• 한국도서관정보학회지
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• 제47권4호
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• pp.411-441
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• 2016

본 연구는 성호 이익의 대표적인 저술인 "성호사설"에 인용된 문헌 443종을 추출하여 인용문헌의 규모 및 문헌의 성격, 중국본의 비중, 최신본의 비중, 주제별 비중 등을 분석하였다. "성호사설" 인용문헌 443종을 살펴본 결과, 고려 조선본이 전체 23.3%, 중국본이 76.7%를 차지하였고, 중국본의 편찬시기를 살펴본 결과, 송대 이전 편찬본이 70% 이상을 차지한 반면, 명 청대 문헌은 22.7%인 것으로 나타났다. 인용문헌의 주제별 비중을 살펴보면 가장 많은 비중을 차지하는 주제영역은 역사서류(歷史書類), 시문집류(詩文集類), 유교경전류(儒敎經典類), 소설필기류(小說筆記類)의 순으로 나타났으며, 성호 이익은 이외에도 잡가류, 유가류, 지리류, 제도규정류, 서화음악류, 자전류, 전기류, 백과사전류 등 다양한 주제에 관심을 가졌던 것으로 조사되었다.

• 사상체질의학회지
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• 제19권3호
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• pp.20-29
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• 2007

1. Objectives We know that the origine of the pe-tsai is from 백채(白菜; pronounced as bak-tsai, meaning white vegetable). But some literatures said that the japanese butterbur(Petasites japonicus (Sieb. et Zucc.) Maxim) is from 백채(白菜;: pronounced as bak-tsai), too. These two words have same origin. It makes us get into a mess. So We are about to study the origine of the pe-tsai more. Also, we investigated its historical origin, properties and Sasang constitutional medicine's efficacy. 2. Methods We reviewed farmings(e.g. 山林經濟, 林園經濟法), dictionarys(e.g. 訓蒙字會), encyclopedia(e.g. 物名攷), books on herbs and medicines to summarize literatures about the pe-tsai. 3. Results and Conclusions (1) The origin of term, pe-tsai is sung, named after a pine tree(松), chineses character pronounced as song) which we can see throughout a year. Also, pe-tsai was called white vegetables(白菜, pronounced as bak-tsai) because its appearance is green and white. Therefore, the pronounciation of sung derives from its character and we also say bak-tsai(白菜), which came from its looks. (2) Today we pronounce pe-tsai inro bae-tsu(배추) in korean. There are pronunciational developments of this word : bak-tsai(白菜) $\to$ bae-tsae $\to$ bae-tsa $\to$ bae-tsa $\to$ bae-tsae(배채) $\to$ bae-tsu(배추). (3) Our ancestor used bak-tsai(白菜) as the name of japenese butterbur, which was different from China. The latter times of Joseon(조선), however, sometimes bak-tsai(白菜) meant pe-tsai. After the year of 1800, bak-tsai(白菜) only meant pe-tsai. So when we try to translate our ancestor's books, we must examine carefully their published year. (4) Pe-tsai is used for baby's erysipelas, boil, fever in the chest, thirst after alcohol drinking and kind of diabetes. It helps digestive organs as well. Pe-tsai is used for stress, fever in the chest and cough with fever of Soyangin and Tayangin in Sasang Constitutional Medicine.

• International Journal of Oral Biology
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• 제45권3호
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• pp.134-142
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• 2020

Colon cancer is one of the most common malignant tumors, but there are still a few validated biomarkers of colon cancer. Exosome-mediated microRNAs (miRNAs) have been recognized as potential biomarkers in cancers, and miRNAs can regulate a variety of genes. Recently, Fusobacterium nucleatum was discovered in the tissues of human colon cancer patients. Its role in colon cancer was highlighted. F. nucleatum may contribute to the progression of colon cancer through the mechanism of exosome-mediated miRNAs transfer. However, the exosomal miRNAs regulation mechanism by F. nucleatum in colon cancer is not well known. Thus, we performed next-generation sequencing to investigate the overall pattern of exosomal miRNAs expression in the colon cancer cell culture supernatant. We have confirmed the alterations of various exosomal miRNAs. In addition, to investigate the function of exosomal miRNAs, a Kyoto Encyclopedia of Genes and Genomes analysis was performed on the target genes of changed miRNAs. Potential target genes were associated with a variety of signaling pathways, and one of these pathways was related to colorectal cancer. These findings suggested that F. nucleatum can alter exosomal miRNAs released from colorectal cancer cells. Furthermore, exosomal miRNAs altered by F. nucleatum could be potential biomarkers for the diagnosis and therapy of colon cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2793-2800
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• 2015

In molecular-targeted cancer therapy, acquired resistance to gemcitabine is a major clinical problem that reduces its effectiveness, resulting in recurrence and metastasis of cancers. In spite of great efforts to reveal the overall mechanism of acquired gemcitabine resistance, no definitive genetic factors have been identified that are absolutely responsible for the resistance process. Therefore, we performed a cross-platform meta-analysis of three publically available microarray datasets for cancer cell lines with acquired gemcitabine resistance, using the R-based RankProd algorithm, and were able to identify a total of 158 differentially expressed genes (DEGs; 76 up- and 82 down-regulated) that are potentially involved in acquired resistance to gemcitabine. Indeed, the top 20 up- and down-regulated DEGs are largely associated with a common process of carcinogenesis in many cells. For the top 50 up- and down-regulated DEGs, we conducted integrated analyses of a gene regulatory network, a gene co-expression network, and a protein-protein interaction network. The identified DEGs were functionally enriched via Gene Ontology hierarchy and Kyoto Encyclopedia of Genes and Genomes pathway analyses. By systemic combinational analysis of the three molecular networks, we could condense the total number of DEGs to final seven genes. Notably, GJA1, LEF1, and CCND2 were contained within the lists of the top 20 up- or down-regulated DEGs. Our study represents a comprehensive overview of the gene expression patterns associated with acquired gemcitabine resistance and theoretical support for further clinical therapeutic studies.

• 정보교육학회논문지
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• 제10권1호
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• pp.13-22
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• 2006

학생들은 인터넷을 이용하여 정보와 자원을 찾을 수 있어야 한다. 또한 정보를 선별하고, 지식으로 변환하고, 이를 다시 남에게 전달하는 등 복합적인 지적능력이 필요하다. 그러나 학생들이 접하는 대부분의 학교, 학급 홈페이지는 정보만을 제공할 뿐, 학생들이 정보를 지식으로 만들 수 있도록 도와주는 기능이 미흡하다. 이는 학습자들이 홈페이지에 접속하는 비율을 낮추는 원인이 되기도 한다. 이에 본 연구에서는 학생들이 정보를 이해하고 해석하여 지식으로 변환할 수 있는 능력을 키울 수 있도록 지식공유기법을 활용한 학급 홈페이지를 개발하였다. 이 홈페이지는 학생들이 지식공유를 할 수 있도록 위키식 지식공유기법과 질문답변식 지식공유기법을 사용하였다. 실험 적용 결과, 학생들이 습득한 정보를 이해하고 해석하는 능력이 높아졌으며, 암묵지를 형식지로 바꾸는 능력도 향상된 것으로 나타났다. 또한 지식을 공유 하면서 새로운 지식을 창조하였으며, 자연스럽게 홈페이지 접속율도 높아졌다.

• 한국전자통신학회논문지
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• 제5권1호
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• pp.102-108
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• 2010

컴퓨터 그래픽스 기술을 접목한 디지털 영상 콘텐츠 산업이 점차 증가하면서, 사용자들은 현실세계와 흡사할 정도의 고품질 애니메이션을 요구하고 있으며, 사이버수족관 및 어류백과사전 등을 통해서 어류의 형태나 유영방식을 관찰하고자 한다. 본 연구에서는 해저 환경을 표현함에 있어서 가장 핵심이 되는 어류의 자연스럽고도 역동적인 움직임을 표현하기 위해 어류 성장 과정 시스템을 설계하고 개발하였다. 본 시스템에서는 기존 어류 유영 방식을 새롭게 보완한 알고리즘을 사용한 시뮬레이션과 기존 모핑 연구에서 제시되지 않은 새로운 모핑 기법을 제안한다. 또한 어류의 성장 과정 중 환경 요인에 따라 발생하는 질병 감염 상태를 현실적으로 표현한다. 기존 어류 연구와 다르게 포괄적인 어류 연구를 진행하여 어류에 관련된 전반적인 특징을 현실적으로 시뮬레이션 하여 살펴보게 된다.

• 한국의사학회지
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• 제14권1호
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• pp.109-124
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• 2001

"의방유취(醫方類聚)"는 150여종 인용문헌의 내용을 91문의 병증문별로 분류한 다음 중복된 내용을 취사하는 등 일련의 정리와 수정과정을 거쳐 방대한 지식정보를 주제별로 정리한 대단위 의학정보사전이라고 할 수 있다. 물론 내용의 구성은 5만여 종에 달하는 치료처방이 중심이 되겠지만, 이에 앞서 전제되는 이론편과 매 문마다 부가된 식치(食治), 금기(禁忌), 침구(鍼灸), 도인(導引) 등 기타 요법 또한 적지 않은 분량이다. 이는 또한 앞서 간행한 "향약집성방(鄕藥集成方)"에서 병증목별로 간단한 몇 가지 조문의 이론과 단방요법 식으로 몇몇 문에만 침구와 도인법이 첨가되었던 것에 비하면 그 비중이 매우 중요시되었음을 알 수 있다. 특히 식치, 금기, 도인법이 이론과 방약에 필수적인 병용요법으로서 별개의 본편으로 구성된 것은 단순한 방약 위주의 대증치료(對症治療) 수준에서 벗어나 질병 발생 이후의 치료에 앞서 예방의학이 중시되었음을 뜻한다. 또 금기, 양생법을 병용함으로써 치료 후처치 또는 재활의학에 대한 관심이 증대되었음을 의미한다. 본고에서는 일반적인 처방서의 기본골격을 이루는 이론과 방약 부문을 제외하고 "의방유취"에서 다른 편으로 독립하여 구성된 식치, 금기, 침구, 도인편을 별도로 분리하여 고찰함으로써 치료편이 갖는 의미와 각 편별 특성을 알아보기로 한다. 먼저 제1절에서는 "의방유취" 구성상 독특하게 구성된 치료편의 구성과 각 편별 소재를 조사하고 그 비중을 가늠해 보았다. 이어 제2절에서는 각 편별 인용문헌을 살펴봄으로써 그 특성을 파악하여 "의방유취"에서 정리된 치료편의 의미를 되새겨 보기로 한다. 제1절이 외형상의 편제 상황을 조사 집계한 것이라면 제2절은 내용상의 특성을 소개하는 개요부라고 할 수 있다. 이것은 방대한 분량의 "의방유취"에 담긴 내용을 손쉽게 파악하고자 하는 입문 연구자에게 다소나마 개략적인 윤곽을 그려볼 수 있도록 기본적인 정보를 제공해 주는 지침서 역할을 하리라고 생각한다.

• 동아시아식생활학회지
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• 제8권4호
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• pp.360-378
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• 1998

Imwonshibyukji was a copying manuscript written around 1825, the 27th year of king Soonjo of the Josun Dynasty. It was a massive home encyclopedia of total 52 books and 100 volumes. The unpublished 'Jeongjoji' of its 17-20th volumes analyzed the cooking methods on the steamed rice and gruel and studied the degree of their usefulness and medical values in the light of the cooking process science. The cooking method on the steamed rice was composed of 14 items, and the general introduction outlined 6 kinds of the rice. These were all quoted from Chinese literatures. The 11 items present the methods on the general production of the rice, 2 on the cooking process, and 1 on the preservation. The main material of the rice was rice, and others were naked barley, prosomillet, foxtail millet, glutinous millet, etc. , and the secondary materials were glutinous rice, small red bean, black soybean, potato, bamboo seed, jujube, taro, gaertner, chestnut powder, persimmon power, julib(Zizania caduciflora), mangcho(Erigeron canadensis), namchok(Nandina domestica), licorice root, nitrous, peach, palmicha(schizandra, jinseng, cheonmoondong(Asparagus), and honey are mixed), etc. The literatures quoted in the rice were all 33, in which 23 were Chinese (69.7%) and 10 were Korean (30.3%). In the case of gruel, the cooking methods on the general gruel were described in 41 items, and on the gruel for a medical treatment were in 48 items, in which there was not a cooking method on the gruel but only its medical values were presented. The materials used for the general gruel were approximately 60 kinds: rice, glutinous rice, munbean, job's tears, rye, soybean, black sesame seed, antler of cervidae, chicken, crucian carp, and various medical materials, etc. The gruel was mainly used for protection and medical treatment, and partly for food for hungry people. The literatures quoted in the gruel were total 57, in which 26 were Korean(45.6%), and 31 were Chinese (54.4%). It can be their characteristics that Almost all of the Chinese literatures on the methods of the steamed rice and gruel do not exist.

• Journal of Plant Biotechnology
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• 제46권4호
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• pp.274-281
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• 2019

Pistacia chinensis Bunge has not only been used as a medicinal plant to treat various illnesses but its young shoots and leaves have also been used as vegetables. In addition, P. chinensis is used as a rootstock for Pistacia vera (pistachio). Here, the transcriptome of P. chinensis was sequenced to enrich genetic resources and identify secondary metabolite biosynthetic pathways using Illumina RNA-seq methods. De novo assembly resulted in 18,524 unigenes with an average length of 873 bp from 19 million RNA-seq reads. A Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation tool assigned KO (KEGG orthology) numbers to 6,553 (36.2%) unigenes, among which 4,061 unigenes were mapped into 391 different metabolic pathways. For terpenoid backbone and carotenoid biosynthesis pathways, 44 and 22 unigenes encode enzymes corresponding to 30 and 16 entries, respectively. Twenty-two unigenes encode proteins for 16 entries of the carotenoid biosynthesis pathway. As for the phenylpropanoid and flavonoid biosynthesis pathways, 63 and 24 unigenes were homologous to 17 and 14 entry proteins, respectively. Mining of simple sequence repeat identified 2,599 simple sequence repeats from P. chinensis unigenes. The results of the present study provide a valuable resource for in-depth studies on comparative and functional genomics to unravel the underlying mechanisms of the medicinal properties of Pistacia L.

• 한국주거학회논문집
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• 제20권4호
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• pp.39-47
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• 2009

The purpose of this study is to find out the changes on the metropolitan condominium apartment unit plans based on the interior spaces related to women such An-bang (master bedroom), bathroom and attached spaces to the master bedroom, living room, diningroom, kitchen, utility room, and balcony. This study used the content analysis method and space syntax. Contents were limited to the floor plans with 3 rooms type and about 105 m2 in the Korean apartment encyclopedia. The unit plans of 2,278, built from October 1975 to January 2008, were analyzed and basically SPSS package 16.0 was employed. The results were as followed. 1) Living room was a core space and an increasing tendency. After 2001, the design trend of living room connected with kitchen and dining room, and dining room changed into one space combining with women's working space such kitchen. It meaned women's working activities became into family public activities as to depending open access. 2) Kitchen had a characteristics that was connected to utility room or back balcony, and the number of extra kitchen increased. Also, the size of DK decreased, but utility size little increased. It was showed the characteristic of this space was still for women. 3) An-bang had a little strong characteristics of married coulpe or women's personal space with bathroom or dress room/powder room. 4) In addition, the values of integration and control of living room and DK were highest. It meant these space were centered in unit plans. Next, the An-bang and dress room/powder room were high. Utility room or balcony's were next, and these were women's working space. Therefore, family's public space was most important, and married couple or women's personal and working space were later in planning.