• Title/Summary/Keyword: End-to-end Delay

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Sequence and Time Interval in Combination of Irradiation and Cis-Diamminedichloroplatinum in C3H Mouse Fibrosarcoma (C3H 마우스 섬유육종에 있어서 방사선 조사와 Cis-diamminedichloroplatinum의 병용시 순서 및 시간간격의 영향)

  • Ha, Sung-Whan;Choi, Eun-Kyung;Park, Charn-Il
    • Radiation Oncology Journal
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    • v.11 no.1
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    • pp.29-34
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    • 1993
  • Experiments have been carried out with C3H mouse fibrosarcoma (FSa II) to determine the effect of different sequence and time intervals between irradiation and administration of cis-diammihedichloroplatinum (cis-DDP) with gross tumors (6 mm in diameter), microscopic tumors (3 days after transplantation of $10^3$ cells) and cells in culture. The drug was administered either 24, 12, 8, 4, 2, 1, 0.5 hour before irradiation, immediately before irradiation, or 0.5, 1, 2, 4, 8, 12, 24 hours after irradiation. In case of in vivo studies, tumor growth delay was used as an end point. Clonogenic cell surviving fraction was used for in vitro studies. Tumor growth delay for gross tumor after 10 Gy radiation plus 10 mg/kg cis-DDP ranged from 6.3 to 10.66 days and the enhancement ratio ranged from 1.37 to 2.23. The most effective combination was when cis-DDP was given 4 hours before irradiation. Tumor growth delay for microscopic tumor after 5 Gy of radiation and 5 mg/kg of cis-DDP ranged from 3.55 to 11.98 days with enhancement ratio from 2.05 to 6.92. Microscopic tumors showed response significantly greater than additive in every time interval and the most effective treatments were when cis-DDP was given 2 and 1 hour before irradiation. In in vitro experiment, the surviving fraction after 6 Gy of radiation and 1 hour exposure to 4 ${\mu}M$ cis-DDP fluctuated as a function of time between treatments, but the difference between maximum and minimum surviving fractions was very small. According to the above results the sequence and time interval between irradiation and chemotherapy is very critical especially for the management of microscopic tumors as in the case of postoperative adjuvant treatment.

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Availability Assessment of Single Frequency Multi-GNSS Real Time Positioning with the RTCM-State Space Representation Parameters (RTCM-SSR 보정요소 기반 1주파 Multi-GNSS 실시간 측위의 효용성 평가)

  • Lee, Yong-Chang;Oh, Seong-Jong
    • Journal of Cadastre & Land InformatiX
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    • v.50 no.1
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    • pp.107-123
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    • 2020
  • With stabilization of the recent multi-GNSS infrastructure, and as multi-GNSS has been proven to be effective in improving the accuracy of the positioning performance in various industrial sectors. In this study, in view that SF(Single frequency) GNSS receivers are widely used due to the low costs, evaluate effectiveness of SF Real Time Point Positioning(SF-RT-PP) based on four multi-GNSS surveying methods with RTCM-SSR correction streams in static and kinematic modes, and also derive response challenges. Results of applying SSR correction streams, CNES presented good results compared to other SSR streams in 2D coordinate. Looking at the results of the SF-RT-PP surveying using SF signals from multi-GNSS, were able to identify the common cause of large deviations in the altitude components, as well as confirm the importance of signal bias correction according to combinations of different types of satellite signals and ionospheric delay compensation algorithm using undifferenced and uncombined observations. In addition, confirmed that the improvement of the infrastructure of Multi-GNSS allows SF-RT-SPP surveying with only one of the four GNSS satellites. In particular, in the case of code-based SF-RT-SPP measurements using SF signals from GPS satellites only, the difference in the application effect between broadcast ephemeris and SSR correction for satellite orbits/clocks was small, but in the case of ionospheric delay compensation, the use of SBAS correction information provided more than twice the accuracy compared to result of the Klobuchar model. With GPS and GLONASS, both the BDS and GALILEO constellations will be fully deployed in the end of 2020, and the greater benefits from the multi-GNSS integration can be expected. Specially, If RT-ionospheric correction services reflecting regional characteristics and SSR correction information reflecting atmospheric characteristics are carried out in real-time, expected that the utilization of SF-RT-PPP survey technology by multi-GNSS and various demands will be created in various industrial sectors.

The Principles of Total Quality Management(TQM) and Its Implementation. (총체적 질관리(Total Quality Management)의 이론적 배경과 그 적용실태)

  • Kang, So-Young
    • Journal of Korean Academy of Nursing Administration
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    • v.1 no.2
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    • pp.388-407
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    • 1995
  • This study is (a) to describe the history of Total Quality Management (TQM) generated in the industry, health care service, and nursing society ; (b) to define the concept, total quality management including the definition of quality ; (C) to explain the each principle of TQM theory developed by main theorists, E. Deming, J. Juran, and B. Crosby ; (d) to give the examples related to TQM implementation at the health care organization ; and (e) to mention the extent to which the health care organizations are able to evaluate their cultural organization toward TQM and have had the way to measure the effect of TQM implementation. TQM referred to Continuous Quality Improvement(CQI), Quality Improvement(QI), and Total Quality Improvement(TQI), was not recognized by experts in the United States industry, but by economists in Japan until the end of the 1970's. However, the United States' government led to introduce the principles of TQM to general industry as well as health care service area so that TQM became a main philosophy to manage the organizations in health care service. TQM is a structured, systematic process for creating organization-wide participation in planning and implementing continuous improvement in quality. E. Deming established the "Chain reaction in Quality" and the fourteen point of TQM. The Chain reaction in quality is to describe the relationship among the reduction of waste, rework, and delay, quality improvement, customer satisfaction, and productivity. There are fourteen points to explain the principles of TQM by E. Deming. Juran defined the "Quality Trilogy" to improve the level of quality in any organization. Quality Trilogy has three steps such as quality planning, quality control, and quality improvement for implementing the TQM projects. Crosby describes his TQM theory by establishing "Four Absolutes" and "Fourteen steps in TQM" implementation. Until now, most healthcare organizations have made efforts to organize the TQM task team and to implement TQM principles with various issues. There are three priorities to select the TQM issues : High-volume, High-risk, and Problem-prone. However, there is no absolute, credible measurement yet to evaluate the effects of TQM implementation in health care organization regardless of the classification of health care organizations, geographical background, and social influence. Thus, developing the evaluation way in terms of TQM is the foremost task in health service area. The most important thing for TQM implementation in the organization is to settle up the concept, cultural transformation from traditional management toward quality.

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A Study on the Method of Legislation on Withholding or Withdrawing of LST -In relation to the introduction of adult guardianship- (연명치료 중단의 입법화 방안에 관한 연구 - 성년후견제도의 도입과 관련하여 -)

  • Lee, Eun-Young
    • The Korean Society of Law and Medicine
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    • v.10 no.2
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    • pp.203-249
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    • 2009
  • It is the so-called Shinchon Severance Hospital Case brought to an end by the decision of the Supreme Court that opened the real discourse of withholding or withdrawing of LST (Life-Sustaining Treatment) in the legal profession as well as medical profession in Korea. Everyone has sympathy with the validity and necessity of legal regulation on withdrawing-including withholding-of LST save the requirements & procedure of withdrawing of LST. In this situation, the legislative bill of amendment to the Korean Civil Law introducing of adult guardianship was pre-announced by the Ministry of Justice on September 18th 2009. The adult guardianship is a guardianship system that supports an mentally handicapped adult to deal with his affairs by support of a guardian. The object of adult guardianship includes affairs of body or well-being as well as property of adult wards. In particular, affairs of medical matters are of importance in the duty and authority of adult guardians. So, the introduction of adult guardianship is of much importance de lege lata as well as de lege ferena in the discussion of withdrawing of LST as a medical treatment. Since the legislation on withdrawing of LST intents to protect the right of death with dignity on the basis of patients' autonomy, the ratio legis of withdrawing of LST is variant from that of adult guardianship. In this context, it seems reasonable to legislate the withdrawing of LST separately from the adultguardianship. In the meantime, the adult guardianship of the legislative bill of amendment to the Korean Civil Law is related to the withdrawing of LST, since the main purpose of adult guardianship is to protect patients' quality of lives and to regulate guardianship contracts based on patients' autonomy. In that context, it seems reasonable to incorporate the legislation of withdrawing of LST into the adult guardianship system. In the latter case, it is not easy to adopt the withdrawing of LST into the legislative bill of the Korean Civil Law for the bill is pre-announced already as previously stated. However, the legislation of withdrawing of LST is not inferior to the legislation of adult guardianship as a matter of urgency. Moreover, it is likely that the legislative bill of Amendment to the Korean Civil Law generates discrepancies in interpretation of the requirements & procedure of withdrawing of LST as the amended German Civil Law did. In short, it is desirable for the legislator to revise the legislative bill despite delay.

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A Case Study of the Deferred Exposure by Real Estate Finance Types: Focusing on the Distortion of Loan and the Overestimation of Value (부동산금융 유형별 익스포저 이연 사례 연구: Loan의 왜곡과 Value의 과대평가 문제를 중심으로)

  • Jeong, Dae-Seok;Hwangbo, Chang
    • The Journal of the Korea Contents Association
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    • v.20 no.6
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    • pp.38-50
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    • 2020
  • The purpose of this study is to identify the risks to financial institutions in terms of expanding potential risks due to the deferral of exposure, by identifying the structures in which real estate finance and financial institutions affect real estate prices at low interest rates. To this end, real estate financing is categorized according to the method of financing and the type of value measurement from a risk management perspective and analyzed for each case. As a result of analysis, in the case of profitable real estate, the rate of real estate is increased by directly decreasing the cap rate and directly affecting the fair value calculation method. In the case of non-profitable real estate, the real estate price is increased by expanding the leverage width of investors or financial institutions. Through the analysis of this case, the continuous increase in real estate prices over the past 10 years has the potential to prevent financial institutions from losing under the circumstances such as the growth of real estate finance due to the advancement of the financial market and the continued low interest rate trend that has continued for 10 years. It is judged that the deferred delay is part of the cause, which leads to an increase in the risk to financial institutions.

A Convergence Study on the Differences in Medical Practices and Medical cost according to Auto Insurance Companies (자동차보험사별 진료특성과 진료비 차이에 관한 융합 연구)

  • Lee, Soo-ja;Lee, Chong Hyung;Park, Arma;Kim, Kwang-Hwan
    • Journal of the Korea Convergence Society
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    • v.8 no.5
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    • pp.61-68
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    • 2017
  • This study investigates the differences in medical practices and medical cost according to auto insurance companies based on 8,589,602 cases that were treated by auto insurance corporation for the year of 2015, from the beginning of January to the end of December. The results of this study can be summarized following. First, in terms of the general characteristic in medical treatment, especially the age, the highest figure in both non-life insurance and mutual aid cooperative was shown in the age of 50 to 59 at 22.8 per cent(p<0.001). Second, in terms of a medical cost per a hospital care, classified by clinic, the costs in the department of internal medicine were much higher than those in the surgical department, and the thoracic surgery among parts of the surgical department showed the highest figures in both non-life insurance and mutual aid cooperative. According to the above summarized results of this study, it can be concluded that Health Insurance Review and Assessment Service has to address the problem on the increase of unnecessary costs and the occurrence of social expenses caused by the delay of patients' rehabilitation and return to their daily lives, by carrying out the evaluation for the appropriateness to organizations that ask for payments of auto insurance.

Manipulation of the Compressed Video for Multimedia Networking : A Bit rate Shaping of the Compressed Video (멀티미디어 네트워킹을 위한 압축 신호상에서 동영상 처리 : 압축 동영상 비트율 변환)

  • 황대환;조규섭;황수용
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.26 no.11A
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    • pp.1908-1924
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    • 2001
  • Interoperability and inter-working in the various network and media environment with different technology background is very important to enlarge the opportunity of service access and to increase the competitive power of service. The ITU-T and advanced counties are planning ahead for provision of GII enabling user to access advanced global communication services supporting multimedia communication applications, embracing all modes of information. In this paper, we especially forced the heterogeneity of end user applications for multimedia networking. The heterogeneity has several technical aspects, like different medium access methods, heterogeneous coding algorithms for audio-visual data and so on. Among these elements, we have been itemized bit rate shaping algorithm on the compressed moving video. Previous manipulations of video has been done on the uncompressed signal domain. That is, compressed video should be converted to linear PCM signal. To do such a procedures, we should decode, manipulate and then encode the video to compressed signal once again. The traditional approach for processing the video signa1 has several critical weak points, requiring complexity to implement, degradation of image quality and large processing delay. The bit rate shaping algorithm proposed in this paper process the manipulation of moving video on the completely compressed domain to cope with above deficit. With this algorithms. we could realized efficient video bit rate shaping and the result of software simulation shows that this method has significant advantage than that of pixel oriented algorithms.

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Changes of Nutritive Value and Productivity According to Stockpiled Period in Mixed Orchardgrass-Tall Fescue Pasture of Jeju Region (제주지역 오차드그라스 및 톨 페스큐 혼파초지의 비축시기별 사초 생산성 및 사료가치 변화)

  • Chae, Hyun Seok;Kim, Nam Young;Woo, Jae Hoon;Back, Kwang Soo;Lee, Wang Shik;Kim, Si Hyun;Hwang, Kyung Jun;Park, Seol Hwa;Park, Nam Gun
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.35 no.2
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    • pp.93-98
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    • 2015
  • This study was conducted to investigate the effect of different stockpiled periods on the nutritive value and productivity of mixed orchardgrass tall-fescue pasture (MOTP). This experiment was conducted at Jeju (island), South Korea, from Sep. 2012 to Nov. 2012. The DM yield of the MOTP had the highest in treatment in late August (2,983 kg/ha). The DM yields of swards were increased significantly by shortening the stockpiled period. The CP of the MOTP was 16.5% to 18.16%, and there did not appear to be a consistent trend in accordance with the duration of the stockpiled periods. The NDF and TDN content of the MOTP increased with the delay of the stockpiled periods, but there is a significant difference between the short- and long-stockpile periods; however, the ADF content of the MOTP decreased with shortened stockpile periods, but again, there is a significant difference between the two periods. In addition, P, Ca, Mg, Na, and Zn of MOTP increased by delaying the stockpile period, but Mn and Cu of MOTP decreased. As shown in the results of this research, the yield of MOTP was not increased by the atrophy of the growth of MOTP due to high temperatures in case where the MOTP was stockpiled from the beginning of August. The stockpile period of MOTP should therefore be started at the end of August to yield a stockpile of MOTP in the autumn.

Repeated Loading Test of Shear-Critical Reinforced Concrete Beams with Headed Shear Reinforcement (헤디드 바를 전단철근으로 사용한 철근콘크리트 보의 전단거동에 관한 반복하중 실험)

  • Kim, Young-Hoon;Lee, Joo-Ha;Yoon, Young-Soo
    • Journal of the Korea Concrete Institute
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    • v.18 no.1 s.91
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    • pp.47-56
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    • 2006
  • The repeated loading responses of four shear-critical reinforced concrete beams with two different shear span-to-depth ratios, were studied. One series of beams was reinforced using pairs of bundled stirrups with $90^{\circ}$ standard hooks, haying free end extensions of $6d_b$. The companion beams contained shear reinforcement made with larger diameter headed bars anchored with 50mm diameter circular heads. A single headed bar had the same area as a pair of bundled stirrups and hence the two series were comparable. The test results indicate that beams containing headed bar stirrups have a superior performance to companion beams containing bundled standard stirrups with improved ductility, larger energy absorption and enhanced post-peak load carrying capability. Due to splitting of the concrete cover and local crushing, the hooks of the standard stirrups opened resulting in loss of anchorage. In contrast, the headed bar stirrups did not lose their anchorage and hence were able to develop strain hardening and also served to delay buckling of the flexural compression steel. Excellent load-deflection predictions were obtained by reducing the tension stiffening to account for repeated load effects.

Ramp Activity Expert System for Scheduling and Co-ordination (공항의 계류장 관리 스케줄링 및 조정을 위한 전문가시스템)

  • Jo, Geun-Sik;Yang, Jong-Yoon
    • Journal of Advanced Navigation Technology
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    • v.2 no.1
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    • pp.61-67
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    • 1998
  • In this paper, we have described the Ramp Activity Coordination Expert System (RACES) which can solve aircraft parking problems. RACES includes a knowledge-based scheduling problem which assigns every daily arriving and departing flight to the gates and remote spots with the domain specific knowledge and heuristics acquired from human experts. RACES processes complex scheduling problem such as dynamic inter-relations among the characteristics of remote spots/gates and aircraft with various other constraints, for example, custome and ground handling factors at an airport. By user-driven modeling for end users and knowledge-driven near optimal scheduling acquired from human experts, RACES can produce parking schedules of aircraft in about 20 seconds for about 400 daily flights, whereas it normally takes about 4 to 5 hours by human experts. Scheduling results in the form of Gantt charts produced by the RACES are also accepted by the domain experts. RACES is also designed to deal with the partial adjustment of the schedule when unexpected events occur. After daily scheduling is completed, the messages for aircraft changes and delay messages are reflected and updated into the schedule according to the knowledge of the domain experts. By analyzing the knowledge model of the domain expert, the reactive scheduling steps are effectively represented as rules and the scenarios of the Graphic User Interfaces (GUI) are designed. Since the modification of the aircraft dispositions such as aircraft changes and cancellations of flights are reflected to the current schedule, the modification should be notified to RACES from the mainframe for the reactive scheduling. The adjustments of the schedule are made semi-automatically by RACES since there are many irregularities in dealing with the partial rescheduling.

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