지식확산(knowledge spillover)을 통한 경로로서 경제의 개방화 진전은 지식확산을 촉진하는데, 이는 부문별 노동생산성에 영향을 미치고 따라서 고용구조에도 영향을 미치게 된다. 21개국의 국제패널자료를 이용하여 실증분석해 본 결과, 경제의 개방화 진전은 상기한 모형이 설명하는 바와 같이 위의 두 가지 경로를 통해 고용구조에 영향을 미침을 확인할 수 있었다.

• 한국콘텐츠학회논문지
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• 제12권10호
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• pp.430-438
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• 2012

본 연구에서는 코스닥 증권시장에 상장된 벤처기업을 대상으로 내생적 성장 연구개발비가 기업가치에 미치는 영향을 분석하였다. 연구방법은 실증연구방법을 택하였으며, 다중회귀분석을 이용하여 코스닥에 상장된 벤처기업을 대상으로 검증을 실시하였다. 분석결과 벤처기업의 내생적 성장 연구개발비가 기업규모에 양(+)의 유의한 영향을 미치고 있는 것으로 나타났다. 반면 유형자산과 광고선전비 및 교육훈련비 등은 음(-)의 유의한 영향을 미치는 것으로 나타났다. 벤처기업의 기업규모가 기업가치에 양(+)의 유의한 영향을 보인 것은 기술개발을 중점적으로 추진하는 벤처기업의 특성상 내생적 성장 무형자산이 기업가치에 유의적인 영향을 미치고 있는 것으로 해석된다. 결론적으로 코스닥 등록 벤처기업의 내생적 성장 연구개발비와 기업가치 간에는 양(+)의 상관관계를 갖고 있는 것으로 검증되었고, 벤처기업은 개발비 등 무형자산에 대한 투자가 집중되는 기업의 특성으로 인하여 벤처기업의 기업규모(총자산)가 기업가치에 양(+)의 유의한 영향을 미치는 것으로 분석되었다.

• 한국발생생물학회지:발생과생식
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• 제4권2호
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• pp.221-229
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• 2000

유선에서 젖의 생산은 뇌하수체 호르몬인 성장 호르몬과 프롤락틴을 포함한 여러 가지 호르몬의 조절을 받는다. 최근의 연구에 따르면 이 호르몬들 중에서 성장호르몬과 프롤락틴은 유선에서도 그 유전자 전사체가 발견된다 본 연구에서는 유선에서 발현되는 성장호르몬이 유선 특이 발현 유전자의 발현에 미치는 영향을 조사하고자 유선 특이 발현 유전자인 베타-락토글로불린($\beta$-lactoglobulin :BLG)의 프로모터를 모델 시스템으로 하여 소와 사람의 성장 호르몬이 유선의 유전자 발현에 끼치는 영향을 조사하였다. 성장 호르몬은 단독으로 처리하였을 패 베타-락토글로불린 유전자 프로모터 활성을 억제하였다. 그러나 젖 분비 호르몬들인 인슐린, 프롤락틴, 글루코코르티코이드와 함께 처리하였을 때는 농도 의존적으로 BLG 프로모터 활성을 상승시키는 효과를 보였다. 성장 호르몬을 유선 세포내에서 발현시켰을때는 적정농도에서 세포 증식과 유선 프로모터 활성을 크게 증진시켰다. 반면 소의 성장 호르몬 유전자 프로모터는 유선 세포에서 뚜렷한 활성을 나타내지 않았다. 이상의 결과는 유선에서 발현되는 뇌하수체 호르몬들은 조절 누수에 의한 유전자 발현이 아니라 생리적 기능을 가지고 있음을 의미한다. 또 인위적으로 성장호르몬의 발현을 조절하여 적정한 양이 발현되도록 하면 젖의 생산을 증진시킬 수 있다는 가능성도 암시한다.

• 농촌계획
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• 제17권3호
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• pp.113-124
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• 2011

This study attempted to propose a space planning of rural villages having been connected by small-regions units as a plan of regional economic growth through cultivating native resources located in rural areas and then developing them. As research methods, this study carried out literature research and empirical study at the same time, and then was progressed to directions of deducing a basic plan by applying alternatives to actual object sites based on the results. Endogenous developments of areas through native resources' developments have been emphasized in Korea recently, and various policies and strategies are being appeared for making regional economic growth under these recognitions. However, rural village planning has directed to physical maintenances centering on functionality till now, and composed of facility repairs and experience projects of urban-rural interchanges mostly so as to solve living environments between cities and agricultural villages. Therefore, this study intended to pose discrimination with existing rural village planning, and set up a growth plan of rural villages by cultivating and developing tangible and intangible native resources having been kept in the rural villages and then commercializing them centering on indigenous native resources.

• Journal of Pharmaceutical Investigation
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• 제23권3호spc1호
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• pp.9-18
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• 1993

Sugar spheres loaded with melatonin (MT) were coated with $Aquacoat^{\circledR}$ to control the release rate of MT over 8 hours. A zero-order release pattern over 8 hours was obtained with 20% coating on 8-10 mesh beads in USP basket dissolution studies. MT in 20% coated beads was quite stable at room temperature with less than 5% MT degraded during 6 months' storage. Dissolution profiles were also unchanged after 6 months. An oral preparation containing MT-loaded uncoated beads for immediate release and 20% coated beads with $Aquacoat^{\circledR}$ for controlled release over 8 hours was evaluated in six human subjects. When total 0.5 mg MT as low dose (immediate release portion of MT, 0.1 mg) was administered to four subjects, average peak plasma MT concentration was reached at about 600 pg/ml and maintained at about 10 pg/ml over 8 hours. Plasma MT concentration-time profiles were similar in shape to computer-simulated profiles. However, maximal plasma MT concentrations were three times greater compared to computer simulated curve. These results suggest that MT dose, ratio of immediate and controlled release MT, and pharmacokinetic parameters selected are adjusted to mimic endogenous MT concentration-time curve. In another study, 0.2 mg MT having 10% of immediate release portion and 80% controlled release portion produced plasma MT concentration-time curve which is more similar to endogenous profiles. A low bioavailability (<20%) may result from extensive first pass metabolism and remaining amounts of MT from controlled beads. A good correlation between plasma MT concentration and urinary excretion rate of 6-sulphatoxymelatonin (6-STMT), a major metabolite of MT was observed. As plasma MT concentration increased, urinary excretion rate of 6-STMT increased concomitantly. The linear relation between plasma MT and urinary excretion rate of 6-STMT was statistically significant. This result suggests that urinary 6-STMT may be used as an index of circadian rhythms of MT in humans.